IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.2m this quarter). Holder counts are more reliable. Shares outstanding: 247.8m as of 2023-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.04. Options: 11 managers hold calls ($10.9m notional), 11 hold puts ($5.9m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 103 | 118 |
| Q1 2023 | 126 | 94 |
| Q2 2023 | 118 | 106 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $19.6m | $3.2m | 0.17 |
| Q4 2022 | $9.1m | $3.8m | 0.42 |
| Q1 2023 | $6.4m | $5.7m | 0.89 |
| Q2 2023 | $10.9m | $5.9m | 0.54 |
Biggest buyers
| VANGUARD GROUP INC | Added | +6.9m |
| BlackRock Inc. | Added | +4.5m |
| PICTET ASSET MANAGEMENT SA | Added | +4.2m |
| DEUTSCHE BANK AG\ | Added | +2.4m |
| Hood River Capital Management LLC | New | +2.0m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +1.1m |
| Brevan Howard Capital Management LP | Added | +947.3k |
| Artisan Partners Limited Partnership | Added | +858.0k |
| PFM Health Sciences, LP | Added | +804.2k |
| DIMENSIONAL FUND ADVISORS LP | Added | +587.8k |
Biggest sellers
| MORGAN STANLEY | Reduced | -4.2m |
| FRANKLIN RESOURCES INC | Reduced | -2.7m |
| CITADEL ADVISORS LLC | Reduced | -2.1m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold out | -1.8m |
| Kynam Capital Management, LP | Sold out | -1.8m |
| D. E. Shaw & Co., Inc. | Reduced | -1.5m |
| NORGES BANK | Reduced | -1.3m |
| PERCEPTIVE ADVISORS LLC | Reduced | -1.3m |
| Balyasny Asset Management L.P. | Reduced | -1.2m |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Sold out | -1.1m |
Biggest calls
| GROUP ONE TRADING LLC | Added | $3.3m464.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.2m311.9k shares |
| CITADEL ADVISORS LLC | Reduced | $2.1m293.5k shares |
| WOLVERINE TRADING, LLC | Added | $1.1m153.6k shares |
| SIMPLEX TRADING, LLC | Added | $694.0k98.7k shares |
| JANE STREET GROUP, LLC | Added | $469.6k66.7k shares |
| Walleye Trading LLC | New | $370.3k52.6k shares |
| CITIGROUP INC | Reduced | $352.0k50.0k shares |
| Caption Management, LLC | Unchanged | $211.2k30.0k shares |
| Walleye Capital LLC | New | $166.8k23.7k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.1m294.3k shares |
| CITADEL ADVISORS LLC | Added | $1.3m180.6k shares |
| GROUP ONE TRADING LLC | Added | $892.0k126.7k shares |
| JANE STREET GROUP, LLC | Added | $455.5k64.7k shares |
| SIMPLEX TRADING, LLC | Added | $369.0k52.5k shares |
| CITIGROUP INC | Reduced | $352.0k50.0k shares |
| Caption Management, LLC | Unchanged | $211.2k30.0k shares |
| WOLVERINE TRADING, LLC | Added | $154.4k21.9k shares |
| Walleye Capital LLC | New | $71.1k10.1k shares |
| Walleye Trading LLC | New | $29.6k4.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 5 | $6.9m | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 4 | $65.3m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
None reported in Q2 2023.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 20.4m $143.6m | Added +6.9m |
| BlackRock Inc. 0.00% of their portfolio | 17.0m $119.7m | Added +4.5m |
| PERCEPTIVE ADVISORS LLC 2.87% of their portfolio | 14.0m $98.8m | Reduced -1.3m |
| STATE STREET CORP 0.01% of their portfolio | 13.6m $95.5m | Reduced -167.2k |
| MHR FUND MANAGEMENT LLC 11.88% of their portfolio | 12.0m $84.5m | Unchanged |
| Point72 Asset Management, L.P. 0.19% of their portfolio | 7.8m $54.8m | Reduced -1.0m |
| Avoro Capital Advisors LLC 0.64% of their portfolio | 6.7m $47.2m | Reduced -320.0k |
| PICTET ASSET MANAGEMENT SA 0.04% of their portfolio | 5.2m $36.4m | Added +4.2m |
| ORBIMED ADVISORS LLC 0.60% of their portfolio | 4.7m $33.1m | Unchanged |
| Artisan Partners Limited Partnership 0.05% of their portfolio | 4.4m $31.2m | Added +858.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.1m $29.1m | Added +1.1m |
| Boxer Capital, LLC 1.21% of their portfolio | 3.7m $26.1m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.7m $25.8m | Reduced -92.5k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 3.6m $25.2m | Added +168.1k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 3.5m $24.9m | Reduced -397.7k |
| MORGAN STANLEY 0.00% of their portfolio | 3.5m $24.6m | Reduced -4.2m |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 3.3m $23.3m | Added +2.4m |
| MPM BIOIMPACT LLC 4.18% of their portfolio | 3.0m $20.8m | Added +335.1k |
| CREDIT SUISSE AG/ 0.02% of their portfolio | 2.8m $19.7m | Added +97.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.6m $18.6m | Added +565.9k |
| Sumitomo Mitsui Trust Group, Inc. 0.01% of their portfolio | 2.5m $17.5m | Reduced -82.5k |
| Amova Asset Management Americas, Inc. 0.18% of their portfolio | 2.5m $17.5m | Reduced -58.4k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 2.2m $15.7m | Added +73.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 2.1m $14.8m | Added +587.8k |
| Hood River Capital Management LLC 0.41% of their portfolio | 2.0m $13.9m | New |
| Long Focus Capital Management, LLC 2.00% of their portfolio | 1.9m $13.2m | Reduced -185.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 1.9m $13.2m | Reduced -42.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.8m $12.8m | Added +516.5k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.70% of their portfolio | 1.8m $12.4m | Added +28.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 1.7m $12.2m | Reduced -142.8k |
| Candriam S.C.A. 0.09% of their portfolio | 1.7m $12.2m | Added +33.9k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 1.5m $10.8m | Reduced -1.2m |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 1.5m $10.8m | Reduced -1.0m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.5m $10.5m | Added +435.4k |
| Brevan Howard Capital Management LP 1.92% of their portfolio | 1.5m $10.4m | Added +947.3k |
| 683 Capital Management, LLC 0.96% of their portfolio | 1.4m $9.9m | Added +75.0k |
| C WorldWide Group Holding A/S 0.12% of their portfolio | 1.4m $9.6m | Unchanged |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.3m $9.4m | Reduced -2.1m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.3m $9.1m | Reduced -138.4k |
| Soleus Capital Management, L.P. 0.97% of their portfolio | 1.2m $8.7m | Reduced -210.0k |
| Aristotle Atlantic Partners, LLC 0.32% of their portfolio | 1.2m $8.6m | Added +201.3k |
| NORGES BANK 0.00% of their portfolio | 1.1m $7.9m | Reduced -1.3m |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 1.1m $7.4m | Reduced -42.5k |
| PFM Health Sciences, LP 0.27% of their portfolio | 946.3k $6.7m | Added +804.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 872.1k $6.1m | Reduced -78.9k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 858.8k $6.0m | Reduced -1.5m |
| Rhenman & Partners Asset Management AB 0.63% of their portfolio | 850.0k $6.0m | Added +163.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 835.5k $5.9m | Added +158.2k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 802.7k $5.7m | Reduced -441.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 797.8k $5.6m | Added +209.8k |
| ARK Investment Management LLC 0.04% of their portfolio | 775.8k $5.5m | Reduced -33.2k |
| QVT Financial LP 0.28% of their portfolio | 678.6k $4.8m | Unchanged |
| Vivo Capital, LLC 0.32% of their portfolio | 655.1k $4.6m | Unchanged |
| CITIGROUP INC 0.01% of their portfolio | 627.3k $4.4m | Reduced -635.3k |
| BANQUE PICTET & CIE SA 0.03% of their portfolio | 534.2k $3.8m | Reduced -138.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 530.1k $3.7m | Reduced -598.8k |
| BARCLAYS PLC 0.00% of their portfolio | 529.6k $3.7m | Added +112.4k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 515.0k $3.6m | Reduced -1.0m |
| FMR LLC 0.00% of their portfolio | 474.7k $3.3m | Reduced -373.5k |
| UBS Group AG 0.00% of their portfolio | 469.8k $3.3m | Added +43.0k |
| ExodusPoint Capital Management, LP 0.04% of their portfolio | 449.9k $3.2m | New |
| Opaleye Management Inc. 0.71% of their portfolio | 421.0k $3.0m | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 417.2k $2.9m | Added +97.9k |
| Swiss National Bank 0.00% of their portfolio | 411.7k $2.9m | Added +156.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 402.3k $2.8m | Added +336.6k |
| Polar Asset Management Partners Inc. 0.06% of their portfolio | 396.7k $2.8m | New |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 390.1k $2.7m | Added +296.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 378.0k $2.7m | Added +130.1k |
| SG Americas Securities, LLC 0.02% of their portfolio | 367.5k $2.6m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 364.6k $2.6m | Added +124.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 364.0k $2.6m | Reduced -245.2k |
| ALGERT GLOBAL LLC 0.11% of their portfolio | 352.3k $2.5m | Reduced -62.7k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 350.8k $2.5m | Added +64.1k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 326.3k $2.3m | Added +177.4k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio | 289.4k $2.0m | Reduced -18.8k |
| GREAT LAKES ADVISORS, LLC 0.02% of their portfolio | 284.2k $2.0m | Reduced -75.0k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 275.0k $1.9m | Reduced -712.1k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 274.1k $1.9m | New |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 272.6k $1.9m | Reduced -162.6k |
| NOMURA HOLDINGS INC 0.02% of their portfolio | 256.1k $1.8m | Reduced -115.0k |
| Cubist Systematic Strategies, LLC 0.02% of their portfolio | 252.6k $1.8m | Reduced -244.4k |
| Velan Capital Investment Management LP 1.59% of their portfolio | 240.0k $1.7m | Added +20.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 235.6k $1.7m | Added +75.5k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 225.9k $1.6m | Reduced -182.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 220.9k $1.6m | Added +56.2k |
| Corient Private Wealth LP 0.00% of their portfolio | 211.6k $1.5m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 205.4k $1.4m | Reduced -179.7k |
| PROFUND ADVISORS LLC 0.07% of their portfolio | 191.1k $1.3m | Reduced -11.0k |
| Hennion & Walsh Asset Management, Inc. 0.08% of their portfolio | 181.5k $1.3m | Added +1.0k |
| Mariner, LLC 0.00% of their portfolio | 179.4k $1.3m | Added +72.1k |
| Legal & General Group Plc 0.00% of their portfolio | 172.0k $1.2m | Added +50.5k |
| TD Asset Management Inc 0.00% of their portfolio | 167.6k $1.2m | Added +50.9k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 165.3k $1.2m | Added +58.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 151.5k $1.1m | Reduced -100.9k |
| Invesco Ltd. 0.00% of their portfolio | 144.6k $1.0m | Added +2.4k |
| Vontobel Holding Ltd. 0.01% of their portfolio | 142.3k $1.0m | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 135.2k $951.9k | Added +25.8k |
| SEVEN EIGHT CAPITAL, LP 0.15% of their portfolio | 132.2k $931.0k | Added +73.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 129.2k $909.6k | Reduced -25.3k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 129.1k $908.8k | Added +31.1k |