Vault-13

MILESTONE PHARMACEUTICALS IN MIST

COM · Common Stock · CUSIP 59935V107

49 institutional holders -2 vs Q1 2023
20,674,40820.7m shares reported held*
61.9% of all shares outstanding*
$58.9mreported value*
4 new 20 added 12 reduced 6 sold out net sold ≈ $2.9m (-1.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($36.9k this quarter). Holder counts are more reliable. Shares outstanding: 33.4m as of 2023-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.85. Options: 3 managers hold calls ($285 notional), 2 hold puts ($17.4k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 47Q4 22: 57Q1 23: 51Q2 23: 4949Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202247
Q4 202257
Q1 202351
Q2 202349

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 39 bought or addedQ4 22: 22 cut or sold outQ4 22Q1 23: 21 bought or addedQ1 23: 28 cut or sold outQ1 23Q2 23: 24 bought or addedQ2 23: 18 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20223922
Q1 20232128
Q2 20232418

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ3 22 calls: $11.6mQ3 22 puts: $9.1mQ3 22P/C 0.79Q4 22 calls: $1.9mQ4 22 puts: $468.5kQ4 22P/C 0.24Q1 23 calls: $840.5kQ1 23 puts: $474.0kQ1 23P/C 0.56Q2 23 calls: $285Q2 23 puts: $17.4kQ2 23P/C 61.00
Numbers
QuarterCallsPutsP/C
Q3 2022$11.6m$9.1m0.79
Q4 2022$1.9m$468.5k0.24
Q1 2023$840.5k$474.0k0.56
Q2 2023$285$17.4k61.00

Biggest buyers

BlackRock Inc. Added +576,842+576.8k
Affinity Asset Advisors, LLC Added +100,686+100.7k
BML Capital Management, LLC Added +52,500+52.5k
Squarepoint Ops LLC New +45,694+45.7k
Lion Point Capital, LP Added +25,000+25.0k
MILLENNIUM MANAGEMENT LLC Added +22,146+22.1k
RENAISSANCE TECHNOLOGIES LLC Added +16,966+17.0k
TWO SIGMA INVESTMENTS, LP Added +16,879+16.9k
Beta Wealth Group, Inc. New +14,127+14.1k
Virtu Financial LLC New +11,743+11.7k

Biggest sellers

Point72 Asset Management, L.P. Reduced -1,042,341-1.0m
CITADEL ADVISORS LLC Reduced -339,743-339.7k
Schonfeld Strategic Advisors LLC Sold out -146,806-146.8k
JPMORGAN CHASE & CO Reduced -128,891-128.9k
BANK OF AMERICA CORP /DE/ Reduced -93,813-93.8k
MARSHALL WACE, LLP Reduced -65,391-65.4k
BARCLAYS PLC Reduced -46,052-46.1k
GSA CAPITAL PARTNERS LLP Reduced -33,428-33.4k
MORGAN STANLEY Reduced -32,816-32.8k
XTX Topco Ltd Sold out -12,636-12.6k

Biggest calls

CITADEL ADVISORS LLC Reduced $285100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC Reduced $0200 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $17.4k6.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
RTW INVESTMENTS, LP 13G · institution no change · filed 2026-05-15 9.9% no change 12.4m≈ $16.6m 2026-05-15
Propel Bio Management, LLC 13G · passive investor new · filed 2025-12-23 9.9% new 8.9m≈ $11.9m 2025-12-23
Pavaki Capital Management LLC 13G · passive investor new · filed 2026-08-07 7.3% new 9.1m≈ $12.2m 2026-08-07
Adage Capital Management, L.P. 13G · institution -3.6 pts · filed 2026-05-13 6.4% -3.6 pts 8.0m≈ $10.7m 2026-05-13

Fell to 5% or below in the last year: Trails Edge Capital Partners, LP (4.3%, 2026-03-26)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
505Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 1 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 5 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20221$28.0k0——
Q3 20220—0——
Q4 20225$327.1k0——
Q1 20230—0——
Q2 20230—0——

None reported in Q2 2023.

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RTW INVESTMENTS, LP 0.18% of their portfolio NEW YORK, NY 3,256,1023.3m $9.3m $9.3m 0.18% Unchanged
2 BlackRock Inc. 0.00% of their portfolio New York, NY 2,651,2002.7m $7.6m $7.6m 0.00% Added +576.8k +576,842
3 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 2,555,2872.6m $7.3m $7.3m 0.00% Added +2.8k +2,822
4 Venrock Adviser, LLC 1.01% of their portfolio NEW YORK, NY 2,208,8122.2m $6.3m $6.3m 1.01% Unchanged
5 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 1,751,1681.8m $5.0m $5.0m 0.01% Added +22.1k +22,146
6 Bleichroeder LP 0.77% of their portfolio NEW YORK, NY 1,326,0851.3m $3.8m $3.8m 0.77% Unchanged
7 Alta Fundamental Advisers LLC 1.41% of their portfolio NEW YORK, NY 897,961898.0k $2.6m $2.6m 1.41% Unchanged
8 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 805,039805.0k $2.3m $2.3m 0.00% Reduced -32.8k -32,816
9 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 800,776800.8k $2.3m $2.3m 0.00% Reduced -46.1k -46,052
10 Boxer Capital, LLC 0.09% of their portfolio San Diego, CA 698,861698.9k $2.0m $2.0m 0.09% Unchanged
11 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 469,750469.8k $1.3m $1.3m 0.00% Reduced -339.7k -339,743
12 Ikarian Capital, LLC 0.44% of their portfolio DALLAS, TX 460,416460.4k $1.3m $1.3m 0.44% Unchanged
13 Lion Point Capital, LP 0.95% of their portfolio NEW YORK, NY 450,207450.2k $1.3m $1.3m 0.95% Added +25.0k +25,000
14 Affinity Asset Advisors, LLC 0.34% of their portfolio NEW YORK, NY 300,068300.1k $855.2k $855.2k 0.34% Added +100.7k +100,686
15 BML Capital Management, LLC 0.70% of their portfolio ZIONSVILLE, IN 272,500272.5k $776.6k $776.6k 0.70% Added +52.5k +52,500
16 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 247,163247.2k $704.4k $704.4k 0.00% Reduced -128.9k -128,891
17 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 232,659232.7k $663.1k $663.1k 0.00% Reduced -1.0m -1,042,341
18 BIT Capital GmbH 0.07% of their portfolio BERLIN, 2M 207,276207.3k $590.7k $590.7k 0.07% Added +9.0k +9,000
19 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 179,987180.0k $513.0k $513.0k 0.00% Reduced -3.3k -3,257
20 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 167,101167.1k $476.2k $476.2k 0.00% Reduced -65.4k -65,391
21 Valeo Financial Advisors, LLC 0.02% of their portfolio CARMEL, IN 118,699118.7k $338.3k $338.3k 0.02% Added +5.0k +5,000
22 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 108,766108.8k $310.0k $310.0k 0.00% Added +17.0k +16,966
23 GSA CAPITAL PARTNERS LLP 0.02% of their portfolio LONDON, X0 66,34066.3k $189.0k $189.0k 0.02% Reduced -33.4k -33,428
24 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 52,18652.2k $148.7k $148.7k 0.00% Added +16.9k +16,879
25 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 45,69445.7k $130.2k $130.2k 0.00% New
26 LMR Partners LLP 0.00% of their portfolio LONDON, X0 38,49538.5k $109.7k $109.7k 0.00% Unchanged
27 Clear Creek Financial Management, LLC 0.02% of their portfolio SILVERDALE, WA 31,92931.9k $91.0k $91.0k 0.02% Reduced -4.0k -4,000
28 HighTower Advisors, LLC 0.00% of their portfolio CHICAGO, IL 31,00031.0k $88.0k $88.0k 0.00% Added +4.8k +4,800
29 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 25,70025.7k $73.2k $73.2k 0.00% Added +11.4k +11,400
30 BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 25,17625.2k $71.8k $71.8k 0.00% Unchanged
31 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 23,26123.3k $66.3k $66.3k 0.00% Added +10.9k +10,875
32 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 21,61121.6k $61.6k $61.6k 0.00% Reduced -388 -388
33 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 18,05618.1k $51.5k $51.5k 0.00% Added +1.6k +1,626
34 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 17,57617.6k $50.1k $50.1k 0.00% Unchanged
35 PVG ASSET MANAGEMENT CORP 0.19% of their portfolio GOLDEN, CO 15,40515.4k $43.9k $43.9k 0.19% Reduced -430 -430
36 Beta Wealth Group, Inc. 0.02% of their portfolio SAN DIEGO, CA 14,12714.1k $40.3k $40.3k 0.02% New
37 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 13,67613.7k $39.0k $39.0k 0.00% Reduced -93.8k -93,813
38 Creative Planning 0.00% of their portfolio OVERLAND PARK, KS 13,08013.1k $37.3k $37.3k 0.00% Unchanged
39 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 12,95713.0k $36.9k $36.9k 0.00% Added +4.0k +4,037
40 Virtu Financial LLC 0.00% of their portfolio New York, NY 11,74311.7k $33.0k $33.0k 0.00% New
41 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 11,11311.1k $31.7k $31.7k 0.00% Added +1.0k +1,016
42 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 10,81010.8k $30.8k $30.8k 0.00% Added +8.7k +8,659
43 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 10,50010.5k $29.9k $29.9k 0.00% Unchanged
44 NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio MONTREAL, A8 3,8503.9k $11.0k $11.0k 0.00% Added +3.8k +3,750
45 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 3,5883.6k $10.0k $10.0k 0.00% New
46 UBS Group AG 0.00% of their portfolio ZURICH, V8 3,3373.3k $9.5k $9.5k 0.00% Added +565 +565
47 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 172172 $490 $490 0.00% Added +73 +73
48 ICA Group Wealth Management, LLC 0.00% of their portfolio DENVER, CO 100100 $285 $285 0.00% Unchanged
49 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged