MILESTONE PHARMACEUTICALS IN MIST
COM · Common Stock · CUSIP 59935V107
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($36.9k this quarter). Holder counts are more reliable. Shares outstanding: 33.4m as of 2023-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.85. Options: 3 managers hold calls ($285 notional), 2 hold puts ($17.4k).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 47 |
| Q4 2022 | 57 |
| Q1 2023 | 51 |
| Q2 2023 | 49 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 39 | 22 |
| Q1 2023 | 21 | 28 |
| Q2 2023 | 24 | 18 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $11.6m | $9.1m | 0.79 |
| Q4 2022 | $1.9m | $468.5k | 0.24 |
| Q1 2023 | $840.5k | $474.0k | 0.56 |
| Q2 2023 | $285 | $17.4k | 61.00 |
Biggest buyers
| BlackRock Inc. | Added | +576.8k |
| Affinity Asset Advisors, LLC | Added | +100.7k |
| BML Capital Management, LLC | Added | +52.5k |
| Squarepoint Ops LLC | New | +45.7k |
| Lion Point Capital, LP | Added | +25.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +22.1k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +17.0k |
| TWO SIGMA INVESTMENTS, LP | Added | +16.9k |
| Beta Wealth Group, Inc. | New | +14.1k |
| Virtu Financial LLC | New | +11.7k |
Biggest sellers
| Point72 Asset Management, L.P. | Reduced | -1.0m |
| CITADEL ADVISORS LLC | Reduced | -339.7k |
| Schonfeld Strategic Advisors LLC | Sold out | -146.8k |
| JPMORGAN CHASE & CO | Reduced | -128.9k |
| BANK OF AMERICA CORP /DE/ | Reduced | -93.8k |
| MARSHALL WACE, LLP | Reduced | -65.4k |
| BARCLAYS PLC | Reduced | -46.1k |
| GSA CAPITAL PARTNERS LLP | Reduced | -33.4k |
| MORGAN STANLEY | Reduced | -32.8k |
| XTX Topco Ltd | Sold out | -12.6k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $285100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0200 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $17.4k6.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RTW INVESTMENTS, LP 13G · institution no change · filed 2026-05-15 | 9.9% |
| Propel Bio Management, LLC 13G · passive investor new · filed 2025-12-23 | 9.9% |
| Pavaki Capital Management LLC 13G · passive investor new · filed 2026-08-07 | 7.3% |
| Adage Capital Management, L.P. 13G · institution -3.6 pts · filed 2026-05-13 | 6.4% |
Fell to 5% or below in the last year: Trails Edge Capital Partners, LP (4.3%, 2026-03-26)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 1 | $28.0k | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 5 | $327.1k | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
None reported in Q2 2023.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 0.18% of their portfolio | 3.3m $9.3m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 2.7m $7.6m | Added +576.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 2.6m $7.3m | Added +2.8k |
| Venrock Adviser, LLC 1.01% of their portfolio | 2.2m $6.3m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.8m $5.0m | Added +22.1k |
| Bleichroeder LP 0.77% of their portfolio | 1.3m $3.8m | Unchanged |
| Alta Fundamental Advisers LLC 1.41% of their portfolio | 898.0k $2.6m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 805.0k $2.3m | Reduced -32.8k |
| BARCLAYS PLC 0.00% of their portfolio | 800.8k $2.3m | Reduced -46.1k |
| Boxer Capital, LLC 0.09% of their portfolio | 698.9k $2.0m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 469.8k $1.3m | Reduced -339.7k |
| Ikarian Capital, LLC 0.44% of their portfolio | 460.4k $1.3m | Unchanged |
| Lion Point Capital, LP 0.95% of their portfolio | 450.2k $1.3m | Added +25.0k |
| Affinity Asset Advisors, LLC 0.34% of their portfolio | 300.1k $855.2k | Added +100.7k |
| BML Capital Management, LLC 0.70% of their portfolio | 272.5k $776.6k | Added +52.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 247.2k $704.4k | Reduced -128.9k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 232.7k $663.1k | Reduced -1.0m |
| BIT Capital GmbH 0.07% of their portfolio | 207.3k $590.7k | Added +9.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 180.0k $513.0k | Reduced -3.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 167.1k $476.2k | Reduced -65.4k |
| Valeo Financial Advisors, LLC 0.02% of their portfolio | 118.7k $338.3k | Added +5.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 108.8k $310.0k | Added +17.0k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 66.3k $189.0k | Reduced -33.4k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 52.2k $148.7k | Added +16.9k |
| Squarepoint Ops LLC 0.00% of their portfolio | 45.7k $130.2k | New |
| LMR Partners LLP 0.00% of their portfolio | 38.5k $109.7k | Unchanged |
| Clear Creek Financial Management, LLC 0.02% of their portfolio | 31.9k $91.0k | Reduced -4.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 31.0k $88.0k | Added +4.8k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 25.7k $73.2k | Added +11.4k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio | 25.2k $71.8k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 23.3k $66.3k | Added +10.9k |
| STATE STREET CORP 0.00% of their portfolio | 21.6k $61.6k | Reduced -388 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 18.1k $51.5k | Added +1.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 17.6k $50.1k | Unchanged |
| PVG ASSET MANAGEMENT CORP 0.19% of their portfolio | 15.4k $43.9k | Reduced -430 |
| Beta Wealth Group, Inc. 0.02% of their portfolio | 14.1k $40.3k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 13.7k $39.0k | Reduced -93.8k |
| Creative Planning 0.00% of their portfolio | 13.1k $37.3k | Unchanged |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 13.0k $36.9k | Added +4.0k |
| Virtu Financial LLC 0.00% of their portfolio | 11.7k $33.0k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 11.1k $31.7k | Added +1.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 10.8k $30.8k | Added +8.7k |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 10.5k $29.9k | Unchanged |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 3.9k $11.0k | Added +3.8k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 3.6k $10.0k | New |
| UBS Group AG 0.00% of their portfolio | 3.3k $9.5k | Added +565 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 172 $490 | Added +73 |
| ICA Group Wealth Management, LLC 0.00% of their portfolio | 100 $285 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |