NEUROCRINE BIOSCIENCES INC NBIX
COM · Common Stock · CUSIP 64125C109 · ISIN US64125C1099
American biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded1992
- Websiteneurocrine.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($30.6m this quarter). Holder counts are more reliable. Shares outstanding: 99.2m as of 2025-07-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $125.69. Options: 11 managers hold calls ($37.7m notional), 11 hold puts ($27.0m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 466 |
| Q4 2022 | 530 |
| Q1 2023 | 488 |
| Q2 2023 | 457 |
| Q3 2023 | 514 |
| Q4 2023 | 555 |
| Q1 2024 | 591 |
| Q2 2024 | 595 |
| Q3 2024 | 576 |
| Q4 2024 | 601 |
| Q1 2025 | 587 |
| Q2 2025 | 587 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 242 | 227 |
| Q4 2023 | 270 | 242 |
| Q1 2024 | 310 | 256 |
| Q2 2024 | 325 | 257 |
| Q3 2024 | 296 | 286 |
| Q4 2024 | 292 | 284 |
| Q1 2025 | 253 | 334 |
| Q2 2025 | 295 | 291 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $83.4m | $77.4m | 0.93 |
| Q4 2024 | $48.0m | $44.2m | 0.92 |
| Q1 2025 | $92.7m | $64.6m | 0.70 |
| Q2 2025 | $37.7m | $27.0m | 0.72 |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +1.6m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.5m |
| CITADEL ADVISORS LLC | Added | +1.2m |
| RTW INVESTMENTS, LP | New | +1.1m |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Added | +740.8k |
| MILLENNIUM MANAGEMENT LLC | Added | +617.6k |
| AQR CAPITAL MANAGEMENT LLC | Added | +435.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +341.6k |
| Pictet Asset Management Holding SA | Added | +308.5k |
| MORGAN STANLEY | Added | +301.5k |
Biggest sellers
| BlackRock, Inc. | Reduced | -1.7m |
| ORBIMED ADVISORS LLC | Reduced | -496.1k |
| Caisse de depot et placement du Quebec | Sold out | -399.6k |
| STATE STREET CORP | Reduced | -393.9k |
| VIRGINIA RETIREMENT SYSTEMS ET Al | Reduced | -334.5k |
| Assenagon Asset Management S.A. | Reduced | -333.2k |
| ARMISTICE CAPITAL, LLC | Reduced | -324.2k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -321.2k |
| BROWN ADVISORY INC | Reduced | -296.3k |
| Invesco Ltd. | Reduced | -278.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $14.5m115.3k shares |
| Twin Tree Management, LP | Added | $9.0m71.3k shares |
| Caption Management, LLC | New | $3.8m30.0k shares |
| JANE STREET GROUP, LLC | Reduced | $3.6m28.8k shares |
| CITADEL ADVISORS LLC | Added | $2.6m20.5k shares |
| UBS Group AG | New | $1.6m12.4k shares |
| WOLVERINE TRADING, LLC | New | $903.0k7.2k shares |
| SIMPLEX TRADING, LLC | Added | $816.0k6.5k shares |
| GROUP ONE TRADING LLC | Reduced | $641.0k5.1k shares |
| GOLDMAN SACHS GROUP INC | New | $402.2k3.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $9.9m79.1k shares |
| Caption Management, LLC | Reduced | $5.0m40.0k shares |
| JANE STREET GROUP, LLC | Reduced | $3.6m29.0k shares |
| Twin Tree Management, LP | Added | $2.4m19.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.2m17.7k shares |
| J. Goldman & Co LP | Reduced | $2.0m15.8k shares |
| GOLDMAN SACHS GROUP INC | New | $1.4m11.3k shares |
| GROUP ONE TRADING LLC | Reduced | $176.0k1.4k shares |
| Walleye Capital LLC | New | $163.4k1.3k shares |
| SIMPLEX TRADING, LLC | Added | $75.0k600 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 12.1% |
| DODGE & COX 13G · institution new · filed 2025-05-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution -1.1 pts · filed 2026-10-15 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 11 | $4.3m | $4.3m |
| Q4 2023 | 0 | — | 6 | $22.4m | $22.4m |
| Q1 2024 | 0 | — | 14 | $76.7m | $76.7m |
| Q2 2024 | 0 | — | 8 | $14.5m | $14.5m |
| Q3 2024 | 0 | — | 7 | $12.9m | $10.9m |
| Q4 2024 | 0 | — | 3 | $626.4k | $626.4k |
| Q1 2025 | 0 | — | 11 | $38.7m | $38.7m |
| Q2 2025 | 0 | — | 2 | $4.5m | $4.5m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-27 | GORMAN KEVIN CHARLES Director | Sold plan | $1.2m9.6k shares |
| 2025-05-05 | RASTETTER WILLIAM H Director | Sold plan | $3.3m30.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.03% of their portfolio | 13.0m $1.6bn | Reduced -1.7m |
| VANGUARD GROUP INC 0.02% of their portfolio | 9.8m $1.2bn | Reduced -134.8k |
| Dodge & Cox 0.39% of their portfolio | 5.6m $699.7m | Added +32.2k |
| STATE STREET CORP 0.02% of their portfolio | 4.5m $561.6m | Reduced -393.9k |
| JPMORGAN CHASE & CO 0.04% of their portfolio | 4.3m $535.7m | Added +1.6m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.04% of their portfolio | 3.1m $387.9m | Added +1.5m |
| RENAISSANCE TECHNOLOGIES LLC 0.40% of their portfolio | 2.4m $297.4m | Reduced -136.3k |
| CITADEL ADVISORS LLC 0.22% of their portfolio | 2.0m $257.5m | Added +1.2m |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 2.0m $255.0m | Reduced -69.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 2.0m $245.6m | Reduced -10.5k |
| Bellevue Group AG 5.04% of their portfolio | 1.8m $228.8m | Unchanged |
| MORGAN STANLEY 0.01% of their portfolio | 1.8m $228.7m | Added +301.5k |
| AQR CAPITAL MANAGEMENT LLC 0.16% of their portfolio | 1.5m $189.8m | Added +435.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.04% of their portfolio | 1.4m $174.4m | Added +228.3k |
| MILLENNIUM MANAGEMENT LLC 0.13% of their portfolio | 1.2m $150.1m | Added +617.6k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 2.66% of their portfolio | 1.2m $146.8m | Reduced -321.2k |
| BRAIDWELL LP 4.99% of their portfolio | 1.2m $145.9m | Reduced -31.5k |
| RTW INVESTMENTS, LP 1.90% of their portfolio | 1.1m $133.5m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.32% of their portfolio | 1.0m $129.7m | Reduced -222.8k |
| NORGES BANK 0.02% of their portfolio | 972.9k $122.3m | Reduced -27.0k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 929.1k $116.8m | Reduced -28.2k |
| RAYMOND JAMES FINANCIAL INC 0.03% of their portfolio | 791.5k $99.5m | Reduced -956 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 789.7k $99.3m | Added +13.9k |
| Thrivent Financial for Lutherans 0.22% of their portfolio | 787.3k $99.0m | Reduced -91.5k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 778.6k $97.9m | Reduced -50.1k |
| JANUS HENDERSON GROUP PLC 0.05% of their portfolio | 776.1k $97.5m | Reduced -7.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.35% of their portfolio | 744.6k $93.6m | Added +740.8k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 703.5k $88.4m | Added +124.1k |
| Pictet Asset Management Holding SA 0.09% of their portfolio | 696.1k $87.5m | Added +308.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 685.9k $86.2m | Reduced -51.6k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 684.4k $86.0m | Added +68.8k |
| ARMISTICE CAPITAL, LLC 3.22% of their portfolio | 676.0k $85.0m | Reduced -324.2k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 653.0k $82.1m | Added +91.9k |
| GW&K Investment Management, LLC 0.69% of their portfolio | 612.4k $77.0m | Added +101.0k |
| UBS Group AG 0.02% of their portfolio | 602.1k $75.7m | Reduced -183.4k |
| BROWN ADVISORY INC 0.10% of their portfolio | 599.2k $75.3m | Reduced -296.3k |
| ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio | 584.4k $73.5m | Added +8.3k |
| IEQ CAPITAL, LLC 0.44% of their portfolio | 573.0k $72.0m | Added +36.0k |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 570.9k $71.8m | Reduced -233.6k |
| PRIMECAP MANAGEMENT CO/CA/ 0.05% of their portfolio | 524.0k $65.9m | Added +141.6k |
| Swedbank AB 0.07% of their portfolio | 503.5k $63.3m | First filing |
| Fiera Capital Corp 0.21% of their portfolio | 490.6k $61.7m | Reduced -3.9k |
| Allspring Global Investments Holdings, LLC 0.10% of their portfolio | 447.9k $57.3m | Added +60.1k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 443.2k $55.7m | Added +127.5k |
| ORBIMED ADVISORS LLC 1.39% of their portfolio | 438.5k $55.1m | Reduced -496.1k |
| FIRST TRUST ADVISORS LP 0.04% of their portfolio | 423.5k $53.2m | Reduced -169.9k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 410.0k $51.5m | Reduced -17.0k |
| Legal & General Group Plc 0.01% of their portfolio | 399.4k $50.2m | Added +16.5k |
| Clearbridge Investments, LLC 0.03% of their portfolio | 342.3k $43.0m | Unchanged |
| AXA S.A. 0.12% of their portfolio | 341.7k $43.0m | Added +8.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 341.6k $42.9m | New |
