Vault-13

IVERIC BIO INC OPHT

COM · Common Stock · CUSIP 46583P102 · ISIN US46583P1021

225 institutional holders +12 vs Q3 2022
147,113,147147.1m shares reported held*
$3.1bnreported value*
49 new 88 added 61 reduced 37 sold out net bought ≈ $265.6m (+12.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $21.41. Options: 14 managers hold calls ($35.2m notional), 14 hold puts ($25.6m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 213Q4 22: 225225Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022213
Q4 2022225

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ3 22 calls: $186.0mQ3 22 puts: $70.9mQ3 22P/C 0.38Q4 22 calls: $35.2mQ4 22 puts: $25.6mQ4 22P/C 0.73
Numbers
QuarterCallsPutsP/C
Q3 2022$186.0m$70.9m0.38
Q4 2022$35.2m$25.6m0.73

Biggest buyers

VANGUARD GROUP INC Added +4,035,242+4.0m
Point72 Asset Management, L.P. Added +2,360,829+2.4m
ALLIANCEBERNSTEIN L.P. Added +1,870,847+1.9m
BlackRock Inc. Added +1,626,091+1.6m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,397,305+1.4m
AMERICAN CENTURY COMPANIES INC New +1,331,374+1.3m
Octagon Capital Advisors LP New +1,278,000+1.3m
TCG Crossover Management, LLC Added +1,263,215+1.3m
Redmile Group, LLC Added +1,102,211+1.1m
TimesSquare Capital Management, LLC New +1,011,640+1.0m

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -5,673,078-5.7m
RTW INVESTMENTS, LP Reduced -2,803,712-2.8m
CITADEL ADVISORS LLC Reduced -2,326,202-2.3m
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -850,000-850.0k
Balyasny Asset Management L.P. Reduced -839,924-839.9k
DEERFIELD MANAGEMENT COMPANY, L.P. Reduced -819,246-819.2k
Ikarian Capital, LLC Reduced -601,762-601.8k
TWO SIGMA ADVISERS, LP Reduced -522,000-522.0k
Vivo Capital, LLC Sold out -483,413-483.4k
PERCEPTIVE ADVISORS LLC Reduced -446,769-446.8k

Biggest calls

CITADEL ADVISORS LLC Reduced $7.4m346.1k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $7.4m345.5k shares
GROUP ONE TRADING LLC Reduced $5.0m233.7k shares
PURA VIDA INVESTMENTS, LLC Reduced $4.9m229.6k shares
JANE STREET GROUP, LLC Reduced $3.7m172.4k shares
Caption Management, LLC Reduced $2.8m128.7k shares
SIMPLEX TRADING, LLC Reduced $2.3m107.7k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $1.5m69.8k shares
WOLVERINE TRADING, LLC Reduced $257.0k12.0k shares
HAP Trading, LLC Reduced $15.0k52.7k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.2m196.2k shares
CITADEL ADVISORS LLC Reduced $3.8m178.9k shares
GROUP ONE TRADING LLC Reduced $3.1m144.6k shares
BOOTHBAY FUND MANAGEMENT, LLC Added $3.1m142.5k shares
J. Goldman & Co LP New $2.9m135.0k shares
JANE STREET GROUP, LLC Reduced $2.4m113.5k shares
JPMORGAN CHASE & CO New $2.3m106.3k shares
Sio Capital Management, LLC Unchanged $1.8m86.4k shares
SIMPLEX TRADING, LLC Reduced $1.6m72.9k shares
PURA VIDA INVESTMENTS, LLC Reduced $421.8k19.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 10,152,00310.2m $217.4m $217.4m 0.01% Added +4.0m +4,035,242
2 BlackRock Inc. 0.01% of their portfolio New York, NY 9,751,1559.8m $208.8m $208.8m 0.01% Added +1.6m +1,626,091
3 Deep Track Capital, LP 7.35% of their portfolio GREENWICH, CT 7,878,1197.9m $168.7m $168.7m 7.35% Added +878.1k +878,119
4 Avoro Capital Advisors LLC 2.16% of their portfolio NEW YORK, NY 6,750,0006.8m $144.5m $144.5m 2.16% Added +850.0k +850,000
5 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 6,336,8366.3m $135.7m $135.7m 0.01% Added +92.5k +92,480
6 TCG Crossover Management, LLC 19.43% of their portfolio PALO ALTO, CA 5,141,1185.1m $110.1m $110.1m 19.43% Added +1.3m +1,263,215
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 4,843,6594.8m $103.7m $103.7m 0.02% Added +1.4m +1,397,305
8 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 4,553,9044.6m $97.5m $97.5m 0.07% Reduced -5.7m -5,673,078
9 Redmile Group, LLC 3.94% of their portfolio LARKSPUR, CA 4,502,1114.5m $96.4m $96.4m 3.94% Added +1.1m +1,102,211
10 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 4,231,9174.2m $90.6m $90.6m 0.04% Added +1.9m +1,870,847
11 Yiheng Capital Management, L.P. 6.00% of their portfolio SAN FRANCISCO, CA 3,613,2543.6m $77.4m $77.4m 6.00% Unchanged
12 DEERFIELD MANAGEMENT COMPANY, L.P. 1.52% of their portfolio New York, NY 3,424,8523.4m $73.3m $73.3m 1.52% Reduced -819.2k -819,246
13 BRAIDWELL LP 2.40% of their portfolio STAMFORD, CT 3,341,3003.3m $71.5m $71.5m 2.40% First filing
14 Point72 Asset Management, L.P. 0.24% of their portfolio STAMFORD, CT 2,967,7293.0m $63.5m $63.5m 0.24% Added +2.4m +2,360,829
15 DEUTSCHE BANK AG\ 0.03% of their portfolio FRANKFURT AM MAIN, 2M 2,430,4492.4m $52.0m $52.0m 0.03% Added +13.6k +13,578
16 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,415,8292.4m $51.7m $51.7m 0.01% Added +355.1k +355,148
17 MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio NEW YORK, NY 2,171,5332.2m $46.5m $46.5m 0.05% Added +846.6k +846,603
18 Capital International Investors 0.01% of their portfolio Los Angeles, CA 2,164,0992.2m $46.3m $46.3m 0.01% Unchanged
19 Soleus Capital Management, L.P. 6.50% of their portfolio GREENWICH, CT 2,114,7282.1m $45.3m $45.3m 6.50% Reduced -387.9k -387,873
20 Polar Capital Holdings Plc 0.32% of their portfolio London, X0 1,868,6281.9m $40.0m $40.0m 0.32% Unchanged
21 ARMISTICE CAPITAL, LLC 1.03% of their portfolio NEW YORK, NY 1,792,0001.8m $38.4m $38.4m 1.03% Added +428.0k +428,000
22 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 1,710,9031.7m $36.6m $36.6m 0.02% Reduced -531 -531
23 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 1,557,2931.6m $33.3m $33.3m 0.01% Added +133.6k +133,638
24 SAMLYN CAPITAL, LLC 0.63% of their portfolio New York, NY 1,501,8751.5m $32.2m $32.2m 0.63% Added +301.4k +301,389
25 Logos Global Management LP 3.76% of their portfolio San Francisco, CA 1,500,0001.5m $32.1m $32.1m 3.76% Unchanged
26 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.20% of their portfolio SAN FRANCISCO, CA 1,462,0001.5m $31.3m $31.3m 0.20% Added +145.0k +145,000
27 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 1,434,2751.4m $30.7m $30.7m 0.01% Reduced -124.9k -124,938
