IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($39.1k this quarter). Holder counts are more reliable. Shares outstanding: 333.9m as of 2025-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.33. Options: 11 managers hold calls ($8.2m notional), 7 hold puts ($6.6m).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
| Q1 2024 | 274 |
| Q2 2024 | 297 |
| Q3 2024 | 288 |
| Q4 2024 | 304 |
| Q1 2025 | 304 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 118 | 106 |
| Q3 2023 | 147 | 83 |
| Q4 2023 | 127 | 106 |
| Q1 2024 | 160 | 114 |
| Q2 2024 | 176 | 122 |
| Q3 2024 | 141 | 130 |
| Q4 2024 | 137 | 122 |
| Q1 2025 | 154 | 146 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $25.3m | $18.7m | 0.74 |
| Q3 2024 | $44.1m | $25.2m | 0.57 |
| Q4 2024 | $28.9m | $36.4m | 1.26 |
| Q1 2025 | $8.2m | $6.6m | 0.80 |
Biggest buyers
| Invenomic Capital Management LP | New | +5.5m |
| Long Focus Capital Management, LLC | Added | +4.1m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Added | +3.9m |
| RENAISSANCE TECHNOLOGIES LLC | New | +3.5m |
| BANK OF AMERICA CORP /DE/ | Added | +2.3m |
| GOLDMAN SACHS GROUP INC | Added | +1.5m |
| TANG CAPITAL MANAGEMENT LLC | Added | +1.3m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | +1.3m |
| Soleus Capital Management, L.P. | Added | +1.2m |
| ExodusPoint Capital Management, LP | New | +1.2m |
Biggest sellers
| PERCEPTIVE ADVISORS LLC | Reduced | -9.4m |
| T. Rowe Price Investment Management, Inc. | Reduced | -3.9m |
| Avoro Capital Advisors LLC | Sold out | -3.5m |
| Balyasny Asset Management L.P. | Reduced | -2.6m |
| Man Group plc | Reduced | -2.4m |
| Assenagon Asset Management S.A. | Reduced | -1.7m |
| RAYMOND JAMES FINANCIAL INC | Reduced | -1.2m |
| GROUP ONE TRADING LLC | Reduced | -1.2m |
| STATE STREET CORP | Reduced | -1.2m |
| Siren, L.L.C. | Sold out | -1.1m |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.1m623.1k shares |
| GROUP ONE TRADING LLC | Reduced | $1.8m548.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.6m470.8k shares |
| CITADEL ADVISORS LLC | Reduced | $1.0m301.1k shares |
| JANE STREET GROUP, LLC | Added | $602.1k180.8k shares |
| WOLVERINE TRADING, LLC | Added | $399.1k112.1k shares |
| MILLENNIUM MANAGEMENT LLC | New | $333.0k100.0k shares |
| Leonteq Securities AG | New | $331.5k100.0k shares |
| LPL Financial LLC | New | $66.6k20.0k shares |
| HB Wealth Management, LLC | New | $6.7k2.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.8m832.3k shares |
| CITADEL ADVISORS LLC | Reduced | $2.2m675.0k shares |
| GROUP ONE TRADING LLC | Reduced | $726.3k218.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $531.0k159.5k shares |
| JANE STREET GROUP, LLC | Reduced | $200.8k60.3k shares |
| WOLVERINE TRADING, LLC | Reduced | $89.7k25.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 2 | $26.6m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 3 | $48.3m | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $503.0k | — |
| Q1 2025 | 0 | — | 0 | — | — |
None reported in Q1 2025.
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 27.8m $92.5m | Added +243.4k |
| MHR FUND MANAGEMENT LLC 9.77% of their portfolio | 24.4m $81.3m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 24.3m $81.0m | Added +838.5k |
| PERCEPTIVE ADVISORS LLC 1.50% of their portfolio | 12.7m $42.3m | Reduced -9.4m |
| STATE STREET CORP 0.00% of their portfolio | 11.0m $36.8m | Reduced -1.2m |
| Long Focus Capital Management, LLC 2.09% of their portfolio | 9.3m $30.8m | Added +4.1m |
| Hood River Capital Management LLC 0.52% of their portfolio | 9.2m $30.7m | Added +224.5k |
| Soleus Capital Management, L.P. 2.03% of their portfolio | 7.8m $25.9m | Added +1.2m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 6.0m $19.9m | Added +96.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 5.8m $19.2m | Added +3.9m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 5.6m $18.6m | Added +1.5m |
| Invenomic Capital Management LP 0.93% of their portfolio | 5.5m $18.3m | New |
| MACQUARIE GROUP LTD 0.02% of their portfolio | 4.8m $16.0m | Added +40.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 4.7m $15.6m | Added +1.0m |
| Artisan Partners Limited Partnership 0.02% of their portfolio | 4.4m $14.7m | Reduced -134.5k |
| MORGAN STANLEY 0.00% of their portfolio | 4.0m $13.4m | Added +58.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 3.5m $11.7m | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 3.5m $11.7m | Added +1.1m |
| Palo Alto Investors LP 2.04% of their portfolio | 3.2m $10.7m | Added +169.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 3.0m $10.0m | Added +2.3m |
| MPM BIOIMPACT LLC 1.55% of their portfolio | 2.7m $9.0m | Added +34.7k |
| UBS Group AG 0.00% of their portfolio | 2.5m $8.3m | Reduced -207.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.4m $8.0m | Reduced -224.0k |
| 683 Capital Management, LLC 0.81% of their portfolio | 2.4m $8.0m | Added +984.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.3m $7.8m | Reduced -71.2k |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 1.9m $6.4m | Reduced -3.9m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.8m $6.2m | Reduced -141.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 1.8m $6.0m | Reduced -860.5k |
| TANG CAPITAL MANAGEMENT LLC 0.33% of their portfolio | 1.8m $6.0m | Added +1.3m |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.7m $5.8m | Added +639.2k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.31% of their portfolio | 1.6m $5.2m | Reduced -25.3k |
| B Group, Inc. 4.34% of their portfolio | 1.5m $5.0m | Added +508.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.3m $4.3m | Reduced -26.6k |
| Apis Capital Advisors, LLC 2.06% of their portfolio | 1.3m $4.3m | Reduced -86.0k |
| C WorldWide Group Holding A/S 0.05% of their portfolio | 1.3m $4.2m | Unchanged |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 1.3m $4.2m | New |
| Orion Investment Co 1.60% of their portfolio | 1.2m $3.9m | Added +116.1k |
| ExodusPoint Capital Management, LP 0.05% of their portfolio | 1.2m $3.9m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 1.1m $3.7m | Unchanged |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 972.7k $3.2m | New |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 920.5k $3.3m | Added +89.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 918.2k $3.1m | Added +52.4k |
| Nuveen, LLC 0.00% of their portfolio | 886.7k $3.0m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 858.6k $2.9m | Added +278.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 685.1k $2.3m | Reduced -182.4k |
| QVT Financial LP 0.22% of their portfolio | 678.6k $2.3m | Unchanged |
| Rhenman & Partners Asset Management AB 0.25% of their portfolio | 647.8k $2.2m | Reduced -587.6k |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 599.9k $2.0m | Added +409.7k |
| BARCLAYS PLC 0.00% of their portfolio | 570.8k $1.9m | Reduced -47.0k |
| Woodline Partners LP 0.01% of their portfolio | 566.9k $1.9m | Added +3.3k |
| CITIGROUP INC 0.00% of their portfolio | 538.3k $1.8m | Added +54.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 522.9k $1.7m | Added +322.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 502.6k $1.8m | Added +259.3k |
| CM Management, LLC 1.67% of their portfolio | 500.0k $1.7m | Added +200.0k |
| GROUP ONE TRADING LLC 0.07% of their portfolio | 475.8k $1.6m | Reduced -1.2m |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 421.5k $1.4m | Reduced -132.6k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 421.1k $1.4m | Reduced -57.4k |
| Swiss National Bank 0.00% of their portfolio | 413.4k $1.4m | Reduced -4.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 398.0k $1.3m | Added +245.7k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 397.0k $1.3m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 389.2k $1.3m | Added +3.4k |
| LPL Financial LLC 0.00% of their portfolio | 376.4k $1.3m | Added +125.7k |
| Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio | 366.8k $1.2m | Added +30.8k |
| HRT FINANCIAL LP 0.01% of their portfolio | 360.7k $1.2m | New |
| Invesco Ltd. 0.00% of their portfolio | 334.3k $1.1m | Added +112.3k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 319.5k $1.1m | Reduced -1.2m |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 280.9k $935.3k | Added +224.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 271.8k $905.2k | Reduced -7.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 263.5k $877.4k | Reduced -501.9k |
| NORGES BANK 0.00% of their portfolio | 260.1k $866.3k | Reduced -156.1k |
| CANTOR FITZGERALD, L. P. 0.03% of their portfolio | 254.9k $848.7k | New |
| Legal & General Group Plc 0.00% of their portfolio | 232.5k $774.2k | Reduced -165 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 220.8k $735.1k | Reduced -6.1k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 209.9k $699.1k | Reduced -2.6m |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 207.2k $690.0k | Added +59.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 203.2k $676.8k | Unchanged |
| Parametrica Management Ltd 1.10% of their portfolio | 195.9k $652.3k | Reduced -65.2k |
| Baird Financial Group, Inc. 0.00% of their portfolio | 195.8k $652.2k | Unchanged |
| NFJ INVESTMENT GROUP, LLC 0.02% of their portfolio | 187.3k $623.8k | Unchanged |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 182.8k $613.2k | Added +4.5k |
| XTX Topco Ltd 0.03% of their portfolio | 181.8k $605.5k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 164.8k $548.9k | Reduced -45.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 158.3k $527.2k | Added +82.8k |
| Curi Capital, LLC 0.01% of their portfolio | 157.7k $525.1k | Added +49.1k |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 155.7k $517.6k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 151.2k $503.5k | Reduced -14.6k |
| GUGGENHEIM CAPITAL LLC 0.00% of their portfolio | 148.3k $494.0k | Added +49.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 147.4k $491.0k | Reduced -22.3k |
| Raiffeisen Bank International AG 0.01% of their portfolio | 147.0k $522.9k | Added +45.0k |
| TD Asset Management Inc 0.00% of their portfolio | 139.9k $465.8k | Reduced -171.2k |
| SG Americas Securities, LLC 0.00% of their portfolio | 134.8k $449.0k | Added +65.1k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 134.5k $448.0k | Reduced -2.0k |
| PFM Health Sciences, LP 0.03% of their portfolio | 132.2k $440.1k | Unchanged |
| Aberdeen Group plc 0.00% of their portfolio | 131.8k $438.9k | Unchanged |
| PIER 88 INVESTMENT PARTNERS LLC 0.08% of their portfolio | 126.9k $422.7k | Added +72.3k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 122.9k $409.4k | New |
| Haven Capital Group, Inc. 0.45% of their portfolio | 121.9k $406.0k | Reduced -2.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 121.1k $403.2k | Reduced -174.1k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 119.0k $396.3k | Added +1.6k |
| Intellectus Partners, LLC 0.10% of their portfolio | 116.2k $387.0k | Added +1.3k |