NEUROCRINE BIOSCIENCES INC NBIX
COM · Common Stock · CUSIP 64125C109 · ISIN US64125C1099
American biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded1992
- Websiteneurocrine.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($23.5m this quarter). Holder counts are more reliable. Shares outstanding: 99.0m as of 2025-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $110.60. Options: 12 managers hold calls ($92.7m notional), 14 hold puts ($64.6m).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 466 |
| Q4 2022 | 530 |
| Q1 2023 | 488 |
| Q2 2023 | 457 |
| Q3 2023 | 514 |
| Q4 2023 | 555 |
| Q1 2024 | 591 |
| Q2 2024 | 595 |
| Q3 2024 | 576 |
| Q4 2024 | 601 |
| Q1 2025 | 587 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 199 | 257 |
| Q3 2023 | 242 | 227 |
| Q4 2023 | 270 | 242 |
| Q1 2024 | 310 | 256 |
| Q2 2024 | 325 | 257 |
| Q3 2024 | 296 | 286 |
| Q4 2024 | 292 | 284 |
| Q1 2025 | 253 | 334 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $129.5m | $57.7m | 0.45 |
| Q3 2024 | $83.4m | $77.4m | 0.93 |
| Q4 2024 | $48.0m | $44.2m | 0.92 |
| Q1 2025 | $92.7m | $64.6m | 0.70 |
Biggest buyers
| Dodge & Cox | Added | +2.5m |
| JPMORGAN CHASE & CO | Added | +1.3m |
| NORGES BANK | Added | +674.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +640.6k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +627.0k |
| Assenagon Asset Management S.A. | Added | +367.3k |
| UBS Group AG | Added | +366.1k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added | +310.4k |
| CITIGROUP INC | Added | +301.0k |
| BRAIDWELL LP | Added | +290.1k |
Biggest sellers
| CITADEL ADVISORS LLC | Reduced | -1.6m |
| DSM CAPITAL PARTNERS LLC | Sold out | -932.6k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -822.3k |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Reduced | -509.0k |
| Rock Springs Capital Management LP | Reduced | -441.5k |
| Invesco Ltd. | Reduced | -382.2k |
| Caisse de depot et placement du Quebec | Reduced | -348.7k |
| California Public Employees Retirement System | Reduced | -286.2k |
| GOLDMAN SACHS GROUP INC | Reduced | -246.4k |
| Bridgewater Associates, LP | Reduced | -245.4k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $49.4m446.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $11.6m104.5k shares |
| JPMORGAN CHASE & CO | Unchanged | $6.3m57.0k shares |
| CITIGROUP INC | Added | $6.3m57.0k shares |
| J. Goldman & Co LP | New | $5.9m53.0k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $5.2m46.6k shares |
| GROUP ONE TRADING LLC | Added | $2.3m20.9k shares |
| Twin Tree Management, LP | Reduced | $2.3m20.4k shares |
| CITADEL ADVISORS LLC | Reduced | $2.2m19.5k shares |
| GARDA CAPITAL PARTNERS LP | New | $995.4k9.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $17.9m161.4k shares |
| Caption Management, LLC | New | $16.6m150.3k shares |
| JPMORGAN CHASE & CO | Unchanged | $6.3m57.0k shares |
| CITIGROUP INC | Added | $6.3m57.0k shares |
| JANE STREET GROUP, LLC | Added | $5.8m52.3k shares |
| J. Goldman & Co LP | Added | $5.5m50.0k shares |
| CITADEL ADVISORS LLC | Added | $3.1m28.3k shares |
| GARDA CAPITAL PARTNERS LP | New | $995.4k9.0k shares |
| Twin Tree Management, LP | Reduced | $818.4k7.4k shares |
| HAP Trading, LLC | New | $676.6k45.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 12.1% |
| DODGE & COX 13G · institution new · filed 2025-05-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution -1.1 pts · filed 2026-10-15 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 3 | $3.8m | $3.8m |
| Q3 2023 | 0 | — | 11 | $4.3m | $4.3m |
| Q4 2023 | 0 | — | 6 | $22.4m | $22.4m |
| Q1 2024 | 0 | — | 14 | $76.7m | $76.7m |
| Q2 2024 | 0 | — | 8 | $14.5m | $14.5m |
| Q3 2024 | 0 | — | 7 | $12.9m | $10.9m |
| Q4 2024 | 0 | — | 3 | $626.4k | $626.4k |
| Q1 2025 | 0 | — | 11 | $38.7m | $38.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-02-14 | ROBERTS EIRY Chief Medical Officer | Sold plan | $57.5k500 shares |
| 2025-02-13 | SHERWIN STEPHEN A Director | Sold plan | $1.6m13.8k shares |
| 2025-02-13 | GORMAN KEVIN CHARLES Director | Sold plan | $681.9k5.8k shares |
| 2025-02-13 | Onyia Jude Chief Scientific Officer | Sold plan | $336.2k2.9k shares |
| 2025-02-13 | ABERNETHY MATT Chief Financial Officer | Sold plan | $298.9k2.6k shares |
| 2025-02-13 | Gano Kyle Chief Executive Officer, director | Sold plan | $298.9k2.6k shares |
| 2025-02-13 | Lippoldt Darin Chief Legal Officer | Sold plan | $255.0k2.2k shares |
| 2025-02-13 | BENEVICH ERIC Chief Commercial Officer | Sold plan | $251.4k2.2k shares |
| 2025-02-13 | Boyer David W. Chief Corp. Affairs Officer | Sold plan | $208.4k1.8k shares |
| 2025-02-13 | ROBERTS EIRY Chief Medical Officer | Sold plan | $200.7k1.7k shares |
| 2025-02-13 | Cooke Julie Chief Human Resources Officer | Sold plan | $181.1k1.6k shares |
| 2025-02-13 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $171.7k1.5k shares |
| 2025-02-10 | GORMAN KEVIN CHARLES Director | Sold plan | $269.2k2.3k shares |
| 2025-02-10 | Gano Kyle Chief Executive Officer, director | Sold plan | $116.0k980 shares |
| 2025-02-10 | BENEVICH ERIC Chief Commercial Officer | Sold plan | $115.9k980 shares |
| 2025-02-10 | ABERNETHY MATT Chief Financial Officer | Sold plan | $115.9k980 shares |
| 2025-02-10 | ROBERTS EIRY Chief Medical Officer | Sold plan | $115.9k980 shares |
| 2025-02-10 | Lippoldt Darin Chief Legal Officer | Sold plan | $107.7k911 shares |
| 2025-02-10 | Boyer David W. Chief Corp. Affairs Officer | Sold plan | $82.8k700 shares |
| 2025-02-10 | Cooke Julie Chief Human Resources Officer | Sold plan | $82.8k700 shares |
| 2025-02-03 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $93.0k623 shares |
| 2025-01-31 | GORMAN KEVIN CHARLES Director | Sold plan | $414.0k2.7k shares |
| 2025-01-31 | Cooke Julie Chief Human Resources Officer | Sold plan | $266.0k1.7k shares |
| 2025-01-31 | Gano Kyle Chief Executive Officer, director | Sold plan | $235.6k1.5k shares |
| 2025-01-31 | ROBERTS EIRY Chief Medical Officer | Sold plan | $222.6k1.5k shares |
| 2025-01-31 | ABERNETHY MATT Chief Financial Officer | Sold plan | $196.1k1.3k shares |
| 2025-01-31 | Lippoldt Darin Chief Legal Officer | Sold plan | $191.1k1.2k shares |
| 2025-01-31 | BENEVICH ERIC Chief Commercial Officer | Sold plan | $184.6k1.2k shares |
| 2025-01-31 | Boyer David W. Chief Corp. Affairs Officer | Sold plan | $168.8k1.1k shares |
| 2025-01-31 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $64.6k422 shares |
The latest 30 of 33 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.03% of their portfolio | 14.7m $1.6bn | Reduced -100.3k |
| VANGUARD GROUP INC 0.02% of their portfolio | 9.9m $1.1bn | Reduced -177.8k |
| Dodge & Cox 0.35% of their portfolio | 5.5m $612.1m | Added +2.5m |
| STATE STREET CORP 0.02% of their portfolio | 4.9m $537.8m | Reduced -29.0k |
| JPMORGAN CHASE & CO 0.02% of their portfolio | 2.7m $295.4m | Added +1.3m |
| RENAISSANCE TECHNOLOGIES LLC 0.42% of their portfolio | 2.5m $276.8m | Added +13.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 2.1m $232.0m | Added +640.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 2.0m $217.4m | Added +94.7k |
| Bellevue Group AG 4.51% of their portfolio | 1.8m $201.3m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 1.5m $170.3m | Added +49.1k |
| MORGAN STANLEY 0.01% of their portfolio | 1.5m $167.9m | Reduced -55.1k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 3.26% of their portfolio | 1.5m $164.7m | Added +627.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.37% of their portfolio | 1.3m $138.8m | Added +310.4k |
| BRAIDWELL LP 4.63% of their portfolio | 1.2m $131.8m | Added +290.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio | 1.2m $128.2m | Added +89.3k |
| AQR CAPITAL MANAGEMENT LLC 0.12% of their portfolio | 1.1m $118.9m | Reduced -822.3k |
| ARMISTICE CAPITAL, LLC 2.96% of their portfolio | 1.0m $110.6m | Added +108.2k |
| NORGES BANK 0.02% of their portfolio | 999.8k $110.6m | Added +674.5k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 957.3k $105.9m | Reduced -24.7k |
| ORBIMED ADVISORS LLC 2.48% of their portfolio | 934.6k $103.4m | Reduced -3.5k |
| BROWN ADVISORY INC 0.14% of their portfolio | 895.5k $99.0m | Reduced -2.8k |
| CITADEL ADVISORS LLC 0.10% of their portfolio | 889.0k $98.3m | Reduced -1.6m |
| Thrivent Financial for Lutherans 0.21% of their portfolio | 878.8k $97.2m | Added +141.0k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 828.7k $91.7m | Reduced -41.6k |
| JENNISON ASSOCIATES LLC 0.06% of their portfolio | 804.5k $89.0m | Reduced -16.2k |
| RAYMOND JAMES FINANCIAL INC 0.03% of their portfolio | 792.5k $87.6m | Reduced -51.4k |
| UBS Group AG 0.02% of their portfolio | 785.5k $86.9m | Added +366.1k |
| JANUS HENDERSON GROUP PLC 0.05% of their portfolio | 784.0k $88.7m | Reduced -10.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 775.8k $85.8m | Added +13.2k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 737.4k $81.6m | Reduced -246.4k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 615.6k $68.1m | Added +65.5k |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 593.4k $65.6m | Added +198.7k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 579.4k $64.1m | Reduced -29.5k |
| MILLENNIUM MANAGEMENT LLC 0.06% of their portfolio | 576.6k $63.8m | Added +157.9k |
| ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio | 576.2k $63.7m | Reduced -1.4k |
| Invesco Ltd. 0.01% of their portfolio | 567.3k $62.7m | Reduced -382.2k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 561.1k $62.1m | Added +77.0k |
| IEQ CAPITAL, LLC 0.47% of their portfolio | 537.0k $59.4m | Reduced -20.9k |
| GW&K Investment Management, LLC 0.52% of their portfolio | 511.4k $56.6m | Reduced -2.7k |
| Fiera Capital Corp 0.20% of their portfolio | 494.5k $54.7m | Reduced -4.6k |
| CITIGROUP INC 0.04% of their portfolio | 466.2k $51.6m | Added +301.0k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 426.9k $47.2m | Reduced -34.8k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.34% of their portfolio | 419.6k $46.4m | First filing |
| Caisse de depot et placement du Quebec 0.09% of their portfolio | 399.6k $44.2m | Reduced -348.7k |
| Assenagon Asset Management S.A. 0.08% of their portfolio | 393.5k $43.5m | Added +367.3k |
| Allspring Global Investments Holdings, LLC 0.07% of their portfolio | 387.8k $41.5m | Reduced -92.8k |
| Pictet Asset Management Holding SA 0.05% of their portfolio | 387.6k $43.1m | Reduced -223.5k |
| Legal & General Group Plc 0.01% of their portfolio | 382.9k $42.4m | Added +37.2k |
| PRIMECAP MANAGEMENT CO/CA/ 0.03% of their portfolio | 382.4k $42.3m | Reduced -11.3k |
| Clearbridge Investments, LLC 0.03% of their portfolio | 342.3k $37.9m | Added +23.0k |
| Hood River Capital Management LLC 0.64% of their portfolio | 337.2k $37.3m | Reduced -17.9k |
| AXA S.A. 0.12% of their portfolio | 333.7k $36.9m | Added +36.0k |
| Candriam S.C.A. 0.23% of their portfolio | 330.8k $36.6m | Added +26.9k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 315.7k $34.9m | Reduced -97.8k |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 314.5k $34.8m | Reduced -6.0k |
