KYMERA THERAPEUTICS INC KYMR
COM · Common Stock · CUSIP 501575104 · ISIN US5015751044
Biopharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWatertown, MA
- Websitekymeratx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.3m this quarter). Holder counts are more reliable. Shares outstanding: 83.2m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $114.33. Options: 7 managers hold calls ($58.8m notional), 10 hold puts ($40.8m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 129 |
| Q4 2022 | 121 |
| Q1 2023 | 128 |
| Q2 2023 | 130 |
| Q3 2023 | 123 |
| Q4 2023 | 138 |
| Q1 2024 | 165 |
| Q2 2024 | 158 |
| Q3 2024 | 177 |
| Q4 2024 | 182 |
| Q1 2025 | 175 |
| Q2 2025 | 211 |
| Q3 2025 | 211 |
| Q4 2025 | 256 |
| Q1 2026 | 257 |
| Q2 2026 | 276 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 87 | 81 |
| Q4 2024 | 82 | 88 |
| Q1 2025 | 86 | 85 |
| Q2 2025 | 130 | 78 |
| Q3 2025 | 120 | 88 |
| Q4 2025 | 155 | 78 |
| Q1 2026 | 130 | 110 |
| Q2 2026 | 141 | 109 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $8.8m | $3.3m | 0.37 |
| Q4 2025 | $8.0m | $15.6m | 1.96 |
| Q1 2026 | $10.8m | $9.9m | 0.92 |
| Q2 2026 | $58.8m | $40.8m | 0.69 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.1m |
| T. Rowe Price Investment Management, Inc. | Added | +792.3k |
| FMR LLC | Added | +649.3k |
| BlackRock, Inc. | Added | +477.3k |
| STATE STREET CORP | Added | +347.5k |
| Clearbridge Investments, LLC | New | +347.2k |
| GOLDMAN SACHS GROUP INC | Added | +298.9k |
| Woodline Partners LP | Added | +297.3k |
| FEDERATED HERMES, INC. | Added | +212.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +171.0k |
Biggest sellers
| Atlas Venture Life Science Advisors, LLC | Reduced | -1.7m |
| BVF INC/IL | Reduced | -1.6m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold out | -561.2k |
| Commodore Capital LP | Reduced | -500.0k |
| Capital Research Global Investors | Reduced | -284.4k |
| Siren, L.L.C. | Reduced | -251.0k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -214.7k |
| Holocene Advisors, LP | Reduced | -200.2k |
| First Turn Management, LLC | Reduced | -152.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -139.0k |
Biggest calls
| DIADEMA PARTNERS LP | New | $17.2m149.7k shares |
| JANE STREET GROUP, LLC | Added | $15.7m137.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $13.8m120.3k shares |
| SIMPLEX TRADING, LLC | Added | $4.8m42.1k shares |
| CITADEL ADVISORS LLC | Added | $3.4m29.9k shares |
| GROUP ONE TRADING LLC | Added | $2.8m24.8k shares |
| Persistent Asset Partners Ltd | New | $1.0m381 shares |
Biggest puts
| Caption Management, LLC | New | $13.8m120.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $8.5m73.8k shares |
| Ikarian Capital, LLC | Unchanged | $5.8m50.4k shares |
| CITADEL ADVISORS LLC | Added | $3.8m33.5k shares |
| 683 Capital Management, LLC | New | $3.4m30.0k shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | $2.9m25.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Added | $1.8m15.4k shares |
| JANE STREET GROUP, LLC | New | $550.4k4.8k shares |
| DLD Asset Management, LP | New | $286.8k2.5k shares |
| SIMPLEX TRADING, LLC | Added | $91.7k800 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +3.1 pts · filed 2026-05-06 | 14.3% |
BAKER BROS. ADVISORS LP
13D · may seek influence
+1.4 pts · filed 2025-12-11
Stated purposeItem 4 of Amendment No. 3 is supplemented and amended, as the case may be, as follows: The disclosure in Item 3 and in Item 6 below is incorporated herein by reference. On December 9, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with Morgan Stanley & Co. LLC, J.P. Morgan Securities LLC, Jefferies LLC, Stifel, Nicolaus & Company, Incorporated, Guggenheim Securities, LLC and Wells Fargo Securities, LLC (the "Underwriters"), related to the public offering (the "Offering") of 7,000,000 shares of common stock of the Issuer ("Common Stock") at a price to the public of $86.00 per share. In addition, the Issuer granted the Underwriters an option exercisable for 30 days from the date of the Underwriting Agreement to purchase, at the public offering price … Full filing |
10.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution +2.1 pts · filed 2026-09-08 | 10.7% |
| T. Rowe Price Investment Management, Inc. 13G · institution new · filed 2026-05-15 | 6.7% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-10-27 | 6.6% |
| BIOTECHNOLOGY VALUE FUND L P 13D · may seek influence -2.2 pts · filed 2026-06-26 | 6.3% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.9%, 2026-08-13), WELLINGTON MANAGEMENT GROUP LLP (4.8%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $122.5k | $122.5k |
| Q1 2025 | 0 | — | 4 | $630.0k | — |
| Q2 2025 | 2 | $42.8m | 5 | $2.9m | $2.8m |
| Q3 2025 | 0 | — | 2 | $5.4m | $5.4m |
| Q4 2025 | 1 | $172.5m | 5 | $46.0m | $24.3m |
| Q1 2026 | 0 | — | 7 | $25.5m | $23.4m |
| Q2 2026 | 0 | — | 7 | $327.8m | $154.1m |
| Q3 2026 | 0 | — | 3 | $16.3m | $15.6m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-04 | Adams Brian Chief Legal Officer | Sold | $744.3k6.4k shares |
| 2026-07-07 | Mainolfi Nello Chief Executive Officer, director | Sold plan | $6.0m50.0k shares |
| 2026-07-01 | Mainolfi Nello Chief Executive Officer, director | Sold plan | $9.2m80.0k shares |
| 2026-07-01 | Goodman Noah Chief Business Officer | Sold plan | $387.3k3.4k shares |
| 2026-06-30 | Jacobs Bruce N. Chief Financial Officer | Sold plan | $8.9m77.1k shares |
| 2026-06-29 | Booth Bruce Director · See footnote | Sold plan | $8.3m76.7k shares |
| 2026-06-26 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Sold | $89.2m837.9k shares |
| 2026-06-26 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Sold | $78.9m740.9k shares |
| 2026-06-26 | BIOTECHNOLOGY VALUE FUND L P +9 Director | Sold | $5.5m51.9k shares |
| 2026-06-25 | Booth Bruce Director · See footnote | Sold plan | $34.8m285.7k shares |
| 2026-06-25 | Booth Bruce Director · See footnote | Sold plan | $30.3m262.6k shares |
| 2026-06-25 | Goodman Noah Chief Business Officer | Sold plan | $570.0k5.0k shares |
| 2026-06-24 | Booth Bruce Director · See footnote | Sold plan | $13.5m134.7k shares |
| 2026-06-23 | Booth Bruce Director · See footnote | Sold plan | $140.8k1.4k shares |
| 2026-06-22 | Booth Bruce Director · See footnote | Sold plan | $24.3m246.3k shares |
| 2026-06-22 | Booth Bruce Director · See footnote | Sold plan | $3.3m31.8k shares |
| 2026-06-22 | Goodman Noah Chief Business Officer | Sold plan | $247.5k2.5k shares |
| 2026-06-18 | Booth Bruce Director · See footnote | Sold plan | $10.5m115.1k shares |
| 2026-06-17 | Booth Bruce Director · See footnote | Sold plan | $9.5m105.1k shares |
| 2026-06-17 | Booth Bruce Director | Sold plan | $1.1m11.7k shares |
| 2026-05-27 | Chadwick Jeremy G Chief Operating Officer | Sold plan | $349.1k4.3k shares |
| 2026-05-26 | Chadwick Jeremy G Chief Operating Officer | Sold plan | $1.0m12.9k shares |
| 2026-05-11 | Ridloff Elena Director | Sold plan | $261.0k3.0k shares |
| 2026-04-29 | Mainolfi Nello Chief Executive Officer, director | Sold plan | $2.4m30.0k shares |
| 2026-04-22 | Booth Bruce Director | Sold plan | $530.8k5.9k shares |
| 2026-04-22 | Chadwick Jeremy G Chief Operating Officer | Sold plan | $27.0k300 shares |
| 2026-04-22 | Booth Bruce Director · See footnote | Sold plan | $9.0k100 shares |
| 2026-04-15 | Booth Bruce Director · See footnote | Sold plan | $282.5k3.1k shares |
| 2026-04-15 | Booth Bruce Director | Sold plan | $197.9k2.2k shares |
| 2026-04-15 | Chadwick Jeremy G Chief Operating Officer | Sold plan | $117.0k1.3k shares |
The latest 30 of 37 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.06% of their portfolio | 12.3m $1.4bn | Added +649.3k |
| BAKER BROS. ADVISORS LP 4.97% of their portfolio | 8.7m $992.7m | Unchanged |
| Avoro Capital Advisors LLC 7.70% of their portfolio | 7.5m $857.1m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.08% of their portfolio | 7.1m $815.6m | Added +1.1m |
| T. Rowe Price Investment Management, Inc. 0.47% of their portfolio | 6.3m $717.5m | Added +792.3k |
| BlackRock, Inc. 0.01% of their portfolio | 5.5m $635.1m | Added +477.3k |
| BVF INC/IL 11.35% of their portfolio | 3.9m $444.0m | Reduced -1.6m |
| WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio | 3.7m $421.4m | Reduced -214.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 3.0m $343.1m | Added +118.1k |
| Siren, L.L.C. 6.83% of their portfolio | 2.9m $336.7m | Reduced -251.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.9m $336.3m | Added +52.1k |
| Atlas Venture Life Science Advisors, LLC 37.05% of their portfolio | 2.8m $326.5m | Reduced -1.7m |
| STATE STREET CORP 0.01% of their portfolio | 2.7m $313.9m | Added +347.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.8m $208.3m | Added +171.0k |
| Capital Research Global Investors 0.02% of their portfolio | 1.4m $159.3m | Reduced -284.4k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.2m $136.2m | Added +298.9k |
| UBS Group AG 0.02% of their portfolio | 1.0m $115.6m | Reduced -16.1k |
| ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio | 981.5k $81.8m | Added +93.5k |
| Driehaus Capital Management LLC 0.61% of their portfolio | 919.2k $105.4m | Reduced -124.3k |
| Merck & Co., Inc. 16.82% of their portfolio | 772.2k $88.5m | Unchanged |
| NORGES BANK 0.01% of their portfolio | 757.2k $86.8m | Not comparable |
| FEDERATED HERMES, INC. 0.12% of their portfolio | 749.4k $85.9m | Added +212.7k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 745.2k $85.4m | Added +152.3k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.79% of their portfolio | 740.9k $85.0m | Reduced -19.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 736.9k $84.5m | Reduced -139.0k |
| Holocene Advisors, LP 0.17% of their portfolio | 636.6k $73.0m | Reduced -200.2k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 581.9k $66.7m | Added +87.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 529.7k $60.7m | Added +34.5k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 515.0k $59.1m | Added +153.3k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.77% of their portfolio | 504.2k $57.8m | Reduced -122.7k |
| JENNISON ASSOCIATES LLC 0.03% of their portfolio | 503.0k $57.7m | Reduced -6.0k |
| Woodline Partners LP 0.18% of their portfolio | 500.9k $57.4m | Added +297.3k |
| Rock Springs Capital Management LP 2.54% of their portfolio | 453.2k $52.0m | Reduced -43.7k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 449.7k $51.6m | Added +22.3k |
| Boxer Capital Management, LLC 3.71% of their portfolio | 429.1k $49.2m | Added +100.0k |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 395.5k $45.0m | Reduced -73.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 378.3k $43.4m | Added +88.9k |
| BRAIDWELL LP 1.60% of their portfolio | 378.2k $43.4m | Added +40.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 375.9k $43.1m | Added +90.0k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 371.4k $42.6m | Added +114.9k |
| Clearbridge Investments, LLC 0.03% of their portfolio | 347.2k $39.8m | New |
| Octagon Capital Advisors LP 3.26% of their portfolio | 310.0k $35.5m | Reduced -115.0k |
| Nextech Invest Ltd. 1.52% of their portfolio | 278.9k $32.0m | Unchanged |
| Alyeska Investment Group, L.P. 0.08% of their portfolio | 276.5k $31.7m | Reduced -66.2k |
| TD Asset Management Inc 0.03% of their portfolio | 272.9k $31.3m | Reduced -14.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 269.9k $31.0m | Added +71.1k |
| Commodore Capital LP 1.71% of their portfolio | 250.0k $28.7m | Reduced -500.0k |
| RTW INVESTMENTS, LP 0.23% of their portfolio | 240.0k $27.5m | Unchanged |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 233.7k $26.8m | Added +24.7k |
| GILDER GAGNON HOWE & CO LLC 0.27% of their portfolio | 229.1k $26.3m | Reduced -6.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 215.6k $24.7m | Added +22.4k |
| Polar Capital Holdings Plc 0.07% of their portfolio | 203.7k $23.4m | Reduced -11.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 200.0k $22.9m | Reduced -135.0k |
| MORGAN STANLEY 0.00% of their portfolio | 194.8k $22.3m | Reduced -17.9k |
| Candriam S.C.A. 0.10% of their portfolio | 192.9k $22.1m | Reduced -8.8k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 167.5k $19.2m | New |
| Eagle Health Investments LP 3.16% of their portfolio | 166.1k $19.1m | Added +20.3k |
| TimesSquare Capital Management, LLC 0.27% of their portfolio | 157.3k $18.0m | Reduced -11.5k |
| WCM INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 151.8k $16.6m | Reduced -571 |
| Connor, Clark & Lunn Investment Management Ltd. 0.03% of their portfolio | 149.9k $17.2m | Added +45.6k |
| Foresite Capital Management VI LLC 2.61% of their portfolio | 146.3k $16.8m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 138.5k $15.9m | Added +10.4k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 135.6k $15.5m | New |
| Deer Management Co. LLC 1.78% of their portfolio | 125.9k $14.4m | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 119.5k $13.7m | Reduced -648 |
| BOONE CAPITAL MANAGEMENT LLC 3.04% of their portfolio | 113.2k $13.0m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 113.1k $12.6m | Reduced -12.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 111.6k $12.8m | Reduced -7.0k |
| ARMISTICE CAPITAL, LLC 0.34% of their portfolio | 106.3k $12.2m | Added +22.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 106.0k $12.2m | Added +14.2k |
| Atika Capital Management LLC 1.18% of their portfolio | 104.0k $11.9m | New |
| First Turn Management, LLC 1.26% of their portfolio | 102.5k $11.8m | Reduced -152.1k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 97.7k $11.2m | Reduced -16.2k |
| Squarepoint Ops LLC 0.02% of their portfolio | 97.2k $11.1m | Added +84.3k |
| Swiss National Bank 0.01% of their portfolio | 90.1k $10.3m | Reduced -4.4k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 89.5k $10.3m | Reduced -13.7k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 80.7k $9.3m | Added +9.0k |
| CITIGROUP INC 0.00% of their portfolio | 77.8k $8.9m | Added +65.5k |
| Burkehill Global Management, LP 0.31% of their portfolio | 75.0k $8.6m | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 74.3k $8.5m | Added +6.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 72.2k $8.3m | Added +45.4k |
| FIFTH THIRD BANCORP 0.01% of their portfolio | 65.7k $7.5m | Added +14.4k |
| Yiheng Capital Management, L.P. 3.20% of their portfolio | 63.4k $7.3m | Reduced -10.0k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 62.2k $7.1m | Added +13.4k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.01% of their portfolio | 61.7k $7.1m | Reduced -2.8k |
| XTX Topco Ltd 0.09% of their portfolio | 61.5k $7.1m | New |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 61.4k $7.0m | Reduced -32.2k |
| Invesco Ltd. 0.00% of their portfolio | 60.8k $7.0m | Reduced -49.6k |
| Nicholas Investment Partners, LP 0.35% of their portfolio | 54.6k $6.3m | Added +27.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 54.4k $6.2m | Reduced -1.9k |
| Patient Square Capital LP 0.84% of their portfolio | 47.5k $5.4m | Reduced -52.5k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 45.8k $5.3m | Added +796 |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.17% of their portfolio | 45.7k $5.2m | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 41.1k $4.7m | Added +2.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 36.8k $4.2m | Reduced -352 |
| MetLife Investment Management, LLC 0.02% of their portfolio | 36.5k $4.2m | Added +5.0k |
| HARBOR CAPITAL ADVISORS, INC. 0.28% of their portfolio | 36.4k $4.2m | Added +2.4k |
| Legal & General Group Plc 0.00% of their portfolio | 36.2k $4.2m | Reduced -497 |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 35.3k $4.0m | Reduced -20.0k |
| Odyssean, LLC 0.64% of their portfolio | 34.5k $4.0m | Added +19.7k |