IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.5m this quarter). Holder counts are more reliable. Shares outstanding: 279.8m as of 2024-05-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.81. Options: 21 managers hold calls ($94.0m notional), 18 hold puts ($31.4m).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
| Q1 2024 | 274 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 103 | 118 |
| Q1 2023 | 126 | 94 |
| Q2 2023 | 118 | 106 |
| Q3 2023 | 147 | 83 |
| Q4 2023 | 127 | 106 |
| Q1 2024 | 160 | 114 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $10.9m | $5.9m | 0.54 |
| Q3 2023 | $33.7m | $16.2m | 0.48 |
| Q4 2023 | $55.3m | $20.5m | 0.37 |
| Q1 2024 | $94.0m | $31.4m | 0.33 |
Biggest buyers
| PERCEPTIVE ADVISORS LLC | Added | +7.3m |
| Avoro Capital Advisors LLC | Added | +5.0m |
| MHR FUND MANAGEMENT LLC | Added | +4.0m |
| JPMORGAN CHASE & CO | Added | +3.1m |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | New | +3.0m |
| Soleus Capital Management, L.P. | Added | +3.0m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Added | +2.5m |
| D. E. Shaw & Co., Inc. | Added | +2.1m |
| VANGUARD GROUP INC | Added | +2.1m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +2.0m |
Biggest sellers
| STATE STREET CORP | Reduced | -6.0m |
| ORBIMED ADVISORS LLC | Sold out | -4.7m |
| Balyasny Asset Management L.P. | Reduced | -2.7m |
| Pictet Asset Management Holding SA | Reduced | -2.0m |
| DEUTSCHE BANK AG\ | Reduced | -1.2m |
| MPM BIOIMPACT LLC | Reduced | -1.1m |
| Invenomic Capital Management LP | Sold out | -1.1m |
| CREDIT SUISSE AG/ | Reduced | -806.3k |
| Schonfeld Strategic Advisors LLC | Reduced | -777.4k |
| Long Focus Capital Management, LLC | Reduced | -735.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $26.8m1.8m shares |
| GROUP ONE TRADING LLC | Added | $22.1m1.5m shares |
| JANE STREET GROUP, LLC | Added | $13.7m923.5k shares |
| SIMPLEX TRADING, LLC | Added | $13.4m901.0k shares |
| CITADEL ADVISORS LLC | Added | $9.0m609.2k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.7m117.5k shares |
| Cubist Systematic Strategies, LLC | New | $1.5m104.3k shares |
| Walleye Capital LLC | Added | $1.0m70.8k shares |
| D. E. Shaw & Co., Inc. | New | $1.0m69.4k shares |
| Caption Management, LLC | Reduced | $741.0k50.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $11.4m769.3k shares |
| CITADEL ADVISORS LLC | Reduced | $5.6m376.0k shares |
| GROUP ONE TRADING LLC | Reduced | $3.6m242.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.3m224.5k shares |
| Caption Management, LLC | Reduced | $1.9m130.0k shares |
| D. E. Shaw & Co., Inc. | New | $1.2m84.2k shares |
| JANE STREET GROUP, LLC | Reduced | $995.9k67.2k shares |
| WOLVERINE TRADING, LLC | Reduced | $994.4k67.1k shares |
| Walleye Capital LLC | Added | $869.9k58.7k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $438.7k29.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 5 | $6.9m | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 4 | $65.3m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 2 | $26.6m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 3 | $48.3m | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-02-20 | Rothbaum Wayne P. Director · By Quogue Capital LLC | Bought | $45.8m5.0m shares |
| 2024-02-20 | MCPEAK MERRILL A Director | Bought | $2.3m250.0k shares |
| 2024-02-20 | Dukes Iain D. Director | Bought | $292.8k32.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.01% of their portfolio | 24.9m $369.2m | Added +2.1m |
| MHR FUND MANAGEMENT LLC 34.36% of their portfolio | 24.0m $355.6m | Added +4.0m |
| BlackRock Inc. 0.01% of their portfolio | 19.9m $295.4m | Added +857.9k |
| PERCEPTIVE ADVISORS LLC 5.03% of their portfolio | 19.3m $285.6m | Added +7.3m |
| Avoro Capital Advisors LLC 2.02% of their portfolio | 11.7m $173.4m | Added +5.0m |
