NEUROCRINE BIOSCIENCES INC NBIX
COM · Common Stock · CUSIP 64125C109 · ISIN US64125C1099
American biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded1992
- Websiteneurocrine.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($55.0m this quarter). Holder counts are more reliable. Shares outstanding: 100.5m as of 2026-04-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $131.55. Options: 12 managers hold calls ($39.1m notional), 12 hold puts ($69.0m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 466 |
| Q4 2022 | 530 |
| Q1 2023 | 488 |
| Q2 2023 | 457 |
| Q3 2023 | 514 |
| Q4 2023 | 555 |
| Q1 2024 | 591 |
| Q2 2024 | 595 |
| Q3 2024 | 576 |
| Q4 2024 | 601 |
| Q1 2025 | 587 |
| Q2 2025 | 587 |
| Q3 2025 | 650 |
| Q4 2025 | 732 |
| Q1 2026 | 699 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 325 | 257 |
| Q3 2024 | 296 | 286 |
| Q4 2024 | 292 | 284 |
| Q1 2025 | 253 | 334 |
| Q2 2025 | 295 | 291 |
| Q3 2025 | 332 | 268 |
| Q4 2025 | 379 | 265 |
| Q1 2026 | 375 | 323 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $37.7m | $27.0m | 0.72 |
| Q3 2025 | $33.1m | $67.7m | 2.05 |
| Q4 2025 | $41.3m | $71.6m | 1.74 |
| Q1 2026 | $39.1m | $69.0m | 1.77 |
Biggest buyers
| TWO SIGMA INVESTMENTS, LP | Added | +2.1m |
| AQR CAPITAL MANAGEMENT LLC | Added | +1.7m |
| Vestal Point Capital, LP | New | +1.2m |
| MILLENNIUM MANAGEMENT LLC | Added | +804.6k |
| VICTORY CAPITAL MANAGEMENT INC | Added | +607.0k |
| BlackRock, Inc. | Added | +555.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +485.3k |
| FIRST TRUST ADVISORS LP | Added | +472.4k |
| Squarepoint Ops LLC | Added | +278.2k |
| JPMORGAN CHASE & CO | Added | +241.7k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -1.7m |
| Bellevue Group AG | Reduced | -1.7m |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Reduced | -1.1m |
| TWO SIGMA ADVISERS, LP | Sold out | -842.6k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -574.3k |
| Zurich Insurance Group Ltd/FI | Sold out | -459.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Sold out | -360.7k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -355.0k |
| ORBIMED ADVISORS LLC | Sold out | -314.2k |
| PERCEPTIVE ADVISORS LLC | Reduced | -266.0k |
Biggest calls
| JANE STREET GROUP, LLC | Reduced | $10.6m80.6k shares |
| JPMORGAN CHASE & CO | Added | $10.4m81.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.5m33.8k shares |
| Caption Management, LLC | Reduced | $4.0m30.0k shares |
| CITIGROUP INC | Reduced | $2.4m18.0k shares |
| Twin Tree Management, LP | Added | $2.3m17.3k shares |
| CITADEL ADVISORS LLC | Reduced | $1.8m13.8k shares |
| IMC-Chicago, LLC | New | $1.6m12.2k shares |
| Walleye Trading LLC | Added | $1.1m8.0k shares |
| Jefferies Financial Group Inc. | New | $329.4k2.5k shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $23.9m181.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $19.2m145.4k shares |
| JPMORGAN CHASE & CO | Added | $10.4m81.0k shares |
| Caption Management, LLC | New | $4.0m30.0k shares |
| CITIGROUP INC | Reduced | $2.4m18.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.2m16.4k shares |
| IMC-Chicago, LLC | Added | $2.0m15.0k shares |
| GOLDMAN SACHS GROUP INC | Added | $1.8m13.7k shares |
| SIG BROKERAGE, LP | New | $1.3m9.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.1m8.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 12.1% |
| DODGE & COX 13G · institution new · filed 2025-05-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution -1.1 pts · filed 2026-10-15 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 8 | $14.5m | $14.5m |
| Q3 2024 | 0 | — | 7 | $12.9m | $10.9m |
| Q4 2024 | 0 | — | 3 | $626.4k | $626.4k |
| Q1 2025 | 0 | — | 11 | $38.7m | $38.7m |
| Q2 2025 | 0 | — | 2 | $4.5m | $4.5m |
| Q3 2025 | 0 | — | 3 | $24.0m | $24.0m |
| Q4 2025 | 0 | — | 6 | $8.9m | $8.8m |
| Q1 2026 | 0 | — | 1 | $4.8m | $4.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-01-16 | Gano Kyle Chief Executive Officer, director | Sold plan | $4.8m36.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.03% of their portfolio | 13.4m $1.8bn | Added +555.0k |
| Dodge & Cox 0.40% of their portfolio | 5.5m $719.4m | Reduced -47.0k |
| JPMORGAN CHASE & CO 0.05% of their portfolio | 5.4m $700.5m | Added +241.7k |
| AQR CAPITAL MANAGEMENT LLC 0.30% of their portfolio | 4.9m $650.7m | Added +1.7m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.03% of their portfolio | 4.7m $622.6m | First filing |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 4.5m $594.4m | First filing |
| STATE STREET CORP 0.02% of their portfolio | 4.4m $573.7m | Added +111.8k |
| TWO SIGMA INVESTMENTS, LP 0.33% of their portfolio | 3.1m $403.2m | Added +2.1m |
| RENAISSANCE TECHNOLOGIES LLC 0.50% of their portfolio | 2.4m $318.7m | Added +180.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 2.1m $280.8m | Added +77.4k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.23% of their portfolio | 1.5m $196.8m | Added +97.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 1.4m $183.1m | Reduced -355.0k |
| Vestal Point Capital, LP 4.60% of their portfolio | 1.2m $164.7m | New |
| MILLENNIUM MANAGEMENT LLC 0.12% of their portfolio | 1.2m $164.3m | Added +804.6k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 1.2m $163.7m | Added +21.6k |
| UBS Group AG 0.03% of their portfolio | 1.2m $160.9m | Added +237.5k |
| MORGAN STANLEY 0.01% of their portfolio | 1.2m $160.6m | Added +9.8k |
| RTW INVESTMENTS, LP 1.39% of their portfolio | 1.1m $139.9m | Unchanged |
| FIRST TRUST ADVISORS LP 0.09% of their portfolio | 959.2k $126.4m | Added +472.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 902.8k $118.9m | Added +52.2k |
| IEQ CAPITAL, LLC 0.47% of their portfolio | 766.0k $100.9m | Added +20.9k |
| VICTORY CAPITAL MANAGEMENT INC 0.06% of their portfolio | 731.6k $96.4m | Added +607.0k |
| ARMISTICE CAPITAL, LLC 3.15% of their portfolio | 724.0k $95.4m | Reduced -96.2k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 711.8k $93.8m | Reduced -4.7k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 702.5k $92.5m | Reduced -36.2k |
| BRAIDWELL LP 2.87% of their portfolio | 652.1k $85.9m | Reduced -99.4k |
| Fiera Capital Corp 0.29% of their portfolio | 651.3k $85.8m | Added +13.8k |
| VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio | 634.3k $83.6m | First filing |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 611.3k $80.5m | Added +78.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.95% of their portfolio | 610.0k $80.4m | Reduced -574.3k |
| Pictet Asset Management Holding SA 0.08% of their portfolio | 602.6k $78.9m | Reduced -174.3k |
| RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio | 601.5k $78.3m | Reduced -29.9k |
| GW&K Investment Management, LLC 0.69% of their portfolio | 593.7k $78.2m | Added +17.1k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 583.8k $76.9m | Added +55.7k |
| Swedbank AB 0.08% of their portfolio | 579.4k $76.3m | Reduced -4.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 571.7k $75.3m | Reduced -150.8k |
| ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio | 523.5k $74.3m | Reduced -32.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.29% of their portfolio | 520.3k $68.5m | Added +485.3k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 512.0k $67.5m | Reduced -73.6k |
| MARSHALL WACE, LLP 0.07% of their portfolio | 509.0k $67.1m | Added +160.1k |
| PRIMECAP MANAGEMENT CO/CA/ 0.05% of their portfolio | 496.3k $65.4m | Reduced -11.4k |
| Squarepoint Ops LLC 0.14% of their portfolio | 488.0k $64.3m | Added +278.2k |
| JANUS HENDERSON GROUP PLC 0.03% of their portfolio | 467.0k $61.5m | Added +7.8k |
| Nuveen, LLC 0.02% of their portfolio | 443.1k $58.4m | Added +156.3k |
| Man Group plc 0.11% of their portfolio | 415.9k $54.8m | Added +184.7k |
| Hood River Capital Management LLC 0.53% of their portfolio | 404.4k $53.3m | Added +15.1k |
| Hudson Bay Capital Management LP 0.31% of their portfolio | 395.9k $52.1m | Added +90.8k |
| Legal & General Group Plc 0.01% of their portfolio | 380.6k $50.1m | Added +50.0k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 365.3k $48.1m | Reduced -2.6k |
| Gotham Asset Management, LLC 0.15% of their portfolio | 360.1k $47.4m | Added +191.6k |
| Invesco Ltd. 0.00% of their portfolio | 356.0k $46.9m | Added +12.6k |
