Vault-13

INSMED INC INSM

COM PAR $.01 · Common Stock · CUSIP 457669307 · ISIN US4576693075

566 institutional holders +48 vs Q2 2025
234,722,932234.7m shares reported held*
110.1% of all shares outstanding*
$33.8bnreported value*
124 new 196 added 195 reduced 69 sold out net bought ≈ $3.7bn (+25.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($32.3m this quarter). Holder counts are more reliable. Shares outstanding: 213.3m as of 2025-10-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $143.83. Options: 35 managers hold calls ($640.6m notional), 30 hold puts ($658.6m).

Trends to Q3 2025

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 239Q4 22: 226Q1 23: 232Q2 23: 225Q3 23: 254Q4 23: 273Q1 24: 290Q2 24: 380Q3 24: 417Q4 24: 441Q1 25: 444Q2 25: 518Q3 25: 566566Q3 22Q2 23Q1 24Q4 24Q3 25
Numbers
QuarterHolders
Q3 2022239
Q4 2022226
Q1 2023232
Q2 2023225
Q3 2023254
Q4 2023273
Q1 2024290
Q2 2024380
Q3 2024417
Q4 2024441
Q1 2025444
Q2 2025518
Q3 2025566

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q4 23: 131 bought or addedQ4 23: 111 cut or sold outQ1 24: 141 bought or addedQ1 24: 126 cut or sold outQ1 24Q2 24: 257 bought or addedQ2 24: 137 cut or sold outQ3 24: 257 bought or addedQ3 24: 152 cut or sold outQ3 24Q4 24: 226 bought or addedQ4 24: 188 cut or sold outQ1 25: 236 bought or addedQ1 25: 195 cut or sold outQ1 25Q2 25: 290 bought or addedQ2 25: 242 cut or sold outQ3 25: 320 bought or addedQ3 25: 264 cut or sold outQ3 25
Numbers
QuarterBought or addedCut or sold out
Q4 2023131111
Q1 2024141126
Q2 2024257137
Q3 2024257152
Q4 2024226188
Q1 2025236195
Q2 2025290242
Q3 2025320264

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200m$400m$600m$800mQ4 24 calls: $235.2mQ4 24 puts: $196.7mQ4 24P/C 0.84Q1 25 calls: $73.0mQ1 25 puts: $144.9mQ1 25P/C 1.99Q2 25 calls: $330.0mQ2 25 puts: $356.0mQ2 25P/C 1.08Q3 25 calls: $640.6mQ3 25 puts: $658.6mQ3 25P/C 1.03
Numbers
QuarterCallsPutsP/C
Q4 2024$235.2m$196.7m0.84
Q1 2025$73.0m$144.9m1.99
Q2 2025$330.0m$356.0m1.08
Q3 2025$640.6m$658.6m1.03

Biggest buyers

JPMORGAN CHASE & CO Added +30,458,953+30.5m
FMR LLC Added +4,087,702+4.1m
VANGUARD GROUP INC Added +2,291,328+2.3m
D. E. Shaw & Co., Inc. Added +2,234,845+2.2m
Orbis Allan Gray Ltd Added +1,726,734+1.7m
Artisan Partners Limited Partnership Added +1,623,342+1.6m
UBS Group AG Added +1,352,785+1.4m
BlackRock, Inc. Added +1,222,472+1.2m
Darwin Global Management, Ltd. Added +1,112,824+1.1m
Castle Hook Partners LP Added +638,749+638.7k

Biggest sellers

PRICE T ROWE ASSOCIATES INC /MD/ Reduced -4,299,239-4.3m
Deep Track Capital, LP Sold out -1,750,000-1.8m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -1,606,949-1.6m
JANUS HENDERSON GROUP PLC Reduced -1,090,359-1.1m
BAKER BROS. ADVISORS LP Reduced -1,009,416-1.0m
GOLDMAN SACHS GROUP INC Reduced -981,578-981.6k
Holocene Advisors, LP Reduced -933,125-933.1k
WESTFIELD CAPITAL MANAGEMENT CO LP Reduced -851,361-851.4k
HRT FINANCIAL LP Sold out -729,597-729.6k
GW&K Investment Management, LLC Reduced -672,513-672.5k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $122.2m848.4k shares
Artia Global Partners LP Added $57.6m400.0k shares
Caption Management, LLC Added $54.4m377.5k shares
CITADEL ADVISORS LLC Added $49.0m340.5k shares
PEAK6 LLC New $48.0m333.0k shares
JANE STREET GROUP, LLC Added $34.3m237.9k shares
Affinity Asset Advisors, LLC New $29.5m205.0k shares
BANK OF AMERICA CORP /DE/ Added $27.7m192.3k shares
CITIGROUP INC New $22.6m157.0k shares
SIMPLEX TRADING, LLC Added $21.4m148.7k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $141.0m978.8k shares
JANE STREET GROUP, LLC Added $112.7m782.4k shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New $72.0m500.0k shares
683 Capital Management, LLC Added $54.0m375.0k shares
Caption Management, LLC Added $46.9m326.0k shares
BANK OF AMERICA CORP /DE/ Added $32.0m222.3k shares
Parallax Volatility Advisers, L.P. Added $29.9m207.8k shares
CITADEL ADVISORS LLC Added $28.1m194.9k shares
GROUP ONE TRADING LLC Added $23.5m163.3k shares
Integral Health Asset Management, LLC New $14.4m100.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +1.3 pts · filed 2026-08-06 7.4% +1.3 pts 16.1m≈ $1.7bn 2026-08-06
BlackRock, Inc. 13G · institution +1.5 pts · filed 2026-01-21 6.6% +1.5 pts 14.1m≈ $1.5bn 2026-01-21
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.3% new 11.5m≈ $1.2bn 2026-04-30

Fell to 5% or below in the last year: Darwin Global Management, Ltd. (3.0%, 2026-08-14), JPMORGAN CHASE & CO (4.7%, 2026-07-22), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Insider purchases and sales in Q3 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q4 23: 0 buyingQ4 23: 4 sellingQ1 24: 0 buyingQ1 24: 7 sellingQ1 24Q2 24: 0 buyingQ2 24: 7 sellingQ3 24: 0 buyingQ3 24: 3 sellingQ3 24Q4 24: 0 buyingQ4 24: 1 sellingQ1 25: 0 buyingQ1 25: 7 sellingQ1 25Q2 25: 1 buyingQ2 25: 7 sellingQ3 25: 0 buyingQ3 25: 7 sellingQ3 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20230—4$4.7m$4.7m
Q1 20240—7$3.7m$3.0m
Q2 20240—7$28.7m$26.9m
Q3 20240—3$25.6m$18.4m
Q4 20240—1$3.7m$3.7m
Q1 20250—7$53.0m$32.1m
Q2 20251$201.7k7$54.6m$49.9m
Q3 20250—7$65.6m$57.2m
DateInsiderTradeSharesPrice ValueTheir holding
2025-09-12 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold plan 76,520 $145.45 $11.1m76.5k shares -68%
2025-09-12 SHAROKY MELVIN MD Director Sold 10,000 $145.39 $1.5m10.0k shares -4%
2025-09-02 Flammer Martina M.D. Chief Medical Officer Sold plan 186,648 $144.34 $26.9m186.6k shares -69%
2025-09-02 Smith Michael Alexander Chief Legal Officer Sold plan 24,272 $143.89 $3.5m24.3k shares -31%
2025-08-20 SHAROKY MELVIN MD Director Sold 10,000 $129.50 $1.3m10.0k shares -4%
2025-08-19 Adsett Roger Chief Operating Officer Sold 25,000 $127.58 $3.2m25.0k shares -19%
2025-08-18 Lewis William Chair and CEO, director · By the Katie Procter Dynasty Trust Sold plan 6,865 $128.40 $881.5k6.9k shares -3%
2025-08-14 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold 10,000 $127.34 $1.3m10.0k shares -11%
2025-08-12 SHAROKY MELVIN MD Director Sold 10,000 $121.58 $1.2m10.0k shares -3%
2025-08-04 Flammer Martina M.D. Chief Medical Officer Sold plan 8,715 $109.50 $954.3k8.7k shares -10%
2025-08-04 Lewis William Chair and CEO, director · By the Katie Procter Dynasty Trust Sold plan 6,830 $109.81 $750.0k6.8k shares -3%
2025-07-21 Bonstein Sara Chief Financial Officer Sold plan 58,400 $102.67 $6.0m58.4k shares -44%
2025-07-15 Lewis William Chair and CEO, director · By the Katie Procter Dynasty Trust Sold plan 6,830 $102.37 $699.2k6.8k shares -3%
2025-07-15 Smith Michael Alexander Chief Legal Officer Sold plan 933 $102.51 $95.6k933 shares -1%
2025-07-11 Smith Michael Alexander Chief Legal Officer Sold plan 748 $96.41 $72.1k748 shares -1%
2025-07-07 Bonstein Sara Chief Financial Officer Sold plan 57,764 $95.86 $5.5m57.8k shares -41%
2025-07-01 Lewis William Chair and CEO, director · By the Katie Procter Dynasty Trust Sold plan 6,830 $98.33 $671.6k6.8k shares -3%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q3 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JPMORGAN CHASE & CO 0.21% of their portfolio NEW YORK, NY 46,095,35246.1m $6.6bn $6.6bn 0.21% Added +30.5m +30,458,953
2 Darwin Global Management, Ltd. 80.54% of their portfolio ST. HELIER, Y9 20,457,44520.5m $2.9bn $2.9bn 80.54% Added +1.1m +1,112,824
3 VANGUARD GROUP INC 0.04% of their portfolio Valley Forge, PA 19,935,82019.9m $2.9bn $2.9bn 0.04% Added +2.3m +2,291,328
4 BlackRock, Inc. 0.03% of their portfolio New York, NY 12,364,90412.4m $1.8bn $1.8bn 0.03% Added +1.2m +1,222,472
5 FMR LLC 0.07% of their portfolio BOSTON, MA 9,180,9639.2m $1.3bn $1.3bn 0.07% Added +4.1m +4,087,702
6 Capital International Investors 0.18% of their portfolio Los Angeles, CA 7,553,8537.6m $1.1bn $1.1bn 0.18% Added +75.0k +74,994
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.11% of their portfolio BALTIMORE, MD 6,931,4666.9m $998.2m $998.2m 0.11% Reduced -4.3m -4,299,239
8 BAKER BROS. ADVISORS LP 6.98% of their portfolio NEW YORK, NY 6,703,4846.7m $965.4m $965.4m 6.98% Reduced -1.0m -1,009,416
9 D. E. Shaw & Co., Inc. 0.66% of their portfolio New York, NY 5,657,4645.7m $814.7m $814.7m 0.66% Added +2.2m +2,234,845
10 Artisan Partners Limited Partnership 1.02% of their portfolio Milwaukee, WI 4,937,6834.9m $711.1m $711.1m 1.02% Added +1.6m +1,623,342
11 STATE STREET CORP 0.02% of their portfolio BOSTON, MA 3,984,3544.0m $573.8m $573.8m 0.02% Reduced -293.5k -293,534
12 GEODE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio BOSTON, MA 3,759,4273.8m $541.5m $541.5m 0.03% Added +418.7k +418,720
13 Orbis Allan Gray Ltd 2.01% of their portfolio HamiltoN, D0 3,250,8683.3m $468.2m $468.2m 2.01% Added +1.7m +1,726,734
14 RTW INVESTMENTS, LP 5.47% of their portfolio NEW YORK, NY 3,084,5583.1m $444.2m $444.2m 5.47% Unchanged
15 AMERIPRISE FINANCIAL INC 0.09% of their portfolio MINNEAPOLIS, MN 2,721,8792.7m $392.0m $392.0m 0.09% Reduced -236.1k -236,094
16 Duquesne Family Office LLC 8.88% of their portfolio New York, NY 2,423,4352.4m $349.0m $349.0m 8.88% Added +170.0k +170,000
17 MILLENNIUM MANAGEMENT LLC 0.26% of their portfolio NEW YORK, NY 2,336,1122.3m $336.4m $336.4m 0.26% Added +214.4k +214,395
18 FRANKLIN RESOURCES INC 0.08% of their portfolio San Mateo, CA 2,139,7252.1m $308.1m $308.1m 0.08% Reduced -210.4k -210,408
19 CITADEL ADVISORS LLC 0.24% of their portfolio MIAMI, FL 2,057,6412.1m $296.3m $296.3m 0.24% Added +524.4k +524,364
20 NWI MANAGEMENT LP 14.99% of their portfolio NEW YORK, NY 2,042,0002.0m $294.1m $294.1m 14.99% Added +602.0k +602,000
21 Invesco Ltd. 0.05% of their portfolio ATLANTA, GA 2,003,8712.0m $288.6m $288.6m 0.05% Added +107.5k +107,538
22 UBS Group AG 0.05% of their portfolio ZURICH, V8 1,646,2391.6m $237.1m $237.1m 0.05% Added +1.4m +1,352,785
23 BANK OF AMERICA CORP /DE/ 0.02% of their portfolio CHARLOTTE, NC 1,601,8061.6m $230.7m $230.7m 0.02% Added +375.1k +375,069
24 Integral Health Asset Management, LLC 16.80% of their portfolio New York, NY 1,600,0001.6m $230.4m $230.4m 16.80% Unchanged
25 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.58% of their portfolio CHICAGO, IL 1,555,0571.6m $223.9m $223.9m 0.58% Reduced -110.5k -110,545
26 Qube Research & Technologies Ltd 0.31% of their portfolio LONDON, X0 1,544,3151.5m $222.4m $222.4m 0.31% Added +462.3k +462,265
27 LORD, ABBETT & CO. LLC 0.62% of their portfolio JERSEY CITY, NJ 1,444,6561.4m $208.0m $208.0m 0.62% Reduced -101.2k -101,203
28 ROYAL BANK OF CANADA 0.03% of their portfolio TORONTO, A6 1,355,3311.4m $195.2m $195.2m 0.03% Added +499.7k +499,729
29 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.29% of their portfolio Boston, MA 1,252,5031.3m $180.4m $180.4m 0.29% Reduced -1.6m -1,606,949
30 JANUS HENDERSON GROUP PLC 0.08% of their portfolio LONDON, X0 1,202,7831.2m $173.2m $173.2m 0.08% Reduced -1.1m -1,090,359
31 Pictet Asset Management Holding SA 0.16% of their portfolio CAROUGE, V8 1,140,8271.1m $163.9m $163.9m 0.16% Reduced -412.8k -412,801
32 Bank of New York Mellon Corp 0.03% of their portfolio NEW YORK, NY 1,138,9011.1m $164.0m $164.0m 0.03% Reduced -58.6k -58,572
33 Castle Hook Partners LP 2.38% of their portfolio NEW YORK, NY 1,091,4051.1m $157.2m $157.2m 2.38% Added +638.7k +638,749
34 Holocene Advisors, LP 0.36% of their portfolio New York, NY 1,083,6811.1m $156.1m $156.1m 0.36% Reduced -933.1k -933,125
35 NORTHERN TRUST CORP 0.02% of their portfolio CHICAGO, IL 1,072,9421.1m $154.5m $154.5m 0.02% Added +103.1k +103,142
36 Clearbridge Investments, LLC 0.12% of their portfolio NEW YORK, NY 1,068,0181.1m $153.8m $153.8m 0.12% Reduced -356.5k -356,544
37 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 4.89% of their portfolio Boston, MA 1,041,8451.0m $150.0m $150.0m 4.89% Added +32.9k +32,908
38 EVENTIDE ASSET MANAGEMENT, LLC 2.38% of their portfolio Boston, MA 1,005,1071.0m $144.7m $144.7m 2.38% Reduced -191.4k -191,387
39 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 975,279975.3k $140.4m $140.4m 0.02% Reduced -324.3k -324,289
40 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 963,631963.6k $138.8m $138.8m 0.01% Reduced -80.2k -80,160
41 Hood River Capital Management LLC 1.50% of their portfolio PALM BEACH GARDENS, FL 881,403881.4k $126.9m $126.9m 1.50% Reduced -18.2k -18,200
42 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 868,772868.8k $125.1m $125.1m 0.04% Reduced -474.4k -474,440
43 PRINCIPAL FINANCIAL GROUP INC 0.06% of their portfolio DES MOINES, IA 864,294864.3k $124.5m $124.5m 0.06% Reduced -483.7k -483,733
44 FIL Ltd 0.10% of their portfolio HAMILTON, D0 851,954852.0k $122.7m $122.7m 0.10% Reduced -313.5k -313,510
45 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 829,317829.3k $119.4m $119.4m 0.02% Reduced -981.6k -981,578
46 Fiera Capital Corp 0.38% of their portfolio MONTREAL, A8 809,121809.1k $116.5m $116.5m 0.38% Added +61.1k +61,084
47 JANE STREET GROUP, LLC 0.13% of their portfolio NEW YORK, NY 791,734791.7k $114.0m $114.0m 0.13% Reduced -561.2k -561,188
48 TWO SIGMA INVESTMENTS, LP 0.17% of their portfolio NEW YORK, NY 772,780772.8k $111.3m $111.3m 0.17% Added +396.3k +396,272
49 RAYMOND JAMES FINANCIAL INC 0.04% of their portfolio ST. PETERSBURG, FL 759,978760.0k $109.4m $109.4m 0.04% Reduced -24.6k -24,573
50 Artia Global Partners LP 18.55% of their portfolio MIAMI, FL 732,212732.2k $105.4m $105.4m 18.55% Reduced -20.5k -20,500
51 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 718,043718.0k $103.4m $103.4m 0.02% Reduced -441.7k -441,656
52 PERCEPTIVE ADVISORS LLC 2.92% of their portfolio NEW YORK, NY 702,130702.1k $101.1m $101.1m 2.92% Added +51.9k +51,878
53 MARSHALL WACE, LLP 0.10% of their portfolio LONDON, X0 658,647658.6k $94.9m $94.9m 0.10% Reduced -454.7k -454,714
54 MAVERICK CAPITAL LTD 1.27% of their portfolio DALLAS, TX 656,539656.5k $94.5m $94.5m 1.27% Reduced -147.6k -147,594
55 MACQUARIE GROUP LTD 0.11% of their portfolio Sydney, NSW 2000, C3 649,847649.8k $93.6m $93.6m 0.11% Reduced -481.1k -481,076
56 Ensign Peak Advisors, Inc 0.15% of their portfolio SALT LAKE CITY, UT 642,034642.0k $92.5m $92.5m 0.15% Added +77.6k +77,645
57 JENNISON ASSOCIATES LLC 0.05% of their portfolio NEW YORK, NY 602,775602.8k $86.8m $86.8m 0.05% Reduced -112.8k -112,831
58 GW&K Investment Management, LLC 0.77% of their portfolio BOSTON, MA 601,803601.8k $86.7m $86.7m 0.77% Reduced -672.5k -672,513
59 SEI INVESTMENTS CO 0.09% of their portfolio OAKS, PA 593,885593.9k $85.5m $85.5m 0.09% Added +160.3k +160,257
60 Nuveen, LLC 0.02% of their portfolio CHARLOTTE, NC 588,122588.1k $84.7m $84.7m 0.02% Reduced -865 -865
61 1832 Asset Management L.P. 0.14% of their portfolio TORONTO, A6 584,800584.8k $84.2m $84.2m 0.14% New
62 WELLS FARGO & COMPANY/MN 0.02% of their portfolio SAN FRANCISCO, CA 513,849513.8k $74.0m $74.0m 0.02% Added +254.6k +254,642
63 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio NEW YORK, NY 512,749512.7k $73.8m $73.8m 0.02% Reduced -183.2k -183,212
64 BANK OF NOVA SCOTIA 0.13% of their portfolio TORONTO, A6 506,245506.2k $72.9m $72.9m 0.13% New
65 ALKEON CAPITAL MANAGEMENT LLC 0.33% of their portfolio New York, NY 500,000500.0k $72.0m $72.0m 0.33% Unchanged
66 LOOMIS SAYLES & CO L P 0.08% of their portfolio BOSTON, MA 492,296492.3k $70.9m $70.9m 0.08% Reduced -301.3k -301,273
67 Palo Alto Investors LP 13.11% of their portfolio PALO ALTO, CA 491,805491.8k $70.8m $70.8m 13.11% Reduced -373.3k -373,308
68 WESTFIELD CAPITAL MANAGEMENT CO LP 0.29% of their portfolio BOSTON, MA 487,927487.9k $70.3m $70.3m 0.29% Reduced -851.4k -851,361
69 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.23% of their portfolio JUPITER, FL 471,649471.6k $67.9m $67.9m 0.23% Added +158.6k +158,596
70 DEERFIELD MANAGEMENT COMPANY, L.P. 1.04% of their portfolio New York, NY 471,000471.0k $67.8m $67.8m 1.04% Reduced -229.7k -229,700
71 Point72 Asset Management, L.P. 0.15% of their portfolio STAMFORD, CT 464,217464.2k $66.9m $66.9m 0.15% Reduced -26.4k -26,450
72 Affinity Asset Advisors, LLC 6.03% of their portfolio NEW YORK, NY 450,000450.0k $64.8m $64.8m 6.03% Reduced -25.0k -25,000
73 NEW YORK STATE COMMON RETIREMENT FUND 0.08% of their portfolio ALBANY, NY 445,876445.9k $64.2m $64.2m 0.08% Added +18.1k +18,123
74 BNP PARIBAS FINANCIAL MARKETS 0.05% of their portfolio PARIS, I0 433,340433.3k $62.4m $62.4m 0.05% Reduced -320.8k -320,820
75 Cormorant Asset Management, LP 4.27% of their portfolio BOSTON, MA 430,000430.0k $61.9m $61.9m 4.27% Reduced -110.0k -110,000
76 TimesSquare Capital Management, LLC 0.88% of their portfolio NEW YORK, NY 425,085425.1k $61.2m $61.2m 0.88% Reduced -448.4k -448,406
77 TD Asset Management Inc 0.05% of their portfolio Toronto, A6 398,256398.3k $57.4m $57.4m 0.05% Added +3.1k +3,062
78 Candriam S.C.A. 0.30% of their portfolio STRASSEN, N4 397,588397.6k $57.3m $57.3m 0.30% Reduced -41.1k -41,100
79 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 386,671386.7k $55.7m $55.7m 0.01% Reduced -25.1k -25,073
80 Rock Springs Capital Management LP 3.24% of their portfolio Baltimore, MD 385,000385.0k $55.4m $55.4m 3.24% Reduced -140.0k -140,000
81 ING GROEP NV 0.29% of their portfolio AMSTERDAM, P7 373,500373.5k $53.8m $53.8m 0.29% New
82 Polar Capital Holdings Plc 0.26% of their portfolio London, X0 371,887371.9k $53.6m $53.6m 0.26% Reduced -326.1k -326,073
83 Swiss National Bank 0.03% of their portfolio ZURICH, V8 371,300371.3k $53.5m $53.5m 0.03% Added +23.9k +23,900
84 VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio San Antonio, TX 354,907354.9k $51.1m $51.1m 0.03% Added +172.1k +172,134
85 RENAISSANCE TECHNOLOGIES LLC 0.07% of their portfolio NEW YORK, NY 352,887352.9k $50.8m $50.8m 0.07% Added +44.2k +44,200
86 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 342,785342.8k $49.4m $49.4m 0.01% Reduced -23.0k -23,042
87 Long Focus Capital Management, LLC 2.78% of their portfolio SAN JUAN, PR 338,000338.0k $48.7m $48.7m 2.78% Reduced -182.2k -182,200
88 FRONTIER CAPITAL MANAGEMENT CO LLC 0.42% of their portfolio Boston, MA 328,884328.9k $47.4m $47.4m 0.42% Added +181.1k +181,083
89 FEDERATED HERMES, INC. 0.08% of their portfolio PITTSBURGH, PA 328,223328.2k $47.3m $47.3m 0.08% Added +219.8k +219,838
90 Patient Square Capital LP 12.57% of their portfolio MENLO PARK, CA 326,400326.4k $47.0m $47.0m 12.57% Reduced -32.4k -32,400
91 First Turn Management, LLC 6.91% of their portfolio DEL MAR, CA 319,773319.8k $46.1m $46.1m 6.91% Reduced -52.9k -52,899
92 Amundi 0.02% of their portfolio Paris, I0 317,096317.1k $50.2m $50.2m 0.02% Added +305.6k +305,597
93 California Public Employees Retirement System 0.03% of their portfolio Sacramento, CA 310,886310.9k $44.8m $44.8m 0.03% Added +88.7k +88,650
94 Brevan Howard Capital Management LP 0.61% of their portfolio ST. HELIER, Y9 294,047294.0k $42.3m $42.3m 0.61% Added +91.5k +91,453
95 SAMLYN CAPITAL, LLC 0.60% of their portfolio New York, NY 292,643292.6k $42.1m $42.1m 0.60% New
96 AQR CAPITAL MANAGEMENT LLC 0.03% of their portfolio Greenwich, CT 287,286287.3k $40.9m $40.9m 0.03% Added +237.6k +237,571
97 Eagle Health Investments LP 10.27% of their portfolio Greenwich, CT 271,600271.6k $39.1m $39.1m 10.27% Reduced -157.0k -157,000
98 FIRST TRUST ADVISORS LP 0.03% of their portfolio Wheaton, IL 240,646240.6k $34.7m $34.7m 0.03% Added +193.3k +193,254
99 Aberdeen Group plc 0.05% of their portfolio EDINBURGH, X0 234,622234.6k $33.8m $33.8m 0.05% Reduced -75.1k -75,127
100 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.05% of their portfolio BALA CYNWYD, PA 233,106233.1k $33.6m $33.6m 0.05% Added +20.9k +20,884