LEXICON PHARMACEUTICALS INC LXRX
COM NEW · Common Stock · CUSIP 528872302 · ISIN US5288723027
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersThe Woodlands, TX
- Founded1995
- Websitelexpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($18.8k this quarter). Holder counts are more reliable. Shares outstanding: 361.5m as of 2024-07-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.69. Options: 7 managers hold calls ($4.2m notional), 7 hold puts ($622.2k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 105 |
| Q1 2023 | 105 |
| Q2 2023 | 124 |
| Q3 2023 | 113 |
| Q4 2023 | 108 |
| Q1 2024 | 119 |
| Q2 2024 | 128 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 46 | 40 |
| Q1 2023 | 51 | 47 |
| Q2 2023 | 79 | 29 |
| Q3 2023 | 54 | 51 |
| Q4 2023 | 53 | 55 |
| Q1 2024 | 64 | 52 |
| Q2 2024 | 71 | 39 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $441.4k | $291.2k | 0.66 |
| Q4 2023 | $521.6k | $475.8k | 0.91 |
| Q1 2024 | $14.3m | $1.3m | 0.09 |
| Q2 2024 | $4.2m | $622.2k | 0.15 |
Biggest buyers
| Artal Group S.A. | Added | +57.5m |
| FMR LLC | Added | +24.8m |
| BRAIDWELL LP | New | +8.3m |
| Nantahala Capital Management, LLC | New | +4.6m |
| Point72 Asset Management, L.P. | Added | +3.5m |
| ORBIMED ADVISORS LLC | Added | +2.3m |
| CITADEL ADVISORS LLC | Added | +2.3m |
| BlackRock Inc. | Added | +2.2m |
| Opaleye Management Inc. | New | +1.9m |
| VANGUARD GROUP INC | Added | +1.3m |
Biggest sellers
| BVF INC/IL | Sold out | -1.7m |
| Cubist Systematic Strategies, LLC | Sold out | -1.4m |
| Schonfeld Strategic Advisors LLC | Reduced | -388.7k |
| MORGAN STANLEY | Reduced | -378.6k |
| ExodusPoint Capital Management, LP | Sold out | -319.1k |
| Nuveen Asset Management, LLC | Reduced | -307.9k |
| GSA CAPITAL PARTNERS LLP | Sold out | -293.3k |
| BOULDER HILL CAPITAL MANAGEMENT LP | Sold out | -256.4k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -170.3k |
| JANE STREET GROUP, LLC | Reduced | -151.7k |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $2.2m1.3m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $933.1k555.4k shares |
| JANE STREET GROUP, LLC | Reduced | $832.9k495.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $158.0k94.4k shares |
| CITADEL ADVISORS LLC | Reduced | $71.7k42.7k shares |
| WOLVERINE TRADING, LLC | New | $31.9k19.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $288.6k171.8k shares |
| CITADEL ADVISORS LLC | Reduced | $163.0k97.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $55.0k33.1k shares |
| GROUP ONE TRADING LLC | Reduced | $54.4k32.4k shares |
| JANE STREET GROUP, LLC | Unchanged | $32.1k19.1k shares |
| WOLVERINE TRADING, LLC | Reduced | $29.1k17.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Invus Global Management, LLC
13D · may seek influence
+3.2 pts · filed 2026-05-08
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: As previously disclosed in Amendment No. 25, on February 2, 2026, Artal Participations S.a.r.l. acquired 367,145.12 shares of Preferred Stock, and on February 17, 2026 Artal Participations S.a r.l. purchased an additional 41,289.58 shares of Preferred Stock, in each case, pursuant to the terms of the Preferred Purchase Agreement. Each share of Preferred Stock would automatically convert into 50 shares (subject to adjustments) of Issuer Common Stock immediately following the satisfaction of all of the following conditions: (i) the approval of the New Charter by the shareholders of the Issuer at the Annual Meeting; (ii) the adoption of the New Charter by the Issuer's board of directors; and (iii) the filing and acceptan… Full filing |
39.4% |
| FMR LLC 13G · institution +1.2 pts · filed 2026-08-06 | 11.7% |
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 2 | $49.3m | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 4 | $72.4m | 0 | — | — |
| Q3 2023 | 2 | $24.8k | 0 | — | — |
