NEKTAR THERAPEUTICS NKTR
COM NEW · Common Stock · CUSIP 640268306 · ISIN US6402683063
American healthcare company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Francisco, CA
- Founded1990
- Websitenektar.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.3m this quarter). Holder counts are more reliable. Shares outstanding: 20.3m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $56.91. Options: 13 managers hold calls ($47.7m notional), 9 hold puts ($75.6m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 1 |
| Q4 2022 | 1 |
| Q1 2023 | 1 |
| Q2 2023 | 0 |
| Q3 2023 | 0 |
| Q4 2023 | 0 |
| Q1 2024 | 0 |
| Q2 2024 | 0 |
| Q3 2024 | 0 |
| Q4 2024 | 0 |
| Q1 2025 | 0 |
| Q2 2025 | 104 |
| Q3 2025 | 146 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 0 | 0 |
| Q1 2023 | 0 | 0 |
| Q2 2023 | 0 | 1 |
| Q3 2025 | 104 | 45 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $0 | $0 | — |
| Q1 2025 | $0 | $0 | — |
| Q2 2025 | $32.1m | $35.6m | 1.11 |
| Q3 2025 | $47.7m | $75.6m | 1.59 |
Biggest buyers
| BVF INC/IL | New | +1.3m |
| MORGAN STANLEY | Added | +857.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +703.0k |
| CITADEL ADVISORS LLC | New | +361.1k |
| TWO SIGMA INVESTMENTS, LP | Added | +354.8k |
| EMERALD ADVISERS, LLC | New | +323.2k |
| Jefferies Financial Group Inc. | New | +303.2k |
| GREAT POINT PARTNERS LLC | New | +300.0k |
| EMERALD MUTUAL FUND ADVISERS TRUST | New | +233.2k |
| VANGUARD GROUP INC | Added | +219.2k |
Biggest sellers
| AQR CAPITAL MANAGEMENT LLC | Sold out | -427.9k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -393.6k |
| Nantahala Capital Management, LLC | Reduced | -291.2k |
| TCG Crossover Management, LLC | Sold out | -266.7k |
| Balyasny Asset Management L.P. | Reduced | -203.5k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -133.3k |
| UBS Group AG | Reduced | -110.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -103.0k |
| Schonfeld Strategic Advisors LLC | Sold out | -101.5k |
| Jain Global LLC | Reduced | -96.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $17.7m311.0k shares |
| CITADEL ADVISORS LLC | Reduced | $7.6m134.3k shares |
| GROUP ONE TRADING LLC | Reduced | $6.8m120.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.9m68.6k shares |
| Caption Management, LLC | New | $2.8m50.0k shares |
| WOLVERINE TRADING, LLC | Added | $2.8m47.4k shares |
| Point72 Asset Management, L.P. | New | $1.8m32.5k shares |
| MILLENNIUM MANAGEMENT LLC | Reduced | $1.4m25.0k shares |
| JANE STREET GROUP, LLC | New | $1.1m19.8k shares |
| HRT FINANCIAL LP | New | $705.0k12.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $31.2m548.2k shares |
| CITADEL ADVISORS LLC | Added | $20.1m353.7k shares |
| GROUP ONE TRADING LLC | Reduced | $7.0m123.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.7m100.6k shares |
| Caption Management, LLC | New | $4.4m77.5k shares |
| WOLVERINE TRADING, LLC | Added | $4.3m73.5k shares |
| Point72 Asset Management, L.P. | New | $1.8m32.5k shares |
| JANE STREET GROUP, LLC | New | $603.1k10.6k shares |
| HRT FINANCIAL LP | New | $392.0k6.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.9 pts · filed 2026-05-06 | 15.0% |
| Two Seas Capital LP 13G · institution +0.7 pts · filed 2026-09-28 | 9.8% |
| BlackRock, Inc. 13G · institution +6.2 pts · filed 2026-07-29 | 7.8% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor -2.7 pts · filed 2026-08-14 | 7.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), SUSQUEHANNA SECURITIES, LLC (4.0%, 2026-02-13)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 3 | $18.0k | — |
| Q1 2024 | 0 | — | 3 | $24.9k | — |
| Q2 2024 | 0 | — | 4 | $76.4k | $23.4k |
| Q3 2024 | 0 | — | 3 | $35.1k | — |
| Q4 2024 | 0 | — | 3 | — | — |
| Q1 2025 | 0 | — | 3 | — | — |
| Q2 2025 | 0 | — | 3 | — | — |
| Q3 2025 | 0 | — | 3 | $938.8k | $859.7k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-09-09 | ROBIN HOWARD W President & CEO, director | Sold plan | $311.2k6.7k shares |
| 2025-09-05 | ROBIN HOWARD W President & CEO, director | Sold plan | $256.9k6.7k shares |
| 2025-09-04 | ROBIN HOWARD W President & CEO, director | Sold plan | $174.1k5.2k shares |
