MILESTONE PHARMACEUTICALS IN MIST
COM · Common Stock · CUSIP 59935V107
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.5m this quarter). Holder counts are more reliable. Shares outstanding: 124.5m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.34. Options: 7 managers hold calls ($288.8k notional), 6 hold puts ($336.7k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 47 |
| Q4 2022 | 57 |
| Q1 2023 | 51 |
| Q2 2023 | 49 |
| Q3 2023 | 40 |
| Q4 2023 | 41 |
| Q1 2024 | 44 |
| Q2 2024 | 41 |
| Q3 2024 | 44 |
| Q4 2024 | 48 |
| Q1 2025 | 44 |
| Q2 2025 | 44 |
| Q3 2025 | 61 |
| Q4 2025 | 80 |
| Q1 2026 | 87 |
| Q2 2026 | 78 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 13 | 11 |
| Q4 2024 | 23 | 20 |
| Q1 2025 | 20 | 27 |
| Q2 2025 | 19 | 19 |
| Q3 2025 | 44 | 11 |
| Q4 2025 | 48 | 18 |
| Q1 2026 | 44 | 33 |
| Q2 2026 | 29 | 36 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $422.8k | $641.2k | 1.52 |
| Q4 2025 | $666.7k | $2.5m | 3.71 |
| Q1 2026 | $425.5k | $718.3k | 1.69 |
| Q2 2026 | $288.8k | $336.7k | 1.17 |
Biggest buyers
| Point72 Asset Management, L.P. | Added | +4.3m |
| Propel Bio Management, LLC | Added | +3.3m |
| Kalehua Capital Management LLC | New | +2.5m |
| Simplify Asset Management Inc. | Added | +1.8m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.6m |
| RTW INVESTMENTS, LP | Added | +1.5m |
| BOOTHBAY FUND MANAGEMENT, LLC | Added | +294.0k |
| Wealthspire Advisors, LLC | Added | +130.0k |
| Cascades Capital Asset Management, LLC | New | +83.6k |
| GUARDIAN WEALTH ADVISORS, LLC / NC | Added | +59.2k |
Biggest sellers
| GOLDMAN SACHS GROUP INC | Sold out | -2.0m |
| Balyasny Asset Management L.P. | Reduced | -630.8k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -277.2k |
| CITADEL ADVISORS LLC | Reduced | -163.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -159.2k |
| MARSHALL WACE, LLP | Reduced | -146.8k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -129.7k |
| GROUP ONE TRADING LLC | Reduced | -129.5k |
| Squarepoint Ops LLC | Reduced | -105.0k |
| JANE STREET GROUP, LLC | Reduced | -101.9k |
Biggest calls
| SIMPLEX TRADING, LLC | Added | $78.8k58.8k shares |
| CITADEL ADVISORS LLC | Added | $75.2k56.1k shares |
| GROUP ONE TRADING LLC | Reduced | $65.1k48.6k shares |
| IMC-Chicago, LLC | Reduced | $31.1k23.2k shares |
| JANE STREET GROUP, LLC | New | $21.4k16.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $16.5k12.3k shares |
| Aptus Capital Advisors, LLC | New | $670500 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $220.2k164.3k shares |
| JANE STREET GROUP, LLC | Reduced | $41.8k31.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $30.3k22.6k shares |
| IMC-Chicago, LLC | New | $26.4k19.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $11.1k8.3k shares |
| GROUP ONE TRADING LLC | Reduced | $7.0k5.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RTW INVESTMENTS, LP 13G · institution no change · filed 2026-05-15 | 9.9% |
| Propel Bio Management, LLC 13G · passive investor new · filed 2025-12-23 | 9.9% |
| Pavaki Capital Management LLC 13G · passive investor new · filed 2026-08-07 | 7.3% |
| Adage Capital Management, L.P. 13G · institution -3.6 pts · filed 2026-05-13 | 6.4% |
Fell to 5% or below in the last year: Trails Edge Capital Partners, LP (4.3%, 2026-03-26)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 5 | $567.5k | — |
| Q1 2026 | 0 | — | 5 | $209.7k | $97.9k |
| Q2 2026 | 0 | — | 1 | $82.5k | $82.5k |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-04-16 | Oliveto Joseph President and CEO, director | Sold plan | $82.5k36.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Pavaki Capital Management LLC 6.92% of their portfolio | 9.1m $12.2m | Added +5.0k |
| RTW INVESTMENTS, LP 0.09% of their portfolio | 7.8m $10.5m | Added +1.5m |
| Propel Bio Management, LLC 5.21% of their portfolio | 7.4m $10.0m | Added +3.3m |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 5.4m $7.3m | Added +4.3m |
| Simplify Asset Management Inc. 0.06% of their portfolio | 3.3m $4.5m | Added +1.8m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 3.1m $4.2m | Added +1.6m |
| Kalehua Capital Management LLC 1.09% of their portfolio | 2.5m $3.4m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 2.0m $2.7m | Reduced -277.2k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.8m $2.4m | Reduced -146.8k |
| Lion Point Capital, LP 5.26% of their portfolio | 820.0k $1.1m | Unchanged |
| TORONTO DOMINION BANK 0.00% of their portfolio | 750.0k $1.0m | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 666.7k $893.3k | Unchanged |
| Boxer Capital Management, LLC 0.07% of their portfolio | 666.7k $893.3k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 635.2k $851.2k | Reduced -88.9k |
| UBS Group AG 0.00% of their portfolio | 465.4k $623.6k | Reduced -29.5k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 462.7k $620.0k | Added +294.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 359.9k $482.3k | Reduced -159.2k |
| Aptus Capital Advisors, LLC 0.00% of their portfolio | 339.4k $454.9k | Added +59.2k |
| GUARDIAN WEALTH ADVISORS, LLC / NC 0.03% of their portfolio | 339.4k $454.9k | Added +59.2k |
| Seven Fleet Capital Management LP 0.06% of their portfolio | 270.2k $362.1k | Reduced -63.1k |
| Squarepoint Ops LLC 0.00% of their portfolio | 231.8k $310.6k | Reduced -105.0k |
| LPL Financial LLC 0.00% of their portfolio | 220.9k $296.0k | Added +27.5k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 220.5k $295.5k | Reduced -630.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 173.7k $232.8k | Reduced -2.8k |
| TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC 0.11% of their portfolio | 150.0k $201.0k | Added +50.0k |
| Wealthspire Advisors, LLC 0.00% of their portfolio | 140.6k $188.4k | Added +130.0k |
| Valeo Financial Advisors, LLC 0.00% of their portfolio | 130.7k $175.1k | Unchanged |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 100.0k $134.0k | Unchanged |
| Cascades Capital Asset Management, LLC 0.04% of their portfolio | 83.6k $112.0k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 64.7k $86.6k | Reduced -84.4k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 57.8k $77.4k | Reduced -101.9k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 54.2k $72.6k | Reduced -95.1k |
| Bay Rivers Group 0.02% of their portfolio | 46.6k $62.5k | Added +16.7k |
| SG Americas Securities, LLC 0.00% of their portfolio | 45.6k $61.0k | Added +3.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 40.8k $54.7k | Unchanged |
| October Effect Ltd 0.05% of their portfolio | 40.0k $53.6k | Reduced -11.9k |
| Focus Partners Wealth 0.00% of their portfolio | 36.0k $48.2k | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 32.9k $44.1k | Reduced -163.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 30.1k $40.3k | Added +3.5k |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 29.8k $39.9k | Unchanged |
| Mariner, LLC 0.00% of their portfolio | 27.8k $37.2k | Reduced -3.0k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 27.0k $36.0k | Reduced -32.7k |
| XTX Topco Ltd 0.00% of their portfolio | 26.3k $35.3k | Reduced -94.3k |
| Welch & Forbes LLC 0.00% of their portfolio | 25.0k $33.5k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 24.2k $32.4k | Added +15.0k |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 23.5k $31.5k | Unchanged |
| Exit Wealth Advisors, LLC. 0.01% of their portfolio | 22.7k $30.4k | Added +7.7k |
| STATE STREET CORP 0.00% of their portfolio | 22.6k $30.2k | Added +233 |
| HighTower Advisors, LLC 0.00% of their portfolio | 20.0k $26.8k | Added +10.0k |
| Stephenson & Company, Inc. 0.01% of their portfolio | 20.0k $26.8k | Unchanged |
| Taylor Financial Group, Inc. 0.01% of their portfolio | 20.0k $26.8k | Added +5.0k |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 16.7k $22.4k | New |
| Cetera Investment Advisers 0.00% of their portfolio | 16.4k $21.9k | Added +1.7k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 16.0k $19.8k | Unchanged |
| Pathstone Holdings, LLC 0.00% of their portfolio | 15.5k $20.8k | Reduced -1.5k |
| AE Wealth Management LLC 0.00% of their portfolio | 15.0k $20.1k | Unchanged |
| Vision Retirement, LLC 0.00% of their portfolio | 15.0k $20.1k | Unchanged |
| EARNED WEALTH ADVISORS, LLC 0.00% of their portfolio | 14.8k $19.8k | Unchanged |
| Bronte Capital Management Pty Ltd. 0.00% of their portfolio | 14.4k $19.3k | Added +4.0k |
| WINTON GROUP Ltd 0.00% of their portfolio | 14.3k $19.2k | New |
| Beta Wealth Group, Inc. 0.01% of their portfolio | 14.1k $18.9k | Unchanged |
| Strategic Family Wealth Counselors, L.L.C. 0.00% of their portfolio | 13.9k $18.6k | Unchanged |
| Creative Planning 0.00% of their portfolio | 13.1k $17.5k | Reduced -330 |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 12.5k $16.8k | Unchanged |
| Safeguard Investment Advisory Group, LLC 0.00% of their portfolio | 12.4k $16.6k | Reduced -12.6k |
| Virtu Financial LLC 0.00% of their portfolio | 11.6k $16.0k | New |
| Eaton Financial Holdings Company, LLC 0.00% of their portfolio | 10.2k $13.7k | Unchanged |
| Secure Asset Management, LLC 0.00% of their portfolio | 10.0k $13.4k | Unchanged |
| INTEGRAL INVESTMENT ADVISORS, INC. 0.00% of their portfolio | 10.0k $13.4k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.7k $9.0k | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 3.2k $4.3k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 3.1k $4.1k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 2.8k $3.8k | Added +1.8k |
| Medallion Wealth Advisors, LLC 0.00% of their portfolio | 340 $456 | Unchanged |
| Rialto Wealth Management, LLC 0.00% of their portfolio | 300 $402 | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 224 $300 | Reduced -129.5k |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 94 $126 | Reduced -1.6k |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 6 $8 | Reduced -5 |