Vault-13

INSMED INC INSM

COM PAR $.01 · Common Stock · CUSIP 457669307 · ISIN US4576693075

518 institutional holders +74 vs Q1 2025
210,845,294210.8m shares reported held*
99.7% of all shares outstanding*
$21.2bnreported value*
125 new 165 added 189 reduced 53 sold out net bought ≈ $1.1bn (+11.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($70.3m this quarter). Holder counts are more reliable. Shares outstanding: 211.4m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $100.53. Options: 29 managers hold calls ($330.0m notional), 27 hold puts ($356.0m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 239Q4 22: 226Q1 23: 232Q2 23: 225Q3 23: 254Q4 23: 273Q1 24: 290Q2 24: 380Q3 24: 417Q4 24: 441Q1 25: 444Q2 25: 518518Q3 22Q2 23Q1 24Q4 24Q2 25
Numbers
QuarterHolders
Q3 2022239
Q4 2022226
Q1 2023232
Q2 2023225
Q3 2023254
Q4 2023273
Q1 2024290
Q2 2024380
Q3 2024417
Q4 2024441
Q1 2025444
Q2 2025518

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q3 23: 133 bought or addedQ3 23: 95 cut or sold outQ4 23: 131 bought or addedQ4 23: 111 cut or sold outQ4 23Q1 24: 141 bought or addedQ1 24: 126 cut or sold outQ2 24: 257 bought or addedQ2 24: 137 cut or sold outQ2 24Q3 24: 257 bought or addedQ3 24: 152 cut or sold outQ4 24: 226 bought or addedQ4 24: 188 cut or sold outQ4 24Q1 25: 236 bought or addedQ1 25: 195 cut or sold outQ2 25: 290 bought or addedQ2 25: 242 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 202313395
Q4 2023131111
Q1 2024141126
Q2 2024257137
Q3 2024257152
Q4 2024226188
Q1 2025236195
Q2 2025290242

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300m$400mQ3 24 calls: $175.9mQ3 24 puts: $270.0mQ3 24P/C 1.54Q4 24 calls: $235.2mQ4 24 puts: $196.7mQ4 24P/C 0.84Q1 25 calls: $73.0mQ1 25 puts: $144.9mQ1 25P/C 1.99Q2 25 calls: $330.0mQ2 25 puts: $356.0mQ2 25P/C 1.08
Numbers
QuarterCallsPutsP/C
Q3 2024$175.9m$270.0m1.54
Q4 2024$235.2m$196.7m0.84
Q1 2025$73.0m$144.9m1.99
Q2 2025$330.0m$356.0m1.08

Biggest buyers

JPMORGAN CHASE & CO Added +9,282,377+9.3m
Darwin Global Management, Ltd. Added +3,946,646+3.9m
D. E. Shaw & Co., Inc. Added +2,687,739+2.7m
BAKER BROS. ADVISORS LP Added +2,332,274+2.3m
FMR LLC Added +1,698,877+1.7m
Orbis Allan Gray Ltd New +1,524,134+1.5m
Deep Track Capital, LP Added +1,495,249+1.5m
MILLENNIUM MANAGEMENT LLC Added +1,442,526+1.4m
JANE STREET GROUP, LLC Added +1,228,335+1.2m
CITADEL ADVISORS LLC Added +1,158,462+1.2m

Biggest sellers

BlackRock, Inc. Reduced -4,906,450-4.9m
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -1,692,836-1.7m
T. Rowe Price Investment Management, Inc. Sold out -1,476,948-1.5m
STATE STREET CORP Reduced -1,469,405-1.5m
MONTANOVA CAPITAL, LLC Reduced -1,253,600-1.3m
MACQUARIE GROUP LTD Reduced -1,231,182-1.2m
FIL Ltd Reduced -1,224,737-1.2m
ALLIANCEBERNSTEIN L.P. Reduced -1,080,301-1.1m
Vestal Point Capital, LP Sold out -1,075,000-1.1m
GEODE CAPITAL MANAGEMENT, LLC Reduced -948,028-948.0k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $100.8m1.0m shares
NWI MANAGEMENT LP New $60.6m602.0k shares
Caption Management, LLC Added $33.6m334.2k shares
GROUP ONE TRADING LLC Added $16.0m159.0k shares
SIMPLEX TRADING, LLC Added $14.9m148.5k shares
JANE STREET GROUP, LLC Reduced $14.7m146.1k shares
Walleye Trading LLC Added $14.3m142.3k shares
LMR Partners LLP New $10.4m103.0k shares
GOLDMAN SACHS GROUP INC New $10.1m100.0k shares
Duquesne Family Office LLC New $10.1m100.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $108.6m1.1m shares
JANE STREET GROUP, LLC Reduced $74.3m737.8k shares
Caption Management, LLC Added $28.4m282.1k shares
GOLDMAN SACHS GROUP INC New $24.2m240.0k shares
Parallax Volatility Advisers, L.P. Unchanged $18.6m185.3k shares
Balyasny Asset Management L.P. New $15.1m150.0k shares
GROUP ONE TRADING LLC Added $14.7m146.3k shares
CITADEL ADVISORS LLC Added $11.0m108.9k shares
SIMPLEX TRADING, LLC Added $10.6m105.0k shares
Jefferies Financial Group Inc. Unchanged $10.1m99.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +1.3 pts · filed 2026-08-06 7.4% +1.3 pts 16.1m≈ $1.7bn 2026-08-06
BlackRock, Inc. 13G · institution +1.5 pts · filed 2026-01-21 6.6% +1.5 pts 14.1m≈ $1.5bn 2026-01-21
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.3% new 11.5m≈ $1.2bn 2026-04-30

Fell to 5% or below in the last year: Darwin Global Management, Ltd. (3.0%, 2026-08-14), JPMORGAN CHASE & CO (4.7%, 2026-07-22), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), PRICE T ROWE ASSOCIATES INC /MD/ (3.3%, 2025-11-14)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q3 23: 0 buyingQ3 23: 1 sellingQ4 23: 0 buyingQ4 23: 4 sellingQ4 23Q1 24: 0 buyingQ1 24: 7 sellingQ2 24: 0 buyingQ2 24: 7 sellingQ2 24Q3 24: 0 buyingQ3 24: 3 sellingQ4 24: 0 buyingQ4 24: 1 sellingQ4 24Q1 25: 0 buyingQ1 25: 7 sellingQ2 25: 1 buyingQ2 25: 7 sellingQ2 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20230—1$14.9k—
Q4 20230—4$4.7m$4.7m
Q1 20240—7$3.7m$3.0m
Q2 20240—7$28.7m$26.9m
Q3 20240—3$25.6m$18.4m
Q4 20240—1$3.7m$3.7m
Q1 20250—7$53.0m$32.1m
Q2 20251$201.7k7$54.6m$49.9m
DateInsiderTradeSharesPrice ValueTheir holding
2025-06-23 Bonstein Sara Chief Financial Officer Sold plan 57,765 $101.78 $5.9m57.8k shares -38%
2025-06-16 Lewis William Chair and CEO, director Sold plan 129,805 $100.39 $13.0m129.8k shares -36%
2025-06-16 Adsett Roger Chief Operating Officer Sold plan 10,686 $98.82 $1.1m10.7k shares -8%
