MAZE THERAPEUTICS INC MAZE
COM · Common Stock · CUSIP 578784100
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($27.5k this quarter). Holder counts are more reliable. Shares outstanding: 43.9m as of 2025-08-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $12.28.
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2025 | 69 |
| Q2 2025 | 76 |
Biggest buyers
| Deep Track Capital, LP | Added | +679.8k |
| Frazier Life Sciences Management, L.P. | Added | +438.3k |
| JANUS HENDERSON GROUP PLC | Added | +154.9k |
| STATE STREET CORP | Added | +80.0k |
| Driehaus Capital Management LLC | Added | +61.3k |
| STRS OHIO | Added | +45.3k |
| BlackRock, Inc. | Added | +32.1k |
| CW Advisors, LLC | New | +30.2k |
| AQR CAPITAL MANAGEMENT LLC | New | +27.5k |
| ALPS ADVISORS INC | New | +23.6k |
Biggest sellers
| ALLIANCEBERNSTEIN L.P. | Reduced | -984.6k |
| FMR LLC | Reduced | -413.8k |
| Logos Global Management LP | Reduced | -325.0k |
| Octagon Capital Advisors LP | Reduced | -290.3k |
| Affinity Asset Advisors, LLC | Sold out | -250.0k |
| VANGUARD GROUP INC | Reduced | -246.9k |
| Casdin Capital, LLC | Reduced | -187.5k |
| Ikarian Capital, LLC | Reduced | -60.0k |
| UBS Group AG | Reduced | -36.7k |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | -21.4k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund X, L.P. 13G · exempt (held before listing) new · filed 2025-05-15 | 9.4% |
| Third Rock Ventures IV, L.P. 13G · exempt (held before listing) -4.6 pts · filed 2026-02-13 | 9.3% |
| Deep Track Capital, LP 13G · passive investor +2.1 pts · filed 2025-08-14 | 9.0% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor +1.3 pts · filed 2026-02-13 | 9.0% |
| JANUS HENDERSON GROUP PLC 13G · institution -1.5 pts · filed 2026-05-15 | 5.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-29 | 5.4% |
Fell to 5% or below in the last year: Paradigm Biocapital Advisors LP (0.0%, 2026-08-14), GV 2019, L.P. (2.9%, 2026-02-06)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| TRV GP IV, LLC 45.63% of their portfolio | 6.1m $74.5m | Unchanged |
| Frazier Life Sciences Management, L.P. 2.24% of their portfolio | 4.6m $56.0m | Added +438.3k |
| ARCH Venture Management, LLC 16.91% of their portfolio | 4.1m $50.6m | Unchanged |
| Deep Track Capital, LP 1.56% of their portfolio | 3.9m $48.5m | Added +679.8k |
| Matrix Capital Management Company, LP 13.69% of their portfolio | 2.5m $30.5m | Unchanged |
| Alphabet Inc. 1.39% of their portfolio | 2.4m $29.6m | Unchanged |
| Foresite Capital Management IV, LLC 20.93% of their portfolio | 2.1m $25.9m | Unchanged |
| a16z Capital Management, L.L.C. 6.67% of their portfolio | 1.7m $20.9m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 1.4m $17.3m | Added +154.9k |
| General Catalyst Group Management, LLC 0.30% of their portfolio | 1.0m $12.7m | Unchanged |
| TRV GP V, LLC 7.04% of their portfolio | 950.8k $11.7m | Unchanged |
| Woodline Partners LP 0.06% of their portfolio | 940.7k $11.5m | Added +11.6k |
| Casdin Capital, LLC 0.85% of their portfolio | 758.9k $9.3m | Reduced -187.5k |
| HARVARD MANAGEMENT CO INC 0.54% of their portfolio | 637.5k $7.8m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 614.7k $7.5m | Added +32.1k |
| Logos Global Management LP 1.00% of their portfolio | 611.9k $7.5m | Reduced -325.0k |
| FMR LLC 0.00% of their portfolio | 554.5k $6.8m | Reduced -413.8k |
| BESSEMER GROUP INC 0.01% of their portfolio | 481.8k $5.9m | Unchanged |
| HHLR ADVISORS, LTD. 0.18% of their portfolio | 457.5k $5.6m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 419.6k $5.1m | Reduced -246.9k |
| SPHERA FUNDS MANAGEMENT LTD. 1.14% of their portfolio | 356.5k $4.4m | Added +899 |
| Foresite Capital Management V, LLC 5.25% of their portfolio | 345.2k $4.2m | Unchanged |
| Ikarian Capital, LLC 1.07% of their portfolio | 262.7k $3.2m | Reduced -60.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 231.2k $2.8m | Added +18.8k |
| Driehaus Capital Management LLC 0.02% of their portfolio | 193.4k $2.4m | Added +61.3k |
| Octagon Capital Advisors LP 0.48% of their portfolio | 177.7k $2.2m | Reduced -290.3k |
| STATE STREET CORP 0.00% of their portfolio | 144.7k $1.8m | Added +80.0k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 125.0k $1.5m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 85.5k $1.0m | Added +14.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio | 75.5k $926.8k | Reduced -21.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 75.2k $922.3k | Added +2.9k |
| UBS Group AG 0.00% of their portfolio | 51.4k $630.7k | Reduced -36.7k |
| STRS OHIO 0.00% of their portfolio | 46.9k $575.5k | Added +45.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 31.8k $390.1k | Reduced -984.6k |
| MORGAN STANLEY 0.00% of their portfolio | 31.8k $390.0k | Added +7.9k |
| CW Advisors, LLC 0.00% of their portfolio | 30.2k $371.0k | New |
| Ghisallo Capital Management LLC 0.01% of their portfolio | 30.0k $368.1k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.5k $337.0k | New |
| ALPS ADVISORS INC 0.00% of their portfolio | 23.6k $289.3k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 21.5k $264.4k | Added +4.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 19.6k $240.5k | Unchanged |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 18.5k $227.5k | New |
| Invesco Ltd. 0.00% of their portfolio | 18.4k $226.1k | Reduced -2.1k |
| BARCLAYS PLC 0.00% of their portfolio | 14.6k $179.6k | Reduced -3 |
| CITIGROUP INC 0.00% of their portfolio | 13.0k $159.4k | Added +6.8k |
| Nuveen, LLC 0.00% of their portfolio | 11.4k $139.6k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 10.6k $129.7k | Reduced -41 |
| Engineers Gate Manager LP 0.00% of their portfolio | 10.2k $125.3k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.9k $109.0k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 7.7k $94.6k | Added +479 |
| Virtus Investment Advisers, LLC 0.03% of their portfolio | 6.9k $85.2k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.8k $70.9k | Added +1.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 5.6k $68.9k | Added +922 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 4.9k $60.1k | Reduced -234 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 4.6k $56.5k | Added +3.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 4.4k $53.6k | Reduced -5.8k |
| Legal & General Group Plc 0.00% of their portfolio | 4.2k $52.0k | Added +3.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.3k $28.2k | Unchanged |
| CWM, LLC 0.00% of their portfolio | 2.3k $28.0k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 2.2k $27.5k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2.2k $26.0k | Added +2.0k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 894 $11.0k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 759 $9.3k | Added +359 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 554 $6.8k | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 505 $6.2k | Added +479 |
| AMALGAMATED BANK 0.00% of their portfolio | 305 $4.0k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 224 $2.7k | Added +150 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 182 $2.2k | New |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 114 $1.4k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 54 $595 | New |
| GAMMA Investing LLC 0.00% of their portfolio | 51 $626 | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 26 $319 | Added +8 |
| Essential Partners LLC 0.00% of their portfolio | 7 $86 | First filing |
| True Wealth Design, LLC 0.00% of their portfolio | 5 $62 | New |
| IFP Advisors, Inc 0.00% of their portfolio | 3 $37 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. — of their portfolio | 0 $0 | Unchanged |