Vault-13

IONIS PHARMACEUTICALS INC IONS 0 04.01.26

NOTE 4/0 · US DOMESTIC · CUSIP 462222AD2

51 institutional holders +4 vs Q1 2023
30,120,50030.1m shares reported held*
$559.5mreported value*
11 new 10 added 15 reduced 7 sold out net bought ≈ $42.4m (-5.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $18.58.

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 41Q4 22: 44Q1 23: 47Q2 23: 5151Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202241
Q4 202244
Q1 202347
Q2 202351

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 18 bought or addedQ4 22: 17 cut or sold outQ4 22Q1 23: 24 bought or addedQ1 23: 15 cut or sold outQ1 23Q2 23: 21 bought or addedQ2 23: 22 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221817
Q1 20232415
Q2 20232122

Biggest buyers

BlackRock Inc. Added +47,090,000+47.1m
Jefferies Financial Group Inc. New +11,464,000+11.5m
CSS LLC/IL Added +10,500,000+10.5m
Linden Advisors LP New +9,240,000+9.2m
Magnetar Financial LLC Added +6,800,000+6.8m
STATE STREET CORP Added +5,200,000+5.2m
SHENKMAN CAPITAL MANAGEMENT INC New +5,035,000+5.0m
Walleye Capital LLC New +5,000,000+5.0m
MORGAN STANLEY Added +860,000+860.0k
CITIGROUP INC New +682,000+682.0k

Biggest sellers

WOLVERINE ASSET MANAGEMENT LLC Reduced -11,910,000-11.9m
AMERIPRISE FINANCIAL INC Sold out -11,840,000-11.8m
BNP PARIBAS FINANCIAL MARKETS Sold out -9,459,000-9.5m
SSI INVESTMENT MANAGEMENT LLC Reduced -6,109,000-6.1m
AXA S.A. Reduced -4,600,000-4.6m
LAZARD ASSET MANAGEMENT LLC Sold out -4,500,000-4.5m
JANE STREET GROUP, LLC Reduced -4,500,000-4.5m
CAPSTONE INVESTMENT ADVISORS, LLC Reduced -2,500,000-2.5m
Thrivent Financial for Lutherans Reduced -1,300,000-1.3m
RWC Asset Management LLP Reduced -600,000-600.0k

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 DEERFIELD MANAGEMENT COMPANY, L.P. 2.58% of their portfolio New York, NY 127,800,000127.8m $121.0m $121.0m 2.58% Unchanged
2 WOLVERINE ASSET MANAGEMENT LLC 1.62% of their portfolio CHICAGO, IL 90,820,00090.8m $86.0m $86.0m 1.62% Reduced -11.9m -11,910,000
3 BRAIDWELL LP 1.63% of their portfolio STAMFORD, CT 52,740,00052.7m $50.0m $50.0m 1.63% Unchanged
4 BlackRock Inc. 0.00% of their portfolio New York, NY 51,082,00051.1m $48.2m $48.2m 0.00% Added +47.1m +47,090,000
5 CSS LLC/IL 1.79% of their portfolio CHICAGO, IL 24,466,00024.5m $23.2m $23.2m 1.79% Added +10.5m +10,500,000
6 MacKay Shields LLC 0.63% of their portfolio New York, NY 23,964,00024.0m $22.7m $22.7m 0.63% Reduced -97.0k -97,000
7 Magnetar Financial LLC 0.49% of their portfolio EVANSTON, IL 23,500,00023.5m $22.2m $22.2m 0.49% Added +6.8m +6,800,000
8 WELLS FARGO & COMPANY/MN 0.01% of their portfolio SAN FRANCISCO, CA 20,311,00020.3m $19.2m $19.2m 0.01% Added +271.0k +271,000
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 18,125,00018.1m $17.2m $17.2m 0.00% Added +5.2m +5,200,000
10 Calamos Advisors LLC 0.08% of their portfolio NAPERVILLE, IL 17,200,00017.2m $16.3m $16.3m 0.08% Reduced -58.0k -58,000
11 CAPSTONE INVESTMENT ADVISORS, LLC 0.43% of their portfolio NEW YORK, NY 15,450,00015.4m $14.6m $14.6m 0.43% Reduced -2.5m -2,500,000
12 Thrivent Financial for Lutherans 0.03% of their portfolio Minneapolis, MN 13,590,00013.6m $12.8m $12.8m 0.03% Reduced -1.3m -1,300,000
13 TENOR CAPITAL MANAGEMENT Co., L.P. 0.26% of their portfolio NEW YORK, NY 13,353,00013.4m $12.6m $12.6m 0.26% Unchanged
14 Sonora Investment Management Group, LLC 0.94% of their portfolio TUCSON, AZ 11,890,00011.9m $11.3m $11.3m 0.94% Added +375.0k +375,000
15 Jefferies Financial Group Inc. 0.23% of their portfolio NEW YORK, NY 11,464,00011.5m $10.9m $10.9m 0.23% New
16 Linden Advisors LP 0.09% of their portfolio New York, NY 9,240,0009.2m $8.7m $8.7m 0.09% New
17 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 7,800,0007.8m $7.4m $7.4m 0.01% Unchanged
18 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 6,585,0006.6m $6.2m $6.2m 0.00% Added +860.0k +860,000
19 SHENKMAN CAPITAL MANAGEMENT INC 0.37% of their portfolio NEW YORK, NY 5,035,0005.0m $4.8m $4.8m 0.37% New
20 Walleye Capital LLC 0.08% of their portfolio NEW YORK, NY 5,000,0005.0m $4.7m $4.7m 0.08% New
21 CAMDEN ASSET MANAGEMENT L P /CA 0.15% of their portfolio Los Angeles, CA 4,650,0004.7m $4.4m $4.4m 0.15% Unchanged
22 STEELHEAD PARTNERS LLC 0.24% of their portfolio SEATTLE, WA 4,000,0004.0m $3.8m $3.8m 0.24% Added +200.0k +200,000
23 Man Group plc 0.01% of their portfolio LONDON, X0 3,700,0003.7m $3.5m $3.5m 0.01% Unchanged
24 DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.00% of their portfolio FRANKFURT AM MAIN, 2M 3,250,0003.2m $3.1m $3.1m 0.00% Unchanged
25 AXA S.A. 0.01% of their portfolio PARIS, I0 3,200,0003.2m $3.0m $3.0m 0.01% Reduced -4.6m -4,600,000
26 RWC Asset Management LLP 0.14% of their portfolio LONDON, X0 3,000,0003.0m $2.8m $2.8m 0.14% Reduced -600.0k -600,000
27 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2,903,0002.9m $2.7m $2.7m 0.00% Reduced -475.0k -475,000
28 TORONTO DOMINION BANK 0.00% of their portfolio TORONTO, ONTARIO, A6 2,000,0002.0m $1.9m $1.9m 0.00% Reduced -500.0k -500,000
29 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 1,500,0001.5m $1.4m $1.4m 0.00% Reduced -4.5m -4,500,000
30 Kohlberg Kravis Roberts & Co. L.P. 0.02% of their portfolio NEW YORK, NY 700,000700.0k $663.7k $663.7k 0.02% Unchanged
31 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 682,000682.0k $643.2k $643.2k 0.00% New
32 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 524,000524.0k $486.8k $486.8k 0.00% Unchanged
33 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 500,000500.0k $473.9k $473.9k 0.00% Unchanged
34 SSI INVESTMENT MANAGEMENT LLC 0.03% of their portfolio Los Angeles, CA 460,000460.0k $433.8k $433.8k 0.03% Reduced -6.1m -6,109,000
35 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 409,000409.0k $385.7k $385.7k 0.00% New
36 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 326,000326.0k $309.0k $309.0k 0.00% Added +310.0k +310,000
37 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 261,000261.0k $246.2k $246.2k 0.00% Unchanged
38 KBC Group NV 0.00% of their portfolio Brussels, C9 200,000200.0k $190.0k $190.0k 0.00% Unchanged
39 Calamos Wealth Management LLC 0.01% of their portfolio NAPERVILLE, IL 153,000153.0k $145.0k $145.0k 0.01% Reduced -25.0k -25,000
40 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 125,000125.0k $118.6k $118.6k 0.00% New
41 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 122,000122.0k $115.6k $115.6k 0.00% New
42 OPPENHEIMER ASSET MANAGEMENT INC. 0.00% of their portfolio NEW YORK, NY 76,00076.0k $71.7k $71.7k 0.00% Added +16.0k +16,000
43 CWM, LLC 0.00% of their portfolio OMAHA, NE 55,00055.0k $52.0k $52.0k 0.00% New
44 Argent Trust Co 0.00% of their portfolio NASHVILLE, TN 25,00025.0k $23.6k $23.6k 0.00% New
45 STEPHENS INC /AR/ 0.00% of their portfolio LITTLE ROCK, AR 22,00022.0k $20.7k $20.7k 0.00% Unchanged
46 Balboa Wealth Partners 0.01% of their portfolio SCOTTSDALE, AZ 18,00018.0k $17.1k $17.1k 0.01% Reduced -2.0k -2,000
47 Iron Horse Wealth Management, LLC 0.00% of their portfolio JOHSTON, IA 8,0008.0k $7.5k $7.5k 0.00% Unchanged
48 Boussard & Gavaudan Investment Management LLP 0.71% of their portfolio London, X0 7,8057.8k $7.4m $7.4m 0.71% Reduced -13.2k -13,195
49 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 3,0003.0k $282.9k $282.9k 0.00% New
50 NATIXIS 0.01% of their portfolio PARIS, I0 695695 $658.9k $658.9k 0.01% Reduced -723 -723
51 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged