Vault-13

NUVALENT INC

COM · CUSIP 670703107

211 institutional holders +3 vs Q1 2025
71,918,30671.9m shares reported held*
$5.5bnreported value*
28 new 94 added 55 reduced 26 sold out net sold ≈ $15.3m (-246.8k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.0m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $76.30. Options: 10 managers hold calls ($22.9m notional), 9 hold puts ($24.5m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 60Q4 22: 97Q1 23: 90Q2 23: 112Q3 23: 117Q4 23: 157Q1 24: 182Q2 24: 174Q3 24: 196Q4 24: 219Q1 25: 208Q2 25: 211211Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 202260
Q4 202297
Q1 202390
Q2 2023112
Q3 2023117
Q4 2023157
Q1 2024182
Q2 2024174
Q3 2024196
Q4 2024219
Q1 2025208
Q2 2025211

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 72 bought or addedQ3 23: 41 cut or sold outQ4 23: 113 bought or addedQ4 23: 31 cut or sold outQ4 23Q1 24: 101 bought or addedQ1 24: 77 cut or sold outQ2 24: 93 bought or addedQ2 24: 88 cut or sold outQ2 24Q3 24: 115 bought or addedQ3 24: 79 cut or sold outQ4 24: 132 bought or addedQ4 24: 75 cut or sold outQ4 24Q1 25: 101 bought or addedQ1 25: 108 cut or sold outQ2 25: 122 bought or addedQ2 25: 81 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20237241
Q4 202311331
Q1 202410177
Q2 20249388
Q3 202411579
Q4 202413275
Q1 2025101108
Q2 202512281

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60m$80mQ3 24 calls: $46.7mQ3 24 puts: $68.5mQ3 24P/C 1.47Q4 24 calls: $66.0mQ4 24 puts: $39.0mQ4 24P/C 0.59Q1 25 calls: $23.4mQ1 25 puts: $16.1mQ1 25P/C 0.69Q2 25 calls: $22.9mQ2 25 puts: $24.5mQ2 25P/C 1.07
Numbers
QuarterCallsPutsP/C
Q3 2024$46.7m$68.5m1.47
Q4 2024$66.0m$39.0m0.59
Q1 2025$23.4m$16.1m0.69
Q2 2025$22.9m$24.5m1.07

Biggest buyers

JPMORGAN CHASE & CO Added +1,095,196+1.1m
T. Rowe Price Investment Management, Inc. Added +643,794+643.8k
JANUS HENDERSON GROUP PLC Added +472,385+472.4k
PRICE T ROWE ASSOCIATES INC /MD/ Added +344,771+344.8k
BRAIDWELL LP Added +334,931+334.9k
BlackRock, Inc. Added +297,895+297.9k
NORGES BANK Added +242,979+243.0k
AMERIPRISE FINANCIAL INC Added +204,002+204.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +180,500+180.5k
BAKER BROS. ADVISORS LP New +143,937+143.9k

Biggest sellers

Logos Global Management LP Sold out -500,000-500.0k
Commodore Capital LP Reduced -480,000-480.0k
Boxer Capital Management, LLC Sold out -450,000-450.0k
MARSHALL WACE, LLP Reduced -360,027-360.0k
Rock Springs Capital Management LP Reduced -334,204-334.2k
Driehaus Capital Management LLC Reduced -314,788-314.8k
SAMLYN CAPITAL, LLC Sold out -309,594-309.6k
Woodline Partners LP Reduced -301,299-301.3k
PERCEPTIVE ADVISORS LLC Reduced -258,788-258.8k
SILVERARC CAPITAL MANAGEMENT, LLC Reduced -203,435-203.4k

Biggest calls

JANE STREET GROUP, LLC Reduced $8.1m105.8k shares
SILVERARC CAPITAL MANAGEMENT, LLC New $7.6m100.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $2.0m25.8k shares
CITIGROUP INC New $1.8m23.4k shares
CITADEL ADVISORS LLC Reduced $1.5m19.4k shares
BARCLAYS PLC New $824.0k10.8k shares
GROUP ONE TRADING LLC Added $534.1k7.0k shares
SIG BROKERAGE, LP New $465.4k6.1k shares
SIMPLEX TRADING, LLC Reduced $99.0k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $7.4m96.9k shares
Caption Management, LLC Added $5.6m74.0k shares
JANE STREET GROUP, LLC Added $4.4m57.2k shares
CITADEL ADVISORS LLC Reduced $4.1m54.1k shares
CITIGROUP INC New $1.8m23.4k shares
JPMORGAN CHASE & CO Unchanged $1.1m14.3k shares
SIMPLEX TRADING, LLC Reduced $114.0k1.5k shares
GROUP ONE TRADING LLC Unchanged $7.6k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

No one currently above 5% in the filings since 19 Dec 2024.

Fell to 5% or below in the last year: Flynn James E (0.0%, 2026-07-17), FMR LLC (1.9%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-27)

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 DEERFIELD MANAGEMENT COMPANY, L.P. 24.91% of their portfolio New York, NY 17,991,02418.0m $1.4bn $1.4bn 24.91% Unchanged
2 FMR LLC 0.04% of their portfolio BOSTON, MA 9,968,84610.0m $760.6m $760.6m 0.04% Added +31.7k +31,653
3 Paradigm Biocapital Advisors LP 17.17% of their portfolio NEW YORK, NY 5,269,4335.3m $402.1m $402.1m 17.17% Unchanged
4 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 4,524,1244.5m $345.2m $345.2m 0.01% Added +84.3k +84,286
5 BlackRock, Inc. 0.01% of their portfolio New York, NY 4,046,2564.0m $308.7m $308.7m 0.01% Added +297.9k +297,895
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 1,795,3731.8m $137.0m $137.0m 0.02% Added +344.8k +344,771
7 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 1,782,5811.8m $136.1m $136.1m 0.07% Added +472.4k +472,385
8 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 1,576,3741.6m $120.3m $120.3m 0.02% Added +134.0k +133,990
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,490,2791.5m $113.7m $113.7m 0.00% Added +59.6k +59,620
10 Bain Capital Life Sciences Investors, LLC 13.82% of their portfolio Boston, MA 1,447,2671.4m $110.4m $110.4m 13.82% Unchanged
11 PERCEPTIVE ADVISORS LLC 3.94% of their portfolio NEW YORK, NY 1,375,1801.4m $104.9m $104.9m 3.94% Reduced -258.8k -258,788
12 Commodore Capital LP 7.41% of their portfolio NEW YORK, NY 1,375,0001.4m $104.9m $104.9m 7.41% Reduced -480.0k -480,000
13 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,197,1871.2m $91.3m $91.3m 0.01% Added +1.1m +1,095,196
14 BRAIDWELL LP 3.07% of their portfolio STAMFORD, CT 1,175,8761.2m $89.7m $89.7m 3.07% Added +334.9k +334,931
15 T. Rowe Price Investment Management, Inc. 0.05% of their portfolio BALTIMORE, MD 1,094,5681.1m $83.5m $83.5m 0.05% Added +643.8k +643,794
16 Vestal Point Capital, LP 4.32% of their portfolio NEW YORK, NY 1,075,0001.1m $82.0m $82.0m 4.32% Unchanged
17 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 996,845996.8k $76.1m $76.1m 0.01% Added +103.4k +103,389
18 Woodline Partners LP 0.36% of their portfolio San Francisco, CA 904,232904.2k $69.0m $69.0m 0.36% Reduced -301.3k -301,299
19 Polar Capital Holdings Plc 0.33% of their portfolio London, X0 816,087816.1k $62.3m $62.3m 0.33% Reduced -130.6k -130,636
20 Fairmount Funds Management LLC 7.19% of their portfolio WEST CONSHOHOCKEN, PA 727,563727.6k $55.5m $55.5m 7.19% Unchanged
21 Pictet Asset Management Holding SA 0.05% of their portfolio CAROUGE, V8 589,832589.8k $45.0m $45.0m 0.05% Added +35.7k +35,691
22 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio Boston, MA 577,500577.5k $44.1m $44.1m 0.07% Added +180.5k +180,500
23 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 535,445535.4k $40.9m $40.9m 0.01% Added +81.8k +81,825
24 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 484,343484.3k $37.0m $37.0m 0.01% Added +204.0k +204,002
25 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 422,722422.7k $32.3m $32.3m 0.00% Added +74.6k +74,642
26 Affinity Asset Advisors, LLC 4.68% of their portfolio NEW YORK, NY 415,000415.0k $31.7m $31.7m 4.68% Reduced -45.0k -45,000
27 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 374,698374.7k $28.6m $28.6m 0.02% Added +92.7k +92,652
28 NORGES BANK 0.00% of their portfolio OSLO, Q8 374,597374.6k $28.6m $28.6m 0.00% Added +243.0k +242,979
29 ArrowMark Colorado Holdings LLC 0.51% of their portfolio Denver, CO 369,858369.9k $28.2m $28.2m 0.51% Added +78.8k +78,754
30 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 346,506346.5k $26.4m $26.4m 0.00% Added +28.7k +28,742
31 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 341,774341.8k $26.1m $26.1m 0.00% Added +13.4k +13,443
