OPUS GENETICS INC IRD
COM · Common Stock · CUSIP 67577R102
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersDurham, NC
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($147.2k this quarter). Holder counts are more reliable. Shares outstanding: 24.8m as of 2024-03-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.01. Options: 4 managers hold calls ($234.5k notional), 2 hold puts ($12.5k).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 36 |
| Q1 2023 | 42 |
| Q2 2023 | 49 |
| Q3 2023 | 50 |
| Q4 2023 | 50 |
| Q1 2024 | 49 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 19 | 13 |
| Q1 2023 | 20 | 11 |
| Q2 2023 | 31 | 19 |
| Q3 2023 | 21 | 23 |
| Q4 2023 | 25 | 20 |
| Q1 2024 | 21 | 18 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $1.4m | $35.6k | 0.03 |
| Q3 2023 | $238.8k | $80.1k | 0.34 |
| Q4 2023 | $435.3k | $12.0k | 0.03 |
| Q1 2024 | $234.5k | $12.5k | 0.05 |
Biggest buyers
| RENAISSANCE TECHNOLOGIES LLC | Added | +111.1k |
| Empowered Funds, LLC | New | +73.2k |
| VANGUARD GROUP INC | Added | +64.4k |
| CITADEL ADVISORS LLC | Added | +64.3k |
| MORGAN STANLEY | Added | +56.1k |
| MACKENZIE FINANCIAL CORP | New | +40.8k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +36.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +20.4k |
| HRT FINANCIAL LP | New | +19.9k |
| Virtu Financial LLC | New | +17.8k |
Biggest sellers
| RICE HALL JAMES & ASSOCIATES, LLC | Reduced | -279.8k |
| MAI Capital Management | Reduced | -167.9k |
| Squarepoint Ops LLC | Sold out | -61.2k |
| Anson Funds Management LP | Sold out | -49.3k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -49.2k |
| VICTORY CAPITAL MANAGEMENT INC | Sold out | -46.9k |
| JANE STREET GROUP, LLC | Sold out | -34.7k |
| LPL Financial LLC | Sold out | -26.0k |
| Richmond Brothers, Inc. | Reduced | -25.3k |
| Diametric Capital, LP | Reduced | -21.9k |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $209.2k104.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $18.0k9.4k shares |
| CITADEL ADVISORS LLC | Reduced | $7.2k3.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $12.5k6.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PERCEPTIVE ADVISORS LLC 13G · passive investor no change · filed 2026-08-14 | 10.0% |
| Adage Capital Management, L.P. 13G · institution new · filed 2026-05-13 | 8.5% |
| Caligan Partners LP 13G · institution -1.2 pts · filed 2026-08-14 | 7.3% |
| BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 | 6.6% |
| Nantahala Capital Management, LLC 13G · institution -3.5 pts · filed 2026-05-15 | 6.5% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 6.1% |
Fell to 5% or below in the last year: Foundation Fighting Blindness Retinal Degeneration Fund (4.7%, 2026-05-20), BIOS Fund III, LP (4.5%, 2026-05-13)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 2 | $61.1k | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 3 | $74.1k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-03-21 | Jhaveri Nirav S. Chief Financial Officer | Bought | $21.0k10.0k shares |
| 2024-03-21 | SCHACHLE JOSEPH K Chief Operating Officer | Bought | $4.1k2.0k shares |
| 2024-03-18 | Magrath George Chief Executive Officer | Bought | $49.0k25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 992.2k $2.0m | Added +64.4k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.03% of their portfolio | 292.0k $586.9k | Reduced -279.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 234.4k $471.2k | Added +15.3k |
| Richmond Brothers, Inc. 0.85% of their portfolio | 227.5k $457.2k | Reduced -25.3k |
| MAI Capital Management 0.00% of their portfolio | 224.0k $450.2k | Reduced -167.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 209.9k $422.0k | Added +36.6k |
| MORGAN STANLEY 0.00% of their portfolio | 168.3k $338.4k | Added +56.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 135.3k $272.0k | Added +111.1k |
| Knoll Capital Management, LLC 0.13% of their portfolio | 100.0k $201.0k | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 96.7k $194.4k | Added +2.4k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 79.5k $159.9k | Added +64.3k |
| Empowered Funds, LLC 0.00% of their portfolio | 73.2k $147.2k | New |
| STATE STREET CORP 0.00% of their portfolio | 70.5k $141.7k | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 65.9k $132.5k | Added +5.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 51.9k $104.4k | Unchanged |
| Diametric Capital, LP 0.06% of their portfolio | 51.4k $103.3k | Reduced -21.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 42.6k $85.6k | Added +20.4k |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 42.3k $85.1k | Unchanged |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 40.8k $82.0k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 36.6k $73.6k | Reduced -49.2k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 33.3k $66.9k | Unchanged |
| TRUST CO OF TOLEDO NA /OH/ 0.01% of their portfolio | 31.0k $62.2k | Unchanged |
| COMERICA BANK 0.00% of their portfolio | 30.0k $60.3k | Unchanged |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 20.6k $41.4k | Reduced -6.1k |
| HRT FINANCIAL LP 0.00% of their portfolio | 19.9k $39.0k | New |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 18.0k $36.2k | Unchanged |
| Virtu Financial LLC 0.00% of their portfolio | 17.8k $36.0k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 17.4k $35.0k | Added +4.0k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 16.5k $33.2k | Reduced -800 |
| Bedel Financial Consulting, Inc. 0.00% of their portfolio | 15.0k $30.1k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 14.2k $28.6k | Added +8.8k |
| Stokes Family Office, LLC 0.00% of their portfolio | 12.1k $24.4k | Unchanged |
| LINCOLN NATIONAL CORP 0.00% of their portfolio | 11.9k $23.9k | Added +200 |
| Summit Trail Advisors, LLC 0.00% of their portfolio | 10.5k $21.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 7.4k $14.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 3.0k $6.0k | Added +15 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 2.1k $4.0k | Reduced -7.9k |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 2.0k $3.4k | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 1.2k $2.4k | Unchanged |
| TOTH FINANCIAL ADVISORY CORP 0.00% of their portfolio | 1.0k $2.0k | Unchanged |
| OPTIMUM INVESTMENT ADVISORS 0.00% of their portfolio | 1.0k $2.0k | Unchanged |
| CarsonAllaria Wealth Management, Ltd. 0.00% of their portfolio | 1.0k $2.0k | Unchanged |
| LANARK FINANCIAL, INC. 0.00% of their portfolio | 600 $1.0k | Unchanged |
| Towne Trust Company, N.A 0.00% of their portfolio | 500 $1.0k | New |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 40 $80 | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 29 $58 | Unchanged |
| ICA Group Wealth Management, LLC 0.00% of their portfolio | 10 $20 | Reduced -20 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 5 $0 | Reduced -15.6k |
| FSA Wealth Management LLC 0.00% of their portfolio | 5 $10 | Unchanged |