MONOPAR THERAPEUTICS INC MNPR
COM NEW · Common Stock · CUSIP 61023L207
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWilmette, IL
- Websitemonopartx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $54.77.
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 7 |
| Q4 2024 | 19 |
| Q1 2025 | 36 |
| Q2 2025 | 44 |
| Q3 2025 | 56 |
| Q4 2025 | 74 |
| Q1 2026 | 82 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 14 | 1 |
| Q1 2025 | 24 | 6 |
| Q2 2025 | 34 | 15 |
| Q3 2025 | 35 | 17 |
| Q4 2025 | 54 | 15 |
| Q1 2026 | 49 | 29 |
Biggest buyers
| Sio Capital Management, LLC | New | +173.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +153.2k |
| Polar Capital Holdings Plc | Added | +120.8k |
| Balyasny Asset Management L.P. | Added | +104.5k |
| Vestal Point Capital, LP | New | +65.4k |
| Walleye Capital LLC | New | +63.1k |
| BlackRock, Inc. | Added | +61.7k |
| Alyeska Investment Group, L.P. | Added | +60.0k |
| Siren, L.L.C. | Added | +57.8k |
| CITADEL ADVISORS LLC | Added | +53.4k |
Biggest sellers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -330.3k |
| Deep Track Capital, LP | Sold out | -95.4k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -51.7k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -23.7k |
| CITIGROUP INC | Reduced | -13.6k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -11.4k |
| Virtu Financial LLC | Sold out | -10.0k |
| TCG Crossover Management, LLC | Reduced | -9.8k |
| MOUNTAIN PACIFIC INVESTMENT ADVISERS LLC | Sold out | -6.1k |
| STATE OF WISCONSIN INVESTMENT BOARD | Sold out | -5.8k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| JANUS HENDERSON GROUP PLC 13G · institution +0.3 pts · filed 2025-11-14 | 19.5% |
| Monopar Therapeutics 13D · may seek influence filed 2025-02-07 | 13.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor no change · filed 2026-02-17 | 9.9% |
| ASTRAZENECA PLC 13G · passive investor filed 2026-02-06 | 7.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.0% |
Fell to 5% or below in the last year: Adage Capital Management, L.P. (4.8%, 2026-08-12), Saturn V Capital Management LP (4.7%, 2026-08-12), Tactic Pharma LLC (4.5%, 2026-01-30)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 1 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $25.2k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 1 | $1.2m | — |
| Q3 2025 | 0 | — | 4 | $36.0m | — |
| Q4 2025 | 1 | $104.9k | 1 | $343.9k | — |
| Q1 2026 | 0 | — | 0 | — | — |
None reported in Q1 2026.
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| JANUS HENDERSON GROUP PLC 0.03% of their portfolio | 1.3m $72.1m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.39% of their portfolio | 667.2k $36.6m | Unchanged |
| Saturn V Capital Management LP 3.43% of their portfolio | 345.6k $18.9m | Added +19.9k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.21% of their portfolio | 323.7k $17.7m | Added +153.2k |
| BlackRock, Inc. 0.00% of their portfolio | 316.6k $17.3m | Added +61.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 309.2k $16.9m | Reduced -330.3k |
| Siren, L.L.C. 0.41% of their portfolio | 270.1k $14.8m | Added +57.8k |
| ADAR1 Capital Management, LLC 0.87% of their portfolio | 264.3k $14.5m | Added +30.4k |
| Polar Capital Holdings Plc 0.05% of their portfolio | 226.5k $12.4m | Added +120.8k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 218.5k $12.0m | First filing |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 174.3k $9.6m | Reduced -51.7k |
| Sio Capital Management, LLC 1.37% of their portfolio | 173.5k $9.5m | New |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 136.4k $7.5m | Added +104.5k |
| TCG Crossover Management, LLC 0.21% of their portfolio | 132.1k $7.2m | Reduced -9.8k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 100.0k $5.5m | Added +60.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 99.9k $5.5m | Added +911 |
| Vivo Capital, LLC 0.41% of their portfolio | 90.5k $5.0m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 88.4k $4.8m | Added +4.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 78.6k $4.3m | Added +13.8k |
| Vestal Point Capital, LP 0.10% of their portfolio | 65.4k $3.6m | New |
| Walleye Capital LLC 0.02% of their portfolio | 63.1k $3.5m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 59.7k $3.3m | Added +53.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 58.4k $3.2m | Added +53.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 53.0k $2.9m | Reduced -23.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 47.7k $2.6m | Added +25.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 46.0k $2.5m | First filing |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.28% of their portfolio | 43.5k $2.4m | New |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 42.4k $2.3m | Added +9.9k |
| UBS Group AG 0.00% of their portfolio | 39.4k $2.2m | Added +35.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 34.7k $1.9m | Added +24.3k |
| Driehaus Capital Management LLC 0.01% of their portfolio | 33.2k $1.8m | Reduced -559 |
| NORTHERN TRUST CORP 0.00% of their portfolio | 31.9k $1.7m | Added +1.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 28.8k $1.6m | Added +25.4k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 28.4k $1.6m | First filing |
| BARCLAYS PLC 0.00% of their portfolio | 24.9k $1.4m | Added +4.7k |
| Jump Financial, LLC 0.02% of their portfolio | 22.8k $1.2m | New |
| MORGAN STANLEY 0.00% of their portfolio | 22.3k $1.2m | Reduced -4.7k |
| Squarepoint Ops LLC 0.00% of their portfolio | 21.8k $1.2m | Added +11.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 14.2k $780.7k | Added +13.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 12.6k $688.1k | Reduced -1.7k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 9.8k $535.0k | Added +4.8k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 7.6k $415.4k | Added +656 |
| WINTON GROUP Ltd 0.01% of their portfolio | 6.8k $374.2k | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 6.8k $373.6k | New |
| Informed Momentum Co LLC 0.04% of their portfolio | 6.2k $341.1k | Reduced -5.1k |
| Creative Planning 0.00% of their portfolio | 6.0k $328.0k | New |
| TD Asset Management Inc 0.00% of their portfolio | 5.9k $322.4k | Added +2.8k |
| GERBER, LLC 0.17% of their portfolio | 5.6k $306.9k | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 5.6k $304.1k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 4.9k $271.0k | Reduced -44 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 4.6k $250.5k | New |
| Engineers Gate Manager LP 0.00% of their portfolio | 4.4k $242.9k | Added +96 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 4.1k $226.7k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 3.7k $201.2k | New |
| Virtus Investment Advisers, LLC 0.06% of their portfolio | 3.7k $200.3k | Added +90 |
| Your Advocates Ltd., LLP 0.06% of their portfolio | 3.3k $183.2k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 2.5k $139.1k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.4k $129.1k | Added +313 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 2.1k $112.6k | Reduced -34 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 1.7k $94.7k | Reduced -3.4k |
| DIADEMA PARTNERS LP 0.04% of their portfolio | 1.6k $89.3k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 1.6k $85.1k | First filing |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 1.2k $65.7k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 979 $53.6k | Reduced -36 |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 964 $52.8k | Unchanged |
| Persistent Asset Partners Ltd 0.02% of their portfolio | 783 $42.9k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 761 $41.7k | Added +414 |
| MEEDER ASSET MANAGEMENT INC 0.00% of their portfolio | 637 $34.9k | Reduced -357 |
| NewEdge Advisors, LLC 0.00% of their portfolio | 600 $32.9k | Unchanged |
| FMR LLC 0.00% of their portfolio | 409 $22.4k | Added +51 |
| Legal & General Group Plc 0.00% of their portfolio | 408 $22.4k | Reduced -71 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 300 $16.4k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 247 $13.5k | Reduced -34 |
| CITIGROUP INC 0.00% of their portfolio | 232 $12.7k | Reduced -13.6k |
| Allworth Financial LP 0.00% of their portfolio | 111 $6.1k | Added +11 |
| US BANCORP \DE\ 0.00% of their portfolio | 72 $3.9k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 49 $2.0k | Reduced -277 |
| Sterling Capital Management LLC 0.00% of their portfolio | 29 $1.6k | Unchanged |
| GAMMA Investing LLC 0.00% of their portfolio | 29 $1.6k | Added +15 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 25 $1.4k | Reduced -2.9k |
| CWM, LLC 0.00% of their portfolio | 15 $822 | Added +10 |
| Kilter Group LLC 0.00% of their portfolio | 1 $55 | New |