KYVERNA THERAPEUTICS INC KYTX
COM · Common Stock · CUSIP 501976104
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersEmeryville, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($187.4k this quarter). Holder counts are more reliable. Shares outstanding: 43.8m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.01. Options: 5 managers hold calls ($1.1m notional), 1 hold puts ($600).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2024 | 91 |
| Q2 2024 | 89 |
| Q3 2024 | 95 |
| Q4 2024 | 89 |
| Q1 2025 | 88 |
| Q2 2025 | 80 |
| Q3 2025 | 75 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 60 | 42 |
| Q3 2024 | 50 | 43 |
| Q4 2024 | 47 | 42 |
| Q1 2025 | 39 | 38 |
| Q2 2025 | 44 | 48 |
| Q3 2025 | 28 | 43 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $205.7k | $10.5k | 0.05 |
| Q1 2025 | $3.1k | $3.1k | 1.00 |
| Q2 2025 | $326.6k | $0 | 0.00 |
| Q3 2025 | $1.1m | $600 | 0.00 |
Biggest buyers
| Woodline Partners LP | New | +252.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | +147.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +130.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +112.0k |
| JANE STREET GROUP, LLC | Added | +111.1k |
| MILLENNIUM MANAGEMENT LLC | Added | +99.1k |
| UBS Group AG | Added | +59.3k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +42.2k |
| AMERICAN CENTURY COMPANIES INC | New | +32.2k |
| BANK OF AMERICA CORP /DE/ | Added | +31.2k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -318.3k |
| CITADEL ADVISORS LLC | Reduced | -307.7k |
| SUPERSTRING CAPITAL MANAGEMENT LP | Sold out | -142.5k |
| Cubist Systematic Strategies, LLC | Reduced | -124.2k |
| GOLDMAN SACHS GROUP INC | Reduced | -93.2k |
| TD Asset Management Inc | Reduced | -87.4k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -86.6k |
| Peapod Lane Capital LLC | Reduced | -78.0k |
| MARSHALL WACE, LLP | Sold out | -62.1k |
| BlackRock, Inc. | Reduced | -51.4k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $406.2k67.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $281.4k46.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $153.0k25.6k shares |
| GROUP ONE TRADING LLC | Added | $138.0k23.0k shares |
| JANE STREET GROUP, LLC | New | $90.0k15.0k shares |
Biggest puts
| GROUP ONE TRADING LLC | New | $600100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Westlake BioPartners Fund I, L.P. 13G · exempt (held before listing) filed 2026-02-06 | 7.8% |
| GordonMD Global Investments LP 13G · passive investor new · filed 2025-11-17 | 7.0% |
| Northpond Ventures III, LP 13G · passive investor filed 2026-02-17 | 6.1% |
| HIRSCHMAN ORIN 13G · institution new · filed 2026-10-19 | 5.9% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-29 | 5.1% |
Fell to 5% or below in the last year: Bain Capital Life Sciences Opportunities III, LP (4.8%, 2026-08-14)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q3 2025.
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| Vida Ventures Advisors, LLC 92.41% of their portfolio | 4.5m $27.1m | Unchanged |
| GILEAD SCIENCES, INC. 1.38% of their portfolio | 4.1m $24.8m | Unchanged |
| Bain Capital Life Sciences Investors, LLC 1.34% of their portfolio | 3.4m $20.2m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.5m $9.1m | Reduced -318.3k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.3m $7.9m | Added +9.9k |
| Insight Holdings Group, LLC 0.37% of their portfolio | 989.1k $5.9m | Unchanged |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 677.6k $4.1m | Reduced -17.4k |
| MBB PUBLIC MARKETS I LLC 0.49% of their portfolio | 614.5k $3.7m | Unchanged |
| Catalio Capital Management, LP 0.65% of their portfolio | 586.9k $3.5m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 551.6k $3.3m | Added +99.1k |
| BlackRock, Inc. 0.00% of their portfolio | 482.1k $2.9m | Reduced -51.4k |
| Kera Capital Partners, Inc. 0.38% of their portfolio | 421.9k $2.5m | Unchanged |
| Peapod Lane Capital LLC 1.71% of their portfolio | 318.8k $1.9m | Reduced -78.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 278.3k $1.7m | Reduced -9.3k |
| Woodline Partners LP 0.01% of their portfolio | 252.2k $1.5m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 202.7k $1.2m | Added +130.4k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 198.9k $1.2m | Added +111.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 174.9k $1.0m | Added +112.0k |
| MORGAN STANLEY 0.00% of their portfolio | 174.2k $1.0m | Reduced -27.8k |
| TD Asset Management Inc 0.00% of their portfolio | 164.8k $988.8k | Reduced -87.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 164.6k $987.7k | Added +42.2k |
| UBS Group AG 0.00% of their portfolio | 157.4k $944.5k | Added +59.3k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 147.7k $886.3k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 132.5k $794.7k | Added +11.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 125.6k $753.5k | Added +7.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 103.8k $622.8k | Reduced -14.5k |
| STATE STREET CORP 0.00% of their portfolio | 91.3k $547.8k | Unchanged |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 81.3k $487.8k | Reduced -13.0k |
| BARCLAYS PLC 0.00% of their portfolio | 76.2k $457.1k | Added +25.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 65.0k $389.8k | Added +31.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 51.7k $310.1k | Unchanged |
| XTX Topco Ltd 0.02% of their portfolio | 49.1k $294.6k | Added +14.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 43.1k $258.8k | Reduced -93.2k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 38.8k $232.9k | Reduced -144 |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 36.7k $220.1k | Added +22.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 34.0k $204.1k | Added +29.6k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 32.2k $193.2k | New |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 27.2k $163.1k | Reduced -28.3k |
| CAXTON CORP 0.60% of their portfolio | 23.0k $137.9k | Unchanged |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 20.4k $122.7k | Reduced -124.2k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 19.4k $116.6k | Reduced -16.8k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 18.9k $113.4k | Reduced -229 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 18.3k $109.7k | Added +14.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 17.7k $106.0k | Reduced -307.7k |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 16.3k $97.8k | New |
| Ethic Inc. 0.00% of their portfolio | 15.4k $92.1k | Reduced -1.7k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 15.2k $90.9k | Reduced -28.8k |
| Trexquant Investment LP 0.00% of their portfolio | 15.1k $90.7k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 13.5k $81.3k | Reduced -86.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 13.3k $80.1k | Reduced -14.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 12.9k $77.3k | New |
| Point72 Asia (Singapore) Pte. Ltd. 0.01% of their portfolio | 10.8k $64.7k | Reduced -1.3k |
| Phoenix Wealth Advisors 0.02% of their portfolio | 10.5k $63.0k | Unchanged |
| CAPITAL ADVISORS INC/OK 0.00% of their portfolio | 10.0k $60.0k | New |
| FMR LLC 0.00% of their portfolio | 7.9k $47.5k | Reduced -262 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 7.6k $45.5k | Reduced -1.1k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 7.5k $195.0k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 6.2k $37.4k | Reduced -4.7k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 4.6k $27.6k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 3.9k $23.5k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 3.3k $19.9k | Reduced -12.5k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 2.5k $14.8k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2.0k $12.0k | Added +137 |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 1.7k $10.0k | Added +2 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.7k $10.0k | Reduced -282 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 1.3k $7.9k | Unchanged |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 898 $5.4k | Reduced -172 |
| CWM, LLC 0.00% of their portfolio | 499 $3.0k | Reduced -7.5k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 301 $1.8k | Unchanged |
| Fourth Dimension Wealth, LLC 0.00% of their portfolio | 250 $1.5k | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 200 $1.2k | Added +55 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 137 $822 | Reduced -23 |
| Advisory Services Network, LLC 0.00% of their portfolio | 86 $516 | New |
| IFP Advisors, Inc 0.00% of their portfolio | 16 $96 | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 11 $66 | New |