KYMERA THERAPEUTICS INC KYMR
COM · Common Stock · CUSIP 501575104 · ISIN US5015751044
Biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWatertown, MA
- Websitekymeratx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.1m this quarter). Holder counts are more reliable. Shares outstanding: 55.5m as of 2023-10-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $25.46. Options: 6 managers hold calls ($2.0m notional), 4 hold puts ($432.7k).
Trends to Q4 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 129 |
| Q4 2022 | 121 |
| Q1 2023 | 128 |
| Q2 2023 | 130 |
| Q3 2023 | 123 |
| Q4 2023 | 138 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 60 | 61 |
| Q1 2023 | 62 | 49 |
| Q2 2023 | 66 | 50 |
| Q3 2023 | 61 | 56 |
| Q4 2023 | 66 | 70 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2023 | $22.0m | $2.6m | 0.12 |
| Q2 2023 | $1.9m | $442.9k | 0.24 |
| Q3 2023 | $680.4k | $60.6k | 0.09 |
| Q4 2023 | $2.0m | $432.7k | 0.22 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +1.2m |
| Artal Group S.A. | Added | +725.4k |
| MORGAN STANLEY | Added | +543.2k |
| GOLDMAN SACHS GROUP INC | Added | +469.9k |
| Schonfeld Strategic Advisors LLC | New | +437.6k |
| BVF INC/IL | Added | +422.8k |
| JPMORGAN CHASE & CO | Added | +402.5k |
| NORGES BANK | Added | +386.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +278.3k |
| BlackRock Inc. | Added | +208.7k |
Biggest sellers
| WASATCH ADVISORS LP | Sold out | -572.9k |
| FMR LLC | Reduced | -335.9k |
| T. Rowe Price Investment Management, Inc. | Reduced | -314.6k |
| AMERICAN CENTURY COMPANIES INC | Reduced | -211.8k |
| Candriam S.C.A. | Reduced | -145.0k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -121.5k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -94.7k |
| STATE STREET CORP | Reduced | -91.6k |
| GILDER GAGNON HOWE & CO LLC | Sold out | -81.9k |
| Point72 Asset Management, L.P. | Sold out | -81.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $499.0k19.6k shares |
| GROUP ONE TRADING LLC | Added | $455.7k17.9k shares |
| CITADEL ADVISORS LLC | Added | $412.5k16.2k shares |
| JANE STREET GROUP, LLC | New | $320.8k12.6k shares |
| SIMPLEX TRADING, LLC | Added | $277.0k10.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | New | $221.5k8.7k shares |
| CITADEL ADVISORS LLC | Added | $206.2k8.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.0k200 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.1 pts · filed 2026-05-06 | 14.3% |
BAKER BROS. ADVISORS LP
13D · may seek influence
+1.4 pts · filed 2025-12-11
Stated purposeItem 4 of Amendment No. 3 is supplemented and amended, as the case may be, as follows: The disclosure in Item 3 and in Item 6 below is incorporated herein by reference. On December 9, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with Morgan Stanley & Co. LLC, J.P. Morgan Securities LLC, Jefferies LLC, Stifel, Nicolaus & Company, Incorporated, Guggenheim Securities, LLC and Wells Fargo Securities, LLC (the "Underwriters"), related to the public offering (the "Offering") of 7,000,000 shares of common stock of the Issuer ("Common Stock") at a price to the public of $86.00 per share. In addition, the Issuer granted the Underwriters an option exercisable for 30 days from the date of the Underwriting Agreement to purchase, at the public offering price … Full filing |
10.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution +2.1 pts · filed 2026-09-08 | 10.7% |
| T. Rowe Price Investment Management, Inc. 13G · institution new · filed 2026-05-15 | 6.7% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-10-27 | 6.6% |
| BIOTECHNOLOGY VALUE FUND L P 13D · may seek influence -2.2 pts · filed 2026-06-26 | 6.3% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.9%, 2026-08-13), WELLINGTON MANAGEMENT GROUP LLP (4.8%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q4 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2022 | 1 | $15.4m | 2 | $3.3m | — |
| Q2 2022 | 1 | $9.2m | 0 | — | — |
| Q3 2022 | 1 | $14.2m | 0 | — | — |
| Q4 2022 | 0 | — | 1 | $27.3m | — |
