NURIX THERAPEUTICS INC NRIX
COM · Common Stock · CUSIP 67080M103
Company in San Francisco, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBrisbane, CA
- Founded2012
- Websitenurixtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($16.2m this quarter). Holder counts are more reliable. Shares outstanding: 76.4m as of 2025-06-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $11.39. Options: 5 managers hold calls ($1.7m notional), 3 hold puts ($172.7k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 119 |
| Q4 2022 | 120 |
| Q1 2023 | 125 |
| Q2 2023 | 128 |
| Q3 2023 | 131 |
| Q4 2023 | 131 |
| Q1 2024 | 141 |
| Q2 2024 | 176 |
| Q3 2024 | 174 |
| Q4 2024 | 177 |
| Q1 2025 | 172 |
| Q2 2025 | 166 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 54 | 61 |
| Q4 2023 | 65 | 62 |
| Q1 2024 | 70 | 61 |
| Q2 2024 | 111 | 62 |
| Q3 2024 | 92 | 87 |
| Q4 2024 | 92 | 78 |
| Q1 2025 | 92 | 82 |
| Q2 2025 | 92 | 74 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $1.8m | $1.2m | 0.66 |
| Q4 2024 | $7.2m | $822.8k | 0.11 |
| Q1 2025 | $777.4k | $95.9k | 0.12 |
| Q2 2025 | $1.7m | $172.7k | 0.10 |
Biggest buyers
| Point72 Asset Management, L.P. | Added | +3.5m |
| UBS Group AG | Added | +915.9k |
| Vestal Point Capital, LP | Added | +874.4k |
| PERCEPTIVE ADVISORS LLC | Added | +799.4k |
| MORGAN STANLEY | Added | +700.3k |
| Sumitomo Mitsui Trust Group, Inc. | Added | +635.7k |
| Amova Asset Management Americas, Inc. | Added | +633.3k |
| Deep Track Capital, LP | Added | +564.9k |
| Kynam Capital Management, LP | Added | +373.6k |
| Handelsbanken Fonder AB | New | +280.0k |
Biggest sellers
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -1.7m |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -1.3m |
| BlackRock, Inc. | Reduced | -1.2m |
| Driehaus Capital Management LLC | Sold out | -715.9k |
| SAMLYN CAPITAL, LLC | Sold out | -515.1k |
| Boxer Capital Management, LLC | Reduced | -388.1k |
| STATE STREET CORP | Reduced | -329.1k |
| Candriam S.C.A. | Reduced | -326.5k |
| Redmile Group, LLC | Reduced | -319.0k |
| TWINBEECH CAPITAL LP | Sold out | -169.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $976.1k85.7k shares |
| CITADEL ADVISORS LLC | Added | $455.6k40.0k shares |
| GROUP ONE TRADING LLC | Added | $230.1k20.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $59.0k5.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $128.7k11.3k shares |
| SIMPLEX TRADING, LLC | Added | $44.0k3.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-23 | 8.2% |
| Vestal Point Capital, LP 13G · institution +1.5 pts · filed 2026-08-14 | 7.8% |
| Deep Track Capital, LP 13G · passive investor +1.3 pts · filed 2026-08-14 | 7.5% |
| BAKER BROS. ADVISORS LP 13G · institution filed 2026-02-17 | 7.2% |
| Rubric Capital Management LP 13G · institution new · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +1.3 pts · filed 2026-05-06 | 5.4% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor new · filed 2026-09-23 | 5.3% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: Redmile Group, LLC (8.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Commodore Capital LP (4.9%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 3 | $43.9k | — |
| Q4 2023 | 0 | — | 3 | $165.0k | $144.5k |
| Q1 2024 | 0 | — | 3 | $114.3k | $68.3k |
| Q2 2024 | 0 | — | 3 | $602.2k | $543.1k |
| Q3 2024 | 0 | — | 3 | $1.5m | $1.3m |
| Q4 2024 | 0 | — | 3 | $886.4k | $643.6k |
| Q1 2025 | 0 | — | 3 | $504.6k | $311.6k |
| Q2 2025 | 0 | — | 3 | $170.4k | $70.2k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-02 | van Houte Hans Chief Financial Officer | Sold plan | $70.2k6.2k shares |
| 2025-04-30 | Hansen Gwenn Chief Scientific Officer | Sold | $38.8k3.4k shares |
| 2025-04-30 | Ring Christine Chief Legal Officer | Sold | $33.3k2.9k shares |
| 2025-04-30 | van Houte Hans Chief Financial Officer | Sold | $28.0k2.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 10.4m $118.9m | Added +110.3k |
| BlackRock, Inc. 0.00% of their portfolio | 6.8m $77.6m | Reduced -1.2m |
