Vault-13

INSMED INC INSM

COM PAR $.01 · Common Stock · CUSIP 457669307 · ISIN US4576693075

674 institutional holders -3 vs Q4 2025
221,580,212221.6m shares reported held*
102.2% of all shares outstanding*
$35.8bnreported value*
89 new 288 added 215 reduced 92 sold out net bought ≈ $862.5m (+5.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($61.1m this quarter). Holder counts are more reliable. Shares outstanding: 216.8m as of 2026-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $161.60. Options: 23 managers hold calls ($352.2m notional), 22 hold puts ($231.9m).

Trends to Q1 2026

Institutional holders

Managers reporting a position, each quarter

0250500750Q3 22: 239Q4 22: 226Q1 23: 232Q2 23: 225Q3 23: 254Q4 23: 273Q1 24: 290Q2 24: 380Q3 24: 417Q4 24: 441Q1 25: 444Q2 25: 518Q3 25: 566Q4 25: 677Q1 26: 674674Q3 22Q3 23Q3 24Q3 25Q1 26
Numbers
QuarterHolders
Q3 2022239
Q4 2022226
Q1 2023232
Q2 2023225
Q3 2023254
Q4 2023273
Q1 2024290
Q2 2024380
Q3 2024417
Q4 2024441
Q1 2025444
Q2 2025518
Q3 2025566
Q4 2025677
Q1 2026674

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
5000500Q2 24: 257 bought or addedQ2 24: 137 cut or sold outQ3 24: 257 bought or addedQ3 24: 152 cut or sold outQ3 24Q4 24: 226 bought or addedQ4 24: 188 cut or sold outQ1 25: 236 bought or addedQ1 25: 195 cut or sold outQ1 25Q2 25: 290 bought or addedQ2 25: 242 cut or sold outQ3 25: 320 bought or addedQ3 25: 264 cut or sold outQ3 25Q4 25: 403 bought or addedQ4 25: 263 cut or sold outQ1 26: 377 bought or addedQ1 26: 307 cut or sold outQ1 26
Numbers
QuarterBought or addedCut or sold out
Q2 2024257137
Q3 2024257152
Q4 2024226188
Q1 2025236195
Q2 2025290242
Q3 2025320264
Q4 2025403263
Q1 2026377307

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200m$400m$600m$800mQ2 25 calls: $330.0mQ2 25 puts: $356.0mQ2 25P/C 1.08Q3 25 calls: $640.6mQ3 25 puts: $658.6mQ3 25P/C 1.03Q4 25 calls: $673.7mQ4 25 puts: $741.7mQ4 25P/C 1.10Q1 26 calls: $352.2mQ1 26 puts: $231.9mQ1 26P/C 0.66
Numbers
QuarterCallsPutsP/C
Q2 2025$330.0m$356.0m1.08
Q3 2025$640.6m$658.6m1.03
Q4 2025$673.7m$741.7m1.10
Q1 2026$352.2m$231.9m0.66

Biggest buyers

FMR LLC Added +3,232,231+3.2m
Artisan Partners Limited Partnership Added +1,683,552+1.7m
BlackRock, Inc. Added +1,613,094+1.6m
Capital World Investors New +1,362,291+1.4m
D. E. Shaw & Co., Inc. Added +1,274,830+1.3m
Paradigm Biocapital Advisors LP New +1,254,488+1.3m
AMERIPRISE FINANCIAL INC Added +1,088,861+1.1m
WESTFIELD CAPITAL MANAGEMENT CO LP Added +1,035,938+1.0m
CITADEL ADVISORS LLC Added +1,025,276+1.0m
JPMORGAN CHASE & CO Added +950,987+951.0k

Biggest sellers

Darwin Global Management, Ltd. Reduced -4,128,093-4.1m
Orbis Allan Gray Ltd Reduced -2,307,133-2.3m
Invesco Ltd. Reduced -1,005,449-1.0m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -946,659-946.7k
Jefferies Financial Group Inc. Reduced -922,839-922.8k
Holocene Advisors, LP Sold out -801,165-801.2k
TWO SIGMA INVESTMENTS, LP Reduced -725,139-725.1k
TWO SIGMA ADVISERS, LP Sold out -395,000-395.0k
JANUS HENDERSON GROUP PLC Reduced -381,251-381.3k
Duquesne Family Office LLC Reduced -327,662-327.7k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $81.0m495.3k shares
CITADEL ADVISORS LLC Reduced $62.1m379.7k shares
JANE STREET GROUP, LLC Reduced $54.7m334.5k shares
CITIGROUP INC Added $32.7m200.0k shares
Squarepoint Ops LLC Added $22.6m138.3k shares
MILLENNIUM MANAGEMENT LLC New $22.5m137.3k shares
JPMORGAN CHASE & CO Added $16.1m105.0k shares
Eversept Partners, LP New $15.4m94.0k shares
Caption Management, LLC Reduced $7.1m43.2k shares
NOMURA HOLDINGS INC Reduced $4.9m30.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $67.0m410.0k shares
Artia Global Partners LP Reduced $45.7m279.7k shares
JANE STREET GROUP, LLC Reduced $17.9m109.7k shares
Caption Management, LLC Reduced $16.4m100.3k shares
Jefferies Financial Group Inc. Unchanged $16.3m99.9k shares
Parallax Volatility Advisers, L.P. Unchanged $14.4m102.3k shares
683 Capital Management, LLC New $9.8m60.0k shares
CITADEL ADVISORS LLC Reduced $8.3m50.8k shares
NOMURA HOLDINGS INC Added $8.2m50.0k shares
Walleye Capital LLC Added $4.4m26.8k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +1.3 pts · filed 2026-08-06 7.4% +1.3 pts 16.1m≈ $1.7bn 2026-08-06
BlackRock, Inc. 13G · institution +1.5 pts · filed 2026-01-21 6.6% +1.5 pts 14.1m≈ $1.5bn 2026-01-21
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.3% new 11.5m≈ $1.2bn 2026-04-30

Fell to 5% or below in the last year: Darwin Global Management, Ltd. (3.0%, 2026-08-14), JPMORGAN CHASE & CO (4.7%, 2026-07-22), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), PRICE T ROWE ASSOCIATES INC /MD/ (3.3%, 2025-11-14)

Insider purchases and sales in Q1 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q2 24: 0 buyingQ2 24: 7 sellingQ3 24: 0 buyingQ3 24: 3 sellingQ3 24Q4 24: 0 buyingQ4 24: 1 sellingQ1 25: 0 buyingQ1 25: 7 sellingQ1 25Q2 25: 1 buyingQ2 25: 7 sellingQ3 25: 0 buyingQ3 25: 7 sellingQ3 25Q4 25: 0 buyingQ4 25: 7 sellingQ1 26: 0 buyingQ1 26: 6 sellingQ1 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20240—7$28.7m$26.9m
Q3 20240—3$25.6m$18.4m
Q4 20240—1$3.7m$3.7m
Q1 20250—7$53.0m$32.1m
Q2 20251$201.7k7$54.6m$49.9m
Q3 20250—7$65.6m$57.2m
Q4 20250—7$44.3m$16.7m
Q1 20260—6$45.2m$40.6m
DateInsiderTradeSharesPrice ValueTheir holding
2026-03-30 Smith Michael Alexander Chief Legal Officer Sold plan 19,638 $150.98 $3.0m19.6k shares -28%
2026-03-19 Lewis William Chair and CEO, director Sold plan 10,699 $143.52 $1.5m10.7k shares -3%
2026-03-05 Lewis William Chair and CEO, director Sold plan 10,699 $146.03 $1.6m10.7k shares -3%
2026-02-24 Smith Michael Alexander Chief Legal Officer Sold plan 24,774 $155.77 $3.9m24.8k shares -32%
2026-02-19 Lewis William Chair and CEO, director Sold plan 10,699 $150.97 $1.6m10.7k shares -3%
2026-02-09 Lewis William Chair and CEO, director Sold plan 13,396 $147.79 $2.0m13.4k shares -4%
2026-02-05 Flammer Martina M.D. Chief Medical Officer Sold plan 869 $152.44 $132.5k869 shares -1%
2026-02-03 Lewis William Chair and CEO, director Sold 3,009 $156.34 $470.4k3.0k shares -1%
2026-02-03 Flammer Martina M.D. Chief Medical Officer Sold plan 795 $155.77 $123.8k795 shares -1%
2026-02-03 Adsett Roger Chief Operating Officer Sold 791 $156.17 $123.5k791 shares -1%
2026-02-03 Bonstein Sara Chief Financial Officer Sold 748 $156.34 $116.9k748 shares -1%
2026-02-03 Smith Michael Alexander Chief Legal Officer Sold 640 $156.27 $100.0k640 shares -1%
2026-02-02 Flammer Martina M.D. Chief Medical Officer Sold plan 7,982 $154.59 $1.2m8.0k shares -9%
2026-01-20 Lewis William Chair and CEO, director Sold plan 10,699 $158.93 $1.7m10.7k shares -3%
2026-01-12 Lewis William Chair and CEO, director Sold plan 19,215 $169.00 $3.2m19.2k shares -6%
2026-01-09 Flammer Martina M.D. Chief Medical Officer Sold plan 1,887 $186.19 $351.3k1.9k shares -2%
2026-01-08 Flammer Martina M.D. Chief Medical Officer Sold plan 4,911 $174.07 $854.9k4.9k shares -5%
2026-01-08 Lewis William Chair and CEO, director Sold 3,223 $174.17 $561.3k3.2k shares -1%
2026-01-08 Adsett Roger Chief Operating Officer Sold 2,059 $174.17 $358.6k2.1k shares -2%
2026-01-08 Bonstein Sara Chief Financial Officer Sold 1,447 $174.17 $252.0k1.4k shares -2%
2026-01-08 Smith Michael Alexander Chief Legal Officer Sold 1,053 $174.17 $183.4k1.1k shares -2%
2026-01-07 Lewis William Chair and CEO, director Sold 2,357 $175.07 $412.6k2.4k shares -1%
2026-01-07 Bonstein Sara Chief Financial Officer Sold 1,678 $175.07 $293.8k1.7k shares -2%
2026-01-07 Flammer Martina M.D. Chief Medical Officer Sold plan 1,434 $175.84 $252.2k1.4k shares -2%
2026-01-07 Adsett Roger Chief Operating Officer Sold 802 $175.07 $140.4k802 shares -1%
2026-01-07 Smith Michael Alexander Chief Legal Officer Sold 709 $175.07 $124.1k709 shares -1%
2026-01-06 Flammer Martina M.D. Chief Medical Officer Sold plan 10,185 $173.80 $1.8m10.2k shares -10%
2026-01-06 Lewis William Chair and CEO, director Sold 4,096 $173.33 $710.0k4.1k shares -1%
2026-01-06 Bonstein Sara Chief Financial Officer Sold 1,517 $173.33 $262.9k1.5k shares -2%
2026-01-06 Adsett Roger Chief Operating Officer Sold 1,429 $173.33 $247.7k1.4k shares -1%

The latest 30 of 33 trades.

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JPMORGAN CHASE & CO 0.25% of their portfolio NEW YORK, NY 24,150,49924.2m $3.7bn $3.7bn 0.25% Added +951.0k +950,987
2 Darwin Global Management, Ltd. 68.33% of their portfolio ST. HELIER, Y9 16,805,18416.8m $2.6bn $2.6bn 68.33% Reduced -4.1m -4,128,093
3 BlackRock, Inc. 0.05% of their portfolio New York, NY 16,678,14616.7m $2.7bn $2.7bn 0.05% Added +1.6m +1,613,094
4 FMR LLC 0.11% of their portfolio BOSTON, MA 13,160,16713.2m $2.2bn $2.2bn 0.11% Added +3.2m +3,232,231
5 VANGUARD PORTFOLIO MANAGEMENT LLC 0.09% of their portfolio MALVERN, PA 10,371,80210.4m $1.7bn $1.7bn 0.09% First filing
6 VANGUARD CAPITAL MANAGEMENT LLC 0.04% of their portfolio MALVERN, PA 9,642,1319.6m $1.6bn $1.6bn 0.04% First filing
7 BAKER BROS. ADVISORS LP 6.97% of their portfolio NEW YORK, NY 7,421,1117.4m $1.2bn $1.2bn 6.97% Added +828.4k +828,365
8 Artisan Partners Limited Partnership 1.74% of their portfolio Milwaukee, WI 6,527,3016.5m $1.1bn $1.1bn 1.74% Added +1.7m +1,683,552
9 Invesco Ltd. 0.10% of their portfolio ATLANTA, GA 6,512,8896.5m $1.1bn $1.1bn 0.10% Reduced -1.0m -1,005,449
10 D. E. Shaw & Co., Inc. 0.72% of their portfolio New York, NY 5,625,8255.6m $919.9m $919.9m 0.72% Added +1.3m +1,274,830
11 Capital International Investors 0.21% of their portfolio Los Angeles, CA 5,595,1945.6m $914.9m $914.9m 0.21% Added +443.5k +443,523
12 STATE STREET CORP 0.03% of their portfolio BOSTON, MA 5,551,6995.6m $907.8m $907.8m 0.03% Added +350.0k +349,955
13 RTW INVESTMENTS, LP 7.88% of their portfolio NEW YORK, NY 4,842,8804.8m $791.9m $791.9m 7.88% Added +1 +1
14 GEODE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio BOSTON, MA 4,450,3894.5m $733.3m $733.3m 0.05% Added +151.3k +151,337
15 PRICE T ROWE ASSOCIATES INC /MD/ 0.06% of their portfolio BALTIMORE, MD 3,092,8073.1m $505.7m $505.7m 0.06% Reduced -946.7k -946,659
16 AMERIPRISE FINANCIAL INC 0.12% of their portfolio MINNEAPOLIS, MN 3,057,7183.1m $500.0m $500.0m 0.12% Added +1.1m +1,088,861
17 FRANKLIN RESOURCES INC 0.10% of their portfolio San Mateo, CA 2,617,2512.6m $428.0m $428.0m 0.10% Reduced -138.3k -138,285
18 CITADEL ADVISORS LLC 0.25% of their portfolio MIAMI, FL 2,182,5712.2m $356.9m $356.9m 0.25% Added +1.0m +1,025,276
19 NWI MANAGEMENT LP 10.14% of their portfolio NEW YORK, NY 2,028,0002.0m $331.6m $331.6m 10.14% Added +51.1k +51,080
20 Orbis Allan Gray Ltd 1.29% of their portfolio HamiltoN, D0 1,872,8241.9m $306.2m $306.2m 1.29% Reduced -2.3m -2,307,133
21 UBS Group AG 0.05% of their portfolio ZURICH, V8 1,737,4811.7m $284.1m $284.1m 0.05% Reduced -130.2k -130,154
22 BANK OF AMERICA CORP /DE/ 0.02% of their portfolio CHARLOTTE, NC 1,502,2811.5m $245.7m $245.7m 0.02% Reduced -223.4k -223,400
23 Integral Health Asset Management, LLC 12.98% of their portfolio New York, NY 1,500,0001.5m $245.3m $245.3m 12.98% Added +250.0k +250,000
24 WESTFIELD CAPITAL MANAGEMENT CO LP 1.01% of their portfolio BOSTON, MA 1,468,4591.5m $240.1m $240.1m 1.01% Added +1.0m +1,035,938
25 SEI INVESTMENTS CO 0.21% of their portfolio OAKS, PA 1,395,7941.4m $228.2m $228.2m 0.21% Added +505.6k +505,624
26 Capital World Investors 0.03% of their portfolio LOS ANGELES, CA 1,362,2911.4m $222.7m $222.7m 0.03% New
27 VANGUARD FIDUCIARY TRUST CO 0.06% of their portfolio MALVERN, PA 1,354,5161.4m $221.5m $221.5m 0.06% First filing
28 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,331,5421.3m $217.7m $217.7m 0.01% Reduced -300.4k -300,364
29 NORTHERN TRUST CORP 0.03% of their portfolio CHICAGO, IL 1,294,0001.3m $211.6m $211.6m 0.03% Added +55.6k +55,562
30 Castle Hook Partners LP 4.20% of their portfolio NEW YORK, NY 1,269,7541.3m $207.6m $207.6m 4.20% Added +16.2k +16,186
31 Bank of New York Mellon Corp 0.04% of their portfolio NEW YORK, NY 1,262,7491.3m $206.5m $206.5m 0.04% Reduced -127.3k -127,293
32 Paradigm Biocapital Advisors LP 4.19% of their portfolio NEW YORK, NY 1,254,4881.3m $205.1m $205.1m 4.19% New
33 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.04% of their portfolio NEW YORK, NY 1,215,0251.2m $198.7m $198.7m 0.04% Added +271.7k +271,719
34 MILLENNIUM MANAGEMENT LLC 0.14% of their portfolio NEW YORK, NY 1,157,7861.2m $189.3m $189.3m 0.14% Reduced -153.9k -153,868
35 Duquesne Family Office LLC 6.43% of their portfolio New York, NY 1,154,0901.2m $188.7m $188.7m 6.43% Reduced -327.7k -327,662
36 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.32% of their portfolio PHILADELPHIA, PA 1,143,7391.1m $187.0m $187.0m 0.32% Reduced -39.3k -39,290
37 Pictet Asset Management Holding SA 0.19% of their portfolio CAROUGE, V8 1,102,2481.1m $178.7m $178.7m 0.19% Added +143.3k +143,285
38 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.03% of their portfolio SAN FRANCISCO, CA 1,069,3901.1m $174.9m $174.9m 0.03% Added +42.0k +42,035
39 Fiera Capital Corp 0.57% of their portfolio MONTREAL, A8 1,021,9701.0m $167.1m $167.1m 0.57% Added +29.1k +29,078
40 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 942,646942.6k $154.1m $154.1m 0.02% Reduced -302.3k -302,267
41 AMERICAN CENTURY COMPANIES INC 0.08% of their portfolio KANSAS CITY, MO 925,799925.8k $151.4m $151.4m 0.08% Added +740.7k +740,709
42 PRINCIPAL FINANCIAL GROUP INC 0.08% of their portfolio DES MOINES, IA 916,464916.5k $149.9m $149.9m 0.08% Added +145.1k +145,106
43 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.49% of their portfolio CHICAGO, IL 902,666902.7k $147.6m $147.6m 0.49% Reduced -318.4k -318,430
44 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.23% of their portfolio Boston, MA 900,000900.0k $147.2m $147.2m 0.23% Added +600.0k +600,000
45 FIL Ltd 0.11% of their portfolio HAMILTON, D0 828,947828.9k $135.5m $135.5m 0.11% Reduced -9.6k -9,562
46 Amundi 0.04% of their portfolio Paris, I0 804,977805.0k $131.6m $131.6m 0.04% Reduced -112.0k -112,021
47 Legal & General Group Plc 0.03% of their portfolio London, X0 787,079787.1k $128.7m $128.7m 0.03% Added +246.8k +246,766
48 RAYMOND JAMES FINANCIAL INC 0.04% of their portfolio ST. PETERSBURG, FL 775,148775.1k $121.4m $121.4m 0.04% Reduced -4.1k -4,106
49 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 688,734688.7k $119.9m $119.9m 0.04% Added +46.0k +46,015
50 Hood River Capital Management LLC 1.13% of their portfolio PALM BEACH GARDENS, FL 688,554688.6k $112.6m $112.6m 1.13% Added +51.0k +50,977
51 AQR CAPITAL MANAGEMENT LLC 0.05% of their portfolio Greenwich, CT 675,485675.5k $108.8m $108.8m 0.05% Added +207.2k +207,225
52 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 4.94% of their portfolio Boston, MA 653,445653.4k $106.9m $106.9m 4.94% Reduced -255.6k -255,635
53 Clearbridge Investments, LLC 0.09% of their portfolio NEW YORK, NY 643,435643.4k $105.2m $105.2m 0.09% Reduced -175.6k -175,576
54 Artia Global Partners LP 23.18% of their portfolio MIAMI, FL 628,712628.7k $102.8m $102.8m 23.18% Reduced -53.5k -53,500
55 Swiss National Bank 0.06% of their portfolio ZURICH, V8 625,912625.9k $102.3m $102.3m 0.06% Added +46.8k +46,800
56 GW&K Investment Management, LLC 0.90% of their portfolio BOSTON, MA 623,048623.0k $101.9m $101.9m 0.90% Added +140.4k +140,378
57 JENNISON ASSOCIATES LLC 0.07% of their portfolio NEW YORK, NY 604,694604.7k $98.9m $98.9m 0.07% Added +42.4k +42,398
58 BNP PARIBAS FINANCIAL MARKETS 0.07% of their portfolio PARIS, I0 604,600604.6k $98.9m $98.9m 0.07% Reduced -310.8k -310,819
59 WELLS FARGO & COMPANY/MN 0.02% of their portfolio SAN FRANCISCO, CA 597,384597.4k $97.7m $97.7m 0.02% Added +10.7k +10,733
60 TimesSquare Capital Management, LLC 1.62% of their portfolio NEW YORK, NY 584,798584.8k $95.6m $95.6m 1.62% Added +94.3k +94,292
61 DEUTSCHE BANK AG\ 0.03% of their portfolio FRANKFURT AM MAIN, 2M 562,474562.5k $92.0m $92.0m 0.03% Reduced -27.6k -27,556
62 EVENTIDE ASSET MANAGEMENT, LLC 1.48% of their portfolio Boston, MA 546,310546.3k $89.3m $89.3m 1.48% Added +62.7k +62,721
63 FEDERATED HERMES, INC. 0.14% of their portfolio PITTSBURGH, PA 538,257538.3k $88.0m $88.0m 0.14% Reduced -94.0k -94,041
64 Nuveen, LLC 0.02% of their portfolio CHARLOTTE, NC 534,750534.8k $87.4m $87.4m 0.02% Reduced -115.7k -115,654
65 ROYAL BANK OF CANADA 0.02% of their portfolio TORONTO, A6 523,101523.1k $85.5m $85.5m 0.02% Added +16.3k +16,290
66 Sumitomo Mitsui Trust Group, Inc. 0.05% of their portfolio CHIYODA-KU, TOKYO, M0 501,282501.3k $82.0m $82.0m 0.05% Added +65.8k +65,840
67 Ensign Peak Advisors, Inc 0.15% of their portfolio SALT LAKE CITY, UT 499,756499.8k $81.7m $81.7m 0.15% Added +117.6k +117,554
68 Affinity Asset Advisors, LLC 4.60% of their portfolio NEW YORK, NY 480,000480.0k $78.5m $78.5m 4.60% Added +30.0k +30,000
69 FRONTIER CAPITAL MANAGEMENT CO LLC 0.79% of their portfolio Boston, MA 469,561469.6k $76.8m $76.8m 0.79% Added +184.7k +184,717
70 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.09% of their portfolio Paris, I0 467,753467.8k $76.5m $76.5m 0.09% Added +139.4k +139,425
71 JANUS HENDERSON GROUP PLC 0.03% of their portfolio LONDON, X0 419,304419.3k $68.6m $68.6m 0.03% Reduced -381.3k -381,251
72 SAMLYN CAPITAL, LLC 1.17% of their portfolio New York, NY 417,205417.2k $68.2m $68.2m 1.17% Added +47.6k +47,630
73 Palo Alto Investors LP 10.39% of their portfolio PALO ALTO, CA 415,269415.3k $67.9m $67.9m 10.39% Reduced -74.2k -74,213
74 Candriam S.C.A. 0.34% of their portfolio STRASSEN, N4 401,735401.7k $65.7m $65.7m 0.34% Added +693 +693
75 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 400,900400.9k $65.5m $65.5m 0.01% Added +1.8k +1,827
76 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 399,044399.0k $65.3m $65.3m 0.01% Reduced -87.1k -87,094
77 LORD, ABBETT & CO. LLC 0.21% of their portfolio JERSEY CITY, NJ 397,261397.3k $65.0m $65.0m 0.21% Reduced -323.6k -323,637
78 VICTORY CAPITAL MANAGEMENT INC 0.04% of their portfolio San Antonio, TX 396,245396.2k $64.8m $64.8m 0.04% Reduced -250.5k -250,469
79 Polar Capital Holdings Plc 0.26% of their portfolio London, X0 368,107368.1k $60.2m $60.2m 0.26% Added +23.9k +23,879
80 GATEWAY INVESTMENT ADVISERS LLC 0.67% of their portfolio CINCINNATI, OH 365,000365.0k $59.7m $59.7m 0.67% Unchanged
81 VANGUARD ASSET MANAGEMENT, Ltd 0.05% of their portfolio London, EC4N 8AF, X0 360,075360.1k $58.9m $58.9m 0.05% First filing
82 Sofinnova Investments, Inc. 2.84% of their portfolio Menlo Park, CA 346,075346.1k $56.6m $56.6m 2.84% Added +189.3k +189,274
83 California Public Employees Retirement System 0.03% of their portfolio Sacramento, CA 344,612344.6k $56.4m $56.4m 0.03% Reduced -10.3k -10,297
84 Rock Springs Capital Management LP 3.03% of their portfolio Baltimore, MD 314,300314.3k $51.4m $51.4m 3.03% Reduced -5.0k -4,950
85 MARSHALL WACE, LLP 0.05% of their portfolio LONDON, X0 312,565312.6k $51.1m $51.1m 0.05% Reduced -77.3k -77,316
86 National Pension Service 0.04% of their portfolio JEONJU-SI, JEOLLABUK-DO, M5 311,881311.9k $51.0m $51.0m 0.04% Added +31.4k +31,439
87 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.05% of their portfolio WEST SACRAMENTO, CA 303,182303.2k $49.6m $49.6m 0.05% Reduced -7.1k -7,148
88 Nearwater Capital Markets, Ltd 1.16% of their portfolio NEW YORK, NY 300,000300.0k $49.1m $49.1m 1.16% Reduced -200.0k -200,000
89 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 299,925299.9k $49.0m $49.0m 0.01% Added +23.8k +23,820
90 Bridgewater Associates, LP 0.22% of their portfolio Westport, CT 295,579295.6k $48.3m $48.3m 0.22% New
91 NEW YORK STATE COMMON RETIREMENT FUND 0.07% of their portfolio ALBANY, NY 293,546293.5k $48.0m $48.0m 0.07% Added +17.3k +17,262
92 ProShare Advisors LLC 0.07% of their portfolio BETHESDA, MD 283,141283.1k $46.3m $46.3m 0.07% Reduced -57.6k -57,599
93 Allspring Global Investments Holdings, LLC 0.08% of their portfolio CHARLOTTE, NC 282,734282.7k $46.6m $46.6m 0.08% Added +62.6k +62,650
94 Aberdeen Group plc 0.07% of their portfolio EDINBURGH, X0 277,016277.0k $45.3m $45.3m 0.07% Added +23.9k +23,904
95 BARCLAYS PLC 0.02% of their portfolio LONDON, X0 275,731275.7k $45.1m $45.1m 0.02% Reduced -169.0k -168,975
96 RHUMBLINE ADVISERS 0.04% of their portfolio BOSTON, MA 272,615272.6k $44.6m $44.6m 0.04% Added +4.3k +4,289
97 NEUBERGER BERMAN GROUP LLC 0.03% of their portfolio NEW YORK, NY 270,700270.7k $44.3m $44.3m 0.03% Added +62.8k +62,831
98 TANG CAPITAL MANAGEMENT LLC 2.16% of their portfolio SAN DIEGO, CA 260,000260.0k $42.5m $42.5m 2.16% Added +200.0k +200,000
99 Mitsubishi UFJ Asset Management Co., Ltd. 0.03% of their portfolio TOKYO, M0 255,247255.2k $41.7m $41.7m 0.03% Added +33.0k +32,981
100 First Turn Management, LLC 4.54% of their portfolio DEL MAR, CA 248,475248.5k $40.6m $40.6m 4.54% Reduced -15.8k -15,818