OPUS GENETICS INC IRD
COM · Common Stock · CUSIP 67577R102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDurham, NC
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($50.1k this quarter). Holder counts are more reliable. Shares outstanding: 31.6m as of 2024-11-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.19. Options: 3 managers hold calls ($19.2k notional), 2 hold puts ($2.1k).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 36 |
| Q1 2023 | 42 |
| Q2 2023 | 49 |
| Q3 2023 | 50 |
| Q4 2023 | 50 |
| Q1 2024 | 49 |
| Q2 2024 | 37 |
| Q3 2024 | 39 |
| Q4 2024 | 44 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 20 | 11 |
| Q2 2023 | 31 | 19 |
| Q3 2023 | 21 | 23 |
| Q4 2023 | 25 | 20 |
| Q1 2024 | 21 | 18 |
| Q2 2024 | 10 | 29 |
| Q3 2024 | 12 | 16 |
| Q4 2024 | 21 | 14 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $234.5k | $12.5k | 0.05 |
| Q2 2024 | $3.1k | $3.1k | 1.00 |
| Q3 2024 | $18.5k | $1.0k | 0.06 |
| Q4 2024 | $19.2k | $2.1k | 0.11 |
Biggest buyers
| Voss Capital, LP | New | +191.0k |
| CITADEL ADVISORS LLC | Added | +89.0k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +74.9k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +41.7k |
| Apollon Wealth Management, LLC | New | +28.1k |
| UBS Group AG | Added | +27.0k |
| JANE STREET GROUP, LLC | New | +18.4k |
| Financial Gravity Companies, Inc. | New | +16.6k |
| TWO SIGMA SECURITIES, LLC | New | +16.2k |
| XTX Topco Ltd | Added | +15.7k |
Biggest sellers
| Richmond Brothers, Inc. | Sold out | -155.6k |
| Knoll Capital Management, LLC | Reduced | -100.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Sold out | -49.8k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Reduced | -49.2k |
| MORGAN STANLEY | Reduced | -27.5k |
| Virtu Financial LLC | Sold out | -23.7k |
| PRELUDE CAPITAL MANAGEMENT, LLC | Sold out | -12.1k |
| COMMONWEALTH EQUITY SERVICES, LLC | Sold out | -11.7k |
| Diametric Capital, LP | Reduced | -4.0k |
| BARCLAYS PLC | Sold out | -1.9k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $15.0k12.6k shares |
| GROUP ONE TRADING LLC | New | $4.2k3.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $2.1k1.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PERCEPTIVE ADVISORS LLC 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution new · filed 2026-05-13 | 8.5% |
| Caligan Partners LP 13G · institution -1.2 pts · filed 2026-08-14 | 7.3% |
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 | 6.6% |
| Nantahala Capital Management, LLC 13G · institution -3.5 pts · filed 2026-05-15 | 6.5% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 6.1% |
Fell to 5% or below in the last year: Foundation Fighting Blindness Retinal Degeneration Fund (4.7%, 2026-05-20), BIOS Fund III, LP (4.5%, 2026-05-13)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 3 | $74.1k | 0 | — | — |
| Q2 2024 | 2 | $14.9k | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 2 | $208.9k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-26 | Magrath George Chief Executive Officer | Bought | $98.0k100.0k shares |
| 2024-11-21 | YERXA BENJAMIN R President, director | Bought | $9.8k10.0k shares |
| 2024-11-18 | Magrath George Chief Executive Officer | Bought | $9.9k9.7k shares |
| 2024-11-15 | Magrath George Chief Executive Officer | Bought | $91.2k90.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| BIOS Capital Management, LP 1.26% of their portfolio | 995.2k $1.2m | First filing |
| VANGUARD GROUP INC 0.00% of their portfolio | 992.2k $1.2m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 314.0k $373.7k | Added +41.7k |
| Voss Capital, LP 0.02% of their portfolio | 191.0k $227.2k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 175.8k $209.2k | Added +89.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 145.5k $173.2k | Added +74.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 116.5k $138.6k | Reduced -49.2k |
| BlackRock, Inc. 0.00% of their portfolio | 109.7k $130.6k | Added +398 |
| STATE STREET CORP 0.00% of their portfolio | 70.5k $83.9k | Unchanged |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 48.3k $57.5k | Added +6.0k |
| XTX Topco Ltd 0.00% of their portfolio | 43.6k $51.9k | Added +15.7k |
| Empowered Funds, LLC 0.00% of their portfolio | 42.1k $50.1k | Added +750 |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 33.3k $39.6k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 32.7k $38.9k | Added +27.0k |
| TRUST CO OF TOLEDO NA /OH/ 0.00% of their portfolio | 31.0k $36.8k | Unchanged |
| COMERICA BANK 0.00% of their portfolio | 30.0k $35.7k | Unchanged |
| Diametric Capital, LP 0.02% of their portfolio | 29.3k $34.9k | Reduced -4.0k |
| MORGAN STANLEY 0.00% of their portfolio | 28.6k $34.0k | Reduced -27.5k |
| Apollon Wealth Management, LLC 0.00% of their portfolio | 28.1k $33.4k | New |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 28.0k $33.3k | Added +10.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 27.3k $32.4k | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 25.0k $29.7k | First filing |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 18.4k $21.8k | New |
| Financial Gravity Companies, Inc. 0.00% of their portfolio | 16.6k $19.7k | New |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 16.2k $19.3k | New |
| Bedel Financial Consulting, Inc. 0.00% of their portfolio | 15.0k $18.1k | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 15.0k $17.8k | First filing |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 13.9k $16.5k | Reduced -5 |
| Stokes Family Office, LLC 0.00% of their portfolio | 12.1k $14.4k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 12.0k $14.3k | New |
| Reliant Investment Partners, LLC 0.01% of their portfolio | 10.0k $11.9k | First filing |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 4.1k $4.9k | Added +711 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.8k $3.3k | Reduced -4 |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 2.0k $2.4k | Unchanged |
| EASTERN BANK 0.00% of their portfolio | 1.0k $1.2k | Unchanged |
| CarsonAllaria Wealth Management, Ltd. 0.00% of their portfolio | 1.0k $1.2k | Unchanged |
| MAI Capital Management 0.00% of their portfolio | 999 $1.2k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 242 $288 | Added +40 |
| RICHARDS, MERRILL & PETERSON, INC. 0.00% of their portfolio | 70 $83 | First filing |
| Knoll Capital Management, LLC 0.00% of their portfolio | 45 $53 | Reduced -100.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 27 $0 | Added +22 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 10 $12 | New |
| FMR LLC 0.00% of their portfolio | 1 $1 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |