KRYSTAL BIOTECH INC KRYS
COM · Common Stock · CUSIP 501147102
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPittsburgh, PA
- Websitekrystalbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.2m this quarter). Holder counts are more reliable. Shares outstanding: 28.6m as of 2024-04-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $177.86. Options: 16 managers hold calls ($112.0m notional), 16 hold puts ($140.1m).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 149 |
| Q4 2022 | 156 |
| Q1 2023 | 162 |
| Q2 2023 | 185 |
| Q3 2023 | 190 |
| Q4 2023 | 196 |
| Q1 2024 | 236 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 76 | 61 |
| Q1 2023 | 76 | 66 |
| Q2 2023 | 97 | 80 |
| Q3 2023 | 108 | 66 |
| Q4 2023 | 95 | 85 |
| Q1 2024 | 128 | 107 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $26.0m | $20.0m | 0.77 |
| Q3 2023 | $22.5m | $38.5m | 1.71 |
| Q4 2023 | $57.9m | $97.6m | 1.69 |
| Q1 2024 | $112.0m | $140.1m | 1.25 |
Biggest buyers
| FMR LLC | Added | +1.9m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +231.3k |
| GOLDMAN SACHS GROUP INC | Added | +206.5k |
| FRANKLIN RESOURCES INC | Added | +104.9k |
| Allspring Global Investments Holdings, LLC | Added | +99.1k |
| Capital World Investors | New | +97.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +93.5k |
| SCOUT INVESTMENTS, INC. | New | +51.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +48.1k |
| Man Group plc | Added | +45.0k |
Biggest sellers
| STATE STREET CORP | Reduced | -292.9k |
| LORD, ABBETT & CO. LLC | Reduced | -252.5k |
| Redmile Group, LLC | Reduced | -224.9k |
| Woodline Partners LP | Reduced | -206.5k |
| FRED ALGER MANAGEMENT, LLC | Sold out | -160.3k |
| TimesSquare Capital Management, LLC | Reduced | -153.3k |
| CREDIT SUISSE AG/ | Reduced | -152.5k |
| Balyasny Asset Management L.P. | Reduced | -132.4k |
| First Turn Management, LLC | Reduced | -111.3k |
| Driehaus Capital Management LLC | Reduced | -86.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $36.4m204.5k shares |
| JANE STREET GROUP, LLC | Added | $24.3m136.6k shares |
| Ikarian Capital, LLC | Unchanged | $17.8m100.0k shares |
| BARCLAYS PLC | New | $8.0m44.8k shares |
| SIMPLEX TRADING, LLC | Added | $7.5m41.9k shares |
| CITADEL ADVISORS LLC | Added | $7.2m40.3k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Unchanged | $4.3m24.0k shares |
| Caption Management, LLC | Reduced | $4.0m22.4k shares |
| MILLENNIUM MANAGEMENT LLC | New | $925.2k5.2k shares |
| PEAK6 Investments LLC | Added | $622.8k3.5k shares |
Biggest puts
| Ikarian Capital, LLC | Reduced | $66.7m375.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $25.8m145.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Added | $18.3m102.8k shares |
| JANE STREET GROUP, LLC | Added | $10.4m58.4k shares |
| CITADEL ADVISORS LLC | Added | $6.1m34.1k shares |
| BARCLAYS PLC | New | $3.6m20.0k shares |
| Caption Management, LLC | Reduced | $3.0m17.0k shares |
| SIMPLEX TRADING, LLC | Added | $2.4m13.4k shares |
| GROUP ONE TRADING LLC | Added | $2.0m11.2k shares |
| TORNO CAPITAL, LLC | New | $889.6k5.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-10-27 | 11.6% |
| Krishnan Krish S 13G · exempt (held before listing) filed 2026-05-04 | 11.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 2 | $4.1m | — |
| Q4 2022 | 0 | — | 2 | $3.1m | — |
| Q1 2023 | 0 | — | 3 | $8.3m | — |
| Q2 2023 | 0 | — | 5 | $30.7m | $18.4m |
| Q3 2023 | 0 | — | 2 | $6.4m | $6.4m |
| Q4 2023 | 0 | — | 2 | $5.3m | $5.3m |
| Q1 2024 | 0 | — | 3 | $12.0m | $12.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-03-11 | Krishnan Krish S President and CEO, director | Sold plan | $4.3m25.0k shares |
| 2024-03-11 | Krishnan Suma President, R&D, director | Sold plan | $4.3m25.0k shares |
| 2024-03-11 | Krishnan Krish S President and CEO, director | Sold plan | $4.3m25.0k shares |
| 2024-03-11 | Krishnan Suma President, R&D, director | Sold plan | $4.3m25.0k shares |
| 2024-02-28 | ROMANO KATHRYN Chief Accounting Officer | Sold plan | $1.2m7.5k shares |
| 2024-02-28 | ROMANO KATHRYN Chief Accounting Officer | Sold plan | $829.4k5.0k shares |
| 2024-02-26 | ROMANO KATHRYN Chief Accounting Officer | Sold plan | $1.1m8.1k shares |
| 2024-01-22 | Romano Kathryn Chief Accounting Officer | Sold plan | $325.0k2.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.05% of their portfolio | 4.2m $755.1m | Added +1.9m |
| Avoro Capital Advisors LLC 5.30% of their portfolio | 2.6m $454.7m | Reduced -10.0k |
| VANGUARD GROUP INC 0.01% of their portfolio | 2.4m $432.9m | Reduced -3.0k |
| BlackRock Inc. 0.01% of their portfolio | 1.8m $321.2m | Reduced -4.2k |
| Redmile Group, LLC 9.85% of their portfolio | 1.5m $268.4m | Reduced -224.9k |
| Frazier Life Sciences Management, L.P. 7.42% of their portfolio | 988.5k $175.9m | Unchanged |
| LORD, ABBETT & CO. LLC 0.29% of their portfolio | 984.5k $175.2m | Reduced -252.5k |
| STATE STREET CORP 0.01% of their portfolio | 944.5k $168.1m | Reduced -292.9k |
| JENNISON ASSOCIATES LLC 0.08% of their portfolio | 670.7k $119.3m | Reduced -53.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 658.6k $117.2m | Added +231.3k |
| MORGAN STANLEY 0.00% of their portfolio | 656.5k $116.8m | Added +17.0k |
| DIMENSIONAL FUND ADVISORS LP 0.03% of their portfolio | 572.9k $101.9m | Added +22.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 525.7k $93.6m | Added +14.5k |
| Hood River Capital Management LLC 1.97% of their portfolio | 495.6k $88.2m | Added +37.1k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 434.6k $77.3m | Added +206.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 350.3k $62.3m | Reduced -76.8k |
| Nuveen Asset Management, LLC 0.02% of their portfolio | 330.4k $58.8m | Added +15.0k |
| CREDIT SUISSE AG/ 0.06% of their portfolio | 321.9k $57.3m | Reduced -152.5k |
| Woodline Partners LP 0.45% of their portfolio | 275.5k $49.0m | Reduced -206.5k |
| Skandinaviska Enskilda Banken AB (publ) 0.19% of their portfolio | 217.7k $38.7m | Reduced -26.3k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 205.1k $36.5m | Reduced -4.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 188.9k $33.6m | Added +3.9k |
| BRAIDWELL LP 1.02% of their portfolio | 177.1k $31.5m | Reduced -19.1k |
| BAKER BROS. ADVISORS LP 0.38% of their portfolio | 169.9k $30.2m | Unchanged |
| Allspring Global Investments Holdings, LLC 0.04% of their portfolio | 158.4k $28.2m | Added +99.1k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 143.0k $25.4m | Reduced -49.9k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.38% of their portfolio | 136.5k $24.3m | Unchanged |
| C WorldWide Group Holding A/S 0.28% of their portfolio | 135.8k $24.2m | Reduced -50.0k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 134.8k $24.0m | Reduced -38.1k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 131.5k $23.4m | Added +104.9k |
| First Turn Management, LLC 3.48% of their portfolio | 130.8k $23.3m | Reduced -111.3k |
| Balyasny Asset Management L.P. 0.06% of their portfolio | 124.2k $22.1m | Reduced -132.4k |
| Driehaus Capital Management LLC 0.20% of their portfolio | 110.2k $19.6m | Reduced -86.2k |
| Handelsbanken Fonder AB 0.08% of their portfolio | 105.2k $18.7m | Reduced -18.0k |
| Rock Springs Capital Management LP 0.47% of their portfolio | 104.0k $18.5m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio | 101.6k $18.1m | Added +93.5k |
| TimesSquare Capital Management, LLC 0.25% of their portfolio | 97.2k $17.3m | Reduced -153.3k |
| Capital World Investors 0.00% of their portfolio | 97.1k $17.3m | New |
| Man Group plc 0.05% of their portfolio | 95.9k $17.1m | Added +45.0k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 93.7k $16.7m | Added +43.1k |
| S SQUARED TECHNOLOGY, LLC 7.37% of their portfolio | 90.2k $16.1m | Reduced -20.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 89.8k $16.0m | Reduced -8.8k |
| Invesco Ltd. 0.00% of their portfolio | 89.6k $15.9m | Added +35.4k |
| Soleus Capital Management, L.P. 1.31% of their portfolio | 84.1k $15.0m | Added +44.1k |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 82.0k $14.6m | Added +14.9k |
| Integral Health Asset Management, LLC 1.40% of their portfolio | 80.0k $14.2m | Reduced -5.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 75.8k $13.5m | Reduced -15.3k |
| TD Asset Management Inc 0.01% of their portfolio | 69.2k $12.3m | Added +28.2k |
| Decheng Capital LLC 1.57% of their portfolio | 65.8k $11.7m | Unchanged |
| Verition Fund Management LLC 0.11% of their portfolio | 61.8k $11.0m | Reduced -34.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 60.7k $10.8m | Added +13.1k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 56.6k $10.1m | Added +48.1k |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 53.4k $9.5m | Reduced -30.7k |
| CITIGROUP INC 0.01% of their portfolio | 52.1k $9.3m | Added +15.6k |
| UBS Group AG 0.00% of their portfolio | 51.0k $9.1m | Added +20.3k |
| SCOUT INVESTMENTS, INC. 0.22% of their portfolio | 51.0k $9.0m | New |
| Vestal Point Capital, LP 0.66% of their portfolio | 45.0k $8.0m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 43.4k $7.7m | Added +27.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 41.3k $7.3m | Added +12.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 39.5k $7.0m | Reduced -35.5k |
| Aberdeen Group plc 0.01% of their portfolio | 39.0k $6.9m | New |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 37.8k $6.7m | Reduced -1.7k |
| GW&K Investment Management, LLC 0.06% of their portfolio | 37.5k $6.7m | New |
| ORBIMED ADVISORS LLC 0.12% of their portfolio | 37.2k $6.6m | Reduced -66.5k |
| Swiss National Bank 0.00% of their portfolio | 36.2k $6.4m | Added +300 |
| Corient Private Wealth LP 0.01% of their portfolio | 36.0k $6.4m | New |
| OBERWEIS ASSET MANAGEMENT INC/ 0.46% of their portfolio | 35.7k $6.4m | New |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 34.2k $6.1m | Reduced -2.2k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 33.8k $6.0m | Added +19.0k |
| Hennion & Walsh Asset Management, Inc. 0.32% of their portfolio | 33.2k $5.9m | Added +1.8k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 32.1k $5.7m | Added +314 |
| Global IMC LLC 1.19% of their portfolio | 28.8k $5.1m | New |
| CASTLEARK MANAGEMENT LLC 0.21% of their portfolio | 28.5k $5.1m | Reduced -3.8k |
| Affinity Asset Advisors, LLC 0.77% of their portfolio | 26.7k $4.8m | Added +1.7k |
| Informed Momentum Co LLC 0.73% of their portfolio | 26.4k $4.7m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 25.0k $4.5m | Added +16.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 24.7k $4.4m | New |
| CWM, LLC 0.02% of their portfolio | 23.9k $4.2m | Reduced -6.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 23.8k $4.2m | Reduced -2.1k |
| BARCLAYS PLC 0.00% of their portfolio | 21.6k $3.8m | Reduced -42.6k |
| J. Goldman & Co LP 0.17% of their portfolio | 21.0k $3.7m | Added +15.6k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 20.9k $3.7m | Added +14.0k |
| Legal & General Group Plc 0.00% of their portfolio | 19.6k $3.5m | Added +458 |
| Rhenman & Partners Asset Management AB 0.32% of their portfolio | 19.0k $3.4m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 18.7k $3.3m | Reduced -1.1k |
| Eversept Partners, LP 0.25% of their portfolio | 18.6k $3.3m | Reduced -62.2k |
| ExodusPoint Capital Management, LP 0.04% of their portfolio | 18.3k $3.3m | Reduced -24.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 18.3k $3.2m | Reduced -2.2k |
| Erste Asset Management GmbH 0.04% of their portfolio | 18.2k $3.2m | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 18.0k $3.2m | Added +3.0k |
| Janney Montgomery Scott LLC 0.01% of their portfolio | 17.8k $3.2m | New |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 17.8k $3.2m | Reduced -7.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 16.8k $3.0m | Reduced -22.3k |
| Trek Financial, LLC 0.24% of their portfolio | 16.7k $3.0m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 16.2k $2.9m | Added +1.3k |
| Fiera Capital Corp 0.01% of their portfolio | 16.1k $2.9m | Added +178 |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 15.5k $2.7m | Unchanged |
| Exome Asset Management LLC 2.24% of their portfolio | 14.7k $2.6m | New |
| Brevan Howard Capital Management LP 0.23% of their portfolio | 14.1k $2.5m | New |
| Ghost Tree Capital, LLC 0.80% of their portfolio | 14.0k $2.5m | Reduced -36.0k |