Vault-13

INSMED INC INSM

COM PAR $.01 · Common Stock · CUSIP 457669307 · ISIN US4576693075

677 institutional holders +111 vs Q3 2025
218,162,423218.2m shares reported held*
101.2% of all shares outstanding*
$38.0bnreported value*
164 new 239 added 182 reduced 81 sold out net sold ≈ $3.6bn (-20.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($59.9m this quarter). Holder counts are more reliable. Shares outstanding: 215.6m as of 2026-02-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $174.05. Options: 35 managers hold calls ($673.7m notional), 28 hold puts ($741.7m).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

0250500750Q3 22: 239Q4 22: 226Q1 23: 232Q2 23: 225Q3 23: 254Q4 23: 273Q1 24: 290Q2 24: 380Q3 24: 417Q4 24: 441Q1 25: 444Q2 25: 518Q3 25: 566Q4 25: 677677Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 2022239
Q4 2022226
Q1 2023232
Q2 2023225
Q3 2023254
Q4 2023273
Q1 2024290
Q2 2024380
Q3 2024417
Q4 2024441
Q1 2025444
Q2 2025518
Q3 2025566
Q4 2025677

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
5000500Q1 24: 141 bought or addedQ1 24: 126 cut or sold outQ2 24: 257 bought or addedQ2 24: 137 cut or sold outQ2 24Q3 24: 257 bought or addedQ3 24: 152 cut or sold outQ4 24: 226 bought or addedQ4 24: 188 cut or sold outQ4 24Q1 25: 236 bought or addedQ1 25: 195 cut or sold outQ2 25: 290 bought or addedQ2 25: 242 cut or sold outQ2 25Q3 25: 320 bought or addedQ3 25: 264 cut or sold outQ4 25: 403 bought or addedQ4 25: 263 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 2024141126
Q2 2024257137
Q3 2024257152
Q4 2024226188
Q1 2025236195
Q2 2025290242
Q3 2025320264
Q4 2025403263

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200m$400m$600m$800mQ1 25 calls: $73.0mQ1 25 puts: $144.9mQ1 25P/C 1.99Q2 25 calls: $330.0mQ2 25 puts: $356.0mQ2 25P/C 1.08Q3 25 calls: $640.6mQ3 25 puts: $658.6mQ3 25P/C 1.03Q4 25 calls: $673.7mQ4 25 puts: $741.7mQ4 25P/C 1.10
Numbers
QuarterCallsPutsP/C
Q1 2025$73.0m$144.9m1.99
Q2 2025$330.0m$356.0m1.08
Q3 2025$640.6m$658.6m1.03
Q4 2025$673.7m$741.7m1.10

Biggest buyers

Invesco Ltd. Added +5,514,467+5.5m
BlackRock, Inc. Added +2,700,148+2.7m
RTW INVESTMENTS, LP Added +1,758,321+1.8m
STATE STREET CORP Added +1,217,390+1.2m
VANGUARD GROUP INC Added +1,140,524+1.1m
Orbis Allan Gray Ltd Added +929,089+929.1k
Jefferies Financial Group Inc. Added +818,242+818.2k
FMR LLC Added +746,973+747.0k
MORGAN STANLEY Added +668,275+668.3k
FRANKLIN RESOURCES INC Added +615,811+615.8k

Biggest sellers

JPMORGAN CHASE & CO Reduced -22,895,840-22.9m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -2,892,000-2.9m
Capital International Investors Reduced -2,402,182-2.4m
Qube Research & Technologies Ltd Sold out -1,544,315-1.5m
D. E. Shaw & Co., Inc. Reduced -1,306,469-1.3m
MILLENNIUM MANAGEMENT LLC Reduced -1,024,458-1.0m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -952,503-952.5k
Duquesne Family Office LLC Reduced -941,683-941.7k
CITADEL ADVISORS LLC Reduced -900,346-900.3k
ROYAL BANK OF CANADA Reduced -848,520-848.5k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $147.9m849.6k shares
SUSQUEHANNA ADVISORS GROUP, INC. New $98.3m565.0k shares
JANE STREET GROUP, LLC Added $97.0m557.1k shares
CITADEL ADVISORS LLC Added $75.3m432.9k shares
FARALLON CAPITAL MANAGEMENT, L.L.C. New $43.5m250.0k shares
Caption Management, LLC Reduced $40.9m235.2k shares
GROUP ONE TRADING LLC Added $23.6m135.7k shares
SIMPLEX TRADING, LLC Reduced $22.3m128.1k shares
JPMORGAN CHASE & CO Reduced $16.4m94.2k shares
TUDOR INVESTMENT CORP ET AL Reduced $11.8m68.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $235.8m1.4m shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Added $94.0m540.0k shares
JANE STREET GROUP, LLC Reduced $80.7m463.6k shares
Artia Global Partners LP New $73.1m420.0k shares
LMR Partners LLP New $47.2m271.4k shares
JPMORGAN CHASE & CO Added $45.7m262.5k shares
Caption Management, LLC Reduced $40.8m234.2k shares
CITADEL ADVISORS LLC Added $38.1m218.8k shares
Parallax Volatility Advisers, L.P. Reduced $17.8m102.3k shares
Jefferies Financial Group Inc. Unchanged $17.4m99.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +1.3 pts · filed 2026-08-06 7.4% +1.3 pts 16.1m≈ $1.7bn 2026-08-06
BlackRock, Inc. 13G · institution +1.5 pts · filed 2026-01-21 6.6% +1.5 pts 14.1m≈ $1.5bn 2026-01-21
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.3% new 11.5m≈ $1.2bn 2026-04-30

Fell to 5% or below in the last year: Darwin Global Management, Ltd. (3.0%, 2026-08-14), JPMORGAN CHASE & CO (4.7%, 2026-07-22), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), PRICE T ROWE ASSOCIATES INC /MD/ (3.3%, 2025-11-14)

Insider purchases and sales in Q4 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q1 24: 0 buyingQ1 24: 7 sellingQ2 24: 0 buyingQ2 24: 7 sellingQ2 24Q3 24: 0 buyingQ3 24: 3 sellingQ4 24: 0 buyingQ4 24: 1 sellingQ4 24Q1 25: 0 buyingQ1 25: 7 sellingQ2 25: 1 buyingQ2 25: 7 sellingQ2 25Q3 25: 0 buyingQ3 25: 7 sellingQ4 25: 0 buyingQ4 25: 7 sellingQ4 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20240—7$3.7m$3.0m
Q2 20240—7$28.7m$26.9m
Q3 20240—3$25.6m$18.4m
Q4 20240—1$3.7m$3.7m
Q1 20250—7$53.0m$32.1m
Q2 20251$201.7k7$54.6m$49.9m
Q3 20250—7$65.6m$57.2m
Q4 20250—7$44.3m$16.7m
DateInsiderTradeSharesPrice ValueTheir holding
2025-12-18 Lewis William Chair and CEO, director Sold plan 10,699 $166.97 $1.8m10.7k shares -3%
2025-12-05 SHAROKY MELVIN MD Director Sold 20,000 $205.01 $4.1m20.0k shares -8%
2025-12-04 Lewis William Chair and CEO, director Sold plan 10,699 $205.62 $2.2m10.7k shares -3%
2025-12-01 Flammer Martina M.D. Chief Medical Officer Sold plan 8,895 $206.98 $1.8m8.9k shares -10%
2025-11-24 ANDERSON ELIZABETH M Director Sold 5,000 $204.58 $1.0m5.0k shares -8%
2025-11-17 LEE LEO Director Sold 75,000 $195.90 $14.7m75.0k shares -58%
2025-11-14 ANDERSON ELIZABETH M Director Sold 10,000 $195.87 $2.0m10.0k shares -14%
2025-11-12 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold 30,000 $194.00 $5.8m30.0k shares -45%
2025-11-11 Flammer Martina M.D. Chief Medical Officer Sold plan 31,226 $189.68 $5.9m31.2k shares -27%
2025-11-03 Smith Michael Alexander Chief Legal Officer Sold plan 27,130 $183.78 $5.0m27.1k shares -33%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JPMORGAN CHASE & CO 0.27% of their portfolio NEW YORK, NY 23,199,51223.2m $4.0bn $4.0bn 0.27% Reduced -22.9m -22,895,840
2 VANGUARD GROUP INC 0.05% of their portfolio Valley Forge, PA 21,076,34421.1m $3.7bn $3.7bn 0.05% Added +1.1m +1,140,524
3 Darwin Global Management, Ltd. 73.78% of their portfolio ST. HELIER, Y9 20,933,27720.9m $3.6bn $3.6bn 73.78% Added +475.8k +475,832
4 BlackRock, Inc. 0.04% of their portfolio New York, NY 15,065,05215.1m $2.6bn $2.6bn 0.04% Added +2.7m +2,700,148
5 FMR LLC 0.09% of their portfolio BOSTON, MA 9,927,9369.9m $1.7bn $1.7bn 0.09% Added +747.0k +746,973
6 Invesco Ltd. 0.12% of their portfolio ATLANTA, GA 7,518,3387.5m $1.3bn $1.3bn 0.12% Added +5.5m +5,514,467
7 BAKER BROS. ADVISORS LP 6.72% of their portfolio NEW YORK, NY 6,592,7466.6m $1.1bn $1.1bn 6.72% Reduced -110.7k -110,738
8 STATE STREET CORP 0.03% of their portfolio BOSTON, MA 5,201,7445.2m $905.3m $905.3m 0.03% Added +1.2m +1,217,390
9 Capital International Investors 0.14% of their portfolio Los Angeles, CA 5,151,6715.2m $896.6m $896.6m 0.14% Reduced -2.4m -2,402,182
10 Artisan Partners Limited Partnership 1.29% of their portfolio Milwaukee, WI 4,843,7494.8m $843.0m $843.0m 1.29% Reduced -93.9k -93,934
11 RTW INVESTMENTS, LP 8.44% of their portfolio NEW YORK, NY 4,842,8794.8m $842.9m $842.9m 8.44% Added +1.8m +1,758,321
12 D. E. Shaw & Co., Inc. 0.58% of their portfolio New York, NY 4,350,9954.4m $757.2m $757.2m 0.58% Reduced -1.3m -1,306,469
13 GEODE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio BOSTON, MA 4,299,0524.3m $751.9m $751.9m 0.05% Added +539.6k +539,625
14 Orbis Allan Gray Ltd 3.05% of their portfolio HamiltoN, D0 4,179,9574.2m $727.5m $727.5m 3.05% Added +929.1k +929,089
15 PRICE T ROWE ASSOCIATES INC /MD/ 0.08% of their portfolio BALTIMORE, MD 4,039,4664.0m $703.0m $703.0m 0.08% Reduced -2.9m -2,892,000
16 NORGES BANK 0.05% of their portfolio OSLO, Q8 2,910,9712.9m $506.6m $506.6m 0.05% Not comparable
17 FRANKLIN RESOURCES INC 0.12% of their portfolio San Mateo, CA 2,755,5362.8m $479.6m $479.6m 0.12% Added +615.8k +615,811
18 NWI MANAGEMENT LP 10.51% of their portfolio NEW YORK, NY 1,976,9202.0m $344.1m $344.1m 10.51% Reduced -65.1k -65,080
19 AMERIPRISE FINANCIAL INC 0.08% of their portfolio MINNEAPOLIS, MN 1,968,8572.0m $342.7m $342.7m 0.08% Reduced -753.0k -753,022
20 UBS Group AG 0.06% of their portfolio ZURICH, V8 1,867,6351.9m $325.0m $325.0m 0.06% Added +221.4k +221,396
21 BANK OF AMERICA CORP /DE/ 0.02% of their portfolio CHARLOTTE, NC 1,725,6811.7m $300.3m $300.3m 0.02% Added +123.9k +123,875
22 MORGAN STANLEY 0.02% of their portfolio NEW YORK, NY 1,631,9061.6m $284.0m $284.0m 0.02% Added +668.3k +668,275
23 Duquesne Family Office LLC 6.11% of their portfolio New York, NY 1,481,7521.5m $257.9m $257.9m 6.11% Reduced -941.7k -941,683
24 Bank of New York Mellon Corp 0.04% of their portfolio NEW YORK, NY 1,390,0421.4m $241.9m $241.9m 0.04% Added +251.1k +251,141
25 MILLENNIUM MANAGEMENT LLC 0.16% of their portfolio NEW YORK, NY 1,311,6541.3m $228.3m $228.3m 0.16% Reduced -1.0m -1,024,458
26 Castle Hook Partners LP 3.14% of their portfolio NEW YORK, NY 1,253,5681.3m $218.2m $218.2m 3.14% Added +162.2k +162,163
27 Integral Health Asset Management, LLC 11.03% of their portfolio New York, NY 1,250,0001.2m $217.6m $217.6m 11.03% Reduced -350.0k -350,000
28 GOLDMAN SACHS GROUP INC 0.03% of their portfolio NEW YORK, NY 1,244,9131.2m $216.7m $216.7m 0.03% Added +415.6k +415,596
29 NORTHERN TRUST CORP 0.03% of their portfolio CHICAGO, IL 1,238,4381.2m $215.5m $215.5m 0.03% Added +165.5k +165,496
30 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.59% of their portfolio CHICAGO, IL 1,221,0961.2m $212.5m $212.5m 0.59% Reduced -334.0k -333,961
31 NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.31% of their portfolio PHILADELPHIA, PA 1,183,0291.2m $205.9m $205.9m 0.31% First filing
32 CITADEL ADVISORS LLC 0.14% of their portfolio MIAMI, FL 1,157,2951.2m $201.4m $201.4m 0.14% Reduced -900.3k -900,346
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.03% of their portfolio SAN FRANCISCO, CA 1,027,3551.0m $178.8m $178.8m 0.03% Added +52.1k +52,076
34 Fiera Capital Corp 0.55% of their portfolio MONTREAL, A8 992,892992.9k $172.8m $172.8m 0.55% Added +183.8k +183,771
35 TWO SIGMA INVESTMENTS, LP 0.25% of their portfolio NEW YORK, NY 962,156962.2k $167.5m $167.5m 0.25% Added +189.4k +189,376
36 Pictet Asset Management Holding SA 0.16% of their portfolio CAROUGE, V8 958,963959.0k $167.3m $167.3m 0.16% Reduced -181.9k -181,864
37 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio NEW YORK, NY 943,306943.3k $164.2m $164.2m 0.03% Added +430.6k +430,557
38 Jefferies Financial Group Inc. 1.32% of their portfolio NEW YORK, NY 926,339926.3k $161.2m $161.2m 1.32% Added +818.2k +818,242
39 Amundi 0.04% of their portfolio Paris, I0 916,998917.0k $159.6m $159.6m 0.04% Added +599.9k +599,902
40 BNP PARIBAS FINANCIAL MARKETS 0.10% of their portfolio PARIS, I0 915,419915.4k $159.3m $159.3m 0.10% Added +482.1k +482,079
41 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 4.45% of their portfolio Boston, MA 909,080909.1k $158.2m $158.2m 4.45% Reduced -132.8k -132,765
42 SEI INVESTMENTS CO 0.15% of their portfolio OAKS, PA 890,170890.2k $154.9m $154.9m 0.15% Added +296.3k +296,285
43 FIL Ltd 0.11% of their portfolio HAMILTON, D0 838,509838.5k $145.9m $145.9m 0.11% Reduced -13.4k -13,445
44 Clearbridge Investments, LLC 0.11% of their portfolio NEW YORK, NY 819,011819.0k $142.5m $142.5m 0.11% Reduced -249.0k -249,007
45 Holocene Advisors, LP 0.29% of their portfolio New York, NY 801,165801.2k $139.4m $139.4m 0.29% Reduced -282.5k -282,516
46 JANUS HENDERSON GROUP PLC 0.06% of their portfolio LONDON, X0 800,555800.6k $139.3m $139.3m 0.06% Reduced -402.2k -402,228
47 RAYMOND JAMES FINANCIAL INC 0.04% of their portfolio ST. PETERSBURG, FL 779,254779.3k $135.6m $135.6m 0.04% Added +19.3k +19,276
48 PRINCIPAL FINANCIAL GROUP INC 0.07% of their portfolio DES MOINES, IA 771,358771.4k $134.2m $134.2m 0.07% Reduced -92.9k -92,936
49 LORD, ABBETT & CO. LLC 0.38% of their portfolio JERSEY CITY, NJ 720,898720.9k $125.5m $125.5m 0.38% Reduced -723.8k -723,758
50 Artia Global Partners LP 19.08% of their portfolio MIAMI, FL 682,212682.2k $118.7m $118.7m 19.08% Reduced -50.0k -50,000
51 Nuveen, LLC 0.03% of their portfolio CHARLOTTE, NC 650,404650.4k $113.2m $113.2m 0.03% Added +62.3k +62,282
52 VICTORY CAPITAL MANAGEMENT INC 0.06% of their portfolio San Antonio, TX 646,714646.7k $112.6m $112.6m 0.06% Added +291.8k +291,807
53 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 642,719642.7k $111.9m $111.9m 0.04% Reduced -226.1k -226,053
54 Hood River Capital Management LLC 1.22% of their portfolio PALM BEACH GARDENS, FL 637,577637.6k $111.0m $111.0m 1.22% Reduced -243.8k -243,826
55 FEDERATED HERMES, INC. 0.18% of their portfolio PITTSBURGH, PA 632,298632.3k $110.0m $110.0m 0.18% Added +304.1k +304,075
56 DEUTSCHE BANK AG\ 0.03% of their portfolio FRANKFURT AM MAIN, 2M 590,030590.0k $102.7m $102.7m 0.03% Added +385.7k +385,676
57 WELLS FARGO & COMPANY/MN 0.02% of their portfolio SAN FRANCISCO, CA 586,651586.7k $102.1m $102.1m 0.02% Added +72.8k +72,802
58 Swiss National Bank 0.06% of their portfolio ZURICH, V8 579,112579.1k $100.8m $100.8m 0.06% Added +207.8k +207,812
59 JENNISON ASSOCIATES LLC 0.06% of their portfolio NEW YORK, NY 562,296562.3k $97.9m $97.9m 0.06% Reduced -40.5k -40,479
60 Legal & General Group Plc 0.02% of their portfolio London, X0 540,313540.3k $94.0m $94.0m 0.02% Added +332.3k +332,292
61 ROYAL BANK OF CANADA 0.02% of their portfolio TORONTO, A6 506,811506.8k $88.2m $88.2m 0.02% Reduced -848.5k -848,520
62 Nearwater Capital Markets, Ltd 1.49% of their portfolio NEW YORK, NY 500,000500.0k $87.0m $87.0m 1.49% Added +300.0k +300,000
63 TimesSquare Capital Management, LLC 1.29% of their portfolio NEW YORK, NY 490,506490.5k $85.4m $85.4m 1.29% Added +65.4k +65,421
64 Palo Alto Investors LP 11.86% of their portfolio PALO ALTO, CA 489,482489.5k $85.2m $85.2m 11.86% Reduced -2.3k -2,323
65 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 486,138486.1k $84.6m $84.6m 0.01% Reduced -231.9k -231,905
66 EVENTIDE ASSET MANAGEMENT, LLC 1.31% of their portfolio Boston, MA 483,589483.6k $84.2m $84.2m 1.31% Reduced -521.5k -521,518
67 GW&K Investment Management, LLC 0.73% of their portfolio BOSTON, MA 482,670482.7k $84.0m $84.0m 0.73% Reduced -119.1k -119,133
68 AQR CAPITAL MANAGEMENT LLC 0.04% of their portfolio Greenwich, CT 468,260468.3k $81.5m $81.5m 0.04% Added +181.0k +180,974
69 Affinity Asset Advisors, LLC 5.63% of their portfolio NEW YORK, NY 450,000450.0k $78.3m $78.3m 5.63% Unchanged
70 BARCLAYS PLC 0.03% of their portfolio LONDON, X0 444,706444.7k $77.4m $77.4m 0.03% Added +330.5k +330,510
71 Sumitomo Mitsui Trust Group, Inc. 0.04% of their portfolio CHIYODA-KU, TOKYO, M0 435,442435.4k $75.8m $75.8m 0.04% New
72 WESTFIELD CAPITAL MANAGEMENT CO LP 0.31% of their portfolio BOSTON, MA 432,521432.5k $75.3m $75.3m 0.31% Reduced -55.4k -55,406
73 Candriam S.C.A. 0.35% of their portfolio STRASSEN, N4 401,042401.0k $69.8m $69.8m 0.35% Added +3.5k +3,454
74 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 399,073399.1k $69.5m $69.5m 0.01% Added +12.4k +12,402
75 TWO SIGMA ADVISERS, LP 0.13% of their portfolio NEW YORK, NY 395,000395.0k $68.7m $68.7m 0.13% Added +343.7k +343,700
76 MARSHALL WACE, LLP 0.07% of their portfolio LONDON, X0 389,881389.9k $67.9m $67.9m 0.07% Reduced -268.8k -268,766
77 Ensign Peak Advisors, Inc 0.12% of their portfolio SALT LAKE CITY, UT 382,202382.2k $66.5m $66.5m 0.12% Reduced -259.8k -259,832
78 Balyasny Asset Management L.P. 0.12% of their portfolio Chicago, IL 380,561380.6k $66.2m $66.2m 0.12% Added +343.1k +343,080
79 SAMLYN CAPITAL, LLC 1.03% of their portfolio New York, NY 369,575369.6k $64.3m $64.3m 1.03% Added +76.9k +76,932
80 GATEWAY INVESTMENT ADVISERS LLC 0.59% of their portfolio CINCINNATI, OH 365,000365.0k $63.5m $63.5m 0.59% New
81 California Public Employees Retirement System 0.04% of their portfolio Sacramento, CA 354,909354.9k $61.8m $61.8m 0.04% Added +44.0k +44,023
82 Polar Capital Holdings Plc 0.27% of their portfolio London, X0 344,228344.2k $59.9m $59.9m 0.27% Reduced -27.7k -27,659
83 ProShare Advisors LLC 0.10% of their portfolio BETHESDA, MD 340,740340.7k $59.3m $59.3m 0.10% Added +333.2k +333,210
84 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.07% of their portfolio Paris, I0 328,328328.3k $57.2m $57.2m 0.07% Added +129.6k +129,626
85 Rock Springs Capital Management LP 2.85% of their portfolio Baltimore, MD 319,250319.2k $55.6m $55.6m 2.85% Reduced -65.8k -65,750
86 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.05% of their portfolio WEST SACRAMENTO, CA 310,330310.3k $54.0m $54.0m 0.05% Added +130.9k +130,928
87 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.08% of their portfolio Boston, MA 300,000300.0k $52.2m $52.2m 0.08% Reduced -952.5k -952,503
88 FRONTIER CAPITAL MANAGEMENT CO LLC 0.53% of their portfolio Boston, MA 284,844284.8k $49.6m $49.6m 0.53% Reduced -44.0k -44,040
89 Zurich Insurance Group Ltd/FI 0.34% of their portfolio ZURICH, V8 281,098281.1k $48.9m $48.9m 0.34% New
90 National Pension Service 0.04% of their portfolio JEONJU-SI, JEOLLABUK-DO, M5 280,442280.4k $48.8m $48.8m 0.04% New
91 NEW YORK STATE COMMON RETIREMENT FUND 0.06% of their portfolio ALBANY, NY 276,284276.3k $48.1m $48.1m 0.06% Reduced -169.6k -169,592
92 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 276,105276.1k $48.1m $48.1m 0.01% Reduced -66.7k -66,680
93 Cormorant Asset Management, LP 2.71% of their portfolio BOSTON, MA 275,000275.0k $47.9m $47.9m 2.71% Reduced -155.0k -155,000
94 RHUMBLINE ADVISERS 0.04% of their portfolio BOSTON, MA 268,326268.3k $46.7m $46.7m 0.04% Added +55.4k +55,423
95 Patient Square Capital LP 9.95% of their portfolio MENLO PARK, CA 267,000267.0k $46.5m $46.5m 9.95% Reduced -59.4k -59,400
96 First Turn Management, LLC 5.26% of their portfolio DEL MAR, CA 264,293264.3k $46.0m $46.0m 5.26% Reduced -55.5k -55,480
97 TD Asset Management Inc 0.04% of their portfolio Toronto, A6 262,478262.5k $45.7m $45.7m 0.04% Reduced -135.8k -135,778
98 AXIOM INVESTORS LLC /DE 0.39% of their portfolio GREENWICH, CT 255,849255.8k $44.5m $44.5m 0.39% Added +148.1k +148,116
99 Aberdeen Group plc 0.07% of their portfolio EDINBURGH, X0 253,112253.1k $44.1m $44.1m 0.07% Added +18.5k +18,490
100 FIRST TRUST ADVISORS LP 0.03% of their portfolio Wheaton, IL 247,940247.9k $43.2m $43.2m 0.03% Added +7.3k +7,294