| STATE STREET CORP 0.01% of their portfolio | 10.4m $154.2m | Reduced -6.0m |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 8.8m $130.0m | Added +3.1m |
| MORGAN STANLEY 0.00% of their portfolio | 8.1m $119.6m | Added +642.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 5.5m $81.6m | Added +469.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 5.3m $78.1m | Added +2.0m |
| Artisan Partners Limited Partnership 0.11% of their portfolio | 5.1m $76.1m | Added +310.6k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 3.8m $56.1m | Added +101.0k |
| Soleus Capital Management, L.P. 4.56% of their portfolio | 3.5m $51.9m | Added +3.0m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.19% of their portfolio | 3.5m $51.8m | Added +2.5m |
| Pictet Asset Management Holding SA 0.05% of their portfolio | 3.3m $47.5m | Reduced -2.0m |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 2.10% of their portfolio | 3.0m $44.0m | New |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 2.9m $42.6m | Reduced -645.5k |
| Hood River Capital Management LLC 0.87% of their portfolio | 2.6m $38.9m | Added +622.7k |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 2.4m $34.9m | Added +2.1m |
| NORTHERN TRUST CORP 0.01% of their portfolio | 2.2m $33.0m | Added +44.5k |
| MPM BIOIMPACT LLC 5.28% of their portfolio | 2.2m $32.6m | Reduced -1.1m |
| Palo Alto Investors LP 3.53% of their portfolio | 2.1m $31.3m | Added +6.0k |
| CREDIT SUISSE AG/ 0.03% of their portfolio | 2.0m $29.8m | Reduced -806.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 2.0m $29.7m | Reduced -630.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.9m $28.4m | Added +166.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.04% of their portfolio | 1.8m $26.9m | Added +218.1k |
| RICE HALL JAMES & ASSOCIATES, LLC 1.45% of their portfolio | 1.7m $25.4m | Reduced -37.1k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 1.7m $24.5m | Added +708.8k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.6m $24.0m | Added +677.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.5m $22.7m | Added +595.4k |
| Woodline Partners LP 0.20% of their portfolio | 1.5m $22.0m | Reduced -121.8k |
| Long Focus Capital Management, LLC 2.40% of their portfolio | 1.4m $20.8m | Reduced -735.2k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 1.3m $19.5m | New |
| 683 Capital Management, LLC 1.85% of their portfolio | 1.2m $18.2m | Reduced -525.0k |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 1.2m $17.8m | Reduced -2.7m |
| NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio | 1.2m $17.3m | Added +142.9k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 1.1m $16.5m | Added +825.0k |
| NORGES BANK 0.00% of their portfolio | 1.1m $16.2m | Reduced -28.5k |
| C WorldWide Group Holding A/S 0.18% of their portfolio | 1.1m $15.7m | Reduced -300.0k |
| Candriam S.C.A. 0.10% of their portfolio | 1.1m $15.7m | Reduced -668.7k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 1.0m $15.1m | Added +498.5k |
| Rhenman & Partners Asset Management AB 1.34% of their portfolio | 955.0k $14.2m | Reduced -161.8k |
| Opaleye Management Inc. 2.90% of their portfolio | 897.0k $13.3m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 834.2k $12.4m | Reduced -16.0k |
| Boxer Capital, LLC 0.55% of their portfolio | 750.0k $11.1m | Reduced -650.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 723.7k $10.7m | Reduced -1.2m |
| UBS Group AG 0.00% of their portfolio | 690.9k $10.2m | Reduced -166.4k |
| BANQUE PICTET & CIE SA 0.11% of their portfolio | 689.4k $10.2m | Reduced -88.7k |
| QVT Financial LP 0.94% of their portfolio | 678.6k $10.1m | Unchanged |
| BRAIDWELL LP 0.32% of their portfolio | 660.0k $9.8m | New |
| Driehaus Capital Management LLC 0.09% of their portfolio | 642.8k $9.5m | New |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 584.1k $8.7m | Reduced -663.4k |
