Vault-13

LEAP THERAPEUTICS INC CYPH

COM NEW · Common Stock · CUSIP 52187K200

47 institutional holders +7 vs Q1 2026
14,664,42614.7m shares reported held*
13.6% of all shares outstanding*
$9.0mreported value*
13 new 16 added 6 reduced 4 sold out net bought ≈ $4.5m (+7.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 107.8m as of 2026-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $0.61. Options: 6 managers hold calls ($934.1k notional), 5 hold puts ($235.8k).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0204060Q2 23: 38Q3 23: 43Q4 23: 44Q1 24: 45Q2 24: 47Q3 24: 49Q4 24: 58Q1 25: 46Q2 25: 44Q3 25: 33Q4 25: 38Q1 26: 40Q2 26: 4747Q2 23Q1 24Q4 24Q3 25Q2 26
Numbers
QuarterHolders
Q2 202338
Q3 202343
Q4 202344
Q1 202445
Q2 202447
Q3 202449
Q4 202458
Q1 202546
Q2 202544
Q3 202533
Q4 202538
Q1 202640
Q2 202647

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q3 24: 19 bought or addedQ3 24: 20 cut or sold outQ4 24: 32 bought or addedQ4 24: 15 cut or sold outQ4 24Q1 25: 20 bought or addedQ1 25: 35 cut or sold outQ2 25: 15 bought or addedQ2 25: 20 cut or sold outQ2 25Q3 25: 10 bought or addedQ3 25: 18 cut or sold outQ4 25: 26 bought or addedQ4 25: 15 cut or sold outQ4 25Q1 26: 12 bought or addedQ1 26: 17 cut or sold outQ2 26: 29 bought or addedQ2 26: 10 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20241920
Q4 20243215
Q1 20252035
Q2 20251520
Q3 20251018
Q4 20252615
Q1 20261217
Q2 20262910

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$250k$500k$750k$1mQ3 25 calls: $36.5kQ3 25 puts: $15.8kQ3 25P/C 0.43Q4 25 calls: $723.0kQ4 25 puts: $875.2kQ4 25P/C 1.21Q1 26 calls: $795.4kQ1 26 puts: $485.0kQ1 26P/C 0.61Q2 26 calls: $934.1kQ2 26 puts: $235.8kQ2 26P/C 0.25
Numbers
QuarterCallsPutsP/C
Q3 2025$36.5k$15.8k0.43
Q4 2025$723.0k$875.2k1.21
Q1 2026$795.4k$485.0k0.61
Q2 2026$934.1k$235.8k0.25

Biggest buyers

VANGUARD CAPITAL MANAGEMENT LLC Added +2,069,160+2.1m
JANE STREET GROUP, LLC New +1,701,926+1.7m
UBS Group AG Added +956,298+956.3k
CITADEL ADVISORS LLC New +836,153+836.2k
XTX Topco Ltd Added +607,671+607.7k
GEODE CAPITAL MANAGEMENT, LLC Added +602,669+602.7k
STATE STREET CORP Added +376,000+376.0k
BlackRock, Inc. Added +280,649+280.6k
VANGUARD FIDUCIARY TRUST CO Added +274,259+274.3k
MORGAN STANLEY Added +137,081+137.1k

Biggest sellers

RENAISSANCE TECHNOLOGIES LLC Sold out -725,120-725.1k
GROUP ONE TRADING LLC Reduced -85,972-86.0k
Texas Capital Bank Wealth Management Services Inc Reduced -66,600-66.6k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -44,956-45.0k
HRT FINANCIAL LP Sold out -37,722-37.7k
SIMPLEX TRADING, LLC Reduced -34,769-34.8k
Key Client Fiduciary Advisors, LLC Reduced -5,322-5.3k
CNB Bank Sold out -5,000-5.0k
LPL Financial LLC Reduced -3,300-3.3k
CITIGROUP INC Sold out -808-808

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $355.8k583.2k shares
CITADEL ADVISORS LLC Added $259.0k423.0k shares
SIMPLEX TRADING, LLC Added $110.6k180.7k shares
JANE STREET GROUP, LLC Added $107.8k176.1k shares
GROUP ONE TRADING LLC Added $94.2k153.8k shares
Key Client Fiduciary Advisors, LLC Unchanged $6.7k11.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $123.2k202.0k shares
JANE STREET GROUP, LLC Added $53.6k87.6k shares
GROUP ONE TRADING LLC Reduced $25.4k41.5k shares
SIMPLEX TRADING, LLC Reduced $16.8k27.4k shares
CITADEL ADVISORS LLC Reduced $16.7k27.3k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Winklevoss Capital Fund, LLC 13D · may seek influence no change · filed 2026-08-19 19.9% no change 24.9m≈ $14.4m 2026-08-19
Severns Sean Michael 13G · passive investor new · filed 2025-11-18 10.6% new 6.0m≈ $3.7m 2025-11-18

