Vault-13

MILESTONE PHARMACEUTICALS IN MIST

COM · Common Stock · CUSIP 59935V107

78 institutional holders -9 vs Q1 2026
47,487,82147.5m shares reported held*
38.1% of all shares outstanding*
$63.6mreported value*
6 new 23 added 23 reduced 13 sold out net bought ≈ $15.2m (+11.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.5m this quarter). Holder counts are more reliable. Shares outstanding: 124.5m as of 2026-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.34. Options: 7 managers hold calls ($288.8k notional), 6 hold puts ($336.7k).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 47Q4 22: 57Q1 23: 51Q2 23: 49Q3 23: 40Q4 23: 41Q1 24: 44Q2 24: 41Q3 24: 44Q4 24: 48Q1 25: 44Q2 25: 44Q3 25: 61Q4 25: 80Q1 26: 87Q2 26: 7878Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 202247
Q4 202257
Q1 202351
Q2 202349
Q3 202340
Q4 202341
Q1 202444
Q2 202441
Q3 202444
Q4 202448
Q1 202544
Q2 202544
Q3 202561
Q4 202580
Q1 202687
Q2 202678

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q3 24: 13 bought or addedQ3 24: 11 cut or sold outQ4 24: 23 bought or addedQ4 24: 20 cut or sold outQ4 24Q1 25: 20 bought or addedQ1 25: 27 cut or sold outQ2 25: 19 bought or addedQ2 25: 19 cut or sold outQ2 25Q3 25: 44 bought or addedQ3 25: 11 cut or sold outQ4 25: 48 bought or addedQ4 25: 18 cut or sold outQ4 25Q1 26: 44 bought or addedQ1 26: 33 cut or sold outQ2 26: 29 bought or addedQ2 26: 36 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20241311
Q4 20242320
Q1 20252027
Q2 20251919
Q3 20254411
Q4 20254818
Q1 20264433
Q2 20262936

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 25 calls: $422.8kQ3 25 puts: $641.2kQ3 25P/C 1.52Q4 25 calls: $666.7kQ4 25 puts: $2.5mQ4 25P/C 3.71Q1 26 calls: $425.5kQ1 26 puts: $718.3kQ1 26P/C 1.69Q2 26 calls: $288.8kQ2 26 puts: $336.7kQ2 26P/C 1.17
Numbers
QuarterCallsPutsP/C
Q3 2025$422.8k$641.2k1.52
Q4 2025$666.7k$2.5m3.71
Q1 2026$425.5k$718.3k1.69
Q2 2026$288.8k$336.7k1.17

Biggest buyers

Point72 Asset Management, L.P. Added +4,325,455+4.3m
Propel Bio Management, LLC Added +3,311,269+3.3m
Kalehua Capital Management LLC New +2,538,474+2.5m
Simplify Asset Management Inc. Added +1,842,974+1.8m
MILLENNIUM MANAGEMENT LLC Added +1,597,894+1.6m
RTW INVESTMENTS, LP Added +1,502,335+1.5m
BOOTHBAY FUND MANAGEMENT, LLC Added +293,994+294.0k
Wealthspire Advisors, LLC Added +130,000+130.0k
Cascades Capital Asset Management, LLC New +83,610+83.6k
GUARDIAN WEALTH ADVISORS, LLC / NC Added +59,200+59.2k

Biggest sellers

GOLDMAN SACHS GROUP INC Sold out -2,000,025-2.0m
Balyasny Asset Management L.P. Reduced -630,827-630.8k
TWO SIGMA INVESTMENTS, LP Reduced -277,161-277.2k
CITADEL ADVISORS LLC Reduced -163,809-163.8k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -159,151-159.2k
MARSHALL WACE, LLP Reduced -146,835-146.8k
RENAISSANCE TECHNOLOGIES LLC Sold out -129,705-129.7k
GROUP ONE TRADING LLC Reduced -129,540-129.5k
Squarepoint Ops LLC Reduced -105,001-105.0k
JANE STREET GROUP, LLC Reduced -101,882-101.9k

