MAZE THERAPEUTICS INC MAZE
COM · Common Stock · CUSIP 578784100
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($87.7k this quarter). Holder counts are more reliable. Shares outstanding: 55.3m as of 2026-05-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $29.86. Options: 9 managers hold calls ($10.4m notional), 7 hold puts ($4.4m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2025 | 69 |
| Q2 2025 | 76 |
| Q3 2025 | 94 |
| Q4 2025 | 143 |
| Q1 2026 | 165 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2025 | 38 | 20 |
| Q3 2025 | 62 | 18 |
| Q4 2025 | 97 | 28 |
| Q1 2026 | 101 | 61 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $0 | $0 | — |
| Q3 2025 | $10.0k | $777.9k | 77.79 |
| Q4 2025 | $1.6m | $0 | 0.00 |
| Q1 2026 | $10.4m | $4.4m | 0.42 |
Biggest buyers
| Paradigm Biocapital Advisors LP | New | +2.7m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +1.2m |
| Cormorant Asset Management, LP | New | +750.0k |
| CITADEL ADVISORS LLC | Added | +327.5k |
| Logos Global Management LP | Added | +285.0k |
| BlackRock, Inc. | Added | +283.3k |
| Candriam S.C.A. | New | +278.2k |
| Balyasny Asset Management L.P. | Added | +261.9k |
| Driehaus Capital Management LLC | Added | +258.1k |
| Aberdeen Group plc | New | +226.2k |
Biggest sellers
| Bellevue Group AG | Sold out | -887.7k |
| Deep Track Capital, LP | Reduced | -768.9k |
| MARSHALL WACE, LLP | Reduced | -536.8k |
| Matrix Capital Management Company, LP | Sold out | -480.0k |
| Woodline Partners LP | Reduced | -385.0k |
| Foresite Capital Management IV, LLC | Reduced | -365.8k |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -324.0k |
| JANUS HENDERSON GROUP PLC | Reduced | -283.7k |
| Ikarian Capital, LLC | Reduced | -265.7k |
| Squadron Capital Management LLC | Reduced | -232.5k |
Biggest calls
| Ally Bridge Group (NY) LLC | New | $3.0m100.0k shares |
| Caption Management, LLC | New | $2.9m97.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.8m60.3k shares |
| NOMURA HOLDINGS INC | New | $892.5k29.9k shares |
| JPMORGAN CHASE & CO | New | $609.2k21.0k shares |
| JANE STREET GROUP, LLC | New | $582.1k19.5k shares |
| PEAK6 LLC | Reduced | $274.6k9.2k shares |
| CITADEL ADVISORS LLC | New | $256.7k8.6k shares |
| SIMPLEX TRADING, LLC | Added | $59.7k2.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $1.3m42.4k shares |
| NOMURA HOLDINGS INC | New | $892.5k29.9k shares |
| CITADEL ADVISORS LLC | New | $743.3k24.9k shares |
| JPMORGAN CHASE & CO | New | $609.2k21.0k shares |
| Ikarian Capital, LLC | New | $429.8k14.4k shares |
| JANE STREET GROUP, LLC | New | $400.0k13.4k shares |
| SIMPLEX TRADING, LLC | New | $41.8k1.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund X, L.P. 13G · exempt (held before listing) new · filed 2025-05-15 | 9.4% |
| Third Rock Ventures IV, L.P. 13G · exempt (held before listing) -4.6 pts · filed 2026-02-13 | 9.3% |
| Deep Track Capital, LP 13G · passive investor +2.1 pts · filed 2025-08-14 | 9.0% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor +1.3 pts · filed 2026-02-13 | 9.0% |
| JANUS HENDERSON GROUP PLC 13G · institution -1.5 pts · filed 2026-05-15 | 5.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-29 | 5.4% |
Fell to 5% or below in the last year: Paradigm Biocapital Advisors LP (0.0%, 2026-08-14), GV 2019, L.P. (2.9%, 2026-02-06), Foresite Capital Fund IV, L.P. (1.4%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $464.0k | — |
| Q4 2025 | 0 | — | 3 | $5.4m | $5.4m |
| Q1 2026 | 0 | — | 4 | $7.1m | $5.9m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-30 | Dandekar Atul CSBO | Sold plan | $220.1k7.5k shares |
| 2026-03-20 | Bernstein Harold President, R&D & CMO | Sold plan | $736.4k15.0k shares |
| 2026-03-10 | Bernstein Harold President, R&D & CMO | Sold plan | $1.5m30.0k shares |
| 2026-03-02 | Bachrodt Amy SVP, Finance | Sold plan | $226.0k5.0k shares |
| 2026-02-27 | Dandekar Atul CSBO | Sold plan | $340.7k7.5k shares |
| 2026-02-02 | Bernstein Harold President, R&D & CMO | Sold plan | $690.3k15.0k shares |
| 2026-02-02 | Bachrodt Amy SVP, Finance | Sold plan | $230.2k5.0k shares |
| 2026-01-29 | Dandekar Atul CSBO | Sold plan | $332.0k7.5k shares |
| 2026-01-22 | Bachrodt Amy SVP, Finance | Sold plan | $227.6k5.0k shares |
| 2026-01-07 | Sohn Catherine A. Director | Sold | $1.1m26.9k shares |
| 2026-01-07 | Bernstein Harold President, R&D & CMO | Sold plan | $1.0m25.2k shares |
| 2026-01-06 | Sohn Catherine A. Director | Sold | $96.3k2.5k shares |
| 2026-01-05 | Bernstein Harold President, R&D & CMO | Sold plan | $16.5k412 shares |
| 2026-01-02 | Bachrodt Amy SVP, Finance | Sold plan | $195.8k5.0k shares |
| 2026-01-02 | Bernstein Harold President, R&D & CMO | Sold plan | $179.2k4.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 3.51% of their portfolio | 4.6m $136.3m | Unchanged |
| TRV GP IV, LLC 50.04% of their portfolio | 4.5m $133.5m | Unchanged |
| ARCH Venture Management, LLC 18.16% of their portfolio | 4.1m $123.0m | Unchanged |
| Deep Track Capital, LP 2.14% of their portfolio | 3.5m $103.8m | Reduced -768.9k |
| JANUS HENDERSON GROUP PLC 0.04% of their portfolio | 2.9m $85.3m | Reduced -283.7k |
| Paradigm Biocapital Advisors LP 1.67% of their portfolio | 2.7m $81.9m | New |
| BlackRock, Inc. 0.00% of their portfolio | 2.6m $76.7m | Added +283.3k |
| a16z Capital Management, L.L.C. 3.94% of their portfolio | 1.7m $50.8m | Unchanged |
| Venrock Adviser, LLC 1.78% of their portfolio | 1.6m $47.8m | Added +53.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.4m $42.9m | First filing |
| Alphabet Inc. 1.03% of their portfolio | 1.4m $41.4m | Unchanged |
| Logos Global Management LP 1.90% of their portfolio | 1.2m $36.9m | Added +285.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 1.2m $35.2m | New |
| General Catalyst Group Management, LLC 16.85% of their portfolio | 1.0m $30.9m | Unchanged |
| TRV GP V, LLC 7.08% of their portfolio | 950.8k $28.4m | Unchanged |
| FMR LLC 0.00% of their portfolio | 864.2k $25.8m | Added +135.6k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 775.7k $23.2m | Added +327.5k |
| ArrowMark Colorado Holdings LLC 0.61% of their portfolio | 767.4k $22.9m | Unchanged |
| Casdin Capital, LLC 1.72% of their portfolio | 758.9k $22.7m | Unchanged |
| Cormorant Asset Management, LP 1.13% of their portfolio | 750.0k $22.4m | New |
| Woodline Partners LP 0.07% of their portfolio | 650.2k $19.4m | Reduced -385.0k |
| STATE STREET CORP 0.00% of their portfolio | 636.7k $19.0m | Added +103.7k |
| Driehaus Capital Management LLC 0.14% of their portfolio | 636.2k $19.0m | Added +258.1k |
| Caligan Partners LP 1.30% of their portfolio | 615.0k $18.4m | Added +64.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 600.0k $17.9m | Added +72.7k |
| BESSEMER GROUP INC 0.02% of their portfolio | 481.8k $14.4m | Unchanged |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 461.2k $13.8m | Added +261.9k |
| Ikarian Capital, LLC 1.62% of their portfolio | 379.0k $11.3m | Reduced -265.7k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.07% of their portfolio | 373.0k $11.1m | Not comparable |
| HHLR ADVISORS, LTD. 0.65% of their portfolio | 366.0k $10.9m | Reduced -91.5k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 310.6k $9.3m | Reduced -536.8k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.20% of their portfolio | 284.5k $8.5m | Reduced -124.9k |
| WASHINGTON UNIVERSITY 5.23% of their portfolio | 280.8k $8.4m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 279.7k $8.3m | Added +165.3k |
| Candriam S.C.A. 0.04% of their portfolio | 278.2k $8.3m | New |
| Squadron Capital Management LLC 3.08% of their portfolio | 257.5k $7.7m | Reduced -232.5k |
| Mass General Brigham, Inc 1.53% of their portfolio | 240.0k $7.2m | Unchanged |
| Freestone Grove Partners LP 0.05% of their portfolio | 235.0k $7.0m | Added +116.1k |
| SPHERA FUNDS MANAGEMENT LTD. 1.17% of their portfolio | 227.3k $6.8m | Added +155.5k |
| Aberdeen Group plc 0.01% of their portfolio | 226.2k $6.8m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 211.4k $6.3m | Added +35.1k |
| MORGAN STANLEY 0.00% of their portfolio | 204.8k $6.1m | Reduced -53.3k |
| Spruce Street Capital LP 1.44% of their portfolio | 200.0k $6.0m | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 195.5k $5.8m | First filing |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 195.1k $5.8m | Added +176.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 186.4k $5.6m | Added +10.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 185.8k $5.5m | Unchanged |
| Foresite Capital Management IV, LLC 1.98% of their portfolio | 156.9k $4.7m | Reduced -365.8k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 151.0k $4.5m | First filing |
| Holocene Advisors, LP 0.01% of their portfolio | 136.2k $4.1m | New |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 134.9k $4.0m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 122.7k $3.7m | Added +7.0k |
| Atika Capital Management LLC 0.53% of their portfolio | 111.5k $3.3m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 107.5k $3.2m | Added +10.8k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 100.0k $3.0m | Reduced -96.1k |
| Integral Health Asset Management, LLC 0.16% of their portfolio | 100.0k $3.0m | Unchanged |
| HighVista Strategies LLC 0.82% of their portfolio | 99.8k $3.0m | Reduced -70.5k |
| UBS Group AG 0.00% of their portfolio | 93.9k $2.8m | Added +65.2k |
| Exome Asset Management LLC 1.55% of their portfolio | 88.5k $2.6m | New |
| Invesco Ltd. 0.00% of their portfolio | 86.4k $2.6m | Reduced -47.6k |
| SummitTX Capital, L.P. 0.08% of their portfolio | 83.8k $2.5m | Added +14.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 74.3k $2.2m | Added +13.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 69.4k $2.1m | Added +1.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 64.8k $2.7m | Added +31.5k |
| Nuveen, LLC 0.00% of their portfolio | 63.4k $1.9m | Added +6.1k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 60.6k $1.8m | Reduced -618 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 59.9k $1.8m | Added +181 |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 59.6k $1.8m | Added +4.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 58.4k $1.7m | Added +38.4k |
| ADAR1 Capital Management, LLC 0.09% of their portfolio | 50.1k $1.5m | Reduced -129.4k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 45.6k $1.4m | Added +11.9k |
| Propel Bio Management, LLC 0.82% of their portfolio | 43.8k $1.3m | New |
| ALPS ADVISORS INC 0.01% of their portfolio | 39.2k $1.2m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 37.2k $1.1m | New |
| DAFNA Capital Management LLC 0.24% of their portfolio | 35.0k $1.0m | New |
| Aquatic Capital Management LLC 0.03% of their portfolio | 35.0k $1.0m | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 32.5k $970.9k | Added +10.0k |
| Parkman Healthcare Partners LLC 0.10% of their portfolio | 31.8k $950.5k | Reduced -177.4k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 31.5k $940.7k | Added +7.8k |
| TWINBEECH CAPITAL LP 0.10% of their portfolio | 31.0k $925.0k | New |
| Seven Fleet Capital Management LP 0.29% of their portfolio | 30.7k $916.6k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 29.9k $892.3k | Reduced -124.6k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.9k $834.2k | Added +506 |
| Walleye Capital LLC 0.01% of their portfolio | 27.9k $834.2k | New |
| XTX Topco Ltd 0.01% of their portfolio | 26.9k $801.6k | Reduced -6.2k |
| Foresite Capital Management V, LLC 0.29% of their portfolio | 25.9k $773.3k | Reduced -60.4k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 25.5k $760.7k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 25.3k $755.2k | New |
| Blackstone Inc. 0.00% of their portfolio | 25.0k $746.0k | Not comparable |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 21.7k $648.6k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 20.3k $604.9k | Added +4.7k |
| ACUTA CAPITAL PARTNERS, LLC 0.41% of their portfolio | 19.3k $577.1k | Reduced -665 |
| Verition Fund Management LLC 0.01% of their portfolio | 19.1k $571.1k | Reduced -3.4k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.04% of their portfolio | 18.1k $541.1k | New |
| Caitong International Asset Management Co., Ltd 0.10% of their portfolio | 17.8k $530.8k | Added +14.3k |
| GILDER GAGNON HOWE & CO LLC 0.01% of their portfolio | 17.5k $522.0k | Reduced -5.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 15.8k $473.0k | Added +8.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 15.8k $471.6k | Reduced -11.3k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 15.2k $453.8k | First filing |
| Engineers Gate Manager LP 0.01% of their portfolio | 15.1k $451.0k | New |