| Sarissa Capital Management LP 22.10% of their portfolio | 309.1k $34.2m | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio | 297.7k $32.9m | Added +158.2k |
| Nuveen, LLC 0.01% of their portfolio | 286.5k $31.7m | First filing |
| Swiss National Bank 0.02% of their portfolio | 285.5k $31.6m | Added +200 |
| Rock Springs Capital Management LP 1.77% of their portfolio | 279.0k $30.9m | Reduced -441.5k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 255.4k $28.2m | Added +8.8k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 248.4k $27.5m | Reduced -4.0k |
| HSBC HOLDINGS PLC 0.02% of their portfolio | 243.0k $26.9m | Added +30.7k |
| SOROS FUND MANAGEMENT LLC 0.47% of their portfolio | 239.8k $26.5m | Added +39.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 237.2k $26.2m | First filing |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 231.5k $25.6m | Reduced -1.4k |
| MACQUARIE GROUP LTD 0.03% of their portfolio | 231.3k $25.6m | Reduced -42.8k |
| Amundi 0.01% of their portfolio | 231.2k $23.8m | Reduced -30.7k |
| Eagle Health Investments LP 6.46% of their portfolio | 225.1k $24.9m | Added +70.1k |
| Aberdeen Group plc 0.05% of their portfolio | 220.3k $24.4m | Added +63.8k |
| RENAISSANCE GROUP LLC 1.03% of their portfolio | 212.1k $23.5m | Reduced -5.5k |
| Alyeska Investment Group, L.P. 0.09% of their portfolio | 206.4k $22.8m | Reduced -42.6k |
| BARCLAYS PLC 0.01% of their portfolio | 200.2k $22.1m | Added +21.9k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 194.7k $21.5m | Added +21.1k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 191.5k $21.2m | Added +157.4k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 191.2k $21.1m | Added +98.7k |
| Sio Capital Management, LLC 6.28% of their portfolio | 187.6k $20.7m | New |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 179.2k $19.8m | Reduced -15.5k |
| CAPITAL FUND MANAGEMENT S.A. 0.25% of their portfolio | 175.6k $19.4m | Added +71.1k |
| SG Americas Securities, LLC 0.07% of their portfolio | 175.6k $19.4m | Added +174.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 174.8k $19.3m | Reduced -3.0k |
| Parkman Healthcare Partners LLC 2.21% of their portfolio | 168.4k $18.6m | Added +52.7k |
| Eversept Partners, LP 2.09% of their portfolio | 167.2k $18.5m | New |
| California Public Employees Retirement System 0.01% of their portfolio | 166.9k $18.5m | Reduced -286.2k |
| GLENMEDE TRUST CO NA 0.09% of their portfolio | 154.8k $17.1m | Reduced -8.5k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 150.7k $16.7m | Added +330 |
| Hudson Bay Capital Management LP 0.11% of their portfolio | 150.4k $16.6m | Added +120.0k |
| TANG CAPITAL MANAGEMENT LLC 0.92% of their portfolio | 150.0k $16.6m | Unchanged |
| Integral Health Asset Management, LLC 1.84% of their portfolio | 150.0k $16.6m | Reduced -10.0k |
| Iron Triangle Partners LP 2.56% of their portfolio | 146.8k $16.2m | Reduced -171.4k |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. 0.16% of their portfolio | 143.4k $15.9m | Added +3.7k |
| Skandinaviska Enskilda Banken AB (publ) 0.08% of their portfolio | 142.8k $15.8m | Reduced -37.6k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 141.4k $15.6m | Reduced -9.0k |
| PKO BP BANKOWY Universal Pension Society JSC 12.67% of their portfolio | 138.8k $15.4m | Added +10.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 136.9k $15.1m | Added +395 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 135.3k $15.0m | Added +124.3k |
| Woodline Partners LP 0.10% of their portfolio | 132.9k $14.7m | New |
| Caption Management, LLC 0.66% of their portfolio | 130.8k $14.5m | New |
| Distillate Capital Partners LLC 0.74% of their portfolio | 129.8k $14.4m | New |
| DNB Asset Management AS 0.07% of their portfolio | 128.1k $14.2m | Added +9.9k |