Vault-13

IONIS PHARMACEUTICALS INC IONS

COM · Common Stock · CUSIP 462222100 · ISIN US4622221004

American pharmaceutical company

439 institutional holders +73 vs Q2 2025
168,511,279168.5m shares reported held*
104.0% of all shares outstanding*
$11.0bnreported value*
111 new 134 added 117 reduced 35 sold out net sold ≈ $41.8m (-781.6k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.5m this quarter). Holder counts are more reliable. Shares outstanding: 162.0m as of 2025-10-23, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $65.48. Options: 29 managers hold calls ($171.8m notional), 17 hold puts ($74.8m).

Trends to Q3 2025

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 350Q4 22: 339Q1 23: 316Q2 23: 307Q3 23: 313Q4 23: 366Q1 24: 362Q2 24: 358Q3 24: 357Q4 24: 359Q1 25: 348Q2 25: 366Q3 25: 439439Q3 22Q2 23Q1 24Q4 24Q3 25
Numbers
QuarterHolders
Q3 2022350
Q4 2022339
Q1 2023316
Q2 2023307
Q3 2023313
Q4 2023366
Q1 2024362
Q2 2024358
Q3 2024357
Q4 2024359
Q1 2025348
Q2 2025366
Q3 2025439

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q4 23: 175 bought or addedQ4 23: 143 cut or sold outQ1 24: 169 bought or addedQ1 24: 179 cut or sold outQ1 24Q2 24: 168 bought or addedQ2 24: 182 cut or sold outQ3 24: 176 bought or addedQ3 24: 159 cut or sold outQ3 24Q4 24: 160 bought or addedQ4 24: 169 cut or sold outQ1 25: 150 bought or addedQ1 25: 184 cut or sold outQ1 25Q2 25: 197 bought or addedQ2 25: 169 cut or sold outQ3 25: 245 bought or addedQ3 25: 152 cut or sold outQ3 25
Numbers
QuarterBought or addedCut or sold out
Q4 2023175143
Q1 2024169179
Q2 2024168182
Q3 2024176159
Q4 2024160169
Q1 2025150184
Q2 2025197169
Q3 2025245152

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ4 24 calls: $26.1mQ4 24 puts: $30.9mQ4 24P/C 1.18Q1 25 calls: $24.8mQ1 25 puts: $18.8mQ1 25P/C 0.76Q2 25 calls: $65.2mQ2 25 puts: $34.9mQ2 25P/C 0.54Q3 25 calls: $171.8mQ3 25 puts: $74.8mQ3 25P/C 0.44
Numbers
QuarterCallsPutsP/C
Q4 2024$26.1m$30.9m1.18
Q1 2025$24.8m$18.8m0.76
Q2 2025$65.2m$34.9m0.54
Q3 2025$171.8m$74.8m0.44

Biggest buyers

Lombard Odier Asset Management (Europe) Ltd New +6,494,000+6.5m
DEERFIELD MANAGEMENT COMPANY, L.P. New +1,979,669+2.0m
MARSHALL WACE, LLP Added +945,729+945.7k
CITADEL ADVISORS LLC Added +907,084+907.1k
AMERICAN CENTURY COMPANIES INC Added +899,476+899.5k
Pictet Asset Management Holding SA Added +784,484+784.5k
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New +750,000+750.0k
NOMURA HOLDINGS INC Added +701,237+701.2k
JPMORGAN CHASE & CO Added +693,958+694.0k
D. E. Shaw & Co., Inc. New +630,938+630.9k

Biggest sellers

T. Rowe Price Investment Management, Inc. Reduced -2,891,792-2.9m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -2,485,000-2.5m
BVF INC/IL Sold out -1,913,385-1.9m
MILLENNIUM MANAGEMENT LLC Reduced -1,869,957-1.9m
Bellevue Group AG Reduced -1,608,747-1.6m
Deep Track Capital, LP Reduced -1,083,400-1.1m
Woodline Partners LP Sold out -732,813-732.8k
TWO SIGMA ADVISERS, LP Reduced -594,500-594.5k
AXA S.A. Sold out -566,883-566.9k
UBS Group AG Reduced -482,333-482.3k

Biggest calls

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New $39.2m599.1k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $32.7m500.0k shares
Balyasny Asset Management L.P. Added $17.0m260.4k shares
GOLDMAN SACHS GROUP INC New $10.9m166.3k shares
BARCLAYS PLC Added $10.1m154.6k shares
CITADEL ADVISORS LLC Added $7.2m109.8k shares
DIADEMA PARTNERS LP New $6.5m100.0k shares
ROYAL BANK OF CANADA New $6.0m91.2k shares
SIMPLEX TRADING, LLC Reduced $4.8m73.7k shares
DLD Asset Management, LP New $4.7m71.5k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $13.5m206.7k shares
GOLDMAN SACHS GROUP INC New $10.5m161.2k shares
BARCLAYS PLC Added $9.6m146.9k shares
ROYAL BANK OF CANADA Reduced $9.1m138.4k shares
CITADEL ADVISORS LLC Added $5.0m76.1k shares
SIMPLEX TRADING, LLC Added $4.9m75.5k shares
JANE STREET GROUP, LLC Added $4.5m68.5k shares
Squarepoint Ops LLC New $3.7m56.1k shares
BANK OF AMERICA CORP /DE/ New $2.9m45.0k shares
Caption Management, LLC Reduced $2.9m45.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Capital World Investors 13G · institution +1.7 pts · filed 2026-05-14 12.8% +1.7 pts 21.2m≈ $1.7bn 2026-05-14
BlackRock, Inc. 13G · institution filed 2025-04-17 5.7% 9.1m≈ $718.9m 2025-04-17
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.0% new 8.3m≈ $661.7m 2026-04-30

Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (3.7%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Insider purchases and sales in Q3 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
20020Q4 23: 0 buyingQ4 23: 8 sellingQ1 24: 0 buyingQ1 24: 10 sellingQ1 24Q2 24: 0 buyingQ2 24: 4 sellingQ3 24: 0 buyingQ3 24: 3 sellingQ3 24Q4 24: 1 buyingQ4 24: 3 sellingQ1 25: 0 buyingQ1 25: 10 sellingQ1 25Q2 25: 1 buyingQ2 25: 3 sellingQ3 25: 0 buyingQ3 25: 14 sellingQ3 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20230—8$15.0m$14.9m
Q1 20240—10$7.1m$897.3k
Q2 20240—4$1.1m$900.9k
Q3 20240—3$829.8k$829.8k
Q4 20241$181.1k3$811.0k$809.0k
Q1 20250—10$5.2m$1.5m
Q2 20251$477.9k3$216.4k—
Q3 20250—14$42.6m$29.3m
DateInsiderTradeSharesPrice ValueTheir holding
2025-09-30 Geary Richard S EVP, Chief Development Officer Sold plan 57,900 $65.24 $3.8m57.9k shares -42%
2025-09-30 HOUGEN ELIZABETH L EVP, Finance & CFO Sold plan 49,800 $65.26 $3.2m49.8k shares -31%
2025-09-30 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 14,827 $64.68 $959.0k14.8k shares -21%
2025-09-29 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 10,473 $64.54 $675.9k10.5k shares -16%
2025-09-12 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 1,700 $64.58 $109.8k1.7k shares -3%
2025-09-09 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 21,000 $64.56 $1.4m21.0k shares -27%
2025-09-09 Baroldi Joseph EVP, Chief Business Officer Sold plan 11,950 $62.16 $742.8k11.9k shares -27%
2025-09-05 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 6,000 $59.60 $357.6k6.0k shares -7%
2025-09-05 Baroldi Joseph EVP, Chief Business Officer Sold plan 250 $62.00 $15.5k250 shares -1%
2025-09-03 Monia Brett P Chief Executive Officer, director Sold 203,814 $60.32 $12.3m203.8k shares -53%
2025-09-03 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 76,850 $60.97 $4.7m76.8k shares -91%
2025-09-03 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 33,909 $60.62 $2.1m33.9k shares -25%
2025-09-03 Baroldi Joseph EVP, Chief Business Officer Sold plan 32,800 $59.34 $1.9m32.8k shares -66%
2025-09-03 KLEIN JOSEPH III Director · by Trust Sold plan 28,000 $60.00 $1.7m28.0k shares -100%
2025-09-03 KLEIN JOSEPH III Director · by Trust Sold plan 28,000 $60.00 $1.7m28.0k shares -100%
2025-09-03 Schneider Eugene EVP, Chf Clinical Develop Ofcr Sold plan 19,658 $60.81 $1.2m19.7k shares -28%
2025-09-03 LOSCALZO JOSEPH Director Sold 16,000 $60.15 $962.4k16.0k shares -31%
2025-09-03 WENDER JOSEPH H Director · by Trust Sold plan 11,200 $60.14 $673.6k11.2k shares -9%
2025-09-03 WENDER JOSEPH H Director · by Trust Sold plan 11,200 $60.14 $673.6k11.2k shares -9%
2025-09-03 Devers Shannon L. EVP, Chief Human Resources Ofc Sold plan 3,162 $61.02 $192.9k3.2k shares -17%
2025-09-02 PARSHALL B LYNNE Director Sold plan 20,000 $50.91 $1.0m20.0k shares -23%
2025-09-02 WENDER JOSEPH H Director · by Trust Sold plan 16,800 $55.87 $938.6k16.8k shares -12%
2025-09-02 WENDER JOSEPH H Director · by Trust Sold plan 16,800 $55.87 $938.6k16.8k shares -12%
2025-09-02 O'NEIL PATRICK R. EVP CLO & General Counsel Sold plan 13,050 $54.51 $711.4k13.1k shares -19%
2025-09-02 Swayze Eric EVP Research Sold plan 11,130 $49.67 $552.9k11.1k shares -23%
2025-09-02 Geary Richard S EVP, Chief Development Officer Sold plan 10,000 $50.37 $503.7k10.0k shares -11%
2025-09-02 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 5,000 $49.14 $245.7k5.0k shares -5%
2025-08-22 Diaz Allene M. Director Sold plan 1,427 $42.53 $60.7k1.4k shares -7%
2025-08-18 BENNETT C FRANK EVP, Chief Scientific Officer Sold plan 10,000 $43.98 $439.8k10.0k shares -10%
2025-08-06 PARSHALL B LYNNE Director Sold plan 5,000 $41.93 $209.7k5.0k shares -6%

The latest 30 of 34 trades.

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q3 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.08% of their portfolio BOSTON, MA 23,689,03823.7m $1.5bn $1.5bn 0.08% Added +46.0k +46,048
2 VANGUARD GROUP INC 0.02% of their portfolio Valley Forge, PA 16,481,73016.5m $1.1bn $1.1bn 0.02% Reduced -233.1k -233,116
3 T. Rowe Price Investment Management, Inc. 0.53% of their portfolio BALTIMORE, MD 13,156,92913.2m $860.7m $860.7m 0.53% Reduced -2.9m -2,891,792
4 Capital World Investors 0.11% of their portfolio LOS ANGELES, CA 12,722,72812.7m $832.3m $832.3m 0.11% Added +182.5k +182,540
5 BlackRock, Inc. 0.01% of their portfolio New York, NY 10,447,94010.4m $683.5m $683.5m 0.01% Reduced -449.0k -448,997
6 WELLINGTON MANAGEMENT GROUP LLP 0.08% of their portfolio Boston, MA 6,588,8116.6m $431.0m $431.0m 0.08% Added +243.0k +243,035
7 Lombard Odier Asset Management (Europe) Ltd 0.46% of their portfolio LONDON, X0 6,494,0006.5m $9.0m $9.0m 0.46% New
8 Bellevue Group AG 8.49% of their portfolio ZURICH, V8 6,244,4516.2m $408.5m $408.5m 8.49% Reduced -1.6m -1,608,747
9 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 4,388,6514.4m $287.1m $287.1m 0.01% Reduced -141.7k -141,747
10 Deep Track Capital, LP 6.95% of their portfolio GREENWICH, CT 3,808,1443.8m $249.1m $249.1m 6.95% Reduced -1.1m -1,083,400
11 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 3,066,2893.1m $200.6m $200.6m 0.01% Added +175.2k +175,194
12 Tweedy, Browne Co LLC 16.48% of their portfolio Stamford, CT 2,901,2162.9m $189.8m $189.8m 16.48% Added +9.3k +9,268
13 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 2,729,6852.7m $178.6m $178.6m 0.02% Reduced -396.4k -396,388
14 CITADEL ADVISORS LLC 0.13% of their portfolio MIAMI, FL 2,402,0652.4m $157.1m $157.1m 0.13% Added +907.1k +907,084
15 TWO SIGMA ADVISERS, LP 0.27% of their portfolio NEW YORK, NY 2,073,1112.1m $135.6m $135.6m 0.27% Reduced -594.5k -594,500
16 DEERFIELD MANAGEMENT COMPANY, L.P. 1.98% of their portfolio New York, NY 1,979,6692.0m $129.5m $129.5m 1.98% New
17 TWO SIGMA INVESTMENTS, LP 0.16% of their portfolio NEW YORK, NY 1,575,9431.6m $103.1m $103.1m 0.16% Reduced -212.4k -212,424
18 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 1,519,9511.5m $99.4m $99.4m 0.02% Added +32.1k +32,133
19 Pictet Asset Management Holding SA 0.09% of their portfolio CAROUGE, V8 1,393,1241.4m $90.5m $90.5m 0.09% Added +784.5k +784,484
20 AMERICAN CENTURY COMPANIES INC 0.05% of their portfolio KANSAS CITY, MO 1,372,2251.4m $89.8m $89.8m 0.05% Added +899.5k +899,476
21 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.14% of their portfolio Boston, MA 1,315,0001.3m $86.0m $86.0m 0.14% Reduced -2.5m -2,485,000
22 ROYAL BANK OF CANADA 0.01% of their portfolio TORONTO, A6 1,226,6241.2m $80.2m $80.2m 0.01% Reduced -373.2k -373,200
23 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,180,3161.2m $77.2m $77.2m 0.00% Reduced -181.9k -181,893
24 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio NEW YORK, NY 1,154,1661.2m $75.5m $75.5m 0.02% Added +363.1k +363,094
25 MACQUARIE GROUP LTD 0.09% of their portfolio Sydney, NSW 2000, C3 1,131,9361.1m $74.1m $74.1m 0.09% Reduced -302.1k -302,137
26 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,088,9361.1m $71.2m $71.2m 0.00% Added +694.0k +693,958
27 Vestal Point Capital, LP 3.19% of their portfolio NEW YORK, NY 1,075,0001.1m $70.3m $70.3m 3.19% Added +575.0k +575,000
28 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.18% of their portfolio Paris, I0 1,059,7211.1m $69.3m $69.3m 0.18% Reduced -291.2k -291,158
29 UBS Group AG 0.01% of their portfolio ZURICH, V8 1,046,9901.0m $68.5m $68.5m 0.01% Reduced -482.3k -482,333
30 Polar Capital Holdings Plc 0.33% of their portfolio London, X0 1,033,6221.0m $67.6m $67.6m 0.33% Added +33.6k +33,622
31 TD Asset Management Inc 0.05% of their portfolio Toronto, A6 960,272960.3k $62.8m $62.8m 0.05% Reduced -144.4k -144,418
32 MARSHALL WACE, LLP 0.07% of their portfolio LONDON, X0 958,829958.8k $62.7m $62.7m 0.07% Added +945.7k +945,729
33 Artisan Partners Limited Partnership 0.08% of their portfolio Milwaukee, WI 890,072890.1k $58.2m $58.2m 0.08% Added +535.1k +535,110
34 Connor, Clark & Lunn Investment Management Ltd. 0.18% of their portfolio VANCOUVER, A1 878,155878.2k $57.4m $57.4m 0.18% Added +612.4k +612,362
35 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.02% of their portfolio Boston, MA 862,593862.6k $56.4m $56.4m 0.02% Added +343.4k +343,409
36 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 855,295855.3k $56.0m $56.0m 0.00% Reduced -140.6k -140,595
37 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 844,943844.9k $55.3m $55.3m 0.01% Added +30.7k +30,693
38 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.18% of their portfolio JUPITER, FL 803,047803.0k $52.5m $52.5m 0.18% Reduced -51.6k -51,587
39 MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio NEW YORK, NY 779,570779.6k $51.0m $51.0m 0.04% Reduced -1.9m -1,869,957
40 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 777,570777.6k $50.9m $50.9m 0.01% Reduced -370 -370
41 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 765,822765.8k $50.1m $50.1m 0.01% Added +397.7k +397,703
42 Balyasny Asset Management L.P. 0.10% of their portfolio Chicago, IL 760,111760.1k $49.7m $49.7m 0.10% Reduced -8.5k -8,537
43 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.60% of their portfolio Boston, MA 750,000750.0k $49.1m $49.1m 1.60% New
44 BANK OF MONTREAL /CAN/ 0.02% of their portfolio TORONTO, A6 747,402747.4k $48.9m $48.9m 0.02% Added +264.1k +264,113
45 NOMURA HOLDINGS INC 0.22% of their portfolio TOKYO, M0 733,398733.4k $48.0m $48.0m 0.22% Added +701.2k +701,237
46 BARCLAYS PLC 0.02% of their portfolio LONDON, X0 714,048714.0k $46.7m $46.7m 0.02% Added +130.8k +130,782
47 ARK Investment Management LLC 0.25% of their portfolio ST. PETERSBURG, FL 631,215631.2k $41.3m $41.3m 0.25% Reduced -269.1k -269,103
48 D. E. Shaw & Co., Inc. 0.03% of their portfolio New York, NY 630,938630.9k $41.3m $41.3m 0.03% New
49 ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.03% of their portfolio BOSTON, MA 630,136630.1k $41.2m $41.2m 0.03% New
50 Candriam S.C.A. 0.21% of their portfolio STRASSEN, N4 611,237611.2k $40.0m $40.0m 0.21% Reduced -113.5k -113,503
51 BAKER BROS. ADVISORS LP 0.27% of their portfolio NEW YORK, NY 566,798566.8k $37.1m $37.1m 0.27% New
52 GROUPAMA ASSET MANAGMENT 0.54% of their portfolio PARIS, I0 561,777561.8k $36.8m $36.8m 0.54% Reduced -99.2k -99,180
53 TANG CAPITAL MANAGEMENT LLC 1.39% of their portfolio SAN DIEGO, CA 550,000550.0k $36.0m $36.0m 1.39% Added +400.0k +400,000
54 Eversept Partners, LP 2.70% of their portfolio NEW YORK, NY 538,661538.7k $35.2m $35.2m 2.70% Reduced -50.2k -50,239
55 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 532,114532.1k $34.8m $34.8m 0.01% Added +4.9k +4,926
56 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 519,070519.1k $34.0m $34.0m 0.01% Added +262.8k +262,835
57 Hudson Bay Capital Management LP 0.20% of their portfolio STAMFORD, CT 515,000515.0k $33.7m $33.7m 0.20% Reduced -235.0k -235,000
58 GROUPAMA ASSET MANAGMENT 0.01% of their portfolio PARIS, I0 500,000500.0k $685.3k $685.3k 0.01% Unchanged
59 RENAISSANCE TECHNOLOGIES LLC 0.04% of their portfolio NEW YORK, NY 486,714486.7k $31.8m $31.8m 0.04% Added +216.0k +216,000
60 PINNACLE ASSOCIATES LTD 0.42% of their portfolio NEW YORK, NY 481,751481.8k $31.5m $31.5m 0.42% Reduced -12.8k -12,788
61 TEACHER RETIREMENT SYSTEM OF TEXAS 0.12% of their portfolio AUSTIN, TX 473,945473.9k $31.0m $31.0m 0.12% Reduced -194.3k -194,328
62 C WorldWide Group Holding A/S 0.43% of their portfolio COPENHAGEN, G7 426,000426.0k $27.9m $27.9m 0.43% Reduced -24.0k -24,000
63 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.04% of their portfolio BALA CYNWYD, PA 420,950420.9k $27.5m $27.5m 0.04% New
64 BOONE CAPITAL MANAGEMENT LLC 8.96% of their portfolio ATLANTA, GA 417,833417.8k $27.3m $27.3m 8.96% New
65 Nuveen, LLC 0.01% of their portfolio CHARLOTTE, NC 415,618415.6k $27.2m $27.2m 0.01% Added +170.5k +170,533
66 Ikarian Capital, LLC 5.49% of their portfolio DALLAS, TX 415,163415.2k $27.2m $27.2m 5.49% New
67 AXA Investment Managers S.A. 0.07% of their portfolio PUTEAUX, I0 406,451406.5k $26.6m $26.6m 0.07% First filing
68 Squarepoint Ops LLC 0.05% of their portfolio NEW YORK, NY 383,792383.8k $25.1m $25.1m 0.05% Added +249.4k +249,397
69 BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio PARIS, I0 383,226383.2k $25.1m $25.1m 0.02% Added +205.5k +205,464
70 JANE STREET GROUP, LLC 0.03% of their portfolio NEW YORK, NY 365,070365.1k $23.9m $23.9m 0.03% New
71 Man Group plc 0.04% of their portfolio LONDON, X0 333,820333.8k $21.8m $21.8m 0.04% Added +324.9k +324,851
72 Legal & General Group Plc 0.00% of their portfolio London, X0 319,565319.6k $20.9m $20.9m 0.00% Reduced -84.8k -84,801
73 Assenagon Asset Management S.A. 0.03% of their portfolio SENNINGERBERG, N4 312,297312.3k $20.4m $20.4m 0.03% Added +294.6k +294,643
74 Alyeska Investment Group, L.P. 0.06% of their portfolio CHICAGO, IL 311,258311.3k $20.4m $20.4m 0.06% Added +152.2k +152,250
75 Rhenman & Partners Asset Management AB 2.24% of their portfolio Stockholm, V7 310,000310.0k $20.3m $20.3m 2.24% Added +128.0k +128,000
76 Swiss National Bank 0.01% of their portfolio ZURICH, V8 293,100293.1k $19.2m $19.2m 0.01% Added +4.5k +4,500
77 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 285,293285.3k $18.7m $18.7m 0.00% Added +75.4k +75,436
78 SECTOR GAMMA AS 4.40% of their portfolio OSLO, Q8 270,963271.0k $17.7m $17.7m 4.40% Reduced -14.9k -14,879
79 GW&K Investment Management, LLC 0.15% of their portfolio BOSTON, MA 264,007264.0k $17.3m $17.3m 0.15% Reduced -184.8k -184,823
80 ALGERT GLOBAL LLC 0.28% of their portfolio SAN FRANCISCO, CA 252,281252.3k $16.5m $16.5m 0.28% Added +214.2k +214,191
81 Privium Fund Management B.V. 2.93% of their portfolio AMSTERDAM, P7 248,894248.9k $16.3m $16.3m 2.93% Reduced -18.7k -18,700
82 RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio ST. PETERSBURG, FL 240,424240.4k $15.7m $15.7m 0.01% Added +29.8k +29,832
83 Jain Global LLC 0.19% of their portfolio NEW YORK, NY 225,739225.7k $14.8m $14.8m 0.19% Added +218.5k +218,544
84 Orion Investment Co 4.67% of their portfolio ST. LOUIS, MO 224,705224.7k $14.7m $14.7m 4.67% Added +7.3k +7,335
85 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 215,845215.8k $14.1m $14.1m 0.01% Added +13.9k +13,852
86 Trexquant Investment LP 0.15% of their portfolio STAMFORD, CT 215,121215.1k $14.1m $14.1m 0.15% Added +86.3k +86,252
87 STIFEL FINANCIAL CORP 0.01% of their portfolio ST. LOUIS, MO 202,628202.6k $13.3m $13.3m 0.01% Added +6.3k +6,271
88 Schonfeld Strategic Advisors LLC 0.09% of their portfolio NEW YORK, NY 200,839200.8k $13.1m $13.1m 0.09% Reduced -248.4k -248,367
89 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 197,434197.4k $12.9m $12.9m 0.02% Added +47.6k +47,595
90 TOCQUEVILLE ASSET MANAGEMENT L.P. 0.18% of their portfolio New York, NY 193,045193.0k $12.6m $12.6m 0.18% Added +5.7k +5,700
91 GREAT LAKES ADVISORS, LLC 0.10% of their portfolio CHICAGO, IL 186,950186.9k $12.2m $12.2m 0.10% Reduced -212.7k -212,696
92 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 182,061182.1k $11.9m $11.9m 0.01% Added +462 +462
93 Cinctive Capital Management LP 0.57% of their portfolio New York, NY 173,819173.8k $11.4m $11.4m 0.57% New
94 Sonora Investment Management Group, LLC 0.79% of their portfolio TUCSON, AZ 169,808169.8k $11.1m $11.1m 0.79% Added +6.6k +6,636
95 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 168,222168.2k $11.0m $11.0m 0.01% Added +81.2k +81,250
96 Sicart Associates LLC 2.91% of their portfolio NEW YORK, NY 164,318164.3k $10.7m $10.7m 2.91% Reduced -21.0k -20,978
97 BOOTHBAY FUND MANAGEMENT, LLC 0.27% of their portfolio NEW YORK, NY 163,462163.5k $10.7m $10.7m 0.27% New
98 Capricorn Fund Managers Ltd 3.58% of their portfolio LONDON, X0 162,800162.8k $10.7m $10.7m 3.58% New
99 Aquatic Capital Management LLC 0.19% of their portfolio CHICAGO, IL 159,045159.0k $10.4m $10.4m 0.19% First filing
100 EDMOND DE ROTHSCHILD HOLDING S.A. 0.16% of their portfolio CHAMBESY, V8 156,690156.7k $10.3m $10.3m 0.16% Reduced -40.9k -40,910