IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($201.1k this quarter). Holder counts are more reliable. Shares outstanding: 446.5m as of 2026-04-15, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.51. Options: 13 managers hold calls ($15.1m notional), 9 hold puts ($14.6m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
| Q1 2024 | 274 |
| Q2 2024 | 297 |
| Q3 2024 | 288 |
| Q4 2024 | 304 |
| Q1 2025 | 304 |
| Q2 2025 | 256 |
| Q3 2025 | 253 |
| Q4 2025 | 263 |
| Q1 2026 | 286 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 176 | 122 |
| Q3 2024 | 141 | 130 |
| Q4 2024 | 137 | 122 |
| Q1 2025 | 154 | 146 |
| Q2 2025 | 130 | 156 |
| Q3 2025 | 123 | 117 |
| Q4 2025 | 147 | 99 |
| Q1 2026 | 176 | 96 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $3.6m | $2.6m | 0.71 |
| Q3 2025 | $7.5m | $4.5m | 0.60 |
| Q4 2025 | $12.0m | $5.9m | 0.49 |
| Q1 2026 | $15.1m | $14.6m | 0.96 |
Biggest buyers
| TWO SIGMA INVESTMENTS, LP | Added | +9.3m |
| D. E. Shaw & Co., Inc. | Added | +4.2m |
| MILLENNIUM MANAGEMENT LLC | Added | +2.8m |
| MARSHALL WACE, LLP | New | +2.4m |
| Nuveen, LLC | Added | +2.3m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +2.0m |
| Knott David M Jr | New | +1.6m |
| BlackRock, Inc. | Added | +1.6m |
| UBS Group AG | Added | +1.2m |
| DIMENSIONAL FUND ADVISORS LP | Added | +1.1m |
Biggest sellers
| Long Focus Capital Management, LLC | Reduced | -6.5m |
| BANK OF AMERICA CORP /DE/ | Reduced | -5.8m |
| Invenomic Capital Management LP | Reduced | -3.5m |
| TWO SIGMA ADVISERS, LP | Sold out | -3.0m |
| MORGAN STANLEY | Reduced | -3.0m |
| STATE STREET CORP | Reduced | -2.7m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -2.0m |
| BARCLAYS PLC | Reduced | -1.1m |
| HRT FINANCIAL LP | Reduced | -869.7k |
| Walleye Capital LLC | Reduced | -792.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.0m1.7m shares |
| CITADEL ADVISORS LLC | Added | $2.7m759.0k shares |
| GROUP ONE TRADING LLC | Reduced | $2.1m584.2k shares |
| SIMPLEX TRADING, LLC | Added | $2.0m569.4k shares |
| DIADEMA PARTNERS LP | New | $1.1m300.0k shares |
| JANE STREET GROUP, LLC | Added | $979.6k279.1k shares |
| Brevan Howard Capital Management LP | New | $282.0k80.4k shares |
| LPL Financial LLC | New | $69.8k19.9k shares |
| Persistent Asset Partners Ltd | New | $30.0k758 shares |
| CWM, LLC | New | $14.5k10.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $7.0m2.0m shares |
| 683 Capital Management, LLC | New | $2.3m644.3k shares |
| CITADEL ADVISORS LLC | Reduced | $1.7m492.2k shares |
| SIMPLEX TRADING, LLC | Added | $1.5m424.3k shares |
| GROUP ONE TRADING LLC | Added | $1.3m363.0k shares |
| JANE STREET GROUP, LLC | Added | $797.8k227.3k shares |
| Walleye Capital LLC | Reduced | $33.0k9.4k shares |
| DIADEMA PARTNERS LP | New | $10.2k2.9k shares |
| Persistent Asset Partners Ltd | New | $1277 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $503.0k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 3 | $107.2k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
None reported in Q1 2026.
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 31.1m $109.1m | Added +1.6m |
| MHR FUND MANAGEMENT LLC 7.43% of their portfolio | 29.0m $101.7m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 17.4m $61.2m | Reduced -2.7m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 16.6m $58.3m | First filing |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 13.7m $48.0m | Added +9.3m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 11.7m $41.1m | First filing |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 9.4m $33.0m | Added +2.8m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 8.8m $30.7m | Added +152.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 8.6m $30.1m | Added +581.0k |
| Invenomic Capital Management LP 1.38% of their portfolio | 8.5m $29.8m | Reduced -3.5m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 8.5m $29.8m | Reduced -5.8m |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 8.0m $28.1m | Added +4.2m |
| Palo Alto Investors LP 3.41% of their portfolio | 6.3m $22.3m | Reduced -767.1k |
| MORGAN STANLEY 0.00% of their portfolio | 6.2m $21.8m | Reduced -3.0m |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 4.2m $14.7m | Added +590.1k |
| Nuveen, LLC 0.00% of their portfolio | 3.7m $12.9m | Added +2.3m |
| HRT FINANCIAL LP 0.04% of their portfolio | 3.5m $12.2m | Reduced -869.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.2m $11.1m | Added +2.0m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 3.0m $10.5m | Reduced -2.0m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.9m $10.1m | Added +295.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.8m $9.8m | Added +30.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 2.6m $9.3m | Added +1.1m |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 2.6m $9.2m | Reduced -531.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.5m $8.3m | Reduced -500.9k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 2.4m $8.3m | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 2.2m $7.7m | First filing |
| Long Focus Capital Management, LLC 0.32% of their portfolio | 2.1m $7.4m | Reduced -6.5m |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.1m $7.3m | Added +78.2k |
| Orion Investment Co 2.30% of their portfolio | 2.1m $7.3m | Added +208.7k |
| Rhenman & Partners Asset Management AB 0.89% of their portfolio | 2.1m $7.2m | Added +460.0k |
| UBS Group AG 0.00% of their portfolio | 1.9m $6.7m | Added +1.2m |
