NEUROCRINE BIOSCIENCES INC NBIX
COM · Common Stock · CUSIP 64125C109 · ISIN US64125C1099
American biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded1992
- Websiteneurocrine.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($42.6m this quarter). Holder counts are more reliable. Shares outstanding: 99.7m as of 2025-10-21, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $140.11. Options: 9 managers hold calls ($33.1m notional), 10 hold puts ($67.7m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 466 |
| Q4 2022 | 530 |
| Q1 2023 | 488 |
| Q2 2023 | 457 |
| Q3 2023 | 514 |
| Q4 2023 | 555 |
| Q1 2024 | 591 |
| Q2 2024 | 595 |
| Q3 2024 | 576 |
| Q4 2024 | 601 |
| Q1 2025 | 587 |
| Q2 2025 | 587 |
| Q3 2025 | 650 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 270 | 242 |
| Q1 2024 | 310 | 256 |
| Q2 2024 | 325 | 257 |
| Q3 2024 | 296 | 286 |
| Q4 2024 | 292 | 284 |
| Q1 2025 | 253 | 334 |
| Q2 2025 | 295 | 291 |
| Q3 2025 | 332 | 268 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $48.0m | $44.2m | 0.92 |
| Q1 2025 | $92.7m | $64.6m | 0.70 |
| Q2 2025 | $37.7m | $27.0m | 0.72 |
| Q3 2025 | $33.1m | $67.7m | 2.05 |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +5.2m |
| AQR CAPITAL MANAGEMENT LLC | Added | +1.3m |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Added | +458.1k |
| TWO SIGMA INVESTMENTS, LP | New | +347.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Added | +286.5k |
| Hood River Capital Management LLC | Added | +244.0k |
| Balyasny Asset Management L.P. | New | +203.4k |
| PERCEPTIVE ADVISORS LLC | Added | +195.0k |
| JANE STREET GROUP, LLC | Added | +192.1k |
| First Turn Management, LLC | New | +181.9k |
Biggest sellers
| CITADEL ADVISORS LLC | Reduced | -1.3m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -622.4k |
| AXA S.A. | Sold out | -341.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -341.6k |
| BRAIDWELL LP | Reduced | -280.1k |
| BlackRock, Inc. | Reduced | -248.5k |
| UBS Group AG | Reduced | -237.6k |
| RAYMOND JAMES FINANCIAL INC | Reduced | -224.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -219.7k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -217.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $20.4m145.1k shares |
| Caption Management, LLC | Unchanged | $4.2m30.0k shares |
| CITADEL ADVISORS LLC | Added | $3.7m26.3k shares |
| JANE STREET GROUP, LLC | Reduced | $1.9m13.4k shares |
| Twin Tree Management, LP | Reduced | $1.1m7.9k shares |
| WOLVERINE TRADING, LLC | Reduced | $883.7k6.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $631.0k4.5k shares |
| GROUP ONE TRADING LLC | Reduced | $238.6k1.7k shares |
| Raiffeisen Bank International AG | New | $56.2k400 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $24.2m172.3k shares |
| BANK OF AMERICA CORP /DE/ | New | $14.9m106.0k shares |
| JANE STREET GROUP, LLC | Added | $8.5m60.3k shares |
| Caption Management, LLC | Added | $7.4m53.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $7.1m50.7k shares |
| Twin Tree Management, LP | Reduced | $2.6m18.7k shares |
| CITADEL ADVISORS LLC | Reduced | $1.8m12.5k shares |
| SIMPLEX TRADING, LLC | Added | $870.0k6.2k shares |
| GOLDMAN SACHS GROUP INC | Reduced | $350.9k2.5k shares |
| GROUP ONE TRADING LLC | Reduced | $14.0k100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 12.1% |
| DODGE & COX 13G · institution new · filed 2025-05-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution -1.1 pts · filed 2026-10-15 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 6 | $22.4m | $22.4m |
| Q1 2024 | 0 | — | 14 | $76.7m | $76.7m |
| Q2 2024 | 0 | — | 8 | $14.5m | $14.5m |
| Q3 2024 | 0 | — | 7 | $12.9m | $10.9m |
| Q4 2024 | 0 | — | 3 | $626.4k | $626.4k |
| Q1 2025 | 0 | — | 11 | $38.7m | $38.7m |
| Q2 2025 | 0 | — | 2 | $4.5m | $4.5m |
| Q3 2025 | 0 | — | 3 | $24.0m | $24.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-08-07 | GORMAN KEVIN CHARLES Director | Sold plan | $13.4m106.3k shares |
| 2025-07-10 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $61.7k457 shares |
| 2025-07-09 | Onyia Jude Chief Scientific Officer | Sold plan | $7.8m59.8k shares |
| 2025-07-02 | Onyia Jude Chief Scientific Officer | Sold plan | $2.6m20.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.03% of their portfolio | 12.7m $1.8bn | Reduced -248.5k |
