LEXICON PHARMACEUTICALS INC LXRX
COM NEW · Common Stock · CUSIP 528872302 · ISIN US5288723027
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersThe Woodlands, TX
- Founded1995
- Websitelexpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 363.4m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.95. Options: 7 managers hold calls ($804.7k notional), 5 hold puts ($145.4k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 105 |
| Q1 2023 | 105 |
| Q2 2023 | 124 |
| Q3 2023 | 113 |
| Q4 2023 | 108 |
| Q1 2024 | 119 |
| Q2 2024 | 128 |
| Q3 2024 | 138 |
| Q4 2024 | 128 |
| Q1 2025 | 128 |
| Q2 2025 | 125 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 54 | 51 |
| Q4 2023 | 53 | 55 |
| Q1 2024 | 64 | 52 |
| Q2 2024 | 71 | 39 |
| Q3 2024 | 69 | 35 |
| Q4 2024 | 64 | 58 |
| Q1 2025 | 64 | 60 |
| Q2 2025 | 57 | 69 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $2.3m | $276.9k | 0.12 |
| Q4 2024 | $547.0k | $162.7k | 0.30 |
| Q1 2025 | $357.7k | $52.0k | 0.15 |
| Q2 2025 | $804.7k | $145.4k | 0.18 |
Biggest buyers
| FMR LLC | Added | +3.6m |
| Sessa Capital IM, L.P. | New | +3.0m |
| GSA CAPITAL PARTNERS LLP | Added | +2.0m |
| MILLENNIUM MANAGEMENT LLC | New | +1.6m |
| ROYAL BANK OF CANADA | Added | +1.5m |
| JANE STREET GROUP, LLC | New | +804.7k |
| HRT FINANCIAL LP | New | +488.5k |
| WELLINGTON MANAGEMENT GROUP LLP | New | +486.7k |
| TWO SIGMA INVESTMENTS, LP | New | +403.9k |
| AQR CAPITAL MANAGEMENT LLC | Added | +229.0k |
Biggest sellers
| BlackRock, Inc. | Reduced | -6.7m |
| Schonfeld Strategic Advisors LLC | Reduced | -3.6m |
| STATE STREET CORP | Reduced | -1.8m |
| UBS Group AG | Reduced | -1.7m |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -1.3m |
| Ikarian Capital, LLC | Reduced | -1.2m |
| TANG CAPITAL MANAGEMENT LLC | Sold out | -1.2m |
| VANGUARD GROUP INC | Reduced | -706.1k |
| NORTHERN TRUST CORP | Reduced | -693.5k |
| ACADIAN ASSET MANAGEMENT LLC | Sold out | -573.7k |
Biggest calls
| SIMPLEX TRADING, LLC | Added | $240.0k254.1k shares |
| CITADEL ADVISORS LLC | Added | $213.1k225.3k shares |
| GROUP ONE TRADING LLC | Added | $159.4k168.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $115.7k121.8k shares |
| JANE STREET GROUP, LLC | New | $59.2k62.6k shares |
| WOLVERINE TRADING, LLC | Reduced | $17.3k21.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $83.1k87.5k shares |
| CITADEL ADVISORS LLC | Reduced | $47.6k50.3k shares |
| GROUP ONE TRADING LLC | Reduced | $14.8k15.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Invus Global Management, LLC
13D · may seek influence
+3.2 pts · filed 2026-05-08
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: As previously disclosed in Amendment No. 25, on February 2, 2026, Artal Participations S.a.r.l. acquired 367,145.12 shares of Preferred Stock, and on February 17, 2026 Artal Participations S.a r.l. purchased an additional 41,289.58 shares of Preferred Stock, in each case, pursuant to the terms of the Preferred Purchase Agreement. Each share of Preferred Stock would automatically convert into 50 shares (subject to adjustments) of Issuer Common Stock immediately following the satisfaction of all of the following conditions: (i) the approval of the New Charter by the shareholders of the Issuer at the Annual Meeting; (ii) the adoption of the New Charter by the Issuer's board of directors; and (iii) the filing and acceptan… Full filing |
39.4% |
| FMR LLC 13G · institution +1.2 pts · filed 2026-08-06 | 11.7% |
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 2 | $24.8k | 0 | — | — |
| Q4 2023 | 3 | $1.4m | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| Artal Group S.A. 13.91% of their portfolio | 136.2m $129.4m | Unchanged |
| Siren, L.L.C. 1.90% of their portfolio | 38.9m $36.8m | Unchanged |
| FMR LLC 0.00% of their portfolio | 38.1m $36.1m | Added +3.6m |
| VANGUARD GROUP INC 0.00% of their portfolio | 8.9m $8.4m | Reduced -706.1k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 4.6m $4.3m | Reduced -3.6m |
| BlackRock, Inc. 0.00% of their portfolio | 3.4m $3.2m | Reduced -6.7m |
| Sessa Capital IM, L.P. 0.09% of their portfolio | 3.0m $2.8m | New |
| GSA CAPITAL PARTNERS LLP 0.19% of their portfolio | 2.8m $2.7m | Added +2.0m |
| CIBC Private Wealth Group LLC 0.00% of their portfolio | 2.5m $2.3m | Added +210.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.4m $2.2m | Reduced -1.3m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.6m $1.6m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.5m $1.5m | Added +1.5m |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.4m $1.3m | Added +229.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 883.2k $835.3k | Reduced -267.5k |
| STATE STREET CORP 0.00% of their portfolio | 818.6k $774.2k | Reduced -1.8m |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 804.7k $761.0k | New |
| Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio | 793.4k $750.3k | Reduced -36.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 755.7k $714.6k | Reduced -195.5k |
| Monaco Asset Management SAM 0.19% of their portfolio | 531.6k $502.7k | Reduced -202.5k |
| HRT FINANCIAL LP 0.00% of their portfolio | 488.5k $461.0k | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 486.7k $460.2k | New |
| Invesco Ltd. 0.00% of their portfolio | 420.7k $397.9k | Added +134.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 416.4k $393.8k | Reduced -693.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 403.9k $382.0k | New |
| UBS Group AG 0.00% of their portfolio | 400.7k $379.1k | Reduced -1.7m |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 346.8k $327.9k | Reduced -19.1k |
| Compagnie Lombard Odier SCmA 0.00% of their portfolio | 330.0k $312.1k | Added +220.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 325.7k $308.1k | Reduced -29.4k |
| Cerity Partners LLC 0.00% of their portfolio | 206.3k $195.1k | Added +35.9k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 192.1k $181.7k | Added +14.8k |
| Ikarian Capital, LLC 0.06% of their portfolio | 176.5k $166.9k | Reduced -1.2m |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 158.2k $149.6k | Added +144.4k |
| Jain Global LLC 0.00% of their portfolio | 151.8k $143.6k | New |
| Virtu Financial LLC 0.01% of their portfolio | 146.8k $139.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 131.4k $124.3k | Reduced -510.2k |
| Aster Capital Management (DIFC) Ltd 0.03% of their portfolio | 130.5k $123.4k | New |
| CWM, LLC 0.00% of their portfolio | 109.3k $103.0k | Added +3.8k |
| LPL Financial LLC 0.00% of their portfolio | 104.4k $98.8k | Added +33.5k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 100.0k $94.6k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 95.6k $90.4k | Reduced -99.8k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 90.9k $86.0k | Unchanged |
| Quantessence Capital LLC 0.02% of their portfolio | 84.1k $79.5k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 74.5k $67.1k | Added +5.2k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 72.9k $69.0k | Added +434 |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 70.0k $66.2k | Reduced -101.1k |
| XTX Topco Ltd 0.00% of their portfolio | 66.3k $62.7k | Added +53.8k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 65.3k $61.8k | Added +28.6k |
| Straight Path Wealth Management 0.02% of their portfolio | 62.7k $59.3k | Unchanged |
| Scientech Research LLC 0.01% of their portfolio | 57.9k $54.7k | New |
| Fortis Group Advisors, LLC 0.01% of their portfolio | 57.8k $61.8k | Added +20.0k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio | 56.1k $53.1k | Reduced -398.8k |
| Catalyst Funds Management Pty Ltd 0.01% of their portfolio | 53.7k $50.8k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 52.7k $49.0k | Reduced -122.3k |
| PINNACLE ASSOCIATES LTD 0.00% of their portfolio | 50.8k $48.1k | Reduced -3.4k |
| CITIGROUP INC 0.00% of their portfolio | 48.5k $45.9k | Reduced -48.4k |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 42.4k $40.1k | New |
| WEDBUSH SECURITIES INC 0.00% of their portfolio | 40.9k $39.0k | Unchanged |
| KWB Wealth 0.00% of their portfolio | 40.6k $18.7k | Unchanged |
| Pallas Capital Advisors LLC 0.00% of their portfolio | 36.8k $34.8k | Added +557 |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 0.01% of their portfolio | 35.7k $33.8k | Unchanged |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 35.6k $33.6k | Added +2.4k |
| BARCLAYS PLC 0.00% of their portfolio | 32.3k $30.5k | Reduced -113.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 32.1k $30.3k | Reduced -64.3k |
| Pathstone Holdings, LLC 0.00% of their portfolio | 30.0k $28.4k | Reduced -1.4k |
| R Squared Ltd 0.02% of their portfolio | 29.6k $28.0k | Not comparable |
| Hudson Bay Capital Management LP 0.00% of their portfolio | 27.0k $25.5k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 26.4k $25.0k | Reduced -37.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 24.7k $23.3k | Reduced -63.5k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 23.7k $22.4k | New |
| OPPENHEIMER & CO INC 0.00% of their portfolio | 23.5k $22.2k | Added +3.4k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 21.5k $20.0k | Reduced -575 |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 21.4k $20.3k | Added +100 |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 21.1k $20.0k | Reduced -518 |
| Invera Wealth Advisors, LLC 0.01% of their portfolio | 20.0k $18.9k | Unchanged |
| TIAA TRUST, NATIONAL ASSOCIATION 0.00% of their portfolio | 20.0k $18.9k | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 19.2k $18.2k | Added +15.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 19.1k $18.1k | Reduced -291.0k |
| Merit Financial Group, LLC 0.00% of their portfolio | 16.7k $15.8k | Added +1.2k |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 16.2k $15.3k | New |
| Jump Financial, LLC 0.00% of their portfolio | 16.0k $15.1k | New |
| HighTower Advisors, LLC 0.00% of their portfolio | 14.9k $14.1k | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 14.0k $13.3k | Added +1.9k |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 14.0k $13.2k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 13.8k $13.0k | Reduced -54.2k |
| Focus Partners Advisor Solutions, LLC 0.00% of their portfolio | 13.7k $13.0k | Added +1.6k |
| ProShare Advisors LLC 0.00% of their portfolio | 13.6k $12.8k | Reduced -27.6k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 12.7k $12.0k | Reduced -15.4k |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 12.2k $12.0k | New |
| Chemistry Wealth Management LLC 0.00% of their portfolio | 12.0k $11.3k | Unchanged |
| HBK Sorce Advisory LLC 0.00% of their portfolio | 11.8k $11.1k | New |
| AVANTAX ADVISORY SERVICES, INC. 0.00% of their portfolio | 11.7k $11.1k | Unchanged |
| NORTH STAR ASSET MANAGEMENT INC 0.00% of their portfolio | 11.5k $10.9k | Unchanged |
| Perennial Investment Advisors, LLC 0.00% of their portfolio | 11.0k $10.4k | New |
| Berger Financial Group, Inc 0.00% of their portfolio | 10.9k $10.3k | Unchanged |
| NBT BANK, N.A. 0.00% of their portfolio | 10.0k $9.5k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 8.7k $8.2k | Reduced -80.4k |
| Point72 (DIFC) Ltd 0.00% of their portfolio | 7.0k $6.6k | Reduced -6.3k |
| Vermillion & White Wealth Management Group, LLC 0.00% of their portfolio | 6.5k $6.1k | New |
| Golden State Wealth Management, LLC 0.00% of their portfolio | 3.7k $3.5k | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 3.0k $2.9k | Added +1.2k |