NEUROCRINE BIOSCIENCES INC NBIX
COM · Common Stock · CUSIP 64125C109 · ISIN US64125C1099
American biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Diego, CA
- Founded1992
- Websiteneurocrine.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($57.8m this quarter). Holder counts are more reliable. Shares outstanding: 99.7m as of 2025-02-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $136.47. Options: 11 managers hold calls ($48.0m notional), 13 hold puts ($44.2m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 466 |
| Q4 2022 | 530 |
| Q1 2023 | 488 |
| Q2 2023 | 457 |
| Q3 2023 | 514 |
| Q4 2023 | 555 |
| Q1 2024 | 591 |
| Q2 2024 | 595 |
| Q3 2024 | 576 |
| Q4 2024 | 601 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 253 | 249 |
| Q2 2023 | 199 | 257 |
| Q3 2023 | 242 | 227 |
| Q4 2023 | 270 | 242 |
| Q1 2024 | 310 | 256 |
| Q2 2024 | 325 | 257 |
| Q3 2024 | 296 | 286 |
| Q4 2024 | 292 | 284 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $88.0m | $61.6m | 0.70 |
| Q2 2024 | $129.5m | $57.7m | 0.45 |
| Q3 2024 | $83.4m | $77.4m | 0.93 |
| Q4 2024 | $48.0m | $44.2m | 0.92 |
Biggest buyers
| Dodge & Cox | Added | +1.7m |
| CITADEL ADVISORS LLC | Added | +773.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +739.2k |
| Thrivent Financial for Lutherans | Added | +712.0k |
| ARMISTICE CAPITAL, LLC | Added | +710.6k |
| ORBIMED ADVISORS LLC | Added | +635.9k |
| BlackRock, Inc. | Added | +526.7k |
| JENNISON ASSOCIATES LLC | Added | +485.9k |
| Iron Triangle Partners LP | New | +318.2k |
| Alyeska Investment Group, L.P. | New | +248.9k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -1.6m |
| Qube Research & Technologies Ltd | Reduced | -618.2k |
| JUPITER ASSET MANAGEMENT LTD | Sold out | -582.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -457.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -454.6k |
| Amundi | Reduced | -394.8k |
| Robeco Institutional Asset Management B.V. | Reduced | -372.6k |
| STATE STREET CORP | Reduced | -257.2k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -243.5k |
| Avidity Partners Management LP | Reduced | -239.6k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $12.5m91.3k shares |
| JANE STREET GROUP, LLC | Reduced | $10.1m74.1k shares |
| JPMORGAN CHASE & CO | Reduced | $7.8m57.0k shares |
| CITADEL ADVISORS LLC | Added | $7.2m52.9k shares |
| CITIGROUP INC | Reduced | $3.7m27.0k shares |
| Twin Tree Management, LP | Added | $3.2m23.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.1m8.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $969.1k7.1k shares |
| GROUP ONE TRADING LLC | Reduced | $737.1k5.4k shares |
| WOLVERINE TRADING, LLC | New | $712.7k5.2k shares |
Biggest puts
| Twin Tree Management, LP | Reduced | $14.5m106.0k shares |
| JPMORGAN CHASE & CO | Reduced | $7.8m57.0k shares |
| J. Goldman & Co LP | New | $6.1m44.5k shares |
| CITIGROUP INC | Reduced | $3.7m27.0k shares |
| CITADEL ADVISORS LLC | Reduced | $3.5m25.8k shares |
| JANE STREET GROUP, LLC | Reduced | $3.4m25.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.2m23.7k shares |
| MILLENNIUM MANAGEMENT LLC | Reduced | $1.2m8.8k shares |
| Squarepoint Ops LLC | New | $587.0k4.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $218.0k1.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-28 | 12.1% |
| DODGE & COX 13G · institution new · filed 2025-05-14 | 5.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution -1.1 pts · filed 2026-10-15 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 12 | $21.0m | — |
| Q2 2023 | 0 | — | 3 | $3.8m | $3.8m |
| Q3 2023 | 0 | — | 11 | $4.3m | $4.3m |
| Q4 2023 | 0 | — | 6 | $22.4m | $22.4m |
| Q1 2024 | 0 | — | 14 | $76.7m | $76.7m |
| Q2 2024 | 0 | — | 8 | $14.5m | $14.5m |
| Q3 2024 | 0 | — | 7 | $12.9m | $10.9m |
| Q4 2024 | 0 | — | 3 | $626.4k | $626.4k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-31 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $37.6k272 shares |
| 2024-12-17 | Delaet Ingrid Chief Regulatory Officer | Sold plan | $147.3k1.1k shares |
| 2024-11-29 | Onyia Jude Chief Scientific Officer | Sold plan | $294.4k2.3k shares |
| 2024-10-03 | Boyer David W. Chief Corp. Affairs Officer | Sold plan | $147.2k1.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.04% of their portfolio | 14.8m $2.0bn | Added +526.7k |
| VANGUARD GROUP INC 0.02% of their portfolio | 10.1m $1.4bn | Added +122.7k |
| STATE STREET CORP 0.03% of their portfolio | 4.9m $667.7m | Reduced -257.2k |
| Dodge & Cox 0.24% of their portfolio | 3.0m $411.7m | Added +1.7m |
| CITADEL ADVISORS LLC 0.32% of their portfolio | 2.5m $346.5m | Added +773.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.50% of their portfolio | 2.5m $339.8m | Reduced -85.1k |
| AQR CAPITAL MANAGEMENT LLC 0.33% of their portfolio | 1.9m $258.9m | Added +53.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 1.9m $255.5m | Added +15.8k |
| Bellevue Group AG 4.78% of their portfolio | 1.8m $248.4m | Reduced -43.8k |
| MORGAN STANLEY 0.02% of their portfolio | 1.6m $214.8m | Added +223.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 1.5m $203.5m | Reduced -184.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 1.5m $198.9m | Added +739.2k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 1.4m $187.2m | Reduced -1.6m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio | 1.1m $146.1m | Added +175.9k |
| GOLDMAN SACHS GROUP INC 0.03% of their portfolio | 983.8k $134.3m | Reduced -33.4k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 981.9k $134.0m | Added +210.3k |
| Invesco Ltd. 0.02% of their portfolio | 949.5k $129.6m | Added +74.8k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.32% of their portfolio | 944.7k $129.0m | Added +124.8k |
| ORBIMED ADVISORS LLC 2.66% of their portfolio | 938.1k $128.1m | Added +635.9k |
| DSM CAPITAL PARTNERS LLC 1.97% of their portfolio | 932.6k $127.3m | Reduced -11.6k |
| BRAIDWELL LP 3.65% of their portfolio | 901.8k $123.1m | Reduced -15.9k |
| BROWN ADVISORY INC 0.16% of their portfolio | 898.3k $122.6m | Reduced -43.9k |
| ARMISTICE CAPITAL, LLC 2.83% of their portfolio | 892.0k $121.8m | Added +710.6k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 870.3k $118.8m | Added +12.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 2.24% of their portfolio | 862.0k $117.7m | Reduced -454.6k |
| RAYMOND JAMES FINANCIAL INC 0.04% of their portfolio | 843.9k $115.2m | First filing |
| JENNISON ASSOCIATES LLC 0.07% of their portfolio | 820.7k $112.0m | Added +485.9k |
| JANUS HENDERSON GROUP PLC 0.06% of their portfolio | 794.1k $108.4m | Added +1.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 762.6k $104.1m | Added +15.3k |
| Caisse de depot et placement du Quebec 0.21% of their portfolio | 748.4k $102.2m | Added +11.4k |
| Thrivent Financial for Lutherans 0.20% of their portfolio | 737.8k $100.7m | Added +712.0k |
| Rock Springs Capital Management LP 3.74% of their portfolio | 720.5k $98.3m | Reduced -218.5k |
| Pictet Asset Management Holding SA 0.09% of their portfolio | 611.1k $83.4m | Reduced -231.1k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 608.9k $83.1m | Reduced -55.4k |
| ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio | 577.6k $78.8m | Reduced -59.3k |
| IEQ CAPITAL, LLC 0.74% of their portfolio | 557.9k $76.2m | Added +45.4k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 550.2k $75.1m | Added +26.5k |
| GW&K Investment Management, LLC 0.60% of their portfolio | 514.1k $70.2m | Added +4.0k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.28% of their portfolio | 512.8k $70.0m | Added +92.1k |
| Fiera Capital Corp 0.21% of their portfolio | 499.1k $68.1m | Reduced -17.7k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 484.0k $66.1m | Reduced -139.6k |
| Allspring Global Investments Holdings, LLC 0.11% of their portfolio | 480.6k $66.2m | Reduced -209.4k |
| DEUTSCHE BANK AG\ 0.02% of their portfolio | 461.8k $63.0m | Added +24.0k |
| California Public Employees Retirement System 0.04% of their portfolio | 453.1k $61.8m | Reduced -9.1k |
| UBS Group AG 0.01% of their portfolio | 419.4k $57.3m | Added +59.9k |
| MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio | 418.7k $57.2m | Added +105.9k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 413.5k $56.4m | Reduced -82.6k |
| FIRST TRUST ADVISORS LP 0.05% of their portfolio | 394.7k $53.9m | Reduced -149.7k |
| PRIMECAP MANAGEMENT CO/CA/ 0.04% of their portfolio | 393.7k $53.7m | Reduced -10.3k |
| Hood River Capital Management LLC 0.72% of their portfolio | 355.1k $48.5m | Added +91.8k |
| Legal & General Group Plc 0.01% of their portfolio | 345.7k $47.2m | Reduced -44.9k |
| Bridgewater Associates, LP 0.21% of their portfolio | 332.6k $45.4m | Added +197.4k |
| NORGES BANK 0.01% of their portfolio | 325.3k $44.4m | Reduced -25.8k |
| RHUMBLINE ADVISERS 0.04% of their portfolio | 320.5k $43.7m | Reduced -1.3k |
| Clearbridge Investments, LLC 0.04% of their portfolio | 319.3k $43.6m | Unchanged |
| Iron Triangle Partners LP 5.06% of their portfolio | 318.2k $43.4m | New |
| Sarissa Capital Management LP 13.07% of their portfolio | 309.1k $42.2m | Reduced -101.4k |
| Candriam S.C.A. 0.24% of their portfolio | 304.0k $41.5m | Reduced -179.3k |
| AXA S.A. 0.12% of their portfolio | 297.7k $40.6m | Added +28.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 289.8k $39.6m | Reduced -243.5k |
| Swiss National Bank 0.03% of their portfolio | 285.3k $38.9m | Reduced -13.4k |
| MACQUARIE GROUP LTD 0.04% of their portfolio | 274.1k $37.4m | Reduced -218.1k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 268.0k $36.6m | Reduced -77.6k |
| Amundi 0.01% of their portfolio | 261.9k $36.3m | Reduced -394.8k |
| Impax Asset Management Group plc 0.16% of their portfolio | 261.6k $35.7m | Added +176.6k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 252.5k $34.5m | Reduced -717 |
| Alyeska Investment Group, L.P. 0.13% of their portfolio | 248.9k $34.0m | New |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 246.6k $33.7m | Reduced -13.8k |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 232.9k $31.8m | Added +916 |
| Avidity Partners Management LP 3.00% of their portfolio | 220.4k $30.1m | Reduced -239.6k |
| RENAISSANCE GROUP LLC 1.23% of their portfolio | 217.6k $29.7m | Added +13.4k |
| HSBC HOLDINGS PLC 0.02% of their portfolio | 212.4k $29.0m | Reduced -10.9k |
| PRUDENTIAL FINANCIAL INC 0.03% of their portfolio | 210.2k $25.1m | Added +33.5k |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 203.2k $27.7m | Reduced -30.3k |
| SOROS FUND MANAGEMENT LLC 0.48% of their portfolio | 200.0k $27.3m | Added +50.0k |
| Logos Global Management LP 3.19% of their portfolio | 200.0k $27.3m | New |
| Balyasny Asset Management L.P. 0.06% of their portfolio | 194.7k $26.6m | New |
| VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio | 189.9k $25.9m | Reduced -14.3k |
| Skandinaviska Enskilda Banken AB (publ) 0.11% of their portfolio | 180.4k $24.7m | Reduced -123.4k |
| BARCLAYS PLC 0.01% of their portfolio | 178.4k $24.3m | Reduced -3.2k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 177.8k $24.3m | Reduced -2.0k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 173.7k $23.7m | Reduced -1.1k |
| NEUBERGER BERMAN GROUP LLC 0.02% of their portfolio | 168.2k $23.0m | Added +8.6k |
| PFM Health Sciences, LP 1.73% of their portfolio | 166.8k $22.8m | New |
| MACKENZIE FINANCIAL CORP 0.01% of their portfolio | 165.7k $22.0m | Added +79.1k |
| CITIGROUP INC 0.02% of their portfolio | 165.2k $22.5m | Reduced -35.3k |
| GLENMEDE TRUST CO NA 0.11% of their portfolio | 163.4k $22.3m | Added +153.1k |
| Integral Health Asset Management, LLC 1.93% of their portfolio | 160.0k $21.8m | New |
| Aberdeen Group plc 0.04% of their portfolio | 156.6k $21.4m | Added +20.1k |
| Eagle Health Investments LP 5.19% of their portfolio | 155.0k $21.2m | Added +26.4k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.14% of their portfolio | 154.9k $21.1m | Added +47.4k |
| SEI INVESTMENTS CO 0.03% of their portfolio | 150.4k $20.5m | Reduced -4.7k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 150.3k $20.5m | Reduced -12.7k |
| TANG CAPITAL MANAGEMENT LLC 1.35% of their portfolio | 150.0k $20.5m | Unchanged |
| Man Group plc 0.06% of their portfolio | 145.2k $19.8m | Reduced -151.0k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 145.1k $19.8m | Reduced -618.2k |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. 0.20% of their portfolio | 139.7k $19.1m | Added +915 |
| FMR LLC 0.00% of their portfolio | 139.7k $19.1m | Reduced -106.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio | 139.4k $19.0m | Added +16.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 136.5k $18.6m | Added +2.4k |