MONOPAR THERAPEUTICS INC MNPR
COM NEW · Common Stock · CUSIP 61023L207
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWilmette, IL
- Websitemonopartx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($34.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $35.67.
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 7 |
| Q4 2024 | 19 |
| Q1 2025 | 36 |
| Q2 2025 | 44 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 14 | 1 |
| Q1 2025 | 24 | 6 |
| Q2 2025 | 34 | 15 |
Biggest buyers
| BlackRock, Inc. | Added | +190.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +48.4k |
| JANUS HENDERSON GROUP PLC | Added | +38.0k |
| Ally Bridge Group (NY) LLC | New | +34.5k |
| VANGUARD GROUP INC | Added | +31.3k |
| STATE STREET CORP | Added | +26.0k |
| NORTHERN TRUST CORP | Added | +22.7k |
| UBS Group AG | Added | +13.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | New | +13.2k |
| Bank of New York Mellon Corp | New | +8.9k |
Biggest sellers
| Point72 Asset Management, L.P. | Reduced | -64.1k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -45.6k |
| MARSHALL WACE, LLP | Sold out | -26.0k |
| GOLDMAN SACHS GROUP INC | Sold out | -18.5k |
| JANE STREET GROUP, LLC | Sold out | -10.4k |
| OMERS ADMINISTRATION Corp | Sold out | -9.0k |
| HRT FINANCIAL LP | Sold out | -8.2k |
| Balyasny Asset Management L.P. | Sold out | -6.1k |
| Ikarian Capital, LLC | Sold out | -5.9k |
| Point72 Asia (Singapore) Pte. Ltd. | Sold out | -1.8k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| JANUS HENDERSON GROUP PLC 13G · institution +0.3 pts · filed 2025-11-14 | 19.5% |
| Monopar Therapeutics 13D · may seek influence filed 2025-02-07 | 13.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor no change · filed 2026-02-17 | 9.9% |
| ASTRAZENECA PLC 13G · passive investor filed 2026-02-06 | 7.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.0% |
Fell to 5% or below in the last year: Adage Capital Management, L.P. (4.8%, 2026-08-12), Saturn V Capital Management LP (4.7%, 2026-08-12), Tactic Pharma LLC (4.5%, 2026-01-30)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 1 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $25.2k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 1 | $1.2m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-04-02 | Tactic Pharma LLC +4 Chief Executive Officer, director | Sold | $1.2m33.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| JANUS HENDERSON GROUP PLC 0.02% of their portfolio | 1.2m $41.6m | Added +38.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 599.2k $21.4m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.31% of their portfolio | 511.2k $18.3m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 205.2k $7.3m | Added +190.7k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 104.0k $3.7m | Reduced -64.1k |
| ADAR1 Capital Management, LLC 0.59% of their portfolio | 101.0k $3.6m | Added +200 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 96.9k $3.5m | Added +48.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 86.5k $3.1m | Added +31.3k |
| Affinity Asset Advisors, LLC 0.36% of their portfolio | 67.5k $2.4m | Added +5.5k |
| STATE STREET CORP 0.00% of their portfolio | 41.8k $1.5m | Added +26.0k |
| Ally Bridge Group (NY) LLC 1.08% of their portfolio | 34.5k $1.2m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 31.8k $1.1m | Added +22.7k |
| UBS Group AG 0.00% of their portfolio | 21.9k $782.6k | Added +13.8k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 14.8k $529.1k | Reduced -45.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 13.2k $474.0k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 8.9k $320.2k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 8.4k $299.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 7.9k $283.8k | Added +6.5k |
| BARCLAYS PLC 0.00% of their portfolio | 7.3k $260.7k | Added +7.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 6.2k $223.0k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 5.8k $209.3k | New |
| GERBER, LLC 0.14% of their portfolio | 5.6k $200.4k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 3.4k $121.1k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.9k $103.8k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 2.5k $90.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.3k $82.3k | Added +2.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 2.2k $79.5k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 2.1k $75.5k | Reduced -369 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.9k $68.7k | Added +1.8k |
| AlphaQuest LLC 0.01% of their portfolio | 1.8k $63.8k | Added +569 |
| CITIGROUP INC 0.00% of their portfolio | 1.4k $51.6k | Added +1.2k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 964 $34.5k | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 600 $21.5k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 453 $16.0k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 431 $15.4k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 415 $14.8k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 347 $12.4k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 254 $9.1k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 139 $5.0k | New |
| Allworth Financial LP 0.00% of their portfolio | 100 $3.6k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 38 $2.0k | Reduced -167 |
| FMR LLC 0.00% of their portfolio | 31 $1.1k | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 10 $358 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |