Vault-13

LYRA THERAPEUTICS INC LYRA

COM · Common Stock · CUSIP 55234L105

40 institutional holders +8 vs Q1 2023
33,698,87733.7m shares reported held*
$138.4mreported value*
11 new 12 added 5 reduced 3 sold out net bought ≈ $60.7m (+14.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $4.11. Options: 3 managers hold calls ($1.0m notional), 3 hold puts ($1.6k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

02040Q3 22: 39Q4 22: 38Q1 23: 32Q2 23: 4040Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202239
Q4 202238
Q1 202332
Q2 202340

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 16 bought or addedQ4 22: 12 cut or sold outQ4 22Q1 23: 7 bought or addedQ1 23: 11 cut or sold outQ1 23Q2 23: 23 bought or addedQ2 23: 8 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221612
Q1 2023711
Q2 2023238

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5mQ3 22 calls: $66.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $37.7kQ4 22 puts: $1.9kQ4 22P/C 0.05Q1 23 calls: $8.9kQ1 23 puts: $1.0kQ1 23P/C 0.12Q2 23 calls: $1.0mQ2 23 puts: $1.6kQ2 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2022$66.0k$00.00
Q4 2022$37.7k$1.9k0.05
Q1 2023$8.9k$1.0k0.12
Q2 2023$1.0m$1.6k0.00

Biggest buyers

ARMISTICE CAPITAL, LLC New +4,012,036+4.0m
PERCEPTIVE ADVISORS LLC Added +3,610,832+3.6m
CITADEL ADVISORS LLC Added +2,841,244+2.8m
Nantahala Capital Management, LLC Added +1,736,712+1.7m
SAMSARA BIOCAPITAL, LLC Added +1,003,010+1.0m
Ikarian Capital, LLC Added +634,941+634.9k
Parkman Healthcare Partners LLC New +600,000+600.0k
Alyeska Investment Group, L.P. New +481,446+481.4k
DAFNA Capital Management LLC New +361,084+361.1k
BOOTHBAY FUND MANAGEMENT, LLC Added +128,954+129.0k

Biggest sellers

PURA VIDA INVESTMENTS, LLC Reduced -583,730-583.7k
MILLENNIUM MANAGEMENT LLC Sold out -58,092-58.1k
BRIDGEWAY CAPITAL MANAGEMENT, LLC Reduced -50,000-50.0k
TWO SIGMA ADVISERS, LP Sold out -28,300-28.3k
Squarepoint Ops LLC Sold out -11,280-11.3k
Tower Research Capital LLC (TRC) Reduced -8,530-8.5k
UBS Group AG Reduced -835-835
NORTHERN TRUST CORP Reduced -116-116

Biggest calls

Alyeska Investment Group, L.P. New $989.4k240.7k shares
CITADEL ADVISORS LLC Reduced $11.9k2.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $1.6k400 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC New $0100 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
PERCEPTIVE ADVISORS LLC 13D · may seek influence filed 2025-08-14 15.6% 255.8k 2025-08-14

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 PERCEPTIVE ADVISORS LLC 1.52% of their portfolio NEW YORK, NY 12,757,56212.8m $52.4m $52.4m 1.52% Added +3.6m +3,610,832
2 ARMISTICE CAPITAL, LLC 0.41% of their portfolio NEW YORK, NY 4,012,0364.0m $16.5m $16.5m 0.41% New
3 Nantahala Capital Management, LLC 1.97% of their portfolio NEW CANAAN, CT 3,957,5424.0m $16.3m $16.3m 1.97% Added +1.7m +1,736,712
4 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 2,849,1782.8m $11.7m $11.7m 0.01% Added +2.8m +2,841,244
5 SAMSARA BIOCAPITAL, LLC 2.01% of their portfolio PALO ALTO, CA 2,780,2612.8m $11.4m $11.4m 2.01% Added +1.0m +1,003,010
6 PURA VIDA INVESTMENTS, LLC 2.37% of their portfolio NEW YORK, NY 1,413,2421.4m $5.7m $5.7m 2.37% Reduced -583.7k -583,730
7 Ikarian Capital, LLC 1.36% of their portfolio DALLAS, TX 978,626978.6k $4.0m $4.0m 1.36% Added +634.9k +634,941
8 Venrock Adviser, LLC 0.61% of their portfolio NEW YORK, NY 924,170924.2k $3.8m $3.8m 0.61% Unchanged
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 790,936790.9k $3.3m $3.3m 0.00% Unchanged
10 Parkman Healthcare Partners LLC 0.43% of their portfolio STAMFORD, CT 600,000600.0k $2.5m $2.5m 0.43% New
11 Soleus Capital Management, L.P. 0.27% of their portfolio GREENWICH, CT 592,417592.4k $2.4m $2.4m 0.27% Unchanged
12 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 481,446481.4k $2.0m $2.0m 0.01% New
13 DAFNA Capital Management LLC 0.41% of their portfolio LOS ANGELES, CA 361,084361.1k $1.5m $1.5m 0.41% New
14 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 302,235302.2k $1.2m $1.2m 0.00% Unchanged
15 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 163,675163.7k $672.7k $672.7k 0.02% Added +129.0k +128,954
16 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 148,840148.8k $611.7k $611.7k 0.00% Unchanged
17 Clearline Capital LP 0.06% of their portfolio NEW YORK, NY 119,128119.1k $489.6k $489.6k 0.06% Unchanged
18 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 112,814112.8k $463.7k $463.7k 0.00% Added +8.0k +8,046
19 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 96,80096.8k $397.8k $397.8k 0.01% Reduced -50.0k -50,000
20 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 71,00071.0k $292.0k $292.0k 0.00% Added +23.1k +23,149
21 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 55,78055.8k $229.3k $229.3k 0.00% Added +18.2k +18,200
22 BlackRock Inc. 0.00% of their portfolio New York, NY 48,61448.6k $199.8k $199.8k 0.00% Added +7.2k +7,234
23 LETKO, BROSSEAU & ASSOCIATES INC 0.00% of their portfolio MONTREAL, A8 31,90031.9k $131.1k $131.1k 0.00% New
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 29,71329.7k $122.1k $122.1k 0.00% Reduced -116 -116
25 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 11,88511.9k $48.8k $48.8k 0.00% New
26 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 1,7951.8k $7.0k $7.0k 0.00% New
27 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,4421.4k $5.9k $5.9k 0.00% Reduced -8.5k -8,530
28 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 1,2941.3k $4.8k $4.8k 0.00% Added +794 +794
29 Ameliora Wealth Management Ltd. 0.00% of their portfolio ZURICH, V8 750750 $3.1k $3.1k 0.00% Unchanged
30 Worth Asset Management, LLC 0.00% of their portfolio DALLAS, TX 650650 $2.7k $2.7k 0.00% Unchanged
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 510510 $2.1k $2.1k 0.00% New
32 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 500500 $2.1k $2.1k 0.00% Unchanged
33 SIGNATUREFD, LLC 0.00% of their portfolio ATLANTA, GA 500500 $2.1k $2.1k 0.00% Unchanged
34 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 296296 $1.2k $1.2k 0.00% New
35 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 119119 $489 $489 0.00% Added +5 +5
36 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 7474 $0 $0 0.00% New
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 3434 $140 $140 0.00% Unchanged
38 UBS Group AG 0.00% of their portfolio ZURICH, V8 1818 $74 $74 0.00% Reduced -835 -835
39 FMR LLC 0.00% of their portfolio BOSTON, MA 1111 $45 $45 0.00% New
40 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged