Vault-13

INSMED INC INSM

COM PAR $.01 · Common Stock · CUSIP 457669307 · ISIN US4576693075

444 institutional holders +3 vs Q4 2024
200,070,088200.1m shares reported held*
109.8% of all shares outstanding*
$15.3bnreported value*
52 new 184 added 150 reduced 45 sold out net bought ≈ $585.6m (+7.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($18.5m this quarter). Holder counts are more reliable. Shares outstanding: 182.1m as of 2025-05-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $76.67. Options: 19 managers hold calls ($73.0m notional), 18 hold puts ($144.9m).

Trends to Q1 2025

Institutional holders

Managers reporting a position, each quarter

0200400600Q3 22: 239Q4 22: 226Q1 23: 232Q2 23: 225Q3 23: 254Q4 23: 273Q1 24: 290Q2 24: 380Q3 24: 417Q4 24: 441Q1 25: 444444Q3 22Q1 23Q3 23Q1 24Q3 24Q1 25
Numbers
QuarterHolders
Q3 2022239
Q4 2022226
Q1 2023232
Q2 2023225
Q3 2023254
Q4 2023273
Q1 2024290
Q2 2024380
Q3 2024417
Q4 2024441
Q1 2025444

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
4000400Q2 23: 103 bought or addedQ2 23: 111 cut or sold outQ3 23: 133 bought or addedQ3 23: 95 cut or sold outQ3 23Q4 23: 131 bought or addedQ4 23: 111 cut or sold outQ1 24: 141 bought or addedQ1 24: 126 cut or sold outQ1 24Q2 24: 257 bought or addedQ2 24: 137 cut or sold outQ3 24: 257 bought or addedQ3 24: 152 cut or sold outQ3 24Q4 24: 226 bought or addedQ4 24: 188 cut or sold outQ1 25: 236 bought or addedQ1 25: 195 cut or sold outQ1 25
Numbers
QuarterBought or addedCut or sold out
Q2 2023103111
Q3 202313395
Q4 2023131111
Q1 2024141126
Q2 2024257137
Q3 2024257152
Q4 2024226188
Q1 2025236195

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200m$400m$600mQ2 24 calls: $470.9mQ2 24 puts: $343.5mQ2 24P/C 0.73Q3 24 calls: $175.9mQ3 24 puts: $270.0mQ3 24P/C 1.54Q4 24 calls: $235.2mQ4 24 puts: $196.7mQ4 24P/C 0.84Q1 25 calls: $73.0mQ1 25 puts: $144.9mQ1 25P/C 1.99
Numbers
QuarterCallsPutsP/C
Q2 2024$470.9m$343.5m0.73
Q3 2024$175.9m$270.0m1.54
Q4 2024$235.2m$196.7m0.84
Q1 2025$73.0m$144.9m1.99

Biggest buyers

JPMORGAN CHASE & CO Added +3,067,774+3.1m
Darwin Global Management, Ltd. Added +2,437,437+2.4m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,799,382+1.8m
Holocene Advisors, LP Added +1,338,710+1.3m
Duquesne Family Office LLC Added +775,580+775.6k
Invesco Ltd. Added +775,234+775.2k
VOYA INVESTMENT MANAGEMENT LLC Added +621,989+622.0k
1832 Asset Management L.P. New +487,800+487.8k
WELLINGTON MANAGEMENT GROUP LLP Added +470,401+470.4k
WESTFIELD CAPITAL MANAGEMENT CO LP Added +468,058+468.1k

Biggest sellers

FMR LLC Reduced -1,461,865-1.5m
Palo Alto Investors LP Reduced -616,312-616.3k
T. Rowe Price Investment Management, Inc. Reduced -505,759-505.8k
Assenagon Asset Management S.A. Reduced -485,415-485.4k
Logos Global Management LP Sold out -450,000-450.0k
First Light Asset Management, LLC Reduced -402,039-402.0k
MPM BIOIMPACT LLC Sold out -389,611-389.6k
Qube Research & Technologies Ltd Sold out -389,033-389.0k
MARSHALL WACE, LLP Reduced -367,978-368.0k
STATE STREET CORP Reduced -358,860-358.9k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $25.6m336.0k shares
JANE STREET GROUP, LLC Added $12.8m167.7k shares
Hudson Bay Capital Management LP New $7.6m100.0k shares
CITADEL ADVISORS LLC Reduced $6.0m78.6k shares
Caption Management, LLC Reduced $4.0m52.3k shares
GROUP ONE TRADING LLC Reduced $3.7m48.0k shares
SIMPLEX TRADING, LLC Reduced $2.5m33.0k shares
BANK OF AMERICA CORP /DE/ New $2.1m27.0k shares
IMC-Chicago, LLC New $1.5m20.2k shares
WOLVERINE TRADING, LLC Reduced $1.5m19.7k shares

Biggest puts

JANE STREET GROUP, LLC Added $56.6m742.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $34.4m451.4k shares
Parallax Volatility Advisers, L.P. Reduced $14.1m185.3k shares
Caption Management, LLC Reduced $11.3m147.8k shares
GROUP ONE TRADING LLC Reduced $8.2m107.3k shares
Jefferies Financial Group Inc. Unchanged $7.6m99.9k shares
CITADEL ADVISORS LLC Reduced $5.1m67.5k shares
J. Goldman & Co LP New $2.3m30.0k shares
SIMPLEX TRADING, LLC Reduced $1.2m15.1k shares
GARDA CAPITAL PARTNERS LP New $1.1m14.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution +1.3 pts · filed 2026-08-06 7.4% +1.3 pts 16.1m≈ $1.7bn 2026-08-06
BlackRock, Inc. 13G · institution +1.5 pts · filed 2026-01-21 6.6% +1.5 pts 14.1m≈ $1.5bn 2026-01-21
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 5.3% new 11.5m≈ $1.2bn 2026-04-30

Fell to 5% or below in the last year: Darwin Global Management, Ltd. (3.0%, 2026-08-14), JPMORGAN CHASE & CO (4.7%, 2026-07-22), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), PRICE T ROWE ASSOCIATES INC /MD/ (3.3%, 2025-11-14)

Insider purchases and sales in Q1 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q2 23: 1 buyingQ2 23: 7 sellingQ3 23: 0 buyingQ3 23: 1 sellingQ3 23Q4 23: 0 buyingQ4 23: 4 sellingQ1 24: 0 buyingQ1 24: 7 sellingQ1 24Q2 24: 0 buyingQ2 24: 7 sellingQ3 24: 0 buyingQ3 24: 3 sellingQ3 24Q4 24: 0 buyingQ4 24: 1 sellingQ1 25: 0 buyingQ1 25: 7 sellingQ1 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20231$385.8k7$1.2m$344.4k
Q3 20230—1$14.9k—
Q4 20230—4$4.7m$4.7m
Q1 20240—7$3.7m$3.0m
Q2 20240—7$28.7m$26.9m
Q3 20240—3$25.6m$18.4m
Q4 20240—1$3.7m$3.7m
Q1 20250—7$53.0m$32.1m
DateInsiderTradeSharesPrice ValueTheir holding
2025-03-17 Lewis William Chair and CEO, director Sold plan 18,750 $77.03 $1.4m18.8k shares -5%
2025-03-17 Lewis William Chair and CEO, director Sold plan 6,830 $77.04 $526.2k6.8k shares -3%
2025-03-03 Lewis William Chair and CEO, director Sold plan 18,750 $77.79 $1.5m18.8k shares -5%
2025-03-03 Lewis William Chair and CEO, director Sold plan 6,830 $77.79 $531.3k6.8k shares -3%
2025-02-18 Lewis William Chair and CEO, director Sold plan 18,750 $81.03 $1.5m18.8k shares -5%
2025-02-18 Bonstein Sara Chief Financial Officer Sold plan 18,322 $80.31 $1.5m18.3k shares -13%
2025-02-18 Lewis William Chair and CEO, director Sold plan 6,830 $81.03 $553.4k6.8k shares -3%
2025-02-12 Bonstein Sara Chief Financial Officer Sold plan 5,019 $80.00 $401.5k5.0k shares -4%
2025-02-11 Bonstein Sara Chief Financial Officer Sold plan 13,302 $80.00 $1.1m13.3k shares -9%
2025-02-10 Adsett Roger Chief Operating Officer Sold plan 42,975 $78.61 $3.4m43.0k shares -23%
2025-02-10 Flammer Martina M.D. Chief Medical Officer Sold plan 37,828 $78.61 $3.0m37.8k shares -27%
2025-02-07 Adsett Roger Chief Operating Officer Sold 100 $79.57 $8.0k100 shares -<1%
2025-02-07 Flammer Martina M.D. Chief Medical Officer Sold 60 $79.59 $4.8k60 shares -<1%
2025-02-07 Wise John Drayton Chief Commercial Officer Sold 10 $78.91 $78910 shares -<1%
2025-02-06 Lewis William Chair and CEO, director Sold 79,350 $80.90 $6.4m79.3k shares -15%
2025-02-06 Adsett Roger Chief Operating Officer Sold 45,605 $80.90 $3.7m45.6k shares -19%
2025-02-06 Flammer Martina M.D. Chief Medical Officer Sold 33,055 $80.90 $2.7m33.1k shares -19%
2025-02-06 Bonstein Sara Chief Financial Officer Sold 28,390 $80.90 $2.3m28.4k shares -15%
2025-02-06 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold 23,500 $80.90 $1.9m23.5k shares -16%
2025-02-06 Smith Michael Alexander Chief Legal Officer Sold 20,650 $80.90 $1.7m20.6k shares -18%
2025-02-06 Wise John Drayton Chief Commercial Officer Sold 7,910 $80.90 $639.9k7.9k shares -6%
2025-02-03 Lewis William Chair and CEO, director Sold plan 18,750 $77.94 $1.5m18.8k shares -5%
2025-02-03 Lewis William Chair and CEO, director Sold plan 6,830 $77.94 $532.3k6.8k shares -3%
2025-01-30 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold plan 91,140 $80.00 $7.3m91.1k shares -48%
2025-01-15 Lewis William Chair and CEO, director Sold plan 31,805 $70.18 $2.2m31.8k shares -8%
2025-01-15 Lewis William Chair and CEO, director Sold plan 6,830 $70.17 $479.3k6.8k shares -3%
2025-01-14 Adsett Roger Chief Operating Officer Sold plan 1,457 $68.72 $100.1k1.5k shares -1%
2025-01-14 Flammer Martina M.D. Chief Medical Officer Sold plan 1,384 $68.72 $95.1k1.4k shares -1%
2025-01-14 Schaeffer Orlov S Nicole Chief People Strategy Officer Sold plan 872 $68.72 $59.9k872 shares -1%
2025-01-10 Flammer Martina M.D. Chief Medical Officer Sold plan 6,172 $63.64 $392.8k6.2k shares -6%

The latest 30 of 52 trades.