| Deep Track Capital, LP 2.22% of their portfolio | 6.1m $69.1m | Added +564.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.5m $50.9m | Added +50.4k |
| Commodore Capital LP 3.17% of their portfolio | 3.9m $45.0m | Reduced -30.3k |
| BAKER BROS. ADVISORS LP 0.43% of their portfolio | 3.9m $44.2m | Unchanged |
| Redmile Group, LLC 4.53% of their portfolio | 3.7m $42.5m | Reduced -319.0k |
| Point72 Asset Management, L.P. 0.10% of their portfolio | 3.7m $42.2m | Added +3.5m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.0m $34.6m | Added +120.5k |
| STATE STREET CORP 0.00% of their portfolio | 2.5m $28.8m | Reduced -329.1k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 2.5m $28.2m | Added +45.7k |
| Soleus Capital Management, L.P. 1.91% of their portfolio | 2.4m $27.6m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 2.2m $24.7m | Added +700.3k |
| Vestal Point Capital, LP 1.20% of their portfolio | 2.0m $22.8m | Added +874.4k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 2.0m $22.8m | Added +244.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $21.4m | Added +157.6k |
| UBS Group AG 0.00% of their portfolio | 1.6m $18.1m | Added +915.9k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 1.6m $18.1m | Added +271.6k |
| ARK Investment Management LLC 0.13% of their portfolio | 1.6m $17.9m | Reduced -15.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 1.5m $16.7m | Reduced -1.7m |
| Sumitomo Mitsui Trust Group, Inc. 0.01% of their portfolio | 1.4m $15.9m | Added +635.7k |
| Amova Asset Management Americas, Inc. 0.16% of their portfolio | 1.4m $15.8m | Added +633.3k |
| Kynam Capital Management, LP 1.44% of their portfolio | 1.2m $13.4m | Added +373.6k |
| PERCEPTIVE ADVISORS LLC 0.47% of their portfolio | 1.1m $12.5m | Added +799.4k |
| Affinity Asset Advisors, LLC 1.63% of their portfolio | 967.6k $11.0m | Added +157.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 927.6k $10.6m | Added +53.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 653.5k $7.4m | Reduced -46.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 607.1k $6.9m | Added +25.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 584.5k $6.7m | Added +77.0k |
| Artisan Partners Limited Partnership 0.01% of their portfolio | 580.7k $6.6m | Reduced -57.9k |
| WASATCH ADVISORS LP 0.03% of their portfolio | 486.9k $5.5m | Reduced -82.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 427.1k $4.9m | Reduced -148.2k |
| Patient Square Capital LP 1.69% of their portfolio | 412.3k $4.7m | Reduced -35.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 374.9k $4.3m | Added +195.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 368.9k $4.2m | Reduced -11.3k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 356.7k $4.1m | Added +62.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 327.2k $3.7m | Reduced -88.0k |
| ArrowMark Colorado Holdings LLC 0.06% of their portfolio | 314.8k $3.6m | Unchanged |
| Integral Health Asset Management, LLC 0.33% of their portfolio | 310.0k $3.5m | Added +35.0k |
| BESSEMER GROUP INC 0.01% of their portfolio | 306.0k $3.5m | Unchanged |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 284.6k $3.2m | Added +89.2k |
| Handelsbanken Fonder AB 0.01% of their portfolio | 280.0k $3.2m | New |
| Candriam S.C.A. 0.02% of their portfolio | 262.4k $3.0m | Reduced -326.5k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 257.8k $2.9m | Added +52.7k |
| BARCLAYS PLC 0.00% of their portfolio | 254.9k $2.9m | Added +110.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 232.1k $2.6m | Added +72.5k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 230.8k $2.6m | Unchanged |
| WestHill Financial Advisors, Inc. 0.55% of their portfolio | 228.3k $2.6m | Unchanged |
| Parkman Healthcare Partners LLC 0.30% of their portfolio | 228.3k $2.6m | Reduced -122.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 226.5k $2.6m | Added +219.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 224.1k $2.6m | Added +19.0k |
| PRIMECAP MANAGEMENT CO/CA/ 0.00% of their portfolio | 210.0k $2.4m | Reduced -22.0k |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 193.5k $2.2m | Added +174.3k |
| Rhenman & Partners Asset Management AB 0.27% of their portfolio | 185.0k $2.1m | Reduced -64.3k |
| Boxer Capital Management, LLC 1.00% of their portfolio | 175.0k $2.0m | Reduced -388.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 158.7k $1.8m | Reduced -98.8k |
| Polar Asset Management Partners Inc. 0.04% of their portfolio | 154.4k $1.8m | New |
| Nuveen, LLC 0.00% of their portfolio | 152.1k $1.7m | Reduced -17.1k |
| Invesco Ltd. 0.00% of their portfolio | 137.3k $1.6m | Added +19.6k |
| Swiss National Bank 0.00% of their portfolio | 131.0k $1.5m | Added +14.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 125.2k $1.4m | Added +14.7k |
| Bollard Group LLC 0.03% of their portfolio | 122.8k $1.4m | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.04% of their portfolio | 117.3k $1.3m | Reduced -28.2k |
| Cinctive Capital Management LP 0.07% of their portfolio | 116.1k $1.3m | Added +77.4k |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 114.5k $1.3m | New |
| Baird Financial Group, Inc. 0.00% of their portfolio | 110.0k $1.3m | New |
| Woodline Partners LP 0.01% of their portfolio | 100.3k $1.1m | Added +67 |
| Jasper Ridge Partners, L.P. 0.03% of their portfolio | 95.7k $1.1m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 93.4k $1.1m | Reduced -996 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 90.9k $1.0m | Reduced -14.8k |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group 0.61% of their portfolio | 85.0k $968.1k | Unchanged |
| NEOS Investment Management LLC 0.01% of their portfolio | 81.1k $923.9k | Added +22.0k |
| Tema ETFs LLC 0.25% of their portfolio | 81.1k $923.9k | Added +22.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 76.5k $871.0k | Reduced -8.2k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 75.7k $862.5k | Reduced -34.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 70.9k $807.1k | Added +9.4k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 70.7k $804.9k | Added +60.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 67.0k $763.1k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 63.3k $721.2k | Unchanged |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 62.9k $716.1k | New |
| Legal & General Group Plc 0.00% of their portfolio | 62.4k $711.0k | Added +3.8k |
| Walleye Capital LLC 0.01% of their portfolio | 62.3k $709.6k | Reduced -11.8k |
| Polymer Capital Management (HK) LTD 0.11% of their portfolio | 58.9k $670.8k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 58.7k $669.1k | Reduced -24.9k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 52.7k $600.1k | Unchanged |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 52.3k $596.1k | Reduced -6.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 52.1k $593.8k | Added +9.3k |
| Trexquant Investment LP 0.01% of their portfolio | 51.5k $587.0k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 50.5k $575.0k | Added +4.8k |
| AlphaQuest LLC 0.05% of their portfolio | 46.3k $527.0k | Added +43.7k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 45.2k $515.0k | Added +3.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 45.0k $513.5k | Reduced -4.8k |
| CITIGROUP INC 0.00% of their portfolio | 43.7k $498.1k | Reduced -96.7k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 43.5k $496.0k | Added +538 |
| TD Asset Management Inc 0.00% of their portfolio | 42.4k $483.2k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 42.4k $482.4k | Reduced -14.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 42.2k $480.5k | Added +11.5k |
| Verition Fund Management LLC 0.00% of their portfolio | 41.9k $477.5k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 37.2k $423.9k | Added +5.6k |
| Engineers Gate Manager LP 0.00% of their portfolio | 34.3k $390.4k | Reduced -18.3k |