Biggest calls

SIMPLEX TRADING, LLC Added $78.8k58.8k shares
CITADEL ADVISORS LLC Added $75.2k56.1k shares
GROUP ONE TRADING LLC Reduced $65.1k48.6k shares
IMC-Chicago, LLC Reduced $31.1k23.2k shares
JANE STREET GROUP, LLC New $21.4k16.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $16.5k12.3k shares
Aptus Capital Advisors, LLC New $670500 shares

Biggest puts

CITADEL ADVISORS LLC Added $220.2k164.3k shares
JANE STREET GROUP, LLC Reduced $41.8k31.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $30.3k22.6k shares
IMC-Chicago, LLC New $26.4k19.7k shares
SIMPLEX TRADING, LLC Reduced $11.1k8.3k shares
GROUP ONE TRADING LLC Reduced $7.0k5.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
RTW INVESTMENTS, LP 13G · institution no change · filed 2026-05-15 9.9% no change 12.4m≈ $16.6m 2026-05-15
Propel Bio Management, LLC 13G · passive investor new · filed 2025-12-23 9.9% new 8.9m≈ $11.9m 2025-12-23
Pavaki Capital Management LLC 13G · passive investor new · filed 2026-08-07 7.3% new 9.1m≈ $12.2m 2026-08-07
Adage Capital Management, L.P. 13G · institution -3.6 pts · filed 2026-05-13 6.4% -3.6 pts 8.0m≈ $10.7m 2026-05-13

Fell to 5% or below in the last year: Trails Edge Capital Partners, LP (4.3%, 2026-03-26)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
505Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 0 buyingQ4 25: 5 sellingQ1 26: 0 buyingQ1 26: 5 sellingQ1 26Q2 26: 0 buyingQ2 26: 1 sellingQ3 26: 0 buyingQ3 26: 0 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—0——
Q4 20250—5$567.5k—
Q1 20260—5$209.7k$97.9k
Q2 20260—1$82.5k$82.5k
Q3 20260—0——
DateInsiderTradeSharesPrice ValueTheir holding
2026-04-16 Oliveto Joseph President and CEO, director Sold plan 36,500 $2.26 $82.5k36.5k shares -8%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Pavaki Capital Management LLC 6.92% of their portfolio PUEBLO, CO 9,067,8489.1m $12.2m $12.2m 6.92% Added +5.0k +5,000
2 RTW INVESTMENTS, LP 0.09% of their portfolio NEW YORK, NY 7,833,3367.8m $10.5m $10.5m 0.09% Added +1.5m +1,502,335
3 Propel Bio Management, LLC 5.21% of their portfolio Los Angeles, CA 7,429,5907.4m $10.0m $10.0m 5.21% Added +3.3m +3,311,269
4 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 5,411,1385.4m $7.3m $7.3m 0.01% Added +4.3m +4,325,455
5 Simplify Asset Management Inc. 0.06% of their portfolio Las Vegas, NV 3,349,3793.3m $4.5m $4.5m 0.06% Added +1.8m +1,842,974
6 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 3,142,2193.1m $4.2m $4.2m 0.00% Added +1.6m +1,597,894
7 Kalehua Capital Management LLC 1.09% of their portfolio DALLAS, TX 2,538,4742.5m $3.4m $3.4m 1.09% New
8 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 2,040,0152.0m $2.7m $2.7m 0.00% Reduced -277.2k -277,161
9 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 1,797,6951.8m $2.4m $2.4m 0.00% Reduced -146.8k -146,835
10 Lion Point Capital, LP 5.26% of their portfolio NEW YORK, NY 820,000820.0k $1.1m $1.1m 5.26% Unchanged
11 TORONTO DOMINION BANK 0.00% of their portfolio TORONTO, ONTARIO, A6 750,000750.0k $1.0m $1.0m 0.00% Unchanged
12 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 666,666666.7k $893.3k $893.3k 0.00% Unchanged
13 Boxer Capital Management, LLC 0.07% of their portfolio San Diego, CA 666,666666.7k $893.3k $893.3k 0.07% Unchanged
14 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 635,211635.2k $851.2k $851.2k 0.00% Reduced -88.9k -88,930
15 UBS Group AG 0.00% of their portfolio ZURICH, V8 465,403465.4k $623.6k $623.6k 0.00% Reduced -29.5k -29,505
16 BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 462,669462.7k $620.0k $620.0k 0.01% Added +294.0k +293,994
17 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 359,895359.9k $482.3k $482.3k 0.00% Reduced -159.2k -159,151
18 Aptus Capital Advisors, LLC 0.00% of their portfolio FAIRHOPE, AL 339,450339.4k $454.9k $454.9k 0.00% Added +59.2k +59,200
19 GUARDIAN WEALTH ADVISORS, LLC / NC 0.03% of their portfolio RALEIGH, NC 339,450339.4k $454.9k $454.9k 0.03% Added +59.2k +59,200
20 Seven Fleet Capital Management LP 0.06% of their portfolio MOUNTAIN VIEW, CA 270,233270.2k $362.1k $362.1k 0.06% Reduced -63.1k -63,100
21 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 231,824231.8k $310.6k $310.6k 0.00% Reduced -105.0k -105,001
22 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 220,873220.9k $296.0k $296.0k 0.00% Added +27.5k +27,500
23 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 220,498220.5k $295.5k $295.5k 0.00% Reduced -630.8k -630,827
24 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 173,704173.7k $232.8k $232.8k 0.00% Reduced -2.8k -2,800
25 TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC 0.11% of their portfolio PORTLAND, OR 150,000150.0k $201.0k $201.0k 0.11% Added +50.0k +50,000
26 Wealthspire Advisors, LLC 0.00% of their portfolio NEW YORK, NY 140,629140.6k $188.4k $188.4k 0.00% Added +130.0k +130,000
27 Valeo Financial Advisors, LLC 0.00% of their portfolio CARMEL, IN 130,699130.7k $175.1k $175.1k 0.00% Unchanged
28 ADAR1 Capital Management, LLC 0.01% of their portfolio AUSTIN, TX 100,000100.0k $134.0k $134.0k 0.01% Unchanged
29 Cascades Capital Asset Management, LLC 0.04% of their portfolio GREENSBORO, NC 83,61083.6k $112.0k $112.0k 0.04% New
30 Quadrature Capital Ltd 0.00% of their portfolio LONDON, X0 64,66164.7k $86.6k $86.6k 0.00% Reduced -84.4k -84,444
31 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 57,78757.8k $77.4k $77.4k 0.00% Reduced -101.9k -101,882
32 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 54,17154.2k $72.6k $72.6k 0.00% Reduced -95.1k -95,120
33 Bay Rivers Group 0.02% of their portfolio Williamsburg, VA 46,63346.6k $62.5k $62.5k 0.02% Added +16.7k +16,722
34 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 45,57445.6k $61.0k $61.0k 0.00% Added +3.1k +3,062
35 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 40,78940.8k $54.7k $54.7k 0.00% Unchanged
36 October Effect Ltd 0.05% of their portfolio VIRGINIA BEACH, VA 40,00040.0k $53.6k $53.6k 0.05% Reduced -11.9k -11,950
37 Focus Partners Wealth 0.00% of their portfolio ST LOUIS, MO 36,00036.0k $48.2k $48.2k 0.00% Unchanged
38 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 32,88732.9k $44.1k $44.1k 0.00% Reduced -163.8k -163,809
39 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 30,07030.1k $40.3k $40.3k 0.00% Added +3.5k +3,470
40 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 29,78129.8k $39.9k $39.9k 0.00% Unchanged
41 Mariner, LLC 0.00% of their portfolio Overland Park, KS 27,83027.8k $37.2k $37.2k 0.00% Reduced -3.0k -3,000
42 Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio FAIRFIELD, IA 26,96027.0k $36.0k $36.0k 0.00% Reduced -32.7k -32,660
43 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 26,31726.3k $35.3k $35.3k 0.00% Reduced -94.3k -94,285
44 Welch & Forbes LLC 0.00% of their portfolio Boston, MA 25,00025.0k $33.5k $33.5k 0.00% Unchanged
45 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 24,18524.2k $32.4k $32.4k 0.00% Added +15.0k +15,038
46 NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio MONTREAL, A8 23,50023.5k $31.5k $31.5k 0.00% Unchanged
47 Exit Wealth Advisors, LLC. 0.01% of their portfolio ATLANTA, GA 22,69222.7k $30.4k $30.4k 0.01% Added +7.7k +7,692
48 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 22,56422.6k $30.2k $30.2k 0.00% Added +233 +233
49 HighTower Advisors, LLC 0.00% of their portfolio CHICAGO, IL 20,00020.0k $26.8k $26.8k 0.00% Added +10.0k +10,000
50 Stephenson & Company, Inc. 0.01% of their portfolio San Clemente, CA 20,00020.0k $26.8k $26.8k 0.01% Unchanged
51 Taylor Financial Group, Inc. 0.01% of their portfolio Roanoke, VA 20,00020.0k $26.8k $26.8k 0.01% Added +5.0k +5,000
52 TWO SIGMA SECURITIES, LLC 0.00% of their portfolio NEW YORK, NY 16,74516.7k $22.4k $22.4k 0.00% New
53 Cetera Investment Advisers 0.00% of their portfolio SCHAUMBURG, IL 16,36816.4k $21.9k $21.9k 0.00% Added +1.7k +1,664
54 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 16,00016.0k $19.8k $19.8k 0.00% Unchanged
55 Pathstone Holdings, LLC 0.00% of their portfolio ENGLEWOOD, NJ 15,50015.5k $20.8k $20.8k 0.00% Reduced -1.5k -1,540
56 AE Wealth Management LLC 0.00% of their portfolio TOPEKA, KS 15,00015.0k $20.1k $20.1k 0.00% Unchanged
57 Vision Retirement, LLC 0.00% of their portfolio RIDGEWOOD, NJ 15,00015.0k $20.1k $20.1k 0.00% Unchanged
58 EARNED WEALTH ADVISORS, LLC 0.00% of their portfolio WALNUT CREEK, CA 14,75614.8k $19.8k $19.8k 0.00% Unchanged
59 Bronte Capital Management Pty Ltd. 0.00% of their portfolio Bondi Junction, C3 14,39014.4k $19.3k $19.3k 0.00% Added +4.0k +3,976
60 WINTON GROUP Ltd 0.00% of their portfolio LONDON, X0 14,30014.3k $19.2k $19.2k 0.00% New
61 Beta Wealth Group, Inc. 0.01% of their portfolio SAN DIEGO, CA 14,12714.1k $18.9k $18.9k 0.01% Unchanged
62 Strategic Family Wealth Counselors, L.L.C. 0.00% of their portfolio FAIRFIELD, NJ 13,87513.9k $18.6k $18.6k 0.00% Unchanged
63 Creative Planning 0.00% of their portfolio OVERLAND PARK, KS 13,08013.1k $17.5k $17.5k 0.00% Reduced -330 -330
64 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 12,50012.5k $16.8k $16.8k 0.00% Unchanged
65 Safeguard Investment Advisory Group, LLC 0.00% of their portfolio Corona, CA 12,40612.4k $16.6k $16.6k 0.00% Reduced -12.6k -12,638
66 Virtu Financial LLC 0.00% of their portfolio New York, NY 11,61311.6k $16.0k $16.0k 0.00% New
67 Eaton Financial Holdings Company, LLC 0.00% of their portfolio Coral Springs, FL 10,25010.2k $13.7k $13.7k 0.00% Unchanged
68 Secure Asset Management, LLC 0.00% of their portfolio Troy, MI 10,00010.0k $13.4k $13.4k 0.00% Unchanged
69 INTEGRAL INVESTMENT ADVISORS, INC. 0.00% of their portfolio TURLOCK, CA 10,00010.0k $13.4k $13.4k 0.00% Unchanged
70 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 6,6986.7k $9.0k $9.0k 0.00% Unchanged
71 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 3,2003.2k $4.3k $4.3k 0.00% Unchanged
72 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 3,0533.1k $4.1k $4.1k 0.00% New
73 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 2,8002.8k $3.8k $3.8k 0.00% Added +1.8k +1,800
74 Medallion Wealth Advisors, LLC 0.00% of their portfolio FARMINGTON, CT 340340 $456 $456 0.00% Unchanged
75 Rialto Wealth Management, LLC 0.00% of their portfolio SYRACUSE, NY 300300 $402 $402 0.00% Unchanged
76 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 224224 $300 $300 0.00% Reduced -129.5k -129,540
77 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 9494 $126 $126 0.00% Reduced -1.6k -1,635
78 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 66 $8 $8 0.00% Reduced -5 -5