| EAGLE ASSET MANAGEMENT INC 0.04% of their portfolio | 551.0k $7.8m | Added +100.6k |
| CITIGROUP INC 0.01% of their portfolio | 539.9k $8.0m | Reduced -214.0k |
| TD Asset Management Inc 0.01% of their portfolio | 505.3k $7.5m | Added +247.8k |
| TANG CAPITAL MANAGEMENT LLC 0.77% of their portfolio | 500.0k $7.4m | Reduced -500.0k |
| GROUP ONE TRADING LLC 0.26% of their portfolio | 488.0k $7.2m | Reduced -88.3k |
| Hennion & Walsh Asset Management, Inc. 0.32% of their portfolio | 407.4k $6.0m | Added +121.4k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 391.6k $5.8m | Added +23.1k |
| Swiss National Bank 0.00% of their portfolio | 379.0k $5.6m | Reduced -60.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 367.8k $5.5m | Added +20.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 359.0k $5.3m | Added +94.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 338.5k $5.0m | Added +5.4k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 333.1k $4.9m | Added +84.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 330.8k $4.9m | Added +6.0k |
| PANAGORA ASSET MANAGEMENT INC 0.03% of their portfolio | 323.7k $4.8m | Reduced -22.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 315.4k $4.7m | Added +62.5k |
| PFM Health Sciences, LP 0.23% of their portfolio | 310.8k $4.6m | New |
| HRT FINANCIAL LP 0.03% of their portfolio | 296.2k $4.4m | Added +1.4k |
| NOMURA ASSET MANAGEMENT CO LTD 0.01% of their portfolio | 278.1k $4.1m | Added +278.1k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 258.3k $3.8m | Reduced -50.5k |
| BARCLAYS PLC 0.00% of their portfolio | 255.4k $3.8m | Reduced -580.8k |
| CM Management, LLC 3.11% of their portfolio | 250.0k $3.7m | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.04% of their portfolio | 244.6k $3.6m | Added +211.5k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 244.4k $3.6m | Reduced -777.4k |
| LPL Financial LLC 0.00% of their portfolio | 240.7k $3.6m | Added +111.5k |
| Brevan Howard Capital Management LP 0.31% of their portfolio | 233.3k $3.5m | Reduced -459.4k |
| Moody Aldrich Partners LLC 0.57% of their portfolio | 224.8k $3.3m | New |
| Handelsbanken Fonder AB 0.01% of their portfolio | 218.9k $3.2m | Added +163.2k |
| Invesco Ltd. 0.00% of their portfolio | 216.8k $3.2m | Reduced -620.4k |
| Informed Momentum Co LLC 0.49% of their portfolio | 213.3k $3.2m | New |
| NFJ INVESTMENT GROUP, LLC 0.09% of their portfolio | 212.2k $3.1m | Reduced -589 |
| Legal & General Group Plc 0.00% of their portfolio | 203.7k $3.0m | Reduced -24.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 199.9k $3.0m | Added +38.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 196.5k $2.9m | Reduced -39.9k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 182.8k $2.7m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 179.8k $2.7m | Reduced -47 |
| SEVEN EIGHT CAPITAL, LP 0.27% of their portfolio | 174.4k $2.6m | New |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 168.0k $2.5m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 159.3k $2.4m | Reduced -418 |
| Bayesian Capital Management, LP 0.21% of their portfolio | 151.7k $2.2m | Added +116.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 145.9k $2.2m | Reduced -406.9k |
| Trexquant Investment LP 0.04% of their portfolio | 140.3k $2.1m | New |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 136.8k $2.0m | Added +6.5k |
| Parametrica Management Ltd 2.81% of their portfolio | 131.6k $2.0m | Reduced -188.7k |
| GREAT LAKES ADVISORS, LLC 0.02% of their portfolio | 129.0k $1.9m | Reduced -7.2k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 122.1k $1.8m | New |
| LMR Partners LLP 0.05% of their portfolio | 121.6k $1.8m | Added +80.4k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 121.1k $1.8m | Unchanged |
| Intellectus Partners, LLC 0.46% of their portfolio | 117.9k $1.7m | Added +1.2k |