32 First Turn Management, LLC 4.57% of their portfolio DEL MAR, CA 320,798320.8k $24.5m $24.5m 4.57% Reduced -11.1k -11,129
33 Candriam S.C.A. 0.13% of their portfolio STRASSEN, N4 301,259301.3k $23.0m $23.0m 0.13% Reduced -52.9k -52,870
34 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 257,940257.9k $19.7m $19.7m 0.00% Added +37.9k +37,924
35 SILVERARC CAPITAL MANAGEMENT, LLC 3.68% of their portfolio BOSTON, MA 235,583235.6k $18.0m $18.0m 3.68% Reduced -203.4k -203,435
36 Driehaus Capital Management LLC 0.13% of their portfolio Chicago, IL 216,422216.4k $16.5m $16.5m 0.13% Reduced -314.8k -314,788
37 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 169,539169.5k $12.9m $12.9m 0.00% Added +19.6k +19,598
38 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 159,630159.6k $12.2m $12.2m 0.00% Unchanged
39 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 156,788156.8k $12.0m $12.0m 0.01% Added +25.8k +25,827
40 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.05% of their portfolio SAN FRANCISCO, CA 150,000150.0k $11.4m $11.4m 0.05% Unchanged
41 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 149,606149.6k $11.4m $11.4m 0.00% Added +53.6k +53,569
42 BAKER BROS. ADVISORS LP 0.11% of their portfolio NEW YORK, NY 143,937143.9k $11.0m $11.0m 0.11% New
43 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 143,375143.4k $10.9m $10.9m 0.00% Added +28.5k +28,549
44 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 139,193139.2k $10.6m $10.6m 0.01% Reduced -97.7k -97,701
45 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 138,969139.0k $10.6m $10.6m 0.00% Added +5.9k +5,875
46 UBS Group AG 0.00% of their portfolio ZURICH, V8 136,744136.7k $10.4m $10.4m 0.00% Added +27.3k +27,265
47 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 135,613135.6k $10.3m $10.3m 0.01% Added +76.8k +76,834
48 Soleus Capital Management, L.P. 0.66% of their portfolio GREENWICH, CT 125,000125.0k $9.5m $9.5m 0.66% Reduced -89.4k -89,357
49 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 123,219123.2k $9.4m $9.4m 0.01% Reduced -117.4k -117,403
50 Parkman Healthcare Partners LLC 1.06% of their portfolio STAMFORD, CT 119,623119.6k $9.1m $9.1m 1.06% Added +9.6k +9,635
51 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 114,761114.8k $8.8m $8.8m 0.00% Reduced -6.6k -6,577
52 Nicholas Investment Partners, LP 0.70% of their portfolio RANCHO SANTA FE, CA 103,722103.7k $7.9m $7.9m 0.70% Reduced -3.0k -2,997
53 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 98,90098.9k $7.5m $7.5m 0.01% Added +31.8k +31,822
54 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 94,84094.8k $7.2m $7.2m 0.01% Reduced -33.6k -33,576
55 Rock Springs Capital Management LP 0.44% of their portfolio Baltimore, MD 93,32893.3k $7.1m $7.1m 0.44% Reduced -334.2k -334,204
56 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 92,77392.8k $7.1m $7.1m 0.00% Added +8.8k +8,797
57 FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 91,43991.4k $7.0m $7.0m 0.03% Reduced -96.5k -96,463
58 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 81,60981.6k $6.2m $6.2m 0.01% Reduced -28.7k -28,747
59 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 80,71080.7k $6.2m $6.2m 0.00% Added +78.7k +78,664
60 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 79,38179.4k $6.1m $6.1m 0.02% Reduced -167.7k -167,665
61 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 76,68876.7k $5.9m $5.9m 0.01% Unchanged
62 Tri Locum Partners LP 1.76% of their portfolio NEW YORK, NY 75,97376.0k $5.8m $5.8m 1.76% Reduced -19.9k -19,852
63 Swiss National Bank 0.00% of their portfolio ZURICH, V8 75,80075.8k $5.8m $5.8m 0.00% Added +5.9k +5,900
64 Schonfeld Strategic Advisors LLC 0.04% of their portfolio NEW YORK, NY 75,34875.3k $5.7m $5.7m 0.04% Reduced -109.5k -109,453
65 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 72,69272.7k $5.5m $5.5m 0.01% Added +23.7k +23,736