| Q4 2023 | 3 | $1.4m | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Artal Group S.A. 7.55% of their portfolio | 175.1m $294.2m | Added +57.5m |
| FMR LLC 0.00% of their portfolio | 38.7m $65.0m | Added +24.8m |
| BlackRock Inc. 0.00% of their portfolio | 9.9m $16.6m | Added +2.2m |
| BRAIDWELL LP 0.44% of their portfolio | 8.3m $13.9m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 7.7m $12.9m | Added +1.3m |
| ORBIMED ADVISORS LLC 0.20% of their portfolio | 5.8m $9.8m | Added +2.3m |
| Nantahala Capital Management, LLC 0.39% of their portfolio | 4.6m $7.7m | New |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 4.1m $6.9m | Added +3.5m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.3m $5.5m | Added +861.4k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 2.4m $4.0m | Added +2.3m |
| NEA Management Company, LLC 0.30% of their portfolio | 2.4m $4.0m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 2.3m $3.9m | Added +326.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 2.1m $3.5m | Added +674.8k |
| Opaleye Management Inc. 0.72% of their portfolio | 1.9m $3.1m | New |
| PINNACLE ASSOCIATES LTD 0.05% of their portfolio | 1.7m $2.9m | Reduced -32.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.4m $2.3m | Added +478.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 1.2m $2.0m | Added +691.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 997.5k $1.7m | Added +131.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 738.6k $1.2m | Added +52.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 597.3k $1.0m | Added +63.1k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 571.5k $3.2m | Reduced -388.7k |
| Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio | 542.9k $912.1k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 401.9k $675.2k | Added +109.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 373.4k $627.4k | Added +217.2k |
| MORGAN STANLEY 0.00% of their portfolio | 354.0k $594.8k | Reduced -378.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 273.0k $458.7k | Added +53.1k |
| BBR PARTNERS, LLC 0.04% of their portfolio | 270.0k $453.6k | Added +240.0k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 216.3k $363.3k | Reduced -307.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 180.9k $303.8k | Added +580 |
| VIRTUS ADVISERS, LLC 0.15% of their portfolio | 180.0k $302.4k | Reduced -113.1k |
| UBS Group AG 0.00% of their portfolio | 161.1k $270.7k | Reduced -5.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 152.8k $256.7k | Added +17.9k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 129.9k $218.2k | Reduced -151.7k |
| Altium Capital Management LLC 0.08% of their portfolio | 122.0k $204.9k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 117.2k $197.0k | Added +11.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 114.1k $191.7k | Added +103.3k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 101.1k $170.0k | Added +6.0k |
| Compagnie Lombard Odier SCmA 0.00% of their portfolio | 94.0k $157.9k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 87.2k $146.5k | Added +1.3k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 84.6k $142.0k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 76.1k $127.8k | Added +26.1k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 70.0k $125.3k | Added +30.0k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 61.8k $103.8k | First filing |
| LPL Financial LLC 0.00% of their portfolio | 61.1k $102.6k | Reduced -28.9k |
| Pathstone Holdings, LLC 0.00% of their portfolio | 60.0k $100.9k | Reduced -2.7k |
| Invesco Ltd. 0.00% of their portfolio | 59.7k $100.4k | Added +9.9k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 55.2k $92.7k | Added +22.3k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 53.1k $89.2k | Added +4.0k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 51.5k $86.4k | Reduced -723 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 50.0k $83.9k | Added +14.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 47.2k $79.3k | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 45.6k $76.6k | Added +14.6k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 45.3k $76.2k | Added +14.0k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 42.5k $71.3k | Reduced -4.5k |
| WEDBUSH SECURITIES INC 0.00% of their portfolio | 40.9k $69.0k | Reduced -800 |
| KWB Wealth 0.01% of their portfolio | 40.6k $97.5k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 39.6k $66.6k | Added +10.7k |
| BARCLAYS PLC 0.00% of their portfolio | 39.4k $66.3k | Reduced -25.2k |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 0.01% of their portfolio | 35.7k $60.0k | Reduced -71.4k |
| ProShare Advisors LLC 0.00% of their portfolio | 34.7k $58.3k | Added +979 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 33.7k $56.6k | Reduced -31 |
| CITIGROUP INC 0.00% of their portfolio | 33.1k $55.7k | Added +15.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 31.9k $53.6k | Reduced -6.8k |
| Prosperity Financial Group, Inc. 0.03% of their portfolio | 31.5k $52.9k | Unchanged |
| GREAT POINT PARTNERS LLC 0.01% of their portfolio | 30.0k $50.4k | New |
| TIAA TRUST, NATIONAL ASSOCIATION 0.00% of their portfolio | 27.1k $45.5k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 23.5k $39.5k | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 22.8k $38.2k | Added +12.2k |
| Cerity Partners LLC 0.00% of their portfolio | 22.5k $37.8k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 22.2k $37.0k | Added +2.9k |
| PRINCIPAL SECURITIES, INC. 0.00% of their portfolio | 20.0k $33.6k | Unchanged |
| CVI Holdings, LLC 0.03% of their portfolio | 20.0k $33.6k | New |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 19.3k $32.5k | Added +3.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 19.2k $32.2k | Reduced -170.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 18.6k $31.3k | Reduced -40.8k |
| Verition Fund Management LLC 0.00% of their portfolio | 18.2k $30.5k | New |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 17.8k $29.9k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 17.0k $28.5k | Reduced -1.1k |
| Kestra Advisory Services, LLC 0.00% of their portfolio | 15.5k $26.0k | Added +1.0k |
| Cresset Asset Management, LLC 0.00% of their portfolio | 15.1k $25.4k | New |
| TRUIST FINANCIAL CORP 0.00% of their portfolio | 13.4k $22.5k | Added +400 |
| NORTH STAR ASSET MANAGEMENT INC 0.00% of their portfolio | 12.6k $21.1k | Unchanged |
| Coyle Financial Counsel LLC 0.01% of their portfolio | 12.5k $30.0k | Unchanged |
| Pinnacle Wealth Management Advisory Group, LLC 0.00% of their portfolio | 12.4k $20.9k | Unchanged |
| Vermillion & White Wealth Management Group, LLC 0.02% of their portfolio | 12.4k $20.9k | Unchanged |
| Chemistry Wealth Management LLC 0.01% of their portfolio | 12.0k $20.2k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 11.5k $19.3k | Added +3.3k |
| CIBC WORLD MARKET INC. 0.00% of their portfolio | 11.0k $18.0k | New |
| Berger Financial Group, Inc 0.00% of their portfolio | 10.9k $18.4k | Unchanged |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 10.9k $18.3k | Added +71 |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 10.9k $18.3k | Added +54 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 10.8k $18.0k | Added +8.7k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 10.8k $18.8k | New |
| Estabrook Capital Management 0.00% of their portfolio | 10.0k $16.8k | Unchanged |
| River Wealth Advisors LLC 0.00% of their portfolio | 10.0k $16.8k | Unchanged |
| LifeSteps Financial, Inc. 0.01% of their portfolio | 10.0k $16.8k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 8.9k $14.9k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 8.3k $14.0k | Reduced -997 |
| Nordwand Advisors, LLC 0.00% of their portfolio | 4.0k $6.7k | Unchanged |
| AMALGAMATED BANK 0.00% of their portfolio | 2.4k $4.0k | Unchanged |