| Q1 2023 | 1 | $1.3m | 4 | $3.9m | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 1 | $5.3m | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-11-03 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Bought | $2.8m197.7k shares |
| 2023-11-02 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Bought | $2.5m216.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2023
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 1.74% of their portfolio | 6.0m $152.7m | Added +1.2m |
| Atlas Venture Life Science Advisors, LLC 17.76% of their portfolio | 5.9m $149.2m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 5.3m $135.8m | Added +278.3k |
| BVF INC/IL 3.29% of their portfolio | 5.2m $131.4m | Added +422.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 4.8m $122.6m | Reduced -7.8k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.0m $101.8m | Added +72.4k |
| Avoro Capital Advisors LLC 1.33% of their portfolio | 3.8m $96.1m | Reduced -80.0k |
| BlackRock Inc. 0.00% of their portfolio | 3.6m $90.8m | Added +208.7k |
| Artal Group S.A. 2.20% of their portfolio | 2.5m $64.4m | Added +725.4k |
| STATE STREET CORP 0.00% of their portfolio | 1.9m $48.2m | Reduced -91.6k |
| Redmile Group, LLC 1.66% of their portfolio | 1.8m $46.4m | Reduced -44.6k |
| Rock Springs Capital Management LP 0.96% of their portfolio | 1.5m $38.8m | Added +17.9k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 1.3m $33.0m | Reduced -314.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.0m $26.1m | Added +402.5k |
| MORGAN STANLEY 0.00% of their portfolio | 882.6k $22.5m | Added +543.2k |
| Aquilo Capital Management, LLC 15.74% of their portfolio | 881.3k $22.4m | Added +99.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 880.5k $22.4m | Added +46.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 674.7k $17.2m | Added +469.9k |
| Deer Management Co. LLC 2.03% of their portfolio | 615.9k $15.7m | Unchanged |
| FMR LLC 0.00% of their portfolio | 534.6k $13.6m | Reduced -335.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 533.7k $13.6m | Reduced -121.5k |
| NORGES BANK 0.00% of their portfolio | 504.1k $12.8m | Added +386.2k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 462.7k $11.8m | Reduced -858 |
| Schonfeld Strategic Advisors LLC 0.09% of their portfolio | 437.6k $11.1m | New |
| BARCLAYS PLC 0.01% of their portfolio | 381.8k $9.7m | Reduced -7.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 371.4k $9.5m | Added +152.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 358.6k $9.1m | Reduced -7.7k |
| Candriam S.C.A. 0.06% of their portfolio | 343.3k $8.7m | Reduced -145.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 306.7k $7.8m | Added +5.0k |
| UBS Group AG 0.00% of their portfolio | 300.5k $7.6m | Added +137.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 241.8k $6.2m | Added +115.0k |
| Trexquant Investment LP 0.12% of their portfolio | 203.6k $5.2m | New |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 196.0k $5.0m | Added +96.9k |
| TD Asset Management Inc 0.00% of their portfolio | 186.5k $4.7m | Added +2.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 185.3k $4.7m | Reduced -42.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 176.5k $4.5m | Reduced -13.2k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 170.9k $4.4m | Reduced -17.6k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 164.2k $4.2m | Added +126.8k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 136.8k $3.5m | Added +42.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 133.6k $3.4m | Added +7.3k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 132.6k $3.4m | Reduced -94.7k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 121.1k $3.1m | New |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 120.2k $3.1m | Reduced -29.9k |
| HRT FINANCIAL LP 0.02% of their portfolio | 107.3k $2.7m | New |
| Woodline Partners LP 0.03% of their portfolio | 100.8k $2.6m | Reduced -2.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 100.1k $2.5m | Added +23.1k |
| ALGERT GLOBAL LLC 0.10% of their portfolio | 99.4k $2.5m | Reduced -29.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 98.3k $2.5m | Reduced -73.6k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 95.6k $2.4m | New |
| CITIGROUP INC 0.00% of their portfolio | 88.9k $2.3m | Reduced -11.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 73.0k $1.9m | Reduced -21 |
| Swiss National Bank 0.00% of their portfolio | 71.0k $1.8m | Reduced -8.1k |
| Propel Bio Management, LLC 1.19% of their portfolio | 56.4k $1.4m | First filing |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 53.5k $1.4m | Reduced -124 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 49.1k $1.3m | Added +18.0k |
| CONGRESS ASSET MANAGEMENT CO 0.01% of their portfolio | 45.3k $1.2m | Added +117 |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 40.2k $1.0m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 38.4k $977.7k | Added +400 |
| Legal & General Group Plc 0.00% of their portfolio | 38.4k $977.4k | Added +7.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 38.3k $975.7k | Reduced -1.8k |
| HARBOR CAPITAL ADVISORS, INC. 0.17% of their portfolio | 34.6k $882.0k | Reduced -570 |
| Campbell & CO Investment Adviser LLC 0.07% of their portfolio | 31.1k $791.7k | New |
| Simplify Asset Management Inc. 0.12% of their portfolio | 30.5k $776.9k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 30.3k $770.9k | Reduced -59.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 30.0k $763.7k | Reduced -58.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 29.6k $753.6k | Reduced -9.0k |
| Squarepoint Ops LLC 0.00% of their portfolio | 28.2k $717.9k | Reduced -2.2k |
| Invesco Ltd. 0.00% of their portfolio | 28.1k $715.1k | Reduced -8.5k |
| Erste Asset Management GmbH 0.01% of their portfolio | 27.0k $724.1k | Unchanged |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 26.1k $665.0k | Unchanged |
| Engineers Gate Manager LP 0.02% of their portfolio | 25.1k $639.6k | New |
| Point72 Middle East FZE 0.04% of their portfolio | 24.6k $627.1k | New |
| Jefferies Financial Group Inc. 0.01% of their portfolio | 24.0k $611.0k | Reduced -940 |
| Capital Impact Advisors, LLC 0.80% of their portfolio | 23.9k $608.2k | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 22.9k $584.1k | Added +524 |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 22.8k $579.8k | Reduced -211.8k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 22.7k $577.4k | New |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 22.6k $575.0k | Reduced -28.5k |
| SEVEN EIGHT CAPITAL, LP 0.07% of their portfolio | 22.4k $570.7k | New |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 22.0k $590.0k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 20.1k $510.9k | Added +184 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 20.0k $508.3k | Unchanged |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 19.9k $506.3k | Reduced -5.6k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 19.1k $484.9k | Reduced -35 |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 18.9k $480.8k | Reduced -76 |
| SG Americas Securities, LLC 0.01% of their portfolio | 18.6k $473.0k | New |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 18.2k $462.8k | First filing |
| AtonRa Partners 0.85% of their portfolio | 16.8k $427.9k | Reduced -2.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 16.6k $423.1k | Reduced -284 |
| ROYCE & ASSOCIATES LP 0.00% of their portfolio | 16.0k $407.5k | New |
| Brevan Howard Capital Management LP 0.04% of their portfolio | 14.2k $361.7k | New |
| Graham Capital Management, L.P. 0.01% of their portfolio | 13.8k $351.2k | New |
| XTX Topco Ltd 0.08% of their portfolio | 13.6k $345.4k | Reduced -8.1k |
| Corton Capital Inc. 0.10% of their portfolio | 12.5k $318.5k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 11.9k $302.0k | Added +7.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 11.6k $294.1k | Reduced -32 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 10.9k $278.2k | Unchanged |
| CORNERCAP INVESTMENT COUNSEL INC 0.05% of their portfolio | 10.8k $275.1k | Added +53 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 10.8k $274.7k | Reduced -25.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 10.2k $259.9k | Reduced -3.1k |