| ACADIAN ASSET MANAGEMENT LLC 0.07% of their portfolio | 350.7k $46.2m | Added +101.6k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 349.2k $46.0m | Reduced -15.4k |
| Allspring Global Investments Holdings, LLC 0.07% of their portfolio | 332.4k $44.1m | Reduced -7.0k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 332.3k $43.8m | Added +21.3k |
| Clearbridge Investments, LLC 0.04% of their portfolio | 310.0k $40.8m | Reduced -42 |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 303.8k $40.0m | Added +6.4k |
| Swiss National Bank 0.02% of their portfolio | 292.6k $38.5m | Added +20.8k |
| Rockefeller Capital Management L.P. 0.07% of their portfolio | 282.1k $37.2m | Added +777 |
| Candriam S.C.A. 0.19% of their portfolio | 275.1k $36.2m | Reduced -18.0k |
| RENAISSANCE GROUP LLC 1.36% of their portfolio | 246.4k $32.5m | Reduced -5.9k |
| BARCLAYS PLC 0.01% of their portfolio | 244.0k $32.1m | Reduced -8.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 238.2k $31.4m | Added +11.8k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.12% of their portfolio | 237.9k $31.3m | Added +149.7k |
| SEI INVESTMENTS CO 0.03% of their portfolio | 235.3k $31.0m | Added +55.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 233.5k $30.8m | Added +19.5k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 231.3k $30.5m | Reduced -10.8k |
| PRUDENTIAL FINANCIAL INC 0.04% of their portfolio | 225.1k $29.6m | Added +95.9k |
| California Public Employees Retirement System 0.02% of their portfolio | 222.4k $29.3m | Added +25.6k |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 220.4k $29.0m | Added +17.8k |
| Russell Investments Group, Ltd. 0.03% of their portfolio | 219.8k $28.9m | Added +95.0k |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 218.7k $28.8m | Added +12.0k |
| PFM Health Sciences, LP 2.99% of their portfolio | 215.7k $28.4m | Added +52.5k |
| Defilade Capital Management, L.P. 3.88% of their portfolio | 209.9k $27.7m | New |
| Amundi 0.01% of their portfolio | 203.6k $26.8m | Added +37.3k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.04% of their portfolio | 195.7k $25.8m | Reduced -60.3k |
| Handelsbanken Fonder AB 0.08% of their portfolio | 187.9k $24.8m | Reduced -13.0k |
| Carmignac Gestion 0.38% of their portfolio | 186.0k $24.5m | Added +122.4k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 184.2k $24.3m | Added +47.6k |
| Susquehanna Portfolio Strategies, LLC 0.36% of their portfolio | 184.0k $24.2m | Unchanged |
| Trexquant Investment LP 0.17% of their portfolio | 183.3k $24.1m | Added +46.1k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 181.5k $23.9m | Added +14.2k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.17% of their portfolio | 175.0k $23.1m | Added +27.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 174.8k $23.0m | Unchanged |
| Pacer Advisors, Inc. 0.06% of their portfolio | 169.2k $22.3m | Added +139.6k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 165.7k $21.8m | Reduced -3.5k |
| Mariner, LLC 0.02% of their portfolio | 160.9k $21.2m | Added +64.9k |
| FMR LLC 0.00% of their portfolio | 154.9k $20.4m | Added +84.4k |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 153.8k $20.3m | Reduced -92.5k |
| PANAGORA ASSET MANAGEMENT INC 0.07% of their portfolio | 151.4k $20.0m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 151.3k $19.9m | Reduced -1.7m |
| Rock Springs Capital Management LP 1.17% of their portfolio | 150.4k $19.8m | Added +24.9k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 150.3k $19.8m | Reduced -8.2k |
| Integral Health Asset Management, LLC 1.05% of their portfolio | 150.0k $19.8m | Unchanged |
| CAPITAL FUND MANAGEMENT S.A. 0.18% of their portfolio | 149.6k $19.7m | Added +69.5k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.08% of their portfolio | 149.1k $19.6m | Reduced -1.1m |
| Andra AP-fonden 0.23% of their portfolio | 148.2k $19.5m | Added +80.3k |
| Bridgewater Associates, LP 0.09% of their portfolio | 148.1k $19.5m | Reduced -1.8k |
| Cerity Partners LLC 0.03% of their portfolio | 144.5k $19.0m | Added +10.8k |
| DNB Asset Management AS 0.07% of their portfolio | 141.2k $18.6m | Added +1.8k |