Fell to 5% or below in the last year: GILEAD SCIENCES, INC. (0.0%, 2026-02-12)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 0 buyingQ4 25: 3 sellingQ1 26: 0 buyingQ1 26: 1 sellingQ1 26Q2 26: 0 buyingQ2 26: 0 sellingQ3 26: 0 buyingQ3 26: 3 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—0——
Q4 20250—3$2.1m—
Q1 20260—1$42.6k—
Q2 20260—0——
Q3 20260—3$34.4k—
DateInsiderTradeSharesPrice ValueTheir holding
2026-09-25 Oei Khing Djien Director Sold 168,750 — —168.8k shares -100%
2026-09-23 Martin Patricia A. Director Sold 50,000 — —50.0k shares -30%
2026-08-26 Dietz Thomas John Director Sold 20,000 $1.72 $34.4k20.0k shares -13%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 3,887,5743.9m $2.4m $2.4m 0.00% Added +2.1m +2,069,160
2 BlackRock, Inc. 0.00% of their portfolio New York, NY 2,622,8232.6m $1.6m $1.6m 0.00% Added +280.6k +280,649
3 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 1,701,9261.7m $1.0m $1.0m 0.00% New
4 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,173,7371.2m $718.8k $718.8k 0.00% Added +602.7k +602,669
5 UBS Group AG 0.00% of their portfolio ZURICH, V8 1,127,3661.1m $689.9k $689.9k 0.00% Added +956.3k +956,298
6 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 836,153836.2k $512.0k $512.0k 0.00% New
7 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 638,329638.3k $390.8k $390.8k 0.01% Added +607.7k +607,671
8 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 571,345571.3k $349.7k $349.7k 0.00% Added +274.3k +274,259
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 516,113516.1k $316.0k $316.0k 0.00% Added +376.0k +376,000
10 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 222,031222.0k $135.9k $135.9k 0.00% Added +134.5k +134,469
11 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 217,997218.0k $133.5k $133.5k 0.00% Reduced -45.0k -44,956
12 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 174,586174.6k $106.9k $106.9k 0.00% Added +137.1k +137,081
13 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 159,194159.2k $97.5k $97.5k 0.00% Reduced -3.3k -3,300
14 Sequoia Financial Advisors, LLC 0.00% of their portfolio Akron, OH 152,500152.5k $93.4k $93.4k 0.00% Added +104.5k +104,500
15 HighTower Advisors, LLC 0.00% of their portfolio CHICAGO, IL 100,580100.6k $61.6k $61.6k 0.00% Added +40.1k +40,080
16 Virtu Financial LLC 0.00% of their portfolio New York, NY 86,78986.8k $53.0k $53.0k 0.00% Added +76.6k +76,601
17 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 80,41180.4k $49.2k $49.2k 0.00% Added +13.8k +13,839
18 Key Client Fiduciary Advisors, LLC 0.01% of their portfolio Fairfield, NJ 75,10275.1k $46.0k $46.0k 0.01% Reduced -5.3k -5,322
19 Farther Finance Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 44,84444.8k $27.5k $27.5k 0.00% Added +42.8k +42,786
20 Texas Capital Bank Wealth Management Services Inc 0.00% of their portfolio Dallas, TX 37,60037.6k $23.0k $23.0k 0.00% Reduced -66.6k -66,600
21 Simplify Asset Management Inc. 0.00% of their portfolio Las Vegas, NV 27,97928.0k $17.1k $17.1k 0.00% Added +6.8k +6,840
22 Spark Investment Management LLC 0.03% of their portfolio NEW YORK, NY 25,90025.9k $15.9k $15.9k 0.03% New
23 Gerber Kawasaki Wealth & Investment Management 0.00% of their portfolio SANTA MONICA, CA 22,00022.0k $13.5k $13.5k 0.00% Unchanged
24 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 21,44421.4k $13.1k $13.1k 0.00% Reduced -86.0k -85,972
25 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 15,74215.7k $9.6k $9.6k 0.00% New
26 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 14,65314.7k $9.0k $9.0k 0.00% New
27 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 13,82113.8k $8.5k $8.5k 0.00% New
28 Keystone Financial Group 0.00% of their portfolio LEXINGTON, KY 11,71211.7k $7.2k $7.2k 0.00% Unchanged
29 Vanguard Global Advisers, LLC 0.00% of their portfolio MALVERN, PA 11,60911.6k $7.1k $7.1k 0.00% Unchanged
30 SIMON QUICK ADVISORS, LLC 0.00% of their portfolio MORRISTOWN, NJ 11,36411.4k $7.0k $7.0k 0.00% New
31 Quadrant Private Wealth Management, LLC 0.00% of their portfolio Center Valley, PA 11,20011.2k $6.9k $6.9k 0.00% Unchanged
32 IHT Wealth Management, LLC 0.00% of their portfolio Chicago, IL 11,00011.0k $6.7k $6.7k 0.00% Unchanged
33 Scientech Research LLC 0.01% of their portfolio JERSEY CITY, NJ 10,18710.2k $6.2k $6.2k 0.01% New
34 BLAIR WILLIAM & CO/IL 0.00% of their portfolio CHICAGO, IL 10,00010.0k $6.1k $6.1k 0.00% Unchanged
35 ADIRONDACK TRUST CO 0.00% of their portfolio SARATOGA SPRINGS, NY 10,00010.0k $6.1k $6.1k 0.00% New
36 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 4,4274.4k $2.7k $2.7k 0.00% Reduced -34.8k -34,769
37 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 1,8501.9k $1.1k $1.1k 0.00% Unchanged
38 HUNTINGTON NATIONAL BANK 0.00% of their portfolio COLUMBUS, OH 1,0001.0k $612 $612 0.00% Unchanged
39 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 704704 $431 $431 0.00% New
40 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 227227 $144 $144 0.00% Unchanged
41 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 200200 $0 $0 0.00% Added +100 +100
42 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 135135 $83 $83 0.00% Unchanged
43 TOMPKINS FINANCIAL CORP 0.00% of their portfolio ITHACA, NY 120120 $73 $73 0.00% Unchanged
44 FMR LLC 0.00% of their portfolio BOSTON, MA 100100 $61 $61 0.00% New
45 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio MILWAUKEE, WI 5050 $31 $31 0.00% New
46 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 11 $1 $1 0.00% New
47 PlanVest Financial, Inc 0.00% of their portfolio GAITHERSBURG, MD 11 $1 $1 0.00% Unchanged