IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($563.6k this quarter). Holder counts are more reliable. Shares outstanding: 255.9m as of 2023-10-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $8.13. Options: 18 managers hold calls ($55.3m notional), 9 hold puts ($20.5m).
Trends to Q4 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 103 | 118 |
| Q1 2023 | 126 | 94 |
| Q2 2023 | 118 | 106 |
| Q3 2023 | 147 | 83 |
| Q4 2023 | 127 | 106 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2023 | $6.4m | $5.7m | 0.89 |
| Q2 2023 | $10.9m | $5.9m | 0.54 |
| Q3 2023 | $33.7m | $16.2m | 0.48 |
| Q4 2023 | $55.3m | $20.5m | 0.37 |
Biggest buyers
| MORGAN STANLEY | Added | +4.9m |
| JPMORGAN CHASE & CO | Added | +2.9m |
| Palo Alto Investors LP | New | +2.1m |
| DEUTSCHE BANK AG\ | Added | +1.4m |
| Invenomic Capital Management LP | New | +1.1m |
| Schonfeld Strategic Advisors LLC | New | +1.0m |
| TANG CAPITAL MANAGEMENT LLC | New | +1.0m |
| Woodline Partners LP | Added | +958.4k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Added | +782.7k |
| BlackRock Inc. | Added | +695.3k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -6.9m |
| Boxer Capital, LLC | Reduced | -2.3m |
| Pictet Asset Management Holding SA | Reduced | -1.7m |
| Point72 Asset Management, L.P. | Sold out | -1.4m |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -1.2m |
| Candriam S.C.A. | Reduced | -1.0m |
| Brevan Howard Capital Management LP | Reduced | -869.9k |
| SECTORAL ASSET MANAGEMENT INC | Reduced | -786.2k |
| Soleus Capital Management, L.P. | Reduced | -684.8k |
| Nuveen Asset Management, LLC | Reduced | -657.6k |
Biggest calls
| Caption Management, LLC | Added | $14.9m1.8m shares |
| GROUP ONE TRADING LLC | Added | $8.6m1.1m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $8.2m1.0m shares |
| Logos Global Management LP | Unchanged | $8.1m1.0m shares |
| SIMPLEX TRADING, LLC | Added | $5.1m628.2k shares |
| CITADEL ADVISORS LLC | Reduced | $2.8m340.3k shares |
| WOLVERINE TRADING, LLC | Added | $2.4m295.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.4m169.2k shares |
| GTS SECURITIES LLC | Reduced | $1.0m125.2k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Added | $900.4k330.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $7.7m952.7k shares |
| CITADEL ADVISORS LLC | Reduced | $3.1m387.4k shares |
| SIMPLEX TRADING, LLC | Added | $2.8m348.7k shares |
| GROUP ONE TRADING LLC | Reduced | $2.5m304.5k shares |
| Caption Management, LLC | Added | $2.2m275.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m158.3k shares |
| WOLVERINE TRADING, LLC | Added | $661.8k81.4k shares |
| Walleye Capital LLC | New | $104.1k12.8k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q4 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 5 | $6.9m | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 4 | $65.3m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 2 | $26.6m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
None reported in Q4 2023.
Holders, Q4 2023
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 22.8m $185.5m | Added +669.4k |
| MHR FUND MANAGEMENT LLC 17.76% of their portfolio | 20.0m $162.6m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 19.1m $155.1m | Added +695.3k |
| STATE STREET CORP 0.01% of their portfolio | 16.4m $133.5m | Reduced -307.9k |
| PERCEPTIVE ADVISORS LLC 2.18% of their portfolio | 12.0m $97.4m | Added +16.5k |
| MORGAN STANLEY 0.00% of their portfolio | 7.4m $60.4m | Added +4.9m |
| Avoro Capital Advisors LLC 0.75% of their portfolio | 6.7m $54.5m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 5.7m $46.2m | Added +2.9m |
| Pictet Asset Management Holding SA 0.05% of their portfolio | 5.3m $42.8m | Reduced -1.7m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 5.0m $41.0m | Added +287.7k |
| Artisan Partners Limited Partnership 0.06% of their portfolio | 4.8m $39.2m | Reduced -208.8k |
| ORBIMED ADVISORS LLC 0.77% of their portfolio | 4.7m $38.3m | Unchanged |
| Balyasny Asset Management L.P. 0.09% of their portfolio | 3.9m $31.9m | Reduced -550.7k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 3.7m $29.9m | Reduced -82.1k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 3.5m $28.6m | Reduced -461.4k |
| MPM BIOIMPACT LLC 6.26% of their portfolio | 3.3m $26.7m | Added +2.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.3m $26.6m | Reduced -320.5k |
| CREDIT SUISSE AG/ 0.02% of their portfolio | 2.8m $22.9m | Reduced -29.2k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 2.6m $21.4m | Reduced -6.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.2m $17.7m | Added +189.7k |
| Long Focus Capital Management, LLC 2.24% of their portfolio | 2.1m $17.4m | Reduced -335.0k |
| Palo Alto Investors LP 1.54% of their portfolio | 2.1m $17.1m | New |
| Hood River Capital Management LLC 0.45% of their portfolio | 2.0m $16.3m | Added +9.2k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 1.9m $15.6m | Added +1.4m |
| RICE HALL JAMES & ASSOCIATES, LLC 0.82% of their portfolio | 1.8m $14.2m | Added +28.2k |
| 683 Capital Management, LLC 1.42% of their portfolio | 1.8m $14.2m | Reduced -300.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.7m $14.2m | Added +54.5k |
| Candriam S.C.A. 0.10% of their portfolio | 1.7m $14.0m | Reduced -1.0m |
| Woodline Partners LP 0.14% of their portfolio | 1.6m $13.0m | Added +958.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 1.6m $13.0m | Added +353.9k |
| Boxer Capital, LLC 0.57% of their portfolio | 1.4m $11.4m | Reduced -2.3m |
| C WorldWide Group Holding A/S 0.15% of their portfolio | 1.4m $11.1m | Unchanged |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 1.2m $10.1m | Reduced -248.7k |
| NORGES BANK 0.00% of their portfolio | 1.1m $9.1m | Unchanged |
| Rhenman & Partners Asset Management AB 0.91% of their portfolio | 1.1m $9.1m | Added +166.8k |
| Invenomic Capital Management LP 0.46% of their portfolio | 1.1m $8.6m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 1.0m $8.3m | Reduced -5.1k |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 1.0m $8.3m | New |
| TANG CAPITAL MANAGEMENT LLC 0.75% of their portfolio | 1.0m $8.1m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 983.1k $8.0m | Added +782.7k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 945.9k $7.7m | Reduced -657.6k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 939.5k $7.6m | Reduced -6.9m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 936.9k $7.6m | Reduced -293.2k |
| Opaleye Management Inc. 1.94% of their portfolio | 897.0k $7.3m | Added +287.0k |
| UBS Group AG 0.00% of their portfolio | 857.3k $7.0m | Added +615.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 850.2k $6.9m | Reduced -3.7k |
| Invesco Ltd. 0.00% of their portfolio | 837.2k $6.8m | Added +686.1k |
| BARCLAYS PLC 0.00% of their portfolio | 836.2k $6.8m | Added +78.2k |
| BANQUE PICTET & CIE SA 0.07% of their portfolio | 778.0k $6.3m | Added +144.2k |
| CITIGROUP INC 0.01% of their portfolio | 753.9k $6.1m | Reduced -183.5k |
| Brevan Howard Capital Management LP 0.57% of their portfolio | 692.8k $5.6m | Reduced -869.9k |
| QVT Financial LP 0.33% of their portfolio | 678.6k $5.5m | Unchanged |
| Cutter Capital Management, LP 2.63% of their portfolio | 677.4k $5.5m | First filing |
| Vivo Capital, LLC 0.44% of their portfolio | 655.1k $5.3m | Unchanged |
| Laurion Capital Management LP 0.19% of their portfolio | 637.7k $5.2m | New |
| GROUP ONE TRADING LLC 0.15% of their portfolio | 576.3k $4.7m | Reduced -49.4k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.03% of their portfolio | 562.0k $4.6m | Not comparable |
| Soleus Capital Management, L.P. 0.50% of their portfolio | 555.0k $4.5m | Reduced -684.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 552.8k $4.5m | Added +251.5k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 522.6k $4.2m | Reduced -27.4k |
| Zimmer Partners, LP 0.15% of their portfolio | 495.0k $4.0m | Reduced -93.0k |
| Cubist Systematic Strategies, LLC 0.05% of their portfolio | 468.8k $3.8m | New |
| EAGLE ASSET MANAGEMENT INC 0.02% of their portfolio | 450.5k $3.7m | New |
| Swiss National Bank 0.00% of their portfolio | 439.5k $3.6m | Reduced -49.9k |
| SIMPLEX TRADING, LLC 0.09% of their portfolio | 374.1k $3.0m | Added +198.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 368.5k $3.0m | Added +16.3k |
| Corient Private Wealth LP 0.01% of their portfolio | 367.0k $3.0m | Added +247.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 347.7k $2.8m | Reduced -185.4k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 346.2k $2.8m | Added +12.2k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 333.1k $2.7m | Reduced -75.6k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 324.7k $2.6m | New |
| Parametrica Management Ltd 4.27% of their portfolio | 320.3k $2.6m | Added +224.9k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 308.8k $2.5m | Added +78.6k |
| HRT FINANCIAL LP 0.02% of their portfolio | 294.8k $2.4m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 286.0k $2.3m | Reduced -103.1k |
| Hennion & Walsh Asset Management, Inc. 0.13% of their portfolio | 286.0k $2.3m | Added +105.5k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 275.0k $2.2m | Reduced -585.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 265.0k $2.2m | Added +1.0k |
| TD Asset Management Inc 0.00% of their portfolio | 257.5k $2.1m | Reduced -78.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 252.9k $2.1m | Reduced -90.3k |
| CM Management, LLC 1.63% of their portfolio | 250.0k $2.0m | Added +50.0k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 248.8k $2.0m | Reduced -12.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 236.4k $1.9m | Reduced -11.0k |
| Legal & General Group Plc 0.00% of their portfolio | 228.3k $1.9m | Added +8.6k |
| Arete Wealth Advisors, LLC 0.13% of their portfolio | 216.2k $1.8m | Added +183.2k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 215.1k $1.7m | Added +177.4k |
| NFJ INVESTMENT GROUP, LLC 0.05% of their portfolio | 212.7k $1.7m | New |
| PROFUND ADVISORS LLC 0.07% of their portfolio | 202.4k $1.6m | Reduced -48.1k |
| SECTORAL ASSET MANAGEMENT INC 0.70% of their portfolio | 198.8k $1.6m | Reduced -786.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 179.9k $1.5m | Reduced -1.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 161.0k $1.3m | Reduced -278 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 159.7k $1.3m | Reduced -6.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 155.1k $1.3m | Added +53.6k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 142.9k $1.2m | Reduced -5.1k |
| Polar Asset Management Partners Inc. 0.03% of their portfolio | 138.0k $1.1m | Reduced -85.9k |
| GREAT LAKES ADVISORS, LLC 0.01% of their portfolio | 136.2k $1.1m | Reduced -140.4k |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 130.3k $1.1m | Added +42.7k |
| LPL Financial LLC 0.00% of their portfolio | 129.1k $1.0m | Added +25.6k |
| WOLVERINE TRADING, LLC 0.01% of their portfolio | 122.1k $992.9k | Added +63.3k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 121.1k $984.6k | Unchanged |