| VANGUARD GROUP INC 0.02% of their portfolio | 9.7m $1.4bn | Reduced -100.5k |
| JPMORGAN CHASE & CO 0.04% of their portfolio | 9.5m $1.3bn | Added +5.2m |
| Dodge & Cox 0.42% of their portfolio | 5.6m $780.0m | Reduced -10.2k |
| STATE STREET CORP 0.02% of their portfolio | 4.3m $610.2m | Reduced -121.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.04% of their portfolio | 2.9m $402.4m | Reduced -219.7k |
| AQR CAPITAL MANAGEMENT LLC 0.25% of their portfolio | 2.8m $388.4m | Added +1.3m |
| RENAISSANCE TECHNOLOGIES LLC 0.45% of their portfolio | 2.4m $339.5m | Added +51.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 2.0m $283.5m | Added +65.6k |
| MORGAN STANLEY 0.02% of their portfolio | 1.8m $256.5m | Added +7.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 1.8m $254.3m | Reduced -217.1k |
| Bellevue Group AG 5.14% of their portfolio | 1.8m $247.5m | Reduced -56.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.57% of their portfolio | 1.2m $168.8m | Added +458.1k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 2.55% of their portfolio | 1.2m $166.3m | Added +16.5k |
| RTW INVESTMENTS, LP 1.84% of their portfolio | 1.1m $149.1m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.11% of their portfolio | 977.2k $137.2m | Reduced -217.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.34% of their portfolio | 948.0k $133.0m | Reduced -84.3k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 925.7k $130.0m | Reduced -3.3k |
| BRAIDWELL LP 3.67% of their portfolio | 880.3k $123.6m | Reduced -280.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 829.5k $116.5m | Added +39.8k |
| CITADEL ADVISORS LLC 0.09% of their portfolio | 793.2k $111.4m | Reduced -1.3m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 765.2k $107.4m | Reduced -622.4k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 761.4k $106.9m | Reduced -17.2k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 710.1k $99.7m | Added +25.7k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 704.3k $98.9m | Added +51.2k |
| ARMISTICE CAPITAL, LLC 3.07% of their portfolio | 697.0k $97.8m | Added +21.0k |
| Pictet Asset Management Holding SA 0.09% of their portfolio | 693.4k $97.3m | Reduced -2.7k |
| IEQ CAPITAL, LLC 0.30% of their portfolio | 692.6k $97.2m | Added +119.6k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 635.0k $89.1m | Reduced -68.6k |
| ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio | 618.1k $86.8m | Added +33.7k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 614.6k $86.3m | Added +171.3k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 609.6k $85.6m | Reduced -76.3k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 595.2k $83.5m | Reduced -180.9k |
| GW&K Investment Management, LLC 0.74% of their portfolio | 594.4k $83.4m | Reduced -18.0k |
| Thrivent Financial for Lutherans 0.16% of their portfolio | 571.8k $80.3m | Reduced -215.5k |
| RAYMOND JAMES FINANCIAL INC 0.03% of their portfolio | 566.9k $79.6m | Reduced -224.6k |
| Swedbank AB 0.08% of their portfolio | 547.3k $76.8m | Added +43.8k |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 520.0k $73.0m | Reduced -50.9k |
| PRIMECAP MANAGEMENT CO/CA/ 0.06% of their portfolio | 512.3k $71.9m | Reduced -11.8k |
| Hood River Capital Management LLC 0.83% of their portfolio | 501.5k $70.4m | Added +244.0k |
| Fiera Capital Corp 0.22% of their portfolio | 479.7k $67.3m | Reduced -10.9k |
| BROWN ADVISORY INC 0.09% of their portfolio | 468.5k $65.8m | Reduced -130.7k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 450.8k $63.3m | Added +40.8k |
| PERCEPTIVE ADVISORS LLC 1.83% of their portfolio | 450.1k $63.2m | Added +195.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.04% of their portfolio | 411.7k $57.8m | Added +286.5k |
| Legal & General Group Plc 0.01% of their portfolio | 400.2k $56.2m | Added +744 |
| Allspring Global Investments Holdings, LLC 0.08% of their portfolio | 382.4k $52.4m | Reduced -65.5k |
| UBS Group AG 0.01% of their portfolio | 364.6k $51.2m | Reduced -237.6k |
| FIRST TRUST ADVISORS LP 0.04% of their portfolio | 363.1k $51.0m | Reduced -60.4k |
| ORBIMED ADVISORS LLC 1.19% of their portfolio | 353.6k $49.6m | Reduced -84.9k |
| TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio | 347.6k $48.8m | New |
| Clearbridge Investments, LLC 0.04% of their portfolio | 336.9k $47.3m | Reduced -5.4k |
| AXA Investment Managers S.A. 0.12% of their portfolio | 323.9k $45.5m | First filing |
| Invesco Ltd. 0.01% of their portfolio | 323.6k $45.4m | Added +34.4k |
| MACQUARIE GROUP LTD 0.05% of their portfolio | 315.5k $44.3m | Added +45.0k |
| BARCLAYS PLC 0.02% of their portfolio | 304.0k $42.7m | Added +32.6k |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 303.5k $42.6m | Reduced -5.7k |
| Sarissa Capital Management LP 23.59% of their portfolio | 303.2k $42.6m | Unchanged |
| SEI INVESTMENTS CO 0.05% of their portfolio | 300.2k $42.1m | Added +79.4k |
| Candriam S.C.A. 0.21% of their portfolio | 287.6k $40.4m | Reduced -10.9k |
| Swiss National Bank 0.02% of their portfolio | 285.3k $40.1m | Reduced -14.1k |
| Connor, Clark & Lunn Investment Management Ltd. 0.12% of their portfolio | 281.1k $39.5m | Added +32.5k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 258.3k $36.3m | Reduced -26.0k |
| RENAISSANCE GROUP LLC 1.33% of their portfolio | 251.6k $35.3m | Reduced -104 |
| Nuveen, LLC 0.01% of their portfolio | 245.0k $34.4m | Added +16.1k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 244.7k $34.3m | Added +2.4k |
| CITIGROUP INC 0.02% of their portfolio | 237.1k $33.3m | Reduced -85.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 231.8k $32.5m | Reduced -12.0k |
| Amundi 0.01% of their portfolio | 230.3k $32.1m | Added +11.1k |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 221.3k $31.1m | Reduced -14.2k |
| Balyasny Asset Management L.P. 0.06% of their portfolio | 203.4k $28.6m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 202.8k $28.5m | Added +4.8k |
| JANE STREET GROUP, LLC 0.03% of their portfolio | 199.2k $28.0m | Added +192.1k |
| California Public Employees Retirement System 0.02% of their portfolio | 194.2k $27.3m | Added +20.8k |
| Rockefeller Capital Management L.P. 0.05% of their portfolio | 193.9k $27.2m | Reduced -32.5k |
| Susquehanna Portfolio Strategies, LLC 0.41% of their portfolio | 184.0k $25.8m | Unchanged |
| HSBC HOLDINGS PLC 0.02% of their portfolio | 183.7k $25.8m | Reduced -5.6k |
| BRAUN STACEY ASSOCIATES INC 0.84% of their portfolio | 183.0k $25.7m | Added +12.7k |
| First Turn Management, LLC 3.83% of their portfolio | 181.9k $25.5m | New |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 180.4k $25.3m | Added +9.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 175.6k $24.6m | Added +800 |
| BOONE CAPITAL MANAGEMENT LLC 7.66% of their portfolio | 166.4k $23.4m | Reduced -13.9k |
| Eagle Health Investments LP 6.00% of their portfolio | 162.8k $22.9m | Reduced -54.4k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 160.8k $22.6m | Added +20.3k |
| TANG CAPITAL MANAGEMENT LLC 0.81% of their portfolio | 150.0k $21.1m | Unchanged |
| Integral Health Asset Management, LLC 1.53% of their portfolio | 150.0k $21.1m | Unchanged |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 148.8k $20.9m | New |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. 0.16% of their portfolio | 147.8k $20.7m | Reduced -91 |
| Parkman Healthcare Partners LLC 2.19% of their portfolio | 141.8k $19.9m | Reduced -24.2k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 138.9k $19.5m | Reduced -52.3k |
| PKO BP BANKOWY Universal Pension Society JSC 11.55% of their portfolio | 138.8k $19.5m | Unchanged |
| Soleus Capital Management, L.P. 1.04% of their portfolio | 138.0k $19.4m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 136.9k $19.2m | Added +1.6k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 136.8k $19.2m | Reduced -43.5k |
| Gotham Asset Management, LLC 0.08% of their portfolio | 136.4k $19.1m | Added +45.2k |
| Freestone Grove Partners LP 0.14% of their portfolio | 132.3k $18.6m | Reduced -35.8k |
| Iron Triangle Partners LP 2.62% of their portfolio | 131.4k $18.4m | New |
| Rakuten Investment Management, Inc. 0.03% of their portfolio | 128.7k $8.6m | First filing |
| C WorldWide Group Holding A/S 0.27% of their portfolio | 125.0k $17.5m | Reduced -10.0k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 124.8k $17.5m | Added +32.0k |