Vault-13

KARYOPHARM THERAPEUTICS INC

COM · CUSIP 48576U106

139 institutional holders +7 vs Q1 2023
81,097,20681.1m shares reported held*
$144.2mreported value*
30 new 43 added 43 reduced 23 sold out net sold ≈ $12.1m (-6.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($798.3k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $1.78. Options: 8 managers hold calls ($612.7k notional), 7 hold puts ($242.1k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 147Q4 22: 156Q1 23: 132Q2 23: 139139Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022147
Q4 2022156
Q1 2023132
Q2 2023139

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 89 bought or addedQ4 22: 63 cut or sold outQ4 22Q1 23: 73 bought or addedQ1 23: 73 cut or sold outQ1 23Q2 23: 73 bought or addedQ2 23: 66 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20228963
Q1 20237373
Q2 20237366

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3m$4mQ3 22 calls: $3.5mQ3 22 puts: $2.1mQ3 22P/C 0.59Q4 22 calls: $1.8mQ4 22 puts: $1.1mQ4 22P/C 0.61Q1 23 calls: $1.0mQ1 23 puts: $515.5kQ1 23P/C 0.50Q2 23 calls: $612.7kQ2 23 puts: $242.1kQ2 23P/C 0.40
Numbers
QuarterCallsPutsP/C
Q3 2022$3.5m$2.1m0.59
Q4 2022$1.8m$1.1m0.61
Q1 2023$1.0m$515.5k0.50
Q2 2023$612.7k$242.1k0.40

Biggest buyers

BlackRock Inc. Added +2,465,093+2.5m
ExodusPoint Capital Management, LP New +2,382,451+2.4m
AIGH Capital Management LLC New +1,773,474+1.8m
VANGUARD GROUP INC Added +1,180,292+1.2m
MILLENNIUM MANAGEMENT LLC Added +1,137,478+1.1m
Parkwood LLC New +1,000,000+1.0m
Qube Research & Technologies Ltd New +703,062+703.1k
JANE STREET GROUP, LLC New +662,363+662.4k
Tejara Capital Ltd Added +642,429+642.4k
AlphaCentric Advisors LLC Added +570,000+570.0k

Biggest sellers

STATE STREET CORP Reduced -7,963,622-8.0m
Rubric Capital Management LP Reduced -3,521,860-3.5m
BANK OF AMERICA CORP /DE/ Reduced -1,821,342-1.8m
BARCLAYS PLC Reduced -1,741,028-1.7m
Nuveen Asset Management, LLC Reduced -1,314,998-1.3m
Avidity Partners Management LP Reduced -1,263,811-1.3m
Opaleye Management Inc. Reduced -1,025,800-1.0m
SILVERARC CAPITAL MANAGEMENT, LLC Reduced -1,022,441-1.0m
Rafferty Asset Management, LLC Sold out -913,301-913.3k
CITIGROUP INC Reduced -691,781-691.8k

Biggest calls

Alyeska Investment Group, L.P. Unchanged $258.7k144.5k shares
GROUP ONE TRADING LLC Added $135.9k75.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $88.6k49.5k shares
WOLVERINE TRADING, LLC New $57.3k31.3k shares
SIMPLEX TRADING, LLC Added $42.0k23.9k shares
PEAK6 Investments LLC New $26.9k15.0k shares
CITADEL ADVISORS LLC Reduced $3.4k1.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $103.1k57.6k shares
CITADEL ADVISORS LLC Added $58.2k32.5k shares
JANE STREET GROUP, LLC Added $29.4k16.4k shares
GROUP ONE TRADING LLC Added $23.4k13.1k shares
WOLVERINE TRADING, LLC New $21.0k11.5k shares
SIMPLEX TRADING, LLC Reduced $7.0k4.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Adage Capital Management, L.P. 13G · institution new · filed 2025-02-12 5.2% new 6.6m 2025-02-12

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.00% of their portfolio New York, NY 11,537,28111.5m $20.7m $20.7m 0.00% Added +2.5m +2,465,093
2 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 8,684,1288.7m $15.5m $15.5m 0.00% Added +1.2m +1,180,292
3 Avidity Partners Management LP 0.52% of their portfolio DALLAS, TX 8,370,1008.4m $15.0m $15.0m 0.52% Reduced -1.3m -1,263,811
4 Palo Alto Investors LP 0.82% of their portfolio PALO ALTO, CA 5,675,8765.7m $10.2m $10.2m 0.82% Unchanged
5 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 3,149,6823.1m $5.6m $5.6m 0.01% Reduced -452.8k -452,778
6 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 2,443,9972.4m $4.4m $4.4m 0.01% Added +459.1k +459,091
7 ExodusPoint Capital Management, LP 0.05% of their portfolio NEW YORK, NY 2,382,4512.4m $4.3m $4.3m 0.05% New
8 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,212,3672.2m $4.0m $4.0m 0.00% Reduced -8.0m -7,963,622
9 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,137,0942.1m $3.8m $3.8m 0.00% Added +365.4k +365,361
10 Opaleye Management Inc. 0.76% of their portfolio BOSTON, MA 1,785,0001.8m $3.2m $3.2m 0.76% Reduced -1.0m -1,025,800
11 AIGH Capital Management LLC 1.30% of their portfolio BALTIMORE, MD 1,773,4741.8m $3.2m $3.2m 1.30% New
12 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,621,0191.6m $2.9m $2.9m 0.00% Added +151.9k +151,872
13 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 1,593,1841.6m $2.9m $2.9m 0.00% Reduced -51.8k -51,750
14 C WorldWide Group Holding A/S 0.03% of their portfolio COPENHAGEN, G7 1,500,0001.5m $2.7m $2.7m 0.03% Unchanged
15 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 1,435,6941.4m $2.6m $2.6m 0.02% Reduced -99.3k -99,332
16 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,151,2411.2m $2.1m $2.1m 0.00% Added +1.1m +1,137,478
17 Tejara Capital Ltd 1.01% of their portfolio London, X0 1,143,9911.1m $2.0m $2.0m 1.01% Added +642.4k +642,429
18 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 1,106,3611.1m $2.0m $2.0m 0.00% Reduced -1.7m -1,741,028
19 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 1,069,0941.1m $1.9m $1.9m 0.00% Added +244.3k +244,345
20 Parkwood LLC 0.12% of their portfolio CLEVELAND, OH 1,000,0001.0m $669.0k $669.0k 0.12% New
21 Rubric Capital Management LP 0.07% of their portfolio NEW YORK, NY 919,196919.2k $1.6m $1.6m 0.07% Reduced -3.5m -3,521,860
22 AlphaCentric Advisors LLC 0.81% of their portfolio SAN JUAN, PR 810,000810.0k $1.4m $1.4m 0.81% Added +570.0k +570,000
23 Altium Capital Management LLC 1.04% of their portfolio NEW YORK, NY 740,000740.0k $1.3m $1.3m 1.04% Added +234.2k +234,219
24 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 703,062703.1k $1.3m $1.3m 0.00% New
25 JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio FLORHAM PARK, NJ 676,855676.9k $1.2m $1.2m 0.01% Reduced -398.2k -398,219
26 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 667,400667.4k $1.2m $1.2m 0.00% Reduced -68.3k -68,300
27 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 662,363662.4k $1.2m $1.2m 0.00% New
28 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 660,616660.6k $1.2m $1.2m 0.00% Added +206.2k +206,150
29 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 606,710606.7k $1.1m $1.1m 0.02% Added +12.9k +12,905
30 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 597,759597.8k $1.1m $1.1m 0.00% Added +48.2k +48,152
31 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 561,799561.8k $1.0m $1.0m 0.00% Added +327.8k +327,750
32 J. Goldman & Co LP 0.06% of their portfolio NEW YORK, NY 539,742539.7k $966.1k $966.1k 0.06% New
33 SILVERARC CAPITAL MANAGEMENT, LLC 0.31% of their portfolio BOSTON, MA 518,985519.0k $929.0k $929.0k 0.31% Reduced -1.0m -1,022,441
34 PLATINUM INVESTMENT MANAGEMENT LTD 0.03% of their portfolio SYDNEY AUSTRALIA 2000, C3 500,000500.0k $895.0k $895.0k 0.03% New
35 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 481,696481.7k $862.2k $862.2k 0.01% Unchanged
36 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 463,534463.5k $829.7k $829.7k 0.00% Reduced -1.3m -1,314,998
37 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 461,096461.1k $825.4k $825.4k 0.00% Added +91.5k +91,491
38 Worth Venture Partners, LLC 0.44% of their portfolio FORT LEE, NJ 445,981446.0k $798.3k $798.3k 0.44% New
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 437,610437.6k $783.3k $783.3k 0.00% Added +275.2k +275,169
40 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 422,316422.3k $755.9k $755.9k 0.00% Reduced -304.4k -304,374
41 Ikarian Capital, LLC 0.24% of their portfolio DALLAS, TX 400,000400.0k $716.0k $716.0k 0.24% Added +100.0k +100,000
42 XTX Topco Ltd 0.12% of their portfolio LONDON, X0 383,848383.8k $687.1k $687.1k 0.12% New
43 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 380,000380.0k $680.0k $680.0k 0.00% Unchanged
44 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 360,145360.1k $644.7k $644.7k 0.00% Added +102.3k +102,289
45 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 347,555347.6k $622.1k $622.1k 0.00% New
46 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 336,439336.4k $602.2k $602.2k 0.00% Reduced -1.8m -1,821,342
47 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 304,343304.3k $544.8k $544.8k 0.00% Added +81.6k +81,632
48 Birchview Capital, LP 0.39% of their portfolio BURLINGTON, VT 291,332291.3k $521.5k $521.5k 0.39% Unchanged
49 FMR LLC 0.00% of their portfolio BOSTON, MA 266,091266.1k $476.3k $476.3k 0.00% Added +36.1k +36,117
50 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 260,200260.2k $465.8k $465.8k 0.00% Reduced -141.3k -141,300
51 Ergoteles LLC 0.02% of their portfolio NEW YORK, NY 237,400237.4k $424.9k $424.9k 0.02% New
52 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 234,430234.4k $419.6k $419.6k 0.00% Added +56.6k +56,600
53 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 225,518225.5k $403.0k $403.0k 0.00% New
54 Swiss National Bank 0.00% of their portfolio ZURICH, V8 223,350223.3k $399.8k $399.8k 0.00% Reduced -8.2k -8,200
55 DAFNA Capital Management LLC 0.09% of their portfolio LOS ANGELES, CA 192,678192.7k $344.9k $344.9k 0.09% Unchanged
56 Atom Investors LP 0.13% of their portfolio AUSTIN, TX 184,619184.6k $330.5k $330.5k 0.13% New
57 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 164,038164.0k $293.6k $293.6k 0.00% Added +83.5k +83,525
58 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 160,004160.0k $286.4k $286.4k 0.00% New
59 PUTNAM INVESTMENTS LLC 0.00% of their portfolio BOSTON, MA 147,803147.8k $264.6k $264.6k 0.00% Added +27.0k +27,035
60 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 134,585134.6k $240.9k $240.9k 0.00% Added +30.3k +30,294
61 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 127,890127.9k $228.9k $228.9k 0.00% Added +4.7k +4,683
62 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 108,539108.5k $194.3k $194.3k 0.00% Reduced -44.1k -44,054
63 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 98,94698.9k $177.0k $177.0k 0.00% New
64 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 95,45595.5k $170.9k $170.9k 0.00% Added +1.1k +1,075
65 Legal & General Group Plc 0.00% of their portfolio London, X0 93,27993.3k $167.0k $167.0k 0.00% Added +44.8k +44,768
66 VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% of their portfolio RICHMOND, VA 92,00092.0k $164.7k $164.7k 0.00% Reduced -40.6k -40,600
67 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 91,62891.6k $356.4k $356.4k 0.00% Unchanged
68 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 89,43189.4k $160.1k $160.1k 0.00% Reduced -101.2k -101,237
69 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 89,00789.0k $159.3k $159.3k 0.00% Reduced -206.2k -206,177
70 Point72 Middle East FZE 0.01% of their portfolio DUBAI, C0 85,93385.9k $153.8k $153.8k 0.01% New
71 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 83,80383.8k $150.0k $150.0k 0.00% New
72 BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 81,73681.7k $146.3k $146.3k 0.00% Added +20.3k +20,326
73 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 77,29777.3k $139.0k $139.0k 0.00% Added +14.5k +14,545
74 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 68,10868.1k $122.0k $122.0k 0.00% Added +7.6k +7,642
75 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 66,42266.4k $118.9k $118.9k 0.00% New
76 Graham Capital Management, L.P. 0.00% of their portfolio ROWAYTON, CT 62,41462.4k $111.7k $111.7k 0.00% New
77 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 60,23560.2k $107.8k $107.8k 0.00% Added +19.0k +18,952
78 Laurion Capital Management LP 0.00% of their portfolio NEW YORK, NY 57,14657.1k $102.3k $102.3k 0.00% New
79 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 54,54154.5k $97.6k $97.6k 0.00% Added +11.3k +11,312
80 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 54,51454.5k $97.6k $97.6k 0.00% Added +16.9k +16,938
81 Quantbot Technologies LP 0.01% of their portfolio NEW YORK, NY 54,39754.4k $97.4k $97.4k 0.01% Added +6.2k +6,200
82 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 47,21747.2k $84.5k $84.5k 0.00% Reduced -120.4k -120,424
83 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 47,08847.1k $84.3k $84.3k 0.00% Added +18.3k +18,328
84 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 45,47145.5k $81.4k $81.4k 0.00% Added +16.6k +16,605
85 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 38,24638.2k $68.5k $68.5k 0.00% Reduced -691.8k -691,781
86 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 38,05338.1k $68.3k $68.3k 0.00% Reduced -61 -61
87 Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio VANCOUVER, A1 37,49037.5k $67.1k $67.1k 0.00% Reduced -150.0k -149,960
88 Weiss Multi-Strategy Advisers LLC 0.00% of their portfolio NEW YORK, NY 35,55935.6k $64.0k $64.0k 0.00% Reduced -3.8k -3,753
89 KENNEDY INVESTMENT GROUP, INC. 0.04% of their portfolio WEST DEPTFORD, NJ 35,00035.0k $62.6k $62.6k 0.04% Added +15.0k +15,000
90 DARK FOREST CAPITAL MANAGEMENT LP 0.01% of their portfolio NEW YORK, NY 34,94334.9k $62.5k $62.5k 0.01% New
91 Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio HONG KONG, K3 33,93133.9k $60.7k $60.7k 0.01% New
92 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 32,83832.8k $58.8k $58.8k 0.00% Reduced -16.0k -16,024
93 Redwood Wealth Management Group, LLC 0.06% of their portfolio MEDFORD, NJ 32,73032.7k $58.6k $58.6k 0.06% Unchanged
94 Centiva Capital, LP 0.00% of their portfolio New York, NY 32,70032.7k $58.5k $58.5k 0.00% New
95 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 32,15532.2k $57.6k $57.6k 0.00% Added +5.1k +5,140
96 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 28,80728.8k $51.6k $51.6k 0.00% Reduced -2.3k -2,283
97 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio AUSTIN, TX 27,84027.8k $50.0k $50.0k 0.00% Reduced -5.2k -5,214
98 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 23,06923.1k $42.0k $42.0k 0.00% Reduced -6.4k -6,365
99 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 22,10722.1k $39.6k $39.6k 0.00% Added +5.1k +5,086
100 Mariner, LLC 0.00% of their portfolio Overland Park, KS 19,98420.0k $35.8k $35.8k 0.00% Reduced -8.1k -8,072