MAZE THERAPEUTICS INC MAZE
COM · Common Stock · CUSIP 578784100
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($90.6k this quarter). Holder counts are more reliable. Shares outstanding: 55.5m as of 2026-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $29.82. Options: 4 managers hold calls ($2.0m notional), 5 hold puts ($2.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2025 | 69 |
| Q2 2025 | 76 |
| Q3 2025 | 94 |
| Q4 2025 | 143 |
| Q1 2026 | 165 |
| Q2 2026 | 162 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2025 | 38 | 20 |
| Q3 2025 | 62 | 18 |
| Q4 2025 | 97 | 28 |
| Q1 2026 | 101 | 61 |
| Q2 2026 | 103 | 76 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $10.0k | $777.9k | 77.79 |
| Q4 2025 | $1.6m | $0 | 0.00 |
| Q1 2026 | $10.4m | $4.4m | 0.42 |
| Q2 2026 | $2.0m | $2.0m | 0.98 |
Biggest buyers
| T. Rowe Price Investment Management, Inc. | New | +2.6m |
| BRAIDWELL LP | New | +1.1m |
| BlackRock, Inc. | Added | +932.4k |
| JPMORGAN CHASE & CO | Added | +905.6k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +734.8k |
| Logos Global Management LP | Added | +700.0k |
| MARSHALL WACE, LLP | Added | +603.9k |
| Frazier Life Sciences Management, L.P. | Added | +465.6k |
| STATE STREET CORP | Added | +360.8k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +342.6k |
Biggest sellers
| Paradigm Biocapital Advisors LP | Sold out | -2.7m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -930.0k |
| Cormorant Asset Management, LP | Sold out | -750.0k |
| Caligan Partners LP | Sold out | -615.0k |
| Balyasny Asset Management L.P. | Reduced | -441.0k |
| WASHINGTON UNIVERSITY | Sold out | -280.8k |
| Freestone Grove Partners LP | Sold out | -235.0k |
| Spruce Street Capital LP | Sold out | -200.0k |
| Foresite Capital Management IV, LLC | Sold out | -156.9k |
| Holocene Advisors, LP | Sold out | -136.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $954.9k32.0k shares |
| NOMURA HOLDINGS INC | Reduced | $626.6k21.0k shares |
| CITADEL ADVISORS LLC | Added | $376.0k12.6k shares |
| GROUP ONE TRADING LLC | New | $89.5k3.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $969.8k32.5k shares |
| NOMURA HOLDINGS INC | Reduced | $626.6k21.0k shares |
| CITADEL ADVISORS LLC | Reduced | $286.5k9.6k shares |
| GROUP ONE TRADING LLC | New | $89.5k3.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $35.8k1.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund X, L.P. 13G · exempt (held before listing) new · filed 2025-05-15 | 9.4% |
| Third Rock Ventures IV, L.P. 13G · exempt (held before listing) -4.6 pts · filed 2026-02-13 | 9.3% |
| Deep Track Capital, LP 13G · passive investor +2.1 pts · filed 2025-08-14 | 9.0% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor +1.3 pts · filed 2026-02-13 | 9.0% |
| JANUS HENDERSON GROUP PLC 13G · institution -1.5 pts · filed 2026-05-15 | 5.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-29 | 5.4% |
Fell to 5% or below in the last year: Paradigm Biocapital Advisors LP (0.0%, 2026-08-14), GV 2019, L.P. (2.9%, 2026-02-06), Foresite Capital Fund IV, L.P. (1.4%, 2025-11-14), Matrix Capital Management Company, LP (3.5%, 2025-11-13)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $464.0k | — |
| Q4 2025 | 0 | — | 3 | $5.4m | $5.4m |
| Q1 2026 | 0 | — | 4 | $7.1m | $5.9m |
| Q2 2026 | 0 | — | 4 | $3.7m | $3.7m |
| Q3 2026 | 0 | — | 4 | $6.0m | $4.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-04 | Bernstein Harold President, R&D & CMO | Sold plan | $254.5k9.7k shares |
| 2026-09-03 | Coloma Jason V Chief Executive Officer, director | Sold | $296.8k11.4k shares |
| 2026-09-03 | Bernstein Harold President, R&D & CMO | Sold | $135.0k5.2k shares |
| 2026-09-03 | Dandekar Atul CSBO | Sold | $84.3k3.2k shares |
| 2026-09-03 | Courtney Phillips GC and Corp. Secretary | Sold | $52.3k2.0k shares |
| 2026-09-02 | Coloma Jason V Chief Executive Officer, director | Sold | $297.2k11.2k shares |
| 2026-09-02 | Bernstein Harold President, R&D & CMO | Sold | $135.2k5.1k shares |
| 2026-09-02 | Dandekar Atul CSBO | Sold | $84.5k3.2k shares |
| 2026-09-02 | Courtney Phillips GC and Corp. Secretary | Sold | $52.4k2.0k shares |
| 2026-09-01 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $838.9k31.9k shares |
| 2026-09-01 | Bernstein Harold President, R&D & CMO | Sold plan | $425.5k16.1k shares |
| 2026-09-01 | Coloma Jason V Chief Executive Officer, director · The Coloma 2021 Irrevocable Trust | Sold plan | $68.2k2.6k shares |
| 2026-08-28 | Dandekar Atul CSBO | Sold plan | $206.8k7.5k shares |
| 2026-08-13 | Bernstein Harold President, R&D & CMO | Sold plan | $445.7k16.1k shares |
| 2026-08-03 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $852.9k31.9k shares |
| 2026-08-03 | Coloma Jason V Chief Executive Officer, director · The Coloma 2021 Irrevocable Trust | Sold plan | $69.3k2.6k shares |
| 2026-07-29 | Dandekar Atul CSBO | Sold plan | $205.1k7.5k shares |
| 2026-07-01 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $956.4k31.9k shares |
| 2026-07-01 | Bernstein Harold President, R&D & CMO | Sold plan | $436.9k14.6k shares |
| 2026-07-01 | Coloma Jason V Chief Executive Officer, director · The Coloma 2021 Irrevocable Trust | Sold plan | $77.7k2.6k shares |
| 2026-06-29 | Dandekar Atul CSBO | Sold plan | $210.2k7.5k shares |
| 2026-06-23 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $621.7k23.9k shares |
| 2026-06-22 | Coloma Jason V Chief Executive Officer, director · The Coloma 2021 Irrevocable Trust | Sold plan | $53.0k2.0k shares |
| 2026-06-22 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $50.8k2.0k shares |
| 2026-06-01 | Bernstein Harold President, R&D & CMO | Sold plan | $381.1k14.9k shares |
| 2026-06-01 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $159.6k6.1k shares |
| 2026-06-01 | Coloma Jason V Chief Executive Officer, director · The Coloma 2021 Irrevocable Trust | Sold plan | $14.5k553 shares |
| 2026-05-29 | Dandekar Atul CSBO | Sold plan | $197.6k7.5k shares |
| 2026-05-26 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $665.6k25.6k shares |
| 2026-05-22 | Coloma Jason V Chief Executive Officer, director · Coloma Family Trust | Sold plan | $117.1k4.5k shares |
The latest 30 of 37 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 3.27% of their portfolio | 5.0m $150.2m | Added +465.6k |
| TRV GP IV, LLC 52.63% of their portfolio | 4.5m $133.5m | Unchanged |
| ARCH Venture Management, LLC 11.18% of their portfolio | 4.1m $123.0m | Unchanged |
| Deep Track Capital, LP 1.64% of their portfolio | 3.7m $111.4m | Added +255.0k |
| BlackRock, Inc. 0.00% of their portfolio | 3.5m $104.5m | Added +932.4k |
| Jupiter Topco LLC 0.04% of their portfolio | 3.4m $101.8m | First filing |
| T. Rowe Price Investment Management, Inc. 0.05% of their portfolio | 2.6m $77.7m | New |
| Logos Global Management LP 2.49% of their portfolio | 1.9m $57.7m | Added +700.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.8m $53.1m | Added +342.6k |
| a16z Capital Management, L.L.C. 0.36% of their portfolio | 1.7m $50.8m | Unchanged |
| Venrock Adviser, LLC 1.45% of their portfolio | 1.6m $47.8m | Unchanged |
| Alphabet Inc. 0.04% of their portfolio | 1.4m $41.4m | Unchanged |
| BRAIDWELL LP 1.26% of their portfolio | 1.1m $34.0m | New |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.19% of their portfolio | 1.1m $33.1m | Added +734.8k |
| FMR LLC 0.00% of their portfolio | 1.1m $31.5m | Added +192.7k |
| General Catalyst Group Management, LLC 16.40% of their portfolio | 1.0m $30.9m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 997.5k $29.8m | Added +360.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 964.0k $28.0m | Added +905.6k |
| Driehaus Capital Management LLC 0.17% of their portfolio | 954.9k $28.5m | Added +318.7k |
| TRV GP V, LLC 5.69% of their portfolio | 950.8k $28.4m | Unchanged |
| MARSHALL WACE, LLP 0.02% of their portfolio | 914.6k $27.3m | Added +603.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 858.1k $25.6m | Added +258.1k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 852.7k $25.4m | Added +77.0k |
| Casdin Capital, LLC 1.26% of their portfolio | 843.9k $25.2m | Added +85.0k |
| ArrowMark Colorado Holdings LLC 0.95% of their portfolio | 767.4k $22.9m | Unchanged |
| Woodline Partners LP 0.07% of their portfolio | 736.2k $22.0m | Added +86.0k |
| BESSEMER GROUP INC 0.02% of their portfolio | 481.8k $14.4m | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. 1.78% of their portfolio | 417.6k $12.5m | Added +190.2k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 393.1k $11.7m | Added +197.6k |
| Aberdeen Group plc 0.02% of their portfolio | 383.8k $11.5m | Added +157.5k |
| Ikarian Capital, LLC 1.85% of their portfolio | 379.0k $11.3m | Unchanged |
| HHLR ADVISORS, LTD. 1.31% of their portfolio | 366.0k $10.9m | Unchanged |
| ADAR1 Capital Management, LLC 0.48% of their portfolio | 339.3k $10.1m | Added +289.2k |
| Squadron Capital Management LLC 3.42% of their portfolio | 335.0k $10.0m | Added +77.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 321.2k $9.6m | Added +126.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 294.7k $8.8m | Added +83.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 293.1k $8.7m | Added +13.4k |
| Candriam S.C.A. 0.04% of their portfolio | 273.9k $8.2m | Reduced -4.2k |
| Hudson Bay Capital Management LP 0.04% of their portfolio | 270.0k $8.1m | Added +261.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 260.6k $7.8m | Added +74.1k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 248.0k $7.4m | Reduced -930.0k |
| Mass General Brigham, Inc 1.98% of their portfolio | 240.0k $7.2m | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 227.4k $6.8m | Added +119.9k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 219.9k $6.6m | Added +68.9k |
| RTW INVESTMENTS, LP 0.05% of their portfolio | 212.0k $6.3m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 199.9k $5.8m | Added +162.7k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 193.0k $5.8m | Added +177.1k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.11% of their portfolio | 188.9k $5.6m | Reduced -95.6k |
| ExodusPoint Capital Management, LP 0.05% of their portfolio | 183.3k $5.5m | New |
| SummitTX Capital, L.P. 0.14% of their portfolio | 176.3k $5.3m | Added +92.5k |
| HighVista Strategies LLC 0.93% of their portfolio | 136.6k $4.1m | Added +36.7k |
| MORGAN STANLEY 0.00% of their portfolio | 135.2k $4.0m | Reduced -69.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 132.9k $4.0m | Added +10.2k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 131.0k $3.9m | Reduced -3.9k |
| Walleye Capital LLC 0.02% of their portfolio | 128.0k $3.8m | Added +100.1k |
| Exome Asset Management LLC 2.11% of their portfolio | 114.7k $3.4m | Added +26.2k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 101.6k $3.0m | Reduced -84.2k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 100.0k $3.0m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 97.6k $2.9m | Added +23.3k |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 93.4k $2.8m | New |
| UBS Group AG 0.00% of their portfolio | 84.7k $2.5m | Reduced -9.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 82.7k $2.5m | Added +22.1k |
| Trexquant Investment LP 0.02% of their portfolio | 81.7k $2.4m | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 80.2k $2.4m | Added +20.6k |
| Nuveen, LLC 0.00% of their portfolio | 78.5k $2.3m | Added +15.1k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 77.8k $2.3m | Added +17.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 77.3k $2.3m | Added +70.8k |
| XTX Topco Ltd 0.03% of their portfolio | 75.3k $2.2m | Added +48.5k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 74.4k $2.2m | Added +65.0k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 66.4k $2.0m | Reduced -3.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 65.5k $2.0m | New |
| DAFNA Capital Management LLC 0.37% of their portfolio | 65.0k $1.9m | Added +30.0k |
| ALPS ADVISORS INC 0.01% of their portfolio | 56.0k $1.7m | Added +16.8k |
| Jump Financial, LLC 0.01% of their portfolio | 47.1k $1.4m | New |
| Swiss National Bank 0.00% of their portfolio | 47.1k $1.4m | New |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 46.2k $1.4m | Added +20.7k |
| Propel Bio Management, LLC 0.68% of their portfolio | 43.8k $1.3m | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 42.9k $1.3m | Added +11.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 37.8k $1.1m | Reduced -27.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 35.0k $1.0m | Added +14.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 32.0k $956.3k | Added +21.7k |
| CITIGROUP INC 0.00% of their portfolio | 30.3k $903.1k | Added +21.7k |
| Quadrature Capital Ltd 0.01% of their portfolio | 30.0k $896.6k | New |
| Invesco Ltd. 0.00% of their portfolio | 28.4k $846.6k | Reduced -58.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 27.2k $810.5k | Reduced -784 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 26.1k $777.7k | Added +24.6k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 23.8k $711.4k | New |
| BARCLAYS PLC 0.00% of their portfolio | 23.7k $708.2k | Added +14.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 23.7k $706.5k | Reduced -1.6k |
| TD Asset Management Inc 0.00% of their portfolio | 22.2k $661.7k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 20.9k $623.6k | Added +6.4k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 20.2k $602.5k | Reduced -441.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 19.4k $579.9k | Added +5.8k |
| Jackson Creek Investment Advisors LLC 0.16% of their portfolio | 18.3k $494.0k | New |
| Verition Fund Management LLC 0.00% of their portfolio | 18.2k $543.1k | Reduced -933 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 17.7k $529.3k | Added +17.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 16.4k $490.4k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 16.4k $489.4k | Added +1.8k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 16.2k $484.8k | Added +3.8k |
| Legal & General Group Plc 0.00% of their portfolio | 15.8k $470.9k | Added +10.0k |