2025-06-16 Lewis William Chair and CEO, director Sold plan 5,204 $100.32 $522.1k5.2k shares -2%
2025-06-11 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold plan 99,172 $93.42 $9.3m99.2k shares -53%
2025-06-11 Flammer Martina M.D. Chief Medical Officer Sold plan 19,423 $94.50 $1.8m19.4k shares -19%
2025-06-10 Bonstein Sara Chief Financial Officer Sold plan 57,766 $89.12 $5.1m57.8k shares -36%
2025-06-10 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold plan 38,300 $88.64 $3.4m38.3k shares -24%
2025-06-10 Flammer Martina M.D. Chief Medical Officer Sold plan 25,740 $88.64 $2.3m25.7k shares -24%
2025-06-05 Smith Michael Alexander Chief Legal Officer Sold plan 1,879 $73.50 $138.1k1.9k shares -3%
2025-06-04 MCGIRR DAVID W J Director Sold plan 3,000 $73.27 $219.8k3.0k shares -3%
2025-06-03 Lewis William Chair and CEO, director Sold plan 5,472 $71.50 $391.2k5.5k shares -2%
2025-06-03 MCGIRR DAVID W J Director Sold plan 3,250 $71.30 $231.7k3.2k shares -3%
2025-06-03 Adsett Roger Chief Operating Officer Sold 1,860 $71.50 $133.0k1.9k shares -1%
2025-06-03 Flammer Martina M.D. Chief Medical Officer Sold 1,686 $71.50 $120.5k1.7k shares -2%
2025-06-03 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold 1,642 $71.50 $117.4k1.6k shares -1%
2025-06-03 Bonstein Sara Chief Financial Officer Sold 1,579 $71.50 $112.9k1.6k shares -1%
2025-06-03 Smith Michael Alexander Chief Legal Officer Sold 1,448 $71.50 $103.5k1.4k shares -2%
2025-06-02 Lewis William Chair and CEO, director · By the Katie Procter Dynasty Trust Sold plan 6,830 $71.31 $487.0k6.8k shares -3%
2025-05-30 Smith Michael Alexander Chief Legal Officer Sold plan 26,327 $69.65 $1.8m26.3k shares -27%
2025-05-21 Desjardins Clarissa Director · By spouse Bought 1,130 $66.35 $75.0k1.1k shares +60%
2025-05-20 Lewis William Chair and CEO, director Sold plan 21,057 $67.65 $1.4m21.1k shares -6%
2025-05-20 Lewis William Chair and CEO, director Sold plan 6,830 $67.72 $462.5k6.8k shares -3%
2025-05-20 Desjardins Clarissa Director · By spouse Bought 1,895 $66.87 $126.7k1.9k shares new
2025-05-16 Flammer Martina M.D. Chief Medical Officer Sold plan 1,799 $67.53 $121.5k1.8k shares -2%
2025-05-15 Flammer Martina M.D. Chief Medical Officer Sold plan 9,925 $65.47 $649.8k9.9k shares -10%
2025-05-14 Lewis William Chair and CEO, director Sold 3,771 $65.61 $247.4k3.8k shares -1%
2025-05-14 Adsett Roger Chief Operating Officer Sold 1,925 $65.61 $126.3k1.9k shares -1%
2025-05-14 Flammer Martina M.D. Chief Medical Officer Sold 1,744 $65.61 $114.4k1.7k shares -2%
2025-05-14 Bonstein Sara Chief Financial Officer Sold 1,634 $65.61 $107.2k1.6k shares -2%

The latest 30 of 41 trades.

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Darwin Global Management, Ltd. 80.75% of their portfolio ST. HELIER, Y9 19,344,62119.3m $1.9bn $1.9bn 80.75% Added +3.9m +3,946,646
2 VANGUARD GROUP INC 0.03% of their portfolio Valley Forge, PA 17,644,49217.6m $1.8bn $1.8bn 0.03% Reduced -623.6k -623,630
3 JPMORGAN CHASE & CO 0.11% of their portfolio NEW YORK, NY 15,636,39915.6m $1.6bn $1.6bn 0.11% Added +9.3m +9,282,377
4 PRICE T ROWE ASSOCIATES INC /MD/ 0.13% of their portfolio BALTIMORE, MD 11,230,70511.2m $1.1bn $1.1bn 0.13% Reduced -1.7m -1,692,836
5 BlackRock, Inc. 0.02% of their portfolio New York, NY 11,142,43211.1m $1.1bn $1.1bn 0.02% Reduced -4.9m -4,906,450
6 BAKER BROS. ADVISORS LP 7.53% of their portfolio NEW YORK, NY 7,712,9007.7m $776.2m $776.2m 7.53% Added +2.3m +2,332,274
7 Capital International Investors 0.13% of their portfolio Los Angeles, CA 7,478,8597.5m $752.7m $752.7m 0.13% Added +280.4k +280,374
8 FMR LLC 0.03% of their portfolio BOSTON, MA 5,093,2615.1m $512.6m $512.6m 0.03% Added +1.7m +1,698,877
9 STATE STREET CORP 0.02% of their portfolio BOSTON, MA 4,277,8884.3m $430.5m $430.5m 0.02% Reduced -1.5m -1,469,405
10 D. E. Shaw & Co., Inc. 0.34% of their portfolio New York, NY 3,422,6193.4m $344.5m $344.5m 0.34% Added +2.7m +2,687,739
11 GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio BOSTON, MA 3,340,7073.3m $336.3m $336.3m 0.02% Reduced -948.0k -948,028
12 Artisan Partners Limited Partnership 0.50% of their portfolio Milwaukee, WI 3,314,3413.3m $333.6m $333.6m 0.50% Added +97.1k +97,073
13 RTW INVESTMENTS, LP 4.42% of their portfolio NEW YORK, NY 3,084,5583.1m $310.4m $310.4m 4.42% Added +70.0k +70,000
14 AMERIPRISE FINANCIAL INC 0.07% of their portfolio MINNEAPOLIS, MN 2,957,9733.0m $297.7m $297.7m 0.07% Added +6.4k +6,351
15 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.48% of their portfolio Boston, MA 2,859,4522.9m $287.8m $287.8m 0.48% Reduced -587.5k -587,492
16 FRANKLIN RESOURCES INC 0.06% of their portfolio San Mateo, CA 2,350,1332.4m $236.5m $236.5m 0.06% Added +201.8k +201,849
17 JANUS HENDERSON GROUP PLC 0.11% of their portfolio LONDON, X0 2,293,1422.3m $230.8m $230.8m 0.11% Added +747.7k +747,723
18 Duquesne Family Office LLC 5.79% of their portfolio New York, NY 2,253,4352.3m $226.8m $226.8m 5.79% Added +884.4k +884,385
19 MILLENNIUM MANAGEMENT LLC 0.19% of their portfolio NEW YORK, NY 2,121,7172.1m $213.5m $213.5m 0.19% Added +1.4m +1,442,526
20 Holocene Advisors, LP 0.50% of their portfolio New York, NY 2,016,8062.0m $203.0m $203.0m 0.50% Reduced -9.6k -9,616
21 NORGES BANK 0.02% of their portfolio OSLO, Q8 1,934,8991.9m $194.7m $194.7m 0.02% Added +192.1k +192,056
22 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 1,896,3331.9m $190.8m $190.8m 0.03% Added +105.0k +105,009
23 GOLDMAN SACHS GROUP INC 0.03% of their portfolio NEW YORK, NY 1,810,8951.8m $182.2m $182.2m 0.03% Added +408.3k +408,274
24 Deep Track Capital, LP 5.66% of their portfolio GREENWICH, CT 1,750,0001.8m $176.1m $176.1m 5.66% Added +1.5m +1,495,249
25 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.44% of their portfolio CHICAGO, IL 1,665,6021.7m $167.6m $167.6m 0.44% Reduced -647.6k -647,615
26 Integral Health Asset Management, LLC 15.04% of their portfolio New York, NY 1,600,0001.6m $161.0m $161.0m 15.04% Added +50.0k +50,000
27 Pictet Asset Management Holding SA 0.16% of their portfolio CAROUGE, V8 1,553,6281.6m $156.2m $156.2m 0.16% Reduced -459.7k -459,701
28 LORD, ABBETT & CO. LLC 0.50% of their portfolio JERSEY CITY, NJ 1,545,8591.5m $155.6m $155.6m 0.50% Added +195.3k +195,272
29 CITADEL ADVISORS LLC 0.13% of their portfolio MIAMI, FL 1,533,2771.5m $154.3m $154.3m 0.13% Added +1.2m +1,158,462
30 Orbis Allan Gray Ltd 0.75% of their portfolio HamiltoN, D0 1,524,1341.5m $153.4m $153.4m 0.75% New
31 NWI MANAGEMENT LP 6.74% of their portfolio NEW YORK, NY 1,440,0001.4m $144.9m $144.9m 6.74% Added +990.0k +990,000
32 Clearbridge Investments, LLC 0.12% of their portfolio NEW YORK, NY 1,424,5621.4m $143.4m $143.4m 0.12% Reduced -404.2k -404,166
33 JANE STREET GROUP, LLC 0.22% of their portfolio NEW YORK, NY 1,352,9221.4m $136.2m $136.2m 0.22% Added +1.2m +1,228,335
34 PRINCIPAL FINANCIAL GROUP INC 0.07% of their portfolio DES MOINES, IA 1,348,0271.3m $135.7m $135.7m 0.07% Reduced -407.3k -407,346
35 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 1,343,2121.3m $135.2m $135.2m 0.04% Reduced -1.1m -1,080,301
36 WESTFIELD CAPITAL MANAGEMENT CO LP 0.57% of their portfolio BOSTON, MA 1,339,2881.3m $134.8m $134.8m 0.57% Reduced -67.3k -67,321
37 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 1,299,5681.3m $130.8m $130.8m 0.02% Reduced -303.1k -303,087
38 GW&K Investment Management, LLC 1.15% of their portfolio BOSTON, MA 1,274,3161.3m $128.2m $128.2m 1.15% Reduced -103.4k -103,410
39 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,226,7371.2m $123.5m $123.5m 0.01% Reduced -126.3k -126,262
40 Bank of New York Mellon Corp 0.02% of their portfolio NEW YORK, NY 1,197,4731.2m $120.5m $120.5m 0.02% Added +40.7k +40,723
41 EVENTIDE ASSET MANAGEMENT, LLC 2.11% of their portfolio Boston, MA 1,196,4941.2m $120.4m $120.4m 2.11% Added +14.8k +14,819
42 FIL Ltd 0.10% of their portfolio HAMILTON, D0 1,165,4641.2m $117.3m $117.3m 0.10% Reduced -1.2m -1,224,737
43 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 1,159,6991.2m $116.7m $116.7m 0.02% Reduced -62.9k -62,928
44 MACQUARIE GROUP LTD 0.14% of their portfolio Sydney, NSW 2000, C3 1,130,9231.1m $113.8m $113.8m 0.14% Reduced -1.2m -1,231,182
45 MARSHALL WACE, LLP 0.13% of their portfolio LONDON, X0 1,113,3611.1m $112.0m $112.0m 0.13% Added +417.1k +417,124
46 Qube Research & Technologies Ltd 0.15% of their portfolio LONDON, X0 1,082,0501.1m $108.9m $108.9m 0.15% New
47 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,043,7911.0m $105.0m $105.0m 0.01% Reduced -15.9k -15,865
48 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 3.96% of their portfolio Boston, MA 1,008,9371.0m $101.5m $101.5m 3.96% Added +304.6k +304,571
49 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 969,800969.8k $97.6m $97.6m 0.01% Reduced -714.0k -714,038
50 Hood River Capital Management LLC 1.26% of their portfolio PALM BEACH GARDENS, FL 899,603899.6k $90.5m $90.5m 1.26% Reduced -658.7k -658,683
51 TimesSquare Capital Management, LLC 1.27% of their portfolio NEW YORK, NY 873,491873.5k $87.9m $87.9m 1.27% Reduced -190.7k -190,657
52 Palo Alto Investors LP 18.52% of their portfolio PALO ALTO, CA 865,113865.1k $87.1m $87.1m 18.52% Reduced -122.0k -122,040
53 ROYAL BANK OF CANADA 0.01% of their portfolio TORONTO, A6 855,602855.6k $86.1m $86.1m 0.01% Added +610.3k +610,340
54 MAVERICK CAPITAL LTD 1.24% of their portfolio DALLAS, TX 804,133804.1k $80.9m $80.9m 1.24% Added +379.0k +379,008
55 LOOMIS SAYLES & CO L P 0.10% of their portfolio BOSTON, MA 793,569793.6k $79.9m $79.9m 0.10% Reduced -215.9k -215,897
56 RAYMOND JAMES FINANCIAL INC 0.03% of their portfolio ST. PETERSBURG, FL 784,551784.6k $79.0m $79.0m 0.03% Added +375.6k +375,614
57 BNP PARIBAS FINANCIAL MARKETS 0.06% of their portfolio PARIS, I0 754,160754.2k $75.9m $75.9m 0.06% Added +292.5k +292,497
58 Artia Global Partners LP 19.48% of their portfolio MIAMI, FL 752,712752.7k $75.8m $75.8m 19.48% Added +434.5k +434,473
59 Fiera Capital Corp 0.26% of their portfolio MONTREAL, A8 748,037748.0k $75.3m $75.3m 0.26% Added +168.8k +168,800
60 HRT FINANCIAL LP 0.39% of their portfolio NEW YORK, NY 729,597729.6k $73.4m $73.4m 0.39% New
61 JENNISON ASSOCIATES LLC 0.04% of their portfolio NEW YORK, NY 715,606715.6k $72.0m $72.0m 0.04% Reduced -32.7k -32,707
62 DEERFIELD MANAGEMENT COMPANY, L.P. 1.28% of their portfolio New York, NY 700,700700.7k $70.5m $70.5m 1.28% Added +242.7k +242,700
63 Polar Capital Holdings Plc 0.37% of their portfolio London, X0 697,960698.0k $70.2m $70.2m 0.37% Reduced -30.8k -30,795
64 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 695,961696.0k $70.0m $70.0m 0.01% Added +156.5k +156,477
65 NOVO HOLDINGS A/S 4.83% of their portfolio HELLERUP, G7 680,000680.0k $68.4m $68.4m 4.83% Reduced -44.7k -44,666
66 PERCEPTIVE ADVISORS LLC 2.46% of their portfolio NEW YORK, NY 650,252650.3k $65.4m $65.4m 2.46% Added +141.0k +140,952
67 Alyeska Investment Group, L.P. 0.22% of their portfolio CHICAGO, IL 603,702603.7k $60.8m $60.8m 0.22% Reduced -131.3k -131,298
68 Nuveen, LLC 0.02% of their portfolio CHARLOTTE, NC 588,987589.0k $59.3m $59.3m 0.02% Reduced -569.1k -569,107
69 BROWN ADVISORY INC 0.08% of their portfolio BALTIMORE, MD 579,846579.8k $58.4m $58.4m 0.08% Reduced -92.6k -92,604
70 Ensign Peak Advisors, Inc 0.10% of their portfolio SALT LAKE CITY, UT 564,389564.4k $56.8m $56.8m 0.10% Reduced -25.0k -25,010
71 Cormorant Asset Management, LP 4.05% of their portfolio BOSTON, MA 540,000540.0k $54.3m $54.3m 4.05% Added +15.0k +15,000
72 Rock Springs Capital Management LP 3.29% of their portfolio Baltimore, MD 525,000525.0k $52.8m $52.8m 3.29% Added +9.1k +9,100
73 Long Focus Capital Management, LLC 3.38% of their portfolio SAN JUAN, PR 520,200520.2k $52.4m $52.4m 3.38% Reduced -110.6k -110,600
74 ALKEON CAPITAL MANAGEMENT LLC 0.24% of their portfolio New York, NY 500,000500.0k $50.3m $50.3m 0.24% New
75 Point72 Asset Management, L.P. 0.12% of their portfolio STAMFORD, CT 490,667490.7k $49.4m $49.4m 0.12% New
