MACROGENICS INC MGNX
COM · Common Stock · CUSIP 556099109 · ISIN US5560991094
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersRockville, MD
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($56.9k this quarter). Holder counts are more reliable. Shares outstanding: 63.2m as of 2025-08-08, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.21. Options: 5 managers hold calls ($82.6k notional), 5 hold puts ($49.6k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 135 |
| Q4 2022 | 137 |
| Q1 2023 | 138 |
| Q2 2023 | 132 |
| Q3 2023 | 129 |
| Q4 2023 | 143 |
| Q1 2024 | 164 |
| Q2 2024 | 148 |
| Q3 2024 | 125 |
| Q4 2024 | 130 |
| Q1 2025 | 130 |
| Q2 2025 | 113 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 59 | 63 |
| Q4 2023 | 71 | 65 |
| Q1 2024 | 95 | 69 |
| Q2 2024 | 77 | 91 |
| Q3 2024 | 50 | 82 |
| Q4 2024 | 55 | 57 |
| Q1 2025 | 53 | 58 |
| Q2 2025 | 53 | 77 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $1.2m | $835.0k | 0.72 |
| Q4 2024 | $173.6k | $643.5k | 3.71 |
| Q1 2025 | $75.5k | $190.5k | 2.52 |
| Q2 2025 | $82.6k | $49.6k | 0.60 |
Biggest buyers
| EcoR1 Capital, LLC | New | +1.6m |
| JANE STREET GROUP, LLC | Added | +511.8k |
| GOLDMAN SACHS GROUP INC | Added | +500.6k |
| Cubist Systematic Strategies, LLC | New | +352.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +339.4k |
| MILLENNIUM MANAGEMENT LLC | Added | +291.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | New | +219.0k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +183.1k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +174.2k |
| CITADEL ADVISORS LLC | New | +171.6k |
Biggest sellers
| BlackRock, Inc. | Reduced | -3.1m |
| Rock Springs Capital Management LP | Sold out | -1.1m |
| STATE STREET CORP | Reduced | -1.1m |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -772.6k |
| GSA CAPITAL PARTNERS LLP | Sold out | -448.5k |
| NORTHERN TRUST CORP | Reduced | -368.4k |
| ARMISTICE CAPITAL, LLC | Reduced | -336.0k |
| JPMORGAN CHASE & CO | Reduced | -284.9k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -247.6k |
| VANGUARD GROUP INC | Reduced | -212.9k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $42.2k34.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $24.7k20.4k shares |
| SIMPLEX TRADING, LLC | Added | $15.0k12.9k shares |
| GROUP ONE TRADING LLC | Reduced | $726600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $25.5k21.1k shares |
| CITADEL ADVISORS LLC | Reduced | $17.9k14.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $6.0k5.1k shares |
| GROUP ONE TRADING LLC | Reduced | $121100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARMISTICE CAPITAL, LLC 13G · institution -1.6 pts · filed 2026-08-14 | 7.9% |
| BlackRock, Inc. 13G · institution +4.2 pts · filed 2026-07-29 | 7.1% |
Fell to 5% or below in the last year: BANK OF AMERICA CORP /DE/ (4.0%, 2026-08-03), MILLENNIUM MANAGEMENT LLC (3.7%, 2026-07-20), VANGUARD GROUP INC (0.0%, 2026-03-27), Frazier Life Sciences Public Fund, L.P. (0.0%, 2026-02-13), Bellevue Group AG (0.0%, 2026-01-06)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 1 | $73.7k | 0 | — | — |
| Q4 2023 | 0 | — | 1 | $190.3k | $190.3k |
| Q1 2024 | 0 | — | 5 | $4.0m | $4.0m |
| Q2 2024 | 0 | — | 1 | $799.1k | $799.1k |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 1 | $1.1k | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Bellevue Group AG 0.26% of their portfolio | 9.9m $12.0m | Reduced -10.0k |
| ARMISTICE CAPITAL, LLC 0.27% of their portfolio | 6.0m $7.2m | Reduced -336.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.2m $5.1m | Reduced -212.9k |
| WASATCH ADVISORS LP 0.02% of their portfolio | 3.3m $3.9m | Added +774 |
| Frazier Life Sciences Management, L.P. 0.15% of their portfolio | 3.2m $3.8m | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 2.5m $3.0m | Added +183.1k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 2.0m $2.4m | Added +291.6k |
| BlackRock, Inc. 0.00% of their portfolio | 1.8m $2.2m | Reduced -3.1m |
| EcoR1 Capital, LLC 0.11% of their portfolio | 1.6m $1.9m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 1.3m $1.6m | Added +174.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 1.0m $1.2m | Added +339.4k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 857.1k $1.0m | Reduced -211.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 758.2k $917.4k | Added +511.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 698.3k $844.9k | Added +500.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 683.5k $827.4k | Reduced -772.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 682.3k $825.6k | Reduced -133.8k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 508.8k $615.7k | Reduced -136.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 460.1k $556.8k | Reduced -284.9k |
| MORGAN STANLEY 0.00% of their portfolio | 446.2k $539.9k | Added +104.7k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 420.0k $508.0k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 407.3k $492.8k | Reduced -247.6k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 405.9k $491.2k | Added +106.9k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 352.1k $426.0k | New |
| PINNACLE ASSOCIATES LTD 0.01% of their portfolio | 351.0k $424.7k | Reduced -125.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 334.3k $404.6k | Reduced -191.2k |
| STATE STREET CORP 0.00% of their portfolio | 300.3k $363.3k | Reduced -1.1m |
| Vestal Point Capital, LP 0.02% of their portfolio | 280.0k $338.8k | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 219.0k $265.0k | New |
| TANG CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 218.9k $264.8k | Unchanged |
| Amundi 0.00% of their portfolio | 214.3k $295.7k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 196.6k $237.9k | Added +83.7k |
| Woodline Partners LP 0.00% of their portfolio | 188.7k $228.3k | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 171.6k $207.6k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 170.1k $205.8k | Reduced -18.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 152.9k $185.0k | Reduced -368.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 133.7k $161.8k | Added +18.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 104.8k $126.7k | Added +52.3k |
| HRT FINANCIAL LP 0.00% of their portfolio | 102.7k $124.0k | Added +71.5k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 100.5k $121.6k | Added +71.8k |
| Leonteq Securities AG 0.01% of their portfolio | 100.0k $121.0k | Added +60.0k |
| Aster Capital Management (DIFC) Ltd 0.02% of their portfolio | 88.1k $106.6k | New |
| Ikarian Capital, LLC 0.03% of their portfolio | 80.1k $96.9k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 75.5k $91.4k | Reduced -156.9k |
| Virtu Financial LLC 0.00% of their portfolio | 67.8k $82.0k | New |
| FMR LLC 0.00% of their portfolio | 63.9k $77.3k | Reduced -184.3k |
| Invesco Ltd. 0.00% of their portfolio | 61.0k $73.8k | Reduced -7.3k |
| Jain Global LLC 0.00% of their portfolio | 59.3k $71.8k | New |
| BARCLAYS PLC 0.00% of their portfolio | 57.8k $70.0k | Reduced -52.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 55.5k $67.1k | Added +45.0k |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 50.2k $60.8k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 49.6k $59.0k | Added +48.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 46.1k $55.8k | Reduced -59.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 45.2k $54.7k | Reduced -19.9k |
| UBS Group AG 0.00% of their portfolio | 43.6k $52.8k | Added +6.0k |
| SPC Financial, Inc. 0.00% of their portfolio | 37.8k $45.7k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 35.2k $42.6k | Reduced -10.7k |
| XML Financial, LLC 0.00% of their portfolio | 32.3k $39.1k | Added +13.2k |
| State of Wyoming 0.00% of their portfolio | 31.6k $38.2k | Added +9.3k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 31.3k $37.9k | Reduced -2.7k |
| Y-Intercept (Hong Kong) Ltd 0.00% of their portfolio | 29.9k $36.2k | New |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 28.5k $34.5k | New |
| Rangeley Capital, LLC 0.04% of their portfolio | 27.0k $32.7k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 26.2k $31.7k | Reduced -1.2k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 26.0k $31.4k | Added +18.8k |
| Walleye Capital LLC 0.00% of their portfolio | 25.2k $30.5k | New |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 24.7k $30.1k | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio | 23.5k $28.4k | Unchanged |
| Engineers Gate Manager LP 0.00% of their portfolio | 23.3k $28.2k | New |
| LPL Financial LLC 0.00% of their portfolio | 21.2k $25.6k | Unchanged |
| Quadrature Capital Ltd 0.00% of their portfolio | 21.1k $25.7k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 20.7k $25.0k | Reduced -1.6k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 20.0k $24.2k | Reduced -66.8k |
| DRW Securities, LLC 0.00% of their portfolio | 18.2k $22.0k | New |
| Evercore Wealth Management, LLC 0.00% of their portfolio | 17.5k $21.2k | Unchanged |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 17.5k $21.2k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 16.4k $19.9k | Unchanged |
| XTX Topco Ltd 0.00% of their portfolio | 15.5k $18.7k | New |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 12.7k $15.3k | Added +82 |
| Jump Financial, LLC 0.00% of their portfolio | 11.5k $14.0k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 11.0k $13.0k | Reduced -29.4k |
| Cerity Partners LLC 0.00% of their portfolio | 10.1k $12.3k | New |
| Northeast Financial Consultants Inc 0.00% of their portfolio | 10.0k $12.1k | New |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 7.5k $9.1k | Added +2.3k |
| Sound Income Strategies, LLC 0.00% of their portfolio | 7.3k $8.8k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 7.2k $8.7k | Reduced -170 |
| US BANCORP \DE\ 0.00% of their portfolio | 5.8k $7.1k | Reduced -577 |
| CWM, LLC 0.00% of their portfolio | 5.4k $7.0k | Reduced -3.0k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 5.0k $6.0k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 4.3k $5.2k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 3.1k $3.7k | Added +16 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 2.4k $2.9k | Added +337 |
| Truvestments Capital LLC 0.00% of their portfolio | 2.4k $2.9k | Unchanged |
| SUMMIT SECURITIES GROUP LLC 0.00% of their portfolio | 2.2k $2.6k | New |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 1.6k $1.9k | Unchanged |
| Manchester Capital Management LLC 0.00% of their portfolio | 1.2k $1.5k | Unchanged |
| IMG Wealth Management, Inc. 0.00% of their portfolio | 1.1k $1.4k | Unchanged |
| Spire Wealth Management 0.00% of their portfolio | 664 $803 | Unchanged |
| Cornerstone Planning Group LLC 0.00% of their portfolio | 560 $946 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 518 $627 | Reduced -30.0k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 499 $604 | Reduced -1.5k |