| Knott David M Jr 3.34% of their portfolio | 1.6m $5.6m | New |
| RICE HALL JAMES & ASSOCIATES, LLC 0.30% of their portfolio | 1.5m $5.3m | Added +89.8k |
| B Group, Inc. 3.90% of their portfolio | 1.5m $5.3m | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 1.4m $5.0m | Added +170.7k |
| Woodline Partners LP 0.02% of their portfolio | 1.3m $4.5m | Added +724.3k |
| C WorldWide Group Holding A/S 0.09% of their portfolio | 1.3m $4.4m | Unchanged |
| Mirador Capital Partners LP 0.53% of their portfolio | 1.1m $3.8m | Added +38.7k |
| Squarepoint Ops LLC 0.01% of their portfolio | 1.0m $3.6m | Added +1.0m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 1.0m $3.6m | New |
| Soleus Capital Management, L.P. 0.14% of their portfolio | 1.0m $3.5m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 956.8k $3.4m | Added +1.3k |
| Susquehanna Portfolio Strategies, LLC 0.05% of their portfolio | 914.4k $3.2m | Unchanged |
| SECTOR GAMMA AS 0.75% of their portfolio | 900.0k $3.2m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 735.0k $2.6m | Added +44.5k |
| QVT Financial LP 0.19% of their portfolio | 678.6k $2.4m | Unchanged |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio | 628.5k $2.2m | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 625.0k $2.2m | Added +16.6k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 624.2k $2.2m | Added +513.6k |
| Swiss National Bank 0.00% of their portfolio | 606.5k $2.1m | Unchanged |
| GROUP ONE TRADING LLC 0.07% of their portfolio | 595.8k $2.1m | Added +427.1k |
| LPL Financial LLC 0.00% of their portfolio | 569.2k $2.0m | Reduced -53.8k |
| GSA CAPITAL PARTNERS LLP 0.12% of their portfolio | 557.1k $2.0m | Reduced -315.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 520.1k $1.8m | Added +58.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 474.1k $1.7m | Added +4.4k |
| CM Management, LLC 1.32% of their portfolio | 450.0k $1.6m | Added +50.0k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 449.6k $1.6m | Added +119.8k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 433.0k $1.5m | Reduced -273.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 425.5k $1.5m | Added +21.1k |
| Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio | 409.5k $1.4m | Reduced -742 |
| Cresset Asset Management, LLC 0.01% of their portfolio | 383.8k $1.3m | Reduced -74.0k |
| Virtus Investment Advisers, LLC 0.37% of their portfolio | 383.8k $1.3m | Added +73.1k |
| Raiffeisen Bank International AG 0.02% of their portfolio | 380.0k $1.3m | Reduced -70.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 373.1k $1.3m | Added +346.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 365.5k $1.3m | Added +134.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 355.8k $1.2m | Added +226.7k |
| CORSAIR CAPITAL MANAGEMENT, L.P. 0.18% of their portfolio | 350.0k $1.2m | Added +50.0k |
| TD Asset Management Inc 0.00% of their portfolio | 340.3k $1.2m | Added +286.8k |
| WINTON GROUP Ltd 0.04% of their portfolio | 337.7k $1.2m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 321.6k $878.1k | Added +62.8k |
| Kennondale Capital Management LLC 0.81% of their portfolio | 318.2k $1.1m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 295.4k $1.0m | Reduced -605 |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 292.9k $1.0m | Reduced -141.1k |
| Virtu Financial LLC 0.04% of their portfolio | 285.8k $1.0m | New |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 248.8k $873.2k | Added +180.7k |
| Monaco Asset Management SAM 0.25% of their portfolio | 225.0k $789.8k | New |
| Legal & General Group Plc 0.00% of their portfolio | 220.2k $772.8k | Reduced -38.5k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 216.0k $758.2k | Added +36.5k |
| Creative Planning 0.00% of their portfolio | 205.6k $721.5k | Added +46.9k |
| Baird Financial Group, Inc. 0.00% of their portfolio | 198.5k $696.9k | Added +41.0k |
| Parametrica Management Ltd 0.78% of their portfolio | 195.9k $687.5k | Unchanged |
| PROFUND ADVISORS LLC 0.03% of their portfolio | 194.8k $683.6k | Reduced -65.9k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 189.4k $664.8k | First filing |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 188.9k $657.3k | Added +4.9k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 184.4k $647.2k | Added +13.6k |
| Tidal Investments LLC 0.00% of their portfolio | 184.1k $646.2k | New |
| Tema ETFs LLC 0.04% of their portfolio | 184.1k $646.2k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 179.2k $628.8k | Added +59.3k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 168.9k $593.0k | Added +131.0k |
| SG Americas Securities, LLC 0.00% of their portfolio | 167.9k $589.0k | Added +112.5k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 163.1k $572.5k | Reduced -35.0k |
| Leonteq Securities AG 0.03% of their portfolio | 160.0k $561.6k | Reduced -35.0k |
| Quadrature Capital Ltd 0.01% of their portfolio | 158.9k $557.8k | Reduced -159.8k |
| Aberdeen Group plc 0.00% of their portfolio | 155.0k $544.0k | Reduced -604.5k |
| Headlands Technologies LLC 0.06% of their portfolio | 153.1k $537.3k | Added +82.4k |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 151.8k $532.9k | Reduced -177.2k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 141.7k $498.0k | Added +50.3k |
| Scientech Research LLC 0.40% of their portfolio | 138.1k $484.9k | Reduced -73.3k |
| Intellectus Partners, LLC 0.10% of their portfolio | 136.4k $478.9k | Added +4.0k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 133.8k $469.8k | First filing |