LEAP THERAPEUTICS INC CYPH
COM NEW · Common Stock · CUSIP 52187K200
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 107.8m as of 2026-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.61. Options: 6 managers hold calls ($934.1k notional), 5 hold puts ($235.8k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2023 | 38 |
| Q3 2023 | 43 |
| Q4 2023 | 44 |
| Q1 2024 | 45 |
| Q2 2024 | 47 |
| Q3 2024 | 49 |
| Q4 2024 | 58 |
| Q1 2025 | 46 |
| Q2 2025 | 44 |
| Q3 2025 | 33 |
| Q4 2025 | 38 |
| Q1 2026 | 40 |
| Q2 2026 | 47 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 19 | 20 |
| Q4 2024 | 32 | 15 |
| Q1 2025 | 20 | 35 |
| Q2 2025 | 15 | 20 |
| Q3 2025 | 10 | 18 |
| Q4 2025 | 26 | 15 |
| Q1 2026 | 12 | 17 |
| Q2 2026 | 29 | 10 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $36.5k | $15.8k | 0.43 |
| Q4 2025 | $723.0k | $875.2k | 1.21 |
| Q1 2026 | $795.4k | $485.0k | 0.61 |
| Q2 2026 | $934.1k | $235.8k | 0.25 |
Biggest buyers
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +2.1m |
| JANE STREET GROUP, LLC | New | +1.7m |
| UBS Group AG | Added | +956.3k |
| CITADEL ADVISORS LLC | New | +836.2k |
| XTX Topco Ltd | Added | +607.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +602.7k |
| STATE STREET CORP | Added | +376.0k |
| BlackRock, Inc. | Added | +280.6k |
| VANGUARD FIDUCIARY TRUST CO | Added | +274.3k |
| MORGAN STANLEY | Added | +137.1k |
Biggest sellers
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -725.1k |
| GROUP ONE TRADING LLC | Reduced | -86.0k |
| Texas Capital Bank Wealth Management Services Inc | Reduced | -66.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -45.0k |
| HRT FINANCIAL LP | Sold out | -37.7k |
| SIMPLEX TRADING, LLC | Reduced | -34.8k |
| Key Client Fiduciary Advisors, LLC | Reduced | -5.3k |
| CNB Bank | Sold out | -5.0k |
| LPL Financial LLC | Reduced | -3.3k |
| CITIGROUP INC | Sold out | -808 |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $355.8k583.2k shares |
| CITADEL ADVISORS LLC | Added | $259.0k423.0k shares |
| SIMPLEX TRADING, LLC | Added | $110.6k180.7k shares |
| JANE STREET GROUP, LLC | Added | $107.8k176.1k shares |
| GROUP ONE TRADING LLC | Added | $94.2k153.8k shares |
| Key Client Fiduciary Advisors, LLC | Unchanged | $6.7k11.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $123.2k202.0k shares |
| JANE STREET GROUP, LLC | Added | $53.6k87.6k shares |
| GROUP ONE TRADING LLC | Reduced | $25.4k41.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $16.8k27.4k shares |
| CITADEL ADVISORS LLC | Reduced | $16.7k27.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Winklevoss Capital Fund, LLC 13D · may seek influence no change · filed 2026-08-19 | 19.9% |
| Severns Sean Michael 13G · passive investor new · filed 2025-11-18 | 10.6% |
Fell to 5% or below in the last year: GILEAD SCIENCES, INC. (0.0%, 2026-02-12)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 3 | $2.1m | — |
| Q1 2026 | 0 | — | 1 | $42.6k | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 3 | $34.4k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-25 | Oei Khing Djien Director | Sold | —168.8k shares |
| 2026-09-23 | Martin Patricia A. Director | Sold | —50.0k shares |
| 2026-08-26 | Dietz Thomas John Director | Sold | $34.4k20.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.9m $2.4m | Added +2.1m |
| BlackRock, Inc. 0.00% of their portfolio | 2.6m $1.6m | Added +280.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 1.7m $1.0m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.2m $718.8k | Added +602.7k |
| UBS Group AG 0.00% of their portfolio | 1.1m $689.9k | Added +956.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 836.2k $512.0k | New |
| XTX Topco Ltd 0.01% of their portfolio | 638.3k $390.8k | Added +607.7k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 571.3k $349.7k | Added +274.3k |
| STATE STREET CORP 0.00% of their portfolio | 516.1k $316.0k | Added +376.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 222.0k $135.9k | Added +134.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 218.0k $133.5k | Reduced -45.0k |
| MORGAN STANLEY 0.00% of their portfolio | 174.6k $106.9k | Added +137.1k |
| LPL Financial LLC 0.00% of their portfolio | 159.2k $97.5k | Reduced -3.3k |
| Sequoia Financial Advisors, LLC 0.00% of their portfolio | 152.5k $93.4k | Added +104.5k |
| HighTower Advisors, LLC 0.00% of their portfolio | 100.6k $61.6k | Added +40.1k |
| Virtu Financial LLC 0.00% of their portfolio | 86.8k $53.0k | Added +76.6k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 80.4k $49.2k | Added +13.8k |
| Key Client Fiduciary Advisors, LLC 0.01% of their portfolio | 75.1k $46.0k | Reduced -5.3k |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 44.8k $27.5k | Added +42.8k |
| Texas Capital Bank Wealth Management Services Inc 0.00% of their portfolio | 37.6k $23.0k | Reduced -66.6k |
| Simplify Asset Management Inc. 0.00% of their portfolio | 28.0k $17.1k | Added +6.8k |
| Spark Investment Management LLC 0.03% of their portfolio | 25.9k $15.9k | New |
| Gerber Kawasaki Wealth & Investment Management 0.00% of their portfolio | 22.0k $13.5k | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 21.4k $13.1k | Reduced -86.0k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 15.7k $9.6k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 14.7k $9.0k | New |
| BARCLAYS PLC 0.00% of their portfolio | 13.8k $8.5k | New |
| Keystone Financial Group 0.00% of their portfolio | 11.7k $7.2k | Unchanged |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 11.6k $7.1k | Unchanged |
| SIMON QUICK ADVISORS, LLC 0.00% of their portfolio | 11.4k $7.0k | New |
| Quadrant Private Wealth Management, LLC 0.00% of their portfolio | 11.2k $6.9k | Unchanged |
| IHT Wealth Management, LLC 0.00% of their portfolio | 11.0k $6.7k | Unchanged |
| Scientech Research LLC 0.01% of their portfolio | 10.2k $6.2k | New |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 10.0k $6.1k | Unchanged |
| ADIRONDACK TRUST CO 0.00% of their portfolio | 10.0k $6.1k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 4.4k $2.7k | Reduced -34.8k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.9k $1.1k | Unchanged |
| HUNTINGTON NATIONAL BANK 0.00% of their portfolio | 1.0k $612 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 704 $431 | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 227 $144 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 200 $0 | Added +100 |
| Allworth Financial LP 0.00% of their portfolio | 135 $83 | Unchanged |
| TOMPKINS FINANCIAL CORP 0.00% of their portfolio | 120 $73 | Unchanged |
| FMR LLC 0.00% of their portfolio | 100 $61 | New |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 50 $31 | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $1 | New |
| PlanVest Financial, Inc 0.00% of their portfolio | 1 $1 | Unchanged |