ZEVRA THERAPEUTICS INC ZVRA
COM NEW · Common Stock · CUSIP 488445206
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($47.1k this quarter). Holder counts are more reliable. Shares outstanding: 58.7m as of 2026-03-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.31. Options: 8 managers hold calls ($14.2m notional), 7 hold puts ($20.7m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 69 |
| Q4 2022 | 71 |
| Q1 2023 | 62 |
| Q2 2023 | 72 |
| Q3 2023 | 78 |
| Q4 2023 | 85 |
| Q1 2024 | 90 |
| Q2 2024 | 94 |
| Q3 2024 | 109 |
| Q4 2024 | 111 |
| Q1 2025 | 112 |
| Q2 2025 | 122 |
| Q3 2025 | 166 |
| Q4 2025 | 159 |
| Q1 2026 | 148 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 54 | 25 |
| Q3 2024 | 62 | 32 |
| Q4 2024 | 61 | 42 |
| Q1 2025 | 58 | 39 |
| Q2 2025 | 68 | 43 |
| Q3 2025 | 108 | 46 |
| Q4 2025 | 80 | 82 |
| Q1 2026 | 67 | 79 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $5.0m | $5.8m | 1.16 |
| Q3 2025 | $24.8m | $12.8m | 0.51 |
| Q4 2025 | $28.0m | $11.4m | 0.41 |
| Q1 2026 | $14.2m | $20.7m | 1.47 |
Biggest buyers
| AIGH Capital Management LLC | New | +1.2m |
| Point72 Asset Management, L.P. | New | +1.2m |
| FMR LLC | Added | +818.4k |
| Nantahala Capital Management, LLC | Added | +750.0k |
| Qube Research & Technologies Ltd | Added | +486.1k |
| DIMENSIONAL FUND ADVISORS LP | Added | +400.3k |
| FLPUTNAM INVESTMENT MANAGEMENT CO | New | +350.5k |
| Propel Bio Management, LLC | Added | +218.7k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | Added | +189.9k |
| Phocas Financial Corp. | New | +159.4k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -544.1k |
| JANE STREET GROUP, LLC | Reduced | -342.8k |
| Caption Management, LLC | Reduced | -284.9k |
| TUDOR INVESTMENT CORP ET AL | Reduced | -249.0k |
| MARSHALL WACE, LLP | Reduced | -229.8k |
| CITADEL ADVISORS LLC | Reduced | -216.2k |
| Trexquant Investment LP | Sold out | -209.7k |
| Tetragon Partners GP Ltd | Sold out | -192.5k |
| ACADIAN ASSET MANAGEMENT LLC | Sold out | -149.6k |
| Squarepoint Ops LLC | Reduced | -134.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.2m452.8k shares |
| CITADEL ADVISORS LLC | Added | $2.3m243.4k shares |
| GROUP ONE TRADING LLC | Added | $1.9m208.4k shares |
| SIMPLEX TRADING, LLC | Added | $1.7m184.0k shares |
| JANE STREET GROUP, LLC | Added | $1.7m178.7k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $1.2m132.7k shares |
| Caption Management, LLC | Reduced | $886.3k95.1k shares |
| GOLDMAN SACHS GROUP INC | Unchanged | $220.0k23.6k shares |
Biggest puts
| Caption Management, LLC | Added | $18.7m2.0m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $609.5k65.4k shares |
| JANE STREET GROUP, LLC | Added | $534.0k57.3k shares |
| CITADEL ADVISORS LLC | Reduced | $391.4k42.0k shares |
| SABBY MANAGEMENT, LLC | Added | $316.9k340 shares |
| SIMPLEX TRADING, LLC | Reduced | $217.2k23.3k shares |
| GROUP ONE TRADING LLC | Reduced | $12.1k1.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +2.8 pts · filed 2026-08-06 | 8.3% |
| Woodline Partners LP 13G · institution +1.9 pts · filed 2026-08-14 | 8.1% |
| BlackRock, Inc. 13G · institution filed 2025-02-05 | 7.6% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Adage Capital Management, L.P. (4.0%, 2025-11-13)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 3 | $140.3k | 0 | — | — |
| Q4 2024 | 1 | $4.0k | 0 | — | — |
| Q1 2025 | 2 | $82.0k | 4 | $920.1k | $920.1k |
| Q2 2025 | 0 | — | 1 | $221.0k | $221.0k |
| Q3 2025 | 3 | $228.4k | 0 | — | — |
| Q4 2025 | 0 | — | 1 | $211.0k | $211.0k |
| Q1 2026 | 0 | — | 5 | $1.2m | $1.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-02-09 | McFarlane Neil F. President and CEO, director | Sold plan | $125.2k14.6k shares |
| 2026-02-03 | Schafer Joshua CCO | Sold plan | $96.5k10.5k shares |
| 2026-02-03 | Sangiovanni Timothy J. SVP, Finance & Corp Controller | Sold plan | $27.5k3.0k shares |
| 2026-02-02 | McFarlane Neil F. President and CEO, director | Sold plan | $853.6k91.0k shares |
| 2026-01-30 | Quartel Adrian W Chief Medical Officer | Sold plan | $40.0k4.5k shares |
| 2026-01-30 | Thompson Rahsaan Chief Legal & Compliance | Sold plan | $36.0k4.1k shares |
| 2026-01-30 | Schafer Joshua CCO | Sold plan | $29.8k3.4k shares |
| 2026-01-30 | Sangiovanni Timothy J. SVP, Finance & Corp Controller | Sold plan | $15.4k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 4.5m $41.5m | Reduced -50.6k |
| Woodline Partners LP 0.12% of their portfolio | 3.5m $32.2m | Added +99 |
| FMR LLC 0.00% of their portfolio | 3.2m $29.9m | Added +818.4k |
| Nantahala Capital Management, LLC 1.47% of their portfolio | 2.5m $23.5m | Added +750.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.5m $23.0m | First filing |
| STATE STREET CORP 0.00% of their portfolio | 1.6m $14.6m | Added +78.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $12.8m | Added +30.2k |
| AIGH Capital Management LLC 2.29% of their portfolio | 1.2m $11.2m | New |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $11.1m | Added +34.3k |
| Legal & General Group Plc 0.00% of their portfolio | 1.2m $10.8m | Added +65.1k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 1.2m $10.8m | New |
| ROYCE & ASSOCIATES LP 0.09% of their portfolio | 988.7k $9.2m | Added +122.9k |
| 683 Capital Management, LLC 0.84% of their portfolio | 975.0k $9.1m | Added +70.0k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 846.5k $7.9m | Reduced -17.3k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 842.3k $7.9m | Added +486.1k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 1.21% of their portfolio | 775.0k $7.2m | Added +189.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 743.1k $6.9m | Added +154.4k |
| Retirement Planning Co of New England, Inc. 2.47% of their portfolio | 651.1k $6.1m | Reduced -11.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 626.7k $5.8m | Reduced -216.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 590.3k $5.5m | Reduced -544.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 554.8k $5.2m | Added +400.3k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 506.0k $4.4m | Unchanged |
| Stonepine Capital Management, LLC 3.93% of their portfolio | 480.0k $4.5m | Reduced -89.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 466.3k $4.3m | First filing |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 443.1k $4.1m | Reduced -249.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 440.0k $4.1m | Reduced -229.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 436.9k $4.1m | Added +18.8k |
| UBS Group AG 0.00% of their portfolio | 422.0k $3.9m | Added +136.6k |
| Stratos Wealth Partners, LTD. 0.04% of their portfolio | 408.0k $3.8m | Reduced -1.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 395.9k $3.7m | First filing |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 378.9k $3.3m | Reduced -33.3k |
| Mystic Asset Management, Inc. 0.78% of their portfolio | 361.3k $3.4m | Added +14.8k |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.05% of their portfolio | 350.5k $3.3m | New |
| Propel Bio Management, LLC 1.66% of their portfolio | 282.4k $2.6m | Added +218.7k |
| Caption Management, LLC 0.11% of their portfolio | 255.2k $2.4m | Reduced -284.9k |
| Janney Montgomery Scott LLC 0.01% of their portfolio | 236.8k $2.2m | Added +34.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 221.1k $2.1m | Reduced -342.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 200.0k $1.9m | Reduced -75.0k |
| Nuveen, LLC 0.00% of their portfolio | 192.6k $1.8m | Added +49.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 186.6k $1.7m | Reduced -106.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 182.9k $1.7m | Reduced -134.2k |
| Hennion & Walsh Asset Management, Inc. 0.06% of their portfolio | 177.2k $1.7m | Added +37.6k |
| Kovack Advisors, Inc. 0.09% of their portfolio | 175.2k $1.6m | Reduced -99 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 172.4k $1.6m | Reduced -1.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 162.0k $1.5m | Reduced -18.6k |
| Phocas Financial Corp. 0.23% of their portfolio | 159.4k $1.5m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 156.4k $1.5m | Reduced -13.9k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 145.2k $1.4m | Reduced -6.2k |
| Diametric Capital, LP 0.26% of their portfolio | 108.0k $1.0m | New |
| CREDIT AGRICOLE S A 0.00% of their portfolio | 106.0k $987.9k | Unchanged |
| Simplify Asset Management Inc. 0.01% of their portfolio | 100.6k $937.9k | Added +58.3k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 79.9k $744.8k | Reduced -101.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 68.1k $634.4k | Reduced -213 |
| Arete Wealth Advisors, LLC 0.05% of their portfolio | 66.4k $617.2k | Reduced -3.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 65.2k $584.1k | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 64.9k $604.5k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 64.8k $604.3k | Reduced -81.5k |
| IFG Advisors, LLC 0.09% of their portfolio | 61.8k $576.4k | Added +32.8k |
| CARRET ASSET MANAGEMENT, LLC 0.05% of their portfolio | 59.5k $554.5k | Added +5.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 54.3k $505.6k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 52.4k $488.7k | Reduced -13.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 51.4k $478.8k | Added +5.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 43.6k $407.0k | Added +11.5k |
| EntryPoint Capital, LLC 0.12% of their portfolio | 42.9k $399.7k | Reduced -10.0k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 42.2k $393.3k | Added +18.7k |
| Engineers Gate Manager LP 0.00% of their portfolio | 39.2k $365.7k | Reduced -4.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 38.3k $357.4k | Added +28.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 36.8k $342.9k | Unchanged |
| Integrated Quantitative Investments LLC 0.06% of their portfolio | 33.3k $310.5k | Reduced -22.8k |
| Invesco Ltd. 0.00% of their portfolio | 32.9k $306.4k | Added +692 |
| STONERIDGE INVESTMENT PARTNERS LLC 0.22% of their portfolio | 32.8k $306.0k | Unchanged |
| Quantinno Capital Management LP 0.00% of their portfolio | 32.0k $298.4k | Added +17.1k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 26.3k $244.9k | Reduced -1.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 26.2k $244.2k | Reduced -40.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 26.1k $243.2k | Added +235 |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 25.9k $241.8k | Added +14.4k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 24.2k $226.0k | First filing |
| Campbell & CO Investment Adviser LLC 0.01% of their portfolio | 23.9k $222.7k | Reduced -14.7k |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 23.3k $217.4k | Added +8.4k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 23.2k $216.5k | Reduced -2.4k |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 23.0k $214.4k | New |
| CITIGROUP INC 0.00% of their portfolio | 21.9k $204.4k | Reduced -96.8k |
| Sanctuary Advisors, LLC 0.00% of their portfolio | 18.5k $172.3k | Reduced -16.0k |
| WINTON GROUP Ltd 0.01% of their portfolio | 16.3k $152.2k | Reduced -9.8k |
| City State Bank 0.04% of their portfolio | 15.5k $144.3k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 15.4k $143.9k | Reduced -84.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 15.1k $141.1k | Reduced -1.8k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 15.0k $139.8k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 15.0k $139.5k | Unchanged |
| DGS Capital Management, LLC 0.02% of their portfolio | 14.8k $138.0k | Unchanged |
| BAILARD, INC. 0.00% of their portfolio | 14.7k $137.0k | Added +1.8k |
| Polymer Capital Management (US) LLC 0.02% of their portfolio | 14.1k $131.5k | Reduced -3.0k |
| PROFUND ADVISORS LLC 0.00% of their portfolio | 13.7k $128.1k | Reduced -4.3k |
| J. Goldman & Co LP 0.01% of their portfolio | 13.5k $125.8k | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 13.5k $125.8k | Added +3.0k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 13.2k $122.9k | Reduced -1.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 12.9k $119.9k | Reduced -68 |
| Kingsview Wealth Management, LLC 0.00% of their portfolio | 12.1k $113.0k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 12.0k $111.8k | Reduced -8.0k |
| Creative Planning 0.00% of their portfolio | 11.7k $108.9k | Added +137 |