28 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 1,412,3361.4m $30.2m $30.2m 0.01% Added +1.0m +1,008,383
29 AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio KANSAS CITY, MO 1,331,3741.3m $28.5m $28.5m 0.02% New
30 Octagon Capital Advisors LP 4.26% of their portfolio NEW YORK, NY 1,278,0001.3m $27.4m $27.4m 4.26% New
31 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,277,4241.3m $27.3m $27.3m 0.01% Added +274.1k +274,126
32 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 1,263,8021.3m $27.1m $27.1m 0.01% Added +163.8k +163,795
33 PURA VIDA INVESTMENTS, LLC 4.25% of their portfolio NEW YORK, NY 1,182,9751.2m $25.3m $25.3m 4.25% Added +207.5k +207,545
34 Candriam S.C.A. 0.16% of their portfolio STRASSEN, N4 1,135,8321.1m $24.3m $24.3m 0.16% Added +533.0k +533,000
35 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 1,093,1781.1m $23.4m $23.4m 0.01% Added +850.5k +850,515
36 MPM BIOIMPACT LLC 5.89% of their portfolio BOSTON, MA 1,059,6881.1m $22.7m $22.7m 5.89% Added +9.7k +9,688
37 TimesSquare Capital Management, LLC 0.31% of their portfolio NEW YORK, NY 1,011,6401.0m $21.7m $21.7m 0.31% New
38 Artal Group S.A. 1.23% of their portfolio LUXEMBOURG, N4 1,000,0001.0m $21.4m $21.4m 1.23% Added +250.0k +250,000
39 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 964,361964.4k $20.6m $20.6m 0.01% Added +140.2k +140,208
40 PFM Health Sciences, LP 0.83% of their portfolio SAN FRANCISCO, CA 917,557917.6k $19.6m $19.6m 0.83% Added +661.3k +661,273
41 KINGDON CAPITAL MANAGEMENT, L.L.C. 4.74% of their portfolio NEW YORK, NY 853,000853.0k $18.3m $18.3m 4.74% New
42 Balyasny Asset Management L.P. 0.06% of their portfolio Chicago, IL 843,311843.3k $18.1m $18.1m 0.06% Reduced -839.9k -839,924
43 Avidity Partners Management LP 0.42% of their portfolio DALLAS, TX 838,407838.4k $18.0m $18.0m 0.42% New
44 GREAT POINT PARTNERS LLC 3.65% of their portfolio Greenwich, CT 825,000825.0k $17.7m $17.7m 3.65% New
45 Boxer Capital, LLC 0.93% of their portfolio San Diego, CA 825,000825.0k $17.7m $17.7m 0.93% New
46 RTW INVESTMENTS, LP 0.36% of their portfolio NEW YORK, NY 821,288821.3k $17.6m $17.6m 0.36% Reduced -2.8m -2,803,712
47 D. E. Shaw & Co., Inc. 0.03% of their portfolio New York, NY 812,967813.0k $17.4m $17.4m 0.03% Added +726.4k +726,378
48 SAMSARA BIOCAPITAL, LLC 3.73% of their portfolio PALO ALTO, CA 808,041808.0k $17.3m $17.3m 3.73% Unchanged
49 Skandinaviska Enskilda Banken AB (publ) 0.13% of their portfolio STOCKHOLM, V7 790,802790.8k $16.9m $16.9m 0.13% Reduced -6.6k -6,584
50 Driehaus Capital Management LLC 0.25% of their portfolio Chicago, IL 782,722782.7k $16.8m $16.8m 0.25% Added +31.2k +31,232
51 EMERALD ADVISERS, LLC 0.79% of their portfolio LEOLA, PA 760,044760.0k $16.3m $16.3m 0.79% Reduced -202.9k -202,863
52 Finepoint Capital LP 4.90% of their portfolio BOSTON, MA 707,600707.6k $15.2m $15.2m 4.90% Reduced -280.0k -280,000
53 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 699,093699.1k $15.0m $15.0m 0.00% Reduced -110.9k -110,940
54 Sofinnova Investments, Inc. 0.83% of their portfolio Menlo Park, CA 638,398638.4k $13.7m $13.7m 0.83% Reduced -182.3k -182,267
55 DAFNA Capital Management LLC 3.65% of their portfolio LOS ANGELES, CA 605,975606.0k $13.0m $13.0m 3.65% Added +204.5k +204,499
56 EMERALD MUTUAL FUND ADVISERS TRUST 0.79% of their portfolio LEOLA, PA 599,181599.2k $12.8m $12.8m 0.79% Reduced -132.9k -132,910
57 Polar Asset Management Partners Inc. 0.18% of their portfolio TORONTO, A6 594,615594.6k $12.7m $12.7m 0.18% Reduced -13.5k -13,485
58 PERCEPTIVE ADVISORS LLC 0.36% of their portfolio NEW YORK, NY 587,400587.4k $12.6m $12.6m 0.36% Reduced -446.8k -446,769
59 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 579,676579.7k $12.4m $12.4m 0.00% Added +134.5k +134,519
60 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 510,440510.4k $10.9m $10.9m 0.00% Added +135.6k +135,596
61 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 506,165506.2k $10.8m $10.8m 0.02% Reduced -120.5k -120,459
62 Artia Global Partners LP 4.15% of their portfolio MIAMI, FL 504,615504.6k $10.8m $10.8m 4.15% First filing
63 FMR LLC 0.00% of their portfolio BOSTON, MA 475,524475.5k $10.2m $10.2m 0.00% Reduced -98.0k -97,968
64 Walleye Capital LLC 0.21% of their portfolio NEW YORK, NY 454,815454.8k $9.7m $9.7m 0.21% Reduced -187.1k -187,136
65 Ghost Tree Capital, LLC 4.11% of their portfolio NEW YORK, NY 450,000450.0k $9.6m $9.6m 4.11% Reduced -13.7k -13,700
66 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 432,880432.9k $9.3m $9.3m 0.00% Added +108.7k +108,726
67 Rhenman & Partners Asset Management AB 0.96% of their portfolio Stockholm, V7 430,000430.0k $9.2m $9.2m 0.96% Added +65.0k +65,000
68 Rafferty Asset Management, LLC 0.07% of their portfolio New York, NY 398,356398.4k $8.5m $8.5m 0.07% Added +25.6k +25,594
69 5AM Venture Management, LLC 2.21% of their portfolio SAN FRANCISCO, CA 384,626384.6k $8.2m $8.2m 2.21% Reduced -124.2k -124,221
70 Ikarian Capital, LLC 3.35% of their portfolio DALLAS, TX 377,021377.0k $8.1m $8.1m 3.35% Reduced -601.8k -601,762
71 PUTNAM INVESTMENTS LLC 0.01% of their portfolio BOSTON, MA 376,909376.9k $8.1m $8.1m 0.01% Added +232.2k +232,209
72 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 373,531373.5k $8.0m $8.0m 0.01% Added +171.4k +171,434
73 ACUTA CAPITAL PARTNERS, LLC 4.75% of their portfolio REDWOOD CITY, CA 360,500360.5k $7.7m $7.7m 4.75% Reduced -203.1k -203,107
74 Eversept Partners, LP 0.73% of their portfolio NEW YORK, NY 350,747350.7k $7.5m $7.5m 0.73% New
75 LORD, ABBETT & CO. LLC 0.01% of their portfolio JERSEY CITY, NJ 326,666326.7k $7.0m $7.0m 0.01% New
76 J. Goldman & Co LP 0.46% of their portfolio NEW YORK, NY 305,378305.4k $6.5m $6.5m 0.46% Added +271.0k +270,971
77 THORNBURG INVESTMENT MANAGEMENT INC 0.11% of their portfolio SANTA FE, NM 294,841294.8k $6.3m $6.3m 0.11% Reduced -14.4k -14,427
78 Swiss National Bank 0.00% of their portfolio ZURICH, V8 275,200275.2k $5.9m $5.9m 0.00% Added +82.0k +82,000
79 UBS Group AG 0.00% of their portfolio ZURICH, V8 270,277270.3k $5.8m $5.8m 0.00% Added +186.9k +186,872
80 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 265,534265.5k $5.7m $5.7m 0.05% Added +36.0k +35,965
81 Tri Locum Partners LP 2.30% of their portfolio NEW YORK, NY 243,079243.1k $5.2m $5.2m 2.30% Added +52.5k +52,482
82 SG Americas Securities, LLC 0.08% of their portfolio NEW YORK, NY 239,776239.8k $5.1m $5.1m 0.08% Added +220.2k +220,173
83 Lombard Odier Asset Management (Switzerland) SA 0.40% of their portfolio PETIT-LANCY, V8 235,559235.6k $5.0m $5.0m 0.40% Added +173.9k +173,942
84 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 234,152234.2k $5.0m $5.0m 0.00% First filing
85 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 232,169232.2k $5.0m $5.0m 0.01% Reduced -2.3m -2,326,202
86 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 229,285229.3k $4.9m $4.9m 0.01% New
87 Pier Capital, LLC 0.80% of their portfolio STAMFORD, CT 228,752228.8k $4.9m $4.9m 0.80% Reduced -3.2k -3,230
88 MOORE CAPITAL MANAGEMENT, LP 0.13% of their portfolio NEW YORK, NY 210,000210.0k $4.5m $4.5m 0.13% Reduced -29.9k -29,944
89 Nicholas Investment Partners, LP 0.39% of their portfolio RANCHO SANTA FE, CA 209,976210.0k $4.5m $4.5m 0.39% Unchanged
90 BOOTHBAY FUND MANAGEMENT, LLC 0.14% of their portfolio NEW YORK, NY 207,977208.0k $4.5m $4.5m 0.14% Added +27.9k +27,908
91 Lisanti Capital Growth, LLC 0.59% of their portfolio NEW YORK, NY 201,760201.8k $4.3m $4.3m 0.59% New
92 Alyeska Investment Group, L.P. 0.04% of their portfolio CHICAGO, IL 200,000200.0k $4.3m $4.3m 0.04% New
93 SPHERA FUNDS MANAGEMENT LTD. 1.32% of their portfolio TEL AVIV, L3 195,591195.6k $4.2m $4.2m 1.32% Reduced -386.2k -386,238
94 Altium Capital Management LLC 2.08% of their portfolio NEW YORK, NY 190,000190.0k $4.1m $4.1m 2.08% Added +65.0k +65,000
95 Monarch Partners Asset Management LLC 1.18% of their portfolio BOSTON, MA 186,706186.7k $4.0m $4.0m 1.18% Added +47.4k +47,391
96 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 181,795181.8k $3.9m $3.9m 0.01% Added +25.8k +25,848
97 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 179,348179.3k $3.8m $3.8m 0.01% Reduced -172.7k -172,698
98 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 165,005165.0k $3.5m $3.5m 0.00% Added +19.4k +19,351
99 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 162,418162.4k $3.5m $3.5m 0.00% Added +22.0k +21,992
100 Global IMC LLC 0.90% of their portfolio SOLANA BEACH, CA 162,104162.1k $3.5m $3.5m 0.90% Reduced -54.1k -54,102