76 Affinity Asset Advisors, LLC 7.07% of their portfolio NEW YORK, NY 475,000475.0k $47.8m $47.8m 7.07% Added +335.0k +335,000
77 Castle Hook Partners LP 0.67% of their portfolio NEW YORK, NY 452,656452.7k $45.6m $45.6m 0.67% New
78 Candriam S.C.A. 0.25% of their portfolio STRASSEN, N4 438,688438.7k $44.2m $44.2m 0.25% Reduced -16.7k -16,720
79 SEI INVESTMENTS CO 0.05% of their portfolio OAKS, PA 433,628433.6k $43.6m $43.6m 0.05% Added +37.6k +37,649
80 Eagle Health Investments LP 10.65% of their portfolio Greenwich, CT 428,600428.6k $43.1m $43.1m 10.65% Reduced -14.7k -14,700
81 NEW YORK STATE COMMON RETIREMENT FUND 0.06% of their portfolio ALBANY, NY 427,753427.8k $43.0m $43.0m 0.06% Added +72.0k +72,031
82 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 411,744411.7k $41.4m $41.4m 0.01% Added +39.7k +39,744
83 VOYA INVESTMENT MANAGEMENT LLC 0.04% of their portfolio ATLANTA, GA 407,679407.7k $41.0m $41.0m 0.04% Reduced -763.2k -763,177
84 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 395,194395.2k $39.8m $39.8m 0.03% Reduced -107.0k -107,038
85 TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio NEW YORK, NY 376,508376.5k $37.9m $37.9m 0.07% Reduced -30.4k -30,395
86 First Turn Management, LLC 7.00% of their portfolio DEL MAR, CA 372,672372.7k $37.5m $37.5m 7.00% Reduced -29.0k -28,957
87 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 365,827365.8k $36.8m $36.8m 0.01% Added +40.5k +40,520
88 Patient Square Capital LP 13.02% of their portfolio MENLO PARK, CA 358,800358.8k $36.1m $36.1m 13.02% Added +28.6k +28,550
89 Swiss National Bank 0.02% of their portfolio ZURICH, V8 347,400347.4k $35.0m $35.0m 0.02% Added +18.1k +18,100
90 Weiss Asset Management LP 0.54% of their portfolio BOSTON, MA 339,825339.8k $34.2m $34.2m 0.54% Not comparable
91 LOS ANGELES CAPITAL MANAGEMENT LLC 0.12% of their portfolio LOS ANGELES, CA 330,800330.8k $33.3m $33.3m 0.12% Added +318.7k +318,716
92 Sofinnova Investments, Inc. 2.15% of their portfolio Menlo Park, CA 313,923313.9k $31.6m $31.6m 2.15% Added +9.7k +9,669
93 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.12% of their portfolio JUPITER, FL 313,053313.1k $31.5m $31.5m 0.12% Added +310.4k +310,376
94 Aberdeen Group plc 0.05% of their portfolio EDINBURGH, X0 309,749309.7k $31.2m $31.2m 0.05% Reduced -26.6k -26,608
95 RENAISSANCE TECHNOLOGIES LLC 0.04% of their portfolio NEW YORK, NY 308,687308.7k $31.1m $31.1m 0.04% New
96 Allspring Global Investments Holdings, LLC 0.05% of their portfolio CHARLOTTE, NC 304,310304.3k $29.7m $29.7m 0.05% Reduced -134.4k -134,364
97 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.07% of their portfolio Paris, I0 302,065302.1k $30.4m $30.4m 0.07% Reduced -311.2k -311,204
98 UBS Group AG 0.01% of their portfolio ZURICH, V8 293,454293.5k $29.5m $29.5m 0.01% Reduced -184.2k -184,182
99 Cubist Systematic Strategies, LLC 0.31% of their portfolio STAMFORD, CT 283,102283.1k $28.5m $28.5m 0.31% New
100 C WorldWide Group Holding A/S 0.37% of their portfolio COPENHAGEN, G7 271,110271.1k $27.3m $27.3m 0.37% Reduced -50.0k -50,000