| 2025-09-04 | Zalevsky Jonathan Chief R&D Officer | Sold plan | $57.7k1.7k shares |
| 2025-09-02 | ROBIN HOWARD W President & CEO, director | Sold plan | $45.2k1.5k shares |
| 2025-09-02 | Zalevsky Jonathan Chief R&D Officer | Sold plan | $14.6k485 shares |
| 2025-08-19 | ROBIN HOWARD W President & CEO, director | Sold | $41.8k1.6k shares |
| 2025-08-19 | Zalevsky Jonathan Chief R&D Officer | Sold | $19.3k725 shares |
| 2025-08-19 | Wilson Mark Andrew Chief Legal Officer | Sold | $18.0k676 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| BVF INC/IL 2.94% of their portfolio | 1.3m $72.6m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 948.6k $54.0m | Added +219.2k |
| MORGAN STANLEY 0.00% of their portfolio | 929.2k $52.9m | Added +857.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.08% of their portfolio | 924.9k $52.6m | Added +703.0k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.25% of their portfolio | 791.0k $45.0m | Not comparable |
| BlackRock, Inc. 0.00% of their portfolio | 609.1k $34.7m | Added +193.9k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 546.0k $31.1m | Reduced -103.0k |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 434.2k $24.7m | Added +354.8k |
| Nantahala Capital Management, LLC 1.47% of their portfolio | 418.5k $23.8m | Reduced -291.2k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 361.1k $20.5m | New |
| 22NW, LP 8.88% of their portfolio | 331.1k $18.8m | Added +185.0k |
| EMERALD ADVISERS, LLC 0.59% of their portfolio | 323.2k $18.4m | New |
| Jefferies Financial Group Inc. 0.16% of their portfolio | 303.2k $17.3m | New |
| GREAT POINT PARTNERS LLC 7.13% of their portfolio | 300.0k $17.1m | New |
| PRIMECAP MANAGEMENT CO/CA/ 0.01% of their portfolio | 289.1k $16.4m | Reduced -10.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 278.5k $15.8m | Added +31.5k |
| ARMISTICE CAPITAL, LLC 0.48% of their portfolio | 268.0k $15.2m | Added +144.0k |
| EMERALD MUTUAL FUND ADVISERS TRUST 0.69% of their portfolio | 233.2k $13.3m | New |
| Woodline Partners LP 0.06% of their portfolio | 233.1k $13.3m | Reduced -13.1k |
| Invesco Ltd. 0.00% of their portfolio | 226.9k $12.9m | Added +194.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 225.2k $12.8m | Added +92.9k |
| GILDER GAGNON HOWE & CO LLC 0.13% of their portfolio | 224.8k $12.8m | Added +195.9k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 182.8k $10.4m | Reduced -203.5k |
| TWO SIGMA ADVISERS, LP 0.02% of their portfolio | 178.9k $10.2m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 171.8k $9.8m | New |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 0.68% of their portfolio | 153.8k $8.8m | New |
| STATE STREET CORP 0.00% of their portfolio | 129.0k $7.3m | Added +78.9k |
| Boxer Capital Management, LLC 2.27% of their portfolio | 125.0k $7.1m | Unchanged |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 123.7k $7.0m | New |
| Sofinnova Investments, Inc. 0.41% of their portfolio | 118.4k $6.7m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 114.7k $6.5m | Added +48.7k |
| Quinn Opportunity Partners LLC 0.46% of their portfolio | 109.9k $6.3m | New |
| Hudson Bay Capital Management LP 0.04% of their portfolio | 107.7k $6.1m | New |
| FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio | 91.8k $5.2m | Added +39.1k |
| Trexquant Investment LP 0.05% of their portfolio | 91.5k $5.2m | New |
| UBS Group AG 0.00% of their portfolio | 90.8k $5.2m | Reduced -110.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 90.0k $5.1m | New |
| Simplify Asset Management Inc. 0.10% of their portfolio | 87.2k $5.0m | Added +35.2k |
| Stonepine Capital Management, LLC 3.93% of their portfolio | 85.0k $4.8m | Added +34.8k |
| Informed Momentum Co LLC 0.50% of their portfolio | 78.2k $4.4m | Added +54.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 77.1k $4.4m | Added +14.6k |
| SIMPLEX TRADING, LLC 0.10% of their portfolio | 76.5k $4.3m | Added +29.5k |
| DIADEMA PARTNERS LP 2.97% of their portfolio | 75.0k $4.3m | New |
| Moody Aldrich Partners LLC 0.80% of their portfolio | 73.7k $4.2m | Added +28.3k |
| ADAR1 Capital Management, LLC 0.41% of their portfolio | 72.0k $4.1m | Added +56.2k |
| Longaeva Partners L.P. 0.76% of their portfolio | 62.7k $3.6m | New |
| Artia Global Partners LP 0.58% of their portfolio | 58.0k $3.3m | New |
| WOLVERINE TRADING, LLC 0.07% of their portfolio | 57.8k $3.4m | Added +42.7k |
| DAFNA Capital Management LLC 0.77% of their portfolio | 55.0k $3.1m | Added +45.0k |
| STEMPOINT CAPITAL LP 0.61% of their portfolio | 53.2k $3.0m | New |
| F/m Investments LLC 0.12% of their portfolio | 53.1k $3.0m | New |
| SUPERSTRING CAPITAL MANAGEMENT LP 2.87% of their portfolio | 51.3k $2.9m | New |
| Eversept Partners, LP 0.22% of their portfolio | 49.9k $2.8m | Reduced -65.1k |
| Propel Bio Management, LLC 2.79% of their portfolio | 49.0k $2.8m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 48.6k $2.8m | Added +27.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 48.0k $2.7m | Reduced -19.6k |
| Cambridge Investment Research Advisors, Inc. 0.01% of their portfolio | 46.6k $2.7m | Added +34.6k |
| READYSTATE ASSET MANAGEMENT LP 0.12% of their portfolio | 45.0k $2.6m | New |
| AWM Investment Company, Inc. 0.21% of their portfolio | 40.0k $2.3m | New |
| FMR LLC 0.00% of their portfolio | 40.0k $2.3m | Added +24.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 39.3k $2.2m | Added +3.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 38.5k $2.2m | Added +14.3k |
| Deuterium Capital Management, LLC 3.08% of their portfolio | 37.3k $2.1m | Unchanged |
| Walleye Capital LLC 0.02% of their portfolio | 36.1k $2.1m | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 34.5k $2.0m | New |
| Jain Global LLC 0.02% of their portfolio | 32.8k $1.9m | Reduced -96.0k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.04% of their portfolio | 30.1k $1.7m | Reduced -36.0k |
| Headlands Technologies LLC 0.14% of their portfolio | 29.8k $1.7m | Added +27.3k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 27.3k $1.6m | Reduced -393.6k |
| Palumbo Wealth Management LLC 0.48% of their portfolio | 26.2k $1.5m | Added +2.4k |
| Verition Fund Management LLC 0.01% of their portfolio | 24.4k $1.4m | New |
| Engineers Gate Manager LP 0.01% of their portfolio | 17.6k $1.0m | New |
| Persistent Asset Partners Ltd 0.71% of their portfolio | 17.3k $982.7k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 17.0k $970.1k | Added +12.0k |
| Erste Asset Management GmbH 0.01% of their portfolio | 17.0k $1.0m | New |
| BARCLAYS PLC 0.00% of their portfolio | 16.7k $949.0k | Added +7.7k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 16.1k $913.6k | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 14.9k $850.4k | Reduced -133.3k |
| CAXTON ASSOCIATES LLP 0.02% of their portfolio | 14.0k $795.3k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 13.7k $782.0k | New |
| HRT FINANCIAL LP 0.00% of their portfolio | 13.2k $748.0k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 12.0k $682.0k | Reduced -5.8k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 10.1k $573.9k | New |
| HB Wealth Management, LLC 0.00% of their portfolio | 9.2k $526.0k | New |
| Glenmede Investment Management, LP 0.00% of their portfolio | 9.2k $523.5k | New |
| DARK FOREST CAPITAL MANAGEMENT LP 0.02% of their portfolio | 9.2k $522.6k | New |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 8.5k $485.3k | Reduced -84.7k |
| Kestra Advisory Services, LLC 0.00% of their portfolio | 7.7k $435.3k | New |
| SummitTX Capital, L.P. 0.02% of their portfolio | 6.8k $386.8k | Reduced -5.6k |
| XTX Topco Ltd 0.02% of their portfolio | 5.9k $335.5k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 5.4k $309.3k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 5.4k $282.1k | Added +38 |
| Gainplan LLC 0.12% of their portfolio | 5.0k $286.5k | Reduced -10.0k |
| Rangeley Capital, LLC 0.26% of their portfolio | 4.9k $278.5k | New |
| LPL Financial LLC 0.00% of their portfolio | 4.8k $270.5k | New |
| FIFTH LANE CAPITAL, LP 0.26% of their portfolio | 4.5k $256.1k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 4.3k $246.2k | New |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 4.1k $233.8k | New |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 4.1k $233.1k | New |
| Birchview Capital, LP 0.17% of their portfolio | 4.0k $228.8k | New |