66 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 66,19566.2k $5.1m $5.1m 0.00% Added +6.7k +6,746
67 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 66,02966.0k $5.0m $5.0m 0.00% Added +13.0k +13,003
68 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 63,84063.8k $4.9m $4.9m 0.00% Added +26.4k +26,440
69 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 61,48661.5k $4.7m $4.7m 0.01% Reduced -360.0k -360,027
70 STEMPOINT CAPITAL LP 1.47% of their portfolio NEW YORK, NY 59,82859.8k $4.6m $4.6m 1.47% Reduced -130.6k -130,573
71 Man Group plc 0.01% of their portfolio LONDON, X0 54,73254.7k $4.2m $4.2m 0.01% Reduced -20.4k -20,424
72 Rhenman & Partners Asset Management AB 0.51% of their portfolio Stockholm, V7 52,50052.5k $4.0m $4.0m 0.51% Unchanged
73 HighVista Strategies LLC 1.41% of their portfolio BOSTON, MA 50,46050.5k $3.9m $3.9m 1.41% Added +10.6k +10,584
74 TANG CAPITAL MANAGEMENT LLC 0.19% of their portfolio SAN DIEGO, CA 50,00050.0k $3.8m $3.8m 0.19% Unchanged
75 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 50,00050.0k $3.8m $3.8m 0.01% Reduced -1.3k -1,303
76 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 49,94049.9k $3.8m $3.8m 0.00% Added +10.3k +10,320
77 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 48,38348.4k $3.7m $3.7m 0.01% Reduced -2.8k -2,809
78 Legal & General Group Plc 0.00% of their portfolio London, X0 44,83744.8k $3.4m $3.4m 0.00% Added +3.5k +3,531
79 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 42,97543.0k $3.3m $3.3m 0.00% Added +21.5k +21,518
80 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 40,18340.2k $3.1m $3.1m 0.00% Added +7.3k +7,339
81 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 38,03838.0k $2.9m $2.9m 0.00% Reduced -27.6k -27,636
82 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 35,78235.8k $2.7m $2.7m 0.02% New
83 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio CAUSEWAY BAY, K3 34,00034.0k $2.6m $2.6m 0.01% Added +3.2k +3,178
84 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 33,71433.7k $2.6m $2.6m 0.00% Added +23.8k +23,840
85 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 33,34733.3k $2.5m $2.5m 0.00% Added +6.8k +6,820
86 NEOS Investment Management LLC 0.03% of their portfolio Westport, CT 31,76231.8k $2.4m $2.4m 0.03% Reduced -2.0k -2,032
87 Tema ETFs LLC 0.64% of their portfolio New York, NY 31,76231.8k $2.4m $2.4m 0.64% Reduced -2.0k -2,032
88 Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio FRANKFURT AM MAIN, 2M 30,56730.6k $2.3m $2.3m 0.00% Reduced -14.7k -14,688
89 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 29,96630.0k $2.3m $2.3m 0.00% Added +2.4k +2,403
90 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 29,20029.2k $2.2m $2.2m 0.00% Added +500 +500
91 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 27,55627.6k $2.1m $2.1m 0.01% Reduced -13.1k -13,118
92 Aquatic Capital Management LLC 0.04% of their portfolio CHICAGO, IL 27,54527.5k $2.1m $2.1m 0.04% Reduced -7.0k -7,031
93 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 25,72025.7k $2.0m $2.0m 0.01% Added +928 +928
94 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 25,70625.7k $2.0m $2.0m 0.01% Added +4.9k +4,943
95 Atom Investors LP 0.16% of their portfolio AUSTIN, TX 24,16024.2k $1.8m $1.8m 0.16% Reduced -24.8k -24,775
96 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 23,73623.7k $1.8m $1.8m 0.00% Added +2.8k +2,800
97 READYSTATE ASSET MANAGEMENT LP 0.07% of their portfolio CHICAGO, IL 23,58823.6k $1.8m $1.8m 0.07% New
98 NATIXIS 0.01% of their portfolio PARIS, I0 22,92022.9k $1.7m $1.7m 0.01% New
99 INTECH INVESTMENT MANAGEMENT LLC 0.02% of their portfolio WEST PALM BEACH, FL 22,88622.9k $1.7m $1.7m 0.02% Added +3.6k +3,624
100 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 22,36222.4k $1.7m $1.7m 0.00% Reduced -1.9k -1,922