IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($124.4k this quarter). Holder counts are more reliable. Shares outstanding: 361.9m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.72. Options: 7 managers hold calls ($3.6m notional), 6 hold puts ($2.6m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
| Q1 2024 | 274 |
| Q2 2024 | 297 |
| Q3 2024 | 288 |
| Q4 2024 | 304 |
| Q1 2025 | 304 |
| Q2 2025 | 256 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 147 | 83 |
| Q4 2023 | 127 | 106 |
| Q1 2024 | 160 | 114 |
| Q2 2024 | 176 | 122 |
| Q3 2024 | 141 | 130 |
| Q4 2024 | 137 | 122 |
| Q1 2025 | 154 | 146 |
| Q2 2025 | 130 | 156 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $44.1m | $25.2m | 0.57 |
| Q4 2024 | $28.9m | $36.4m | 1.26 |
| Q1 2025 | $8.2m | $6.6m | 0.80 |
| Q2 2025 | $3.6m | $2.6m | 0.71 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +9.2m |
| MHR FUND MANAGEMENT LLC | Added | +4.5m |
| TWO SIGMA INVESTMENTS, LP | Added | +4.2m |
| ROYAL BANK OF CANADA | Added | +4.2m |
| Invenomic Capital Management LP | Added | +2.8m |
| Long Focus Capital Management, LLC | Added | +2.6m |
| MORGAN STANLEY | Added | +2.4m |
| CITADEL ADVISORS LLC | Added | +2.4m |
| TWO SIGMA ADVISERS, LP | New | +2.3m |
| JANE STREET GROUP, LLC | Added | +1.9m |
Biggest sellers
| PERCEPTIVE ADVISORS LLC | Sold out | -12.7m |
| Hood River Capital Management LLC | Sold out | -9.2m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -5.1m |
| MACQUARIE GROUP LTD | Sold out | -4.8m |
| Soleus Capital Management, L.P. | Reduced | -4.5m |
| Artisan Partners Limited Partnership | Sold out | -4.4m |
| MPM BIOIMPACT LLC | Sold out | -2.7m |
| VANGUARD GROUP INC | Reduced | -2.7m |
| 683 Capital Management, LLC | Sold out | -2.4m |
| T. Rowe Price Investment Management, Inc. | Reduced | -1.7m |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $936.0k544.2k shares |
| CITADEL ADVISORS LLC | Added | $738.6k429.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $718.0k418.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $652.2k379.2k shares |
| JANE STREET GROUP, LLC | Added | $413.8k240.6k shares |
| LPL Financial LLC | Added | $120.4k70.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $992.8k577.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $835.1k485.5k shares |
| SIMPLEX TRADING, LLC | Added | $415.0k241.8k shares |
| GROUP ONE TRADING LLC | Reduced | $194.9k113.3k shares |
| JANE STREET GROUP, LLC | Added | $114.0k66.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 2 | $26.6m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 3 | $48.3m | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $503.0k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 3 | $107.2k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-05 | Kirby Daniel Gordon Chief Commercial Officer | Bought | $55.2k30.0k shares |
| 2025-05-23 | Puri Raj K. Chief Regulatory Officer | Bought | $9.7k5.6k shares |
| 2025-05-14 | Vogt Frederick G Interim CEO & General Counsel, director | Bought | $42.2k25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| MHR FUND MANAGEMENT LLC 5.53% of their portfolio | 29.0m $49.8m | Added +4.5m |
| VANGUARD GROUP INC 0.00% of their portfolio | 25.1m $43.1m | Reduced -2.7m |
| BlackRock, Inc. 0.00% of their portfolio | 23.2m $40.0m | Reduced -1.1m |
| Long Focus Capital Management, LLC 1.31% of their portfolio | 11.8m $20.3m | Added +2.6m |
| STATE STREET CORP 0.00% of their portfolio | 9.9m $17.0m | Reduced -1.2m |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 9.3m $16.0m | Added +9.2m |
| Invenomic Capital Management LP 0.81% of their portfolio | 8.3m $14.3m | Added +2.8m |
| MORGAN STANLEY 0.00% of their portfolio | 6.5m $11.1m | Added +2.4m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 6.2m $10.6m | Added +220.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 4.9m $8.4m | Added +1.4m |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 4.8m $8.2m | Added +4.2m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 4.7m $8.2m | Reduced -822.0k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 4.6m $8.0m | Added +4.2m |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 4.6m $7.9m | Reduced -92.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 4.1m $7.1m | Added +2.4m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 4.0m $6.9m | Added +1.0m |
| Palo Alto Investors LP 1.25% of their portfolio | 3.4m $5.9m | Added +218.0k |
| Soleus Capital Management, L.P. 0.39% of their portfolio | 3.3m $5.6m | Reduced -4.5m |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 2.9m $5.0m | Reduced -577.4k |
| Orion Investment Co 1.42% of their portfolio | 2.3m $4.0m | Added +1.2m |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 2.3m $4.0m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.1m $3.6m | Reduced -223.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.1m $3.6m | Reduced -289.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 2.1m $3.6m | Added +269.3k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 2.0m $3.5m | Added +1.9m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.9m $3.3m | Added +68.7k |
| TANG CAPITAL MANAGEMENT LLC 0.16% of their portfolio | 1.8m $3.1m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 1.8m $3.1m | Reduced -717.3k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.15% of their portfolio | 1.6m $2.7m | Added +22.4k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 1.5m $2.6m | Added +1.3m |
| B Group, Inc. 2.23% of their portfolio | 1.5m $2.6m | Unchanged |
| C WorldWide Group Holding A/S 0.03% of their portfolio | 1.3m $2.2m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.2m $2.1m | Reduced -37.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 1.1m $1.8m | Added +215.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 897.4k $1.5m | Added +394.8k |
| BARCLAYS PLC 0.00% of their portfolio | 884.3k $1.5m | Added +313.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 856.6k $1.5m | Added +458.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 780.6k $1.3m | Reduced -137.6k |
| Nuveen, LLC 0.00% of their portfolio | 778.8k $1.3m | Reduced -108.0k |
| CITIGROUP INC 0.00% of their portfolio | 714.9k $1.2m | Added +176.5k |
| CM Management, LLC 1.10% of their portfolio | 700.0k $1.2m | Added +200.0k |
| QVT Financial LP 0.16% of their portfolio | 678.6k $1.2m | Unchanged |
| Voss Capital, LP 0.08% of their portfolio | 672.6k $1.2m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 657.2k $1.1m | Reduced -5.1m |
| Invesco Ltd. 0.00% of their portfolio | 653.9k $1.1m | Added +319.7k |
| Rhenman & Partners Asset Management AB 0.14% of their portfolio | 647.8k $1.1m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 620.4k $1.1m | Reduced -64.7k |
| Quinn Opportunity Partners LLC 0.09% of their portfolio | 614.2k $1.1m | New |
| Woodline Partners LP 0.01% of their portfolio | 567.7k $976.4k | Added +765 |
| GROUP ONE TRADING LLC 0.03% of their portfolio | 553.5k $952.0k | Added +77.7k |
| Aberdeen Group plc 0.00% of their portfolio | 516.3k $888.0k | Added +384.5k |
| Voleon Capital Management LP 0.05% of their portfolio | 509.7k $876.6k | New |
| Swiss National Bank 0.00% of their portfolio | 501.2k $862.0k | Added +87.8k |
| Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio | 499.3k $858.7k | Added +132.5k |
| LPL Financial LLC 0.00% of their portfolio | 484.3k $833.0k | Added +107.9k |
| Polar Asset Management Partners Inc. 0.02% of their portfolio | 433.9k $746.3k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 410.5k $706.0k | Added +21.3k |
| CAPITAL FUND MANAGEMENT S.A. 0.01% of their portfolio | 374.9k $644.9k | Reduced -225.0k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 361.8k $622.3k | Added +254.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 324.1k $557.4k | Added +4.6k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 292.5k $503.0k | Reduced -129.1k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 286.6k $492.0k | Added +244.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 274.0k $471.3k | Added +2.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 258.9k $445.3k | Reduced -4.6k |
| Legal & General Group Plc 0.00% of their portfolio | 232.7k $400.2k | Added +208 |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 231.7k $398.4k | Added +172.1k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 225.6k $388.1k | Added +60.8k |
| Kennondale Capital Management LLC 0.39% of their portfolio | 223.1k $383.7k | New |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 196.6k $338.0k | Added +170.7k |
| Parametrica Management Ltd 0.63% of their portfolio | 195.9k $336.9k | Unchanged |
| Virtus Investment Advisers, LLC 0.11% of their portfolio | 192.4k $330.9k | Added +147.3k |
| Cresset Asset Management, LLC 0.00% of their portfolio | 190.3k $327.3k | Added +112.0k |
| Baird Financial Group, Inc. 0.00% of their portfolio | 189.8k $326.5k | Reduced -6.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 188.9k $324.9k | Added +111.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 183.1k $315.0k | Reduced -20.1k |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 182.4k $314.0k | Reduced -1.7m |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 171.7k $295.3k | Reduced -35.5k |
| DNB Asset Management AS 0.00% of their portfolio | 163.5k $281.2k | Added +71.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 154.7k $265.7k | Reduced -28.1k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 151.0k $259.7k | Reduced -232 |
| Raiffeisen Bank International AG 0.00% of their portfolio | 147.0k $261.5k | Unchanged |
| Quadrature Capital Ltd 0.00% of their portfolio | 144.1k $247.2k | Added +111.4k |
| TD Asset Management Inc 0.00% of their portfolio | 139.9k $240.6k | Unchanged |
| Intellectus Partners, LLC 0.05% of their portfolio | 131.1k $225.4k | Added +14.8k |
| PORTLAND INVESTMENT COUNSEL INC. 0.06% of their portfolio | 130.0k $219.7k | Added +30.0k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 123.6k $212.6k | Added +91.2k |
| GUGGENHEIM CAPITAL LLC 0.00% of their portfolio | 122.9k $211.3k | Reduced -25.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 111.2k $191.3k | Added +71.6k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 108.0k $185.7k | Reduced -112.8k |
| Haven Capital Group, Inc. 0.16% of their portfolio | 106.5k $183.0k | Reduced -15.4k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 100.0k $170.0k | Unchanged |
| Handelsbanken Fonder AB 0.00% of their portfolio | 96.9k $167.0k | Added +24.2k |
| Leonteq Securities AG 0.01% of their portfolio | 95.0k $163.4k | New |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 91.3k $156.7k | Unchanged |
| GRANDFIELD & DODD, LLC 0.01% of their portfolio | 91.1k $156.6k | Added +100 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 88.9k $153.6k | Added +45.9k |
| Jain Global LLC 0.00% of their portfolio | 82.1k $141.2k | Added +59.9k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 76.1k $130.9k | Added +14.9k |
| Creative Planning 0.00% of their portfolio | 76.0k $130.7k | Added +10.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 72.1k $124.0k | Reduced -1.0m |