| CITIGROUP INC 0.03% of their portfolio | 322.1k $40.5m | Reduced -144.1k |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 309.2k $38.9m | Reduced -5.3k |
| Sarissa Capital Management LP 24.68% of their portfolio | 303.2k $38.1m | Reduced -6.0k |
| Swiss National Bank 0.02% of their portfolio | 299.4k $37.6m | Added +13.9k |
| Candriam S.C.A. 0.22% of their portfolio | 298.6k $37.5m | Reduced -32.3k |
| Invesco Ltd. 0.01% of their portfolio | 289.2k $36.4m | Reduced -278.1k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 284.3k $35.7m | Added +28.9k |
| BARCLAYS PLC 0.01% of their portfolio | 271.4k $34.1m | Added +71.2k |
| MACQUARIE GROUP LTD 0.04% of their portfolio | 270.5k $34.0m | Added +39.2k |
| Hood River Capital Management LLC 0.45% of their portfolio | 257.5k $32.4m | Reduced -79.6k |
| PERCEPTIVE ADVISORS LLC 1.20% of their portfolio | 255.1k $32.1m | Added +155.0k |
| FMR LLC 0.00% of their portfolio | 254.8k $32.0m | Added +158.9k |
| RENAISSANCE GROUP LLC 1.23% of their portfolio | 251.7k $31.6m | Added +39.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.11% of their portfolio | 248.6k $31.3m | Added +192.8k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 243.7k $30.6m | Reduced -4.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 242.3k $30.5m | Added +159.5k |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 235.5k $29.6m | Added +4.0k |
| Nuveen, LLC 0.01% of their portfolio | 228.9k $28.8m | Reduced -57.6k |
| Rockefeller Capital Management L.P. 0.03% of their portfolio | 226.5k $28.5m | Added +204.9k |
| SEI INVESTMENTS CO 0.03% of their portfolio | 220.8k $27.7m | Added +79.3k |
| Amundi 0.01% of their portfolio | 219.2k $28.4m | Reduced -12.0k |
| Eagle Health Investments LP 6.74% of their portfolio | 217.2k $27.3m | Reduced -7.9k |
| Zurich Insurance Group Ltd/FI 0.21% of their portfolio | 211.9k $26.6m | New |
| CAPITAL FUND MANAGEMENT S.A. 0.28% of their portfolio | 203.6k $25.6m | Added +28.0k |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 198.0k $24.9m | Added +75.7k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 191.3k $24.0m | Added +80 |
| HSBC HOLDINGS PLC 0.02% of their portfolio | 189.2k $23.8m | Reduced -53.8k |
| Susquehanna Portfolio Strategies, LLC 0.51% of their portfolio | 184.0k $23.1m | New |
| BOONE CAPITAL MANAGEMENT LLC 9.72% of their portfolio | 180.3k $22.7m | New |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 180.3k $22.7m | Added +29.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 174.8k $22.0m | Unchanged |
| California Public Employees Retirement System 0.01% of their portfolio | 173.4k $21.8m | Added +6.5k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 170.8k $21.5m | Reduced -24.0k |
| BRAUN STACEY ASSOCIATES INC 0.77% of their portfolio | 170.4k $21.4m | New |
| Freestone Grove Partners LP 0.16% of their portfolio | 168.1k $21.1m | Added +162.9k |
| Squarepoint Ops LLC 0.05% of their portfolio | 166.6k $20.9m | New |
| Parkman Healthcare Partners LLC 2.41% of their portfolio | 166.0k $20.9m | Reduced -2.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 4.19% of their portfolio | 163.0k $20.5m | Added +90.4k |
| TANG CAPITAL MANAGEMENT LLC 0.95% of their portfolio | 150.0k $18.9m | Unchanged |
| Integral Health Asset Management, LLC 1.76% of their portfolio | 150.0k $18.9m | Unchanged |
| Logos Global Management LP 2.52% of their portfolio | 150.0k $18.9m | New |
| Rhenman & Partners Asset Management AB 2.37% of their portfolio | 149.2k $18.8m | Added +59.4k |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. 0.17% of their portfolio | 147.9k $18.6m | Added +4.5k |
| PRUDENTIAL FINANCIAL INC 0.02% of their portfolio | 145.3k $17.8m | Added +26.0k |
| LOOMIS SAYLES & CO L P 0.02% of their portfolio | 140.5k $17.7m | New |
| PKO BP BANKOWY Universal Pension Society JSC 11.97% of their portfolio | 138.8k $17.4m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 135.3k $17.0m | Reduced -1.6k |
| C WorldWide Group Holding A/S 0.23% of their portfolio | 135.0k $17.0m | Added +20.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 125.2k $15.7m | Added +58.6k |