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.03% of their portfolio Valley Forge, PA 18,268,12218.3m $1.4bn $1.4bn 0.03% Added +49.1k +49,149
2 BlackRock, Inc. 0.03% of their portfolio New York, NY 16,048,88216.0m $1.2bn $1.2bn 0.03% Added +15.9k +15,938
3 Darwin Global Management, Ltd. 82.08% of their portfolio ST. HELIER, Y9 15,397,97515.4m $1.2bn $1.2bn 82.08% Added +2.4m +2,437,437
4 PRICE T ROWE ASSOCIATES INC /MD/ 0.12% of their portfolio BALTIMORE, MD 12,923,54112.9m $985.9m $985.9m 0.12% Added +219.1k +219,131
5 Capital International Investors 0.11% of their portfolio Los Angeles, CA 7,198,4857.2m $549.2m $549.2m 0.11% Added +81.5k +81,488
6 JPMORGAN CHASE & CO 0.04% of their portfolio NEW YORK, NY 6,354,0226.4m $484.7m $484.7m 0.04% Added +3.1m +3,067,774
7 STATE STREET CORP 0.02% of their portfolio BOSTON, MA 5,747,2935.7m $438.5m $438.5m 0.02% Reduced -358.9k -358,860
8 BAKER BROS. ADVISORS LP 4.54% of their portfolio NEW YORK, NY 5,380,6265.4m $410.5m $410.5m 4.54% Added +373.8k +373,763
9 GEODE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio BOSTON, MA 4,288,7354.3m $327.3m $327.3m 0.03% Added +201.6k +201,592
10 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.49% of their portfolio Boston, MA 3,446,9443.4m $263.0m $263.0m 0.49% Added +1.8m +1,799,382
11 FMR LLC 0.02% of their portfolio BOSTON, MA 3,394,3843.4m $259.0m $259.0m 0.02% Reduced -1.5m -1,461,865
12 Artisan Partners Limited Partnership 0.40% of their portfolio Milwaukee, WI 3,217,2683.2m $245.4m $245.4m 0.40% Added +90.9k +90,929
13 RTW INVESTMENTS, LP 3.52% of their portfolio NEW YORK, NY 3,014,5583.0m $230.0m $230.0m 3.52% Unchanged
14 AMERIPRISE FINANCIAL INC 0.06% of their portfolio MINNEAPOLIS, MN 2,951,6223.0m $225.2m $225.2m 0.06% Added +101.5k +101,525
15 ALLIANCEBERNSTEIN L.P. 0.07% of their portfolio NASHVILLE, TN 2,423,5132.4m $184.9m $184.9m 0.07% Added +60.0k +59,952
16 FIL Ltd 0.17% of their portfolio HAMILTON, D0 2,390,2012.4m $182.3m $182.3m 0.17% Reduced -248.0k -247,959
17 MACQUARIE GROUP LTD 0.22% of their portfolio Sydney, NSW 2000, C3 2,362,1052.4m $180.2m $180.2m 0.22% Added +48.9k +48,946
18 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.50% of their portfolio CHICAGO, IL 2,313,2172.3m $176.5m $176.5m 0.50% Reduced -120.2k -120,226
19 FRANKLIN RESOURCES INC 0.05% of their portfolio San Mateo, CA 2,148,2842.1m $163.9m $163.9m 0.05% Reduced -11.8k -11,819
20 Holocene Advisors, LP 0.46% of their portfolio New York, NY 2,026,4222.0m $154.6m $154.6m 0.46% Added +1.3m +1,338,710
21 Pictet Asset Management Holding SA 0.17% of their portfolio CAROUGE, V8 2,013,3292.0m $153.9m $153.9m 0.17% Added +53.6k +53,611
22 Clearbridge Investments, LLC 0.12% of their portfolio NEW YORK, NY 1,828,7281.8m $139.5m $139.5m 0.12% Reduced -49.7k -49,722
23 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 1,791,3241.8m $136.7m $136.7m 0.03% Added +775.2k +775,234
24 PRINCIPAL FINANCIAL GROUP INC 0.08% of their portfolio DES MOINES, IA 1,755,3731.8m $133.9m $133.9m 0.08% Reduced -62.3k -62,270
25 NORGES BANK 0.02% of their portfolio OSLO, Q8 1,742,8431.7m $133.0m $133.0m 0.02% Reduced -91.0k -90,967
26 NORTHERN TRUST CORP 0.02% of their portfolio CHICAGO, IL 1,683,8381.7m $128.5m $128.5m 0.02% Reduced -66.8k -66,804
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 1,602,6551.6m $122.3m $122.3m 0.02% Added +56.0k +56,048
28 Hood River Capital Management LLC 2.03% of their portfolio PALM BEACH GARDENS, FL 1,558,2861.6m $118.9m $118.9m 2.03% Added +32.7k +32,658
29 Integral Health Asset Management, LLC 13.10% of their portfolio New York, NY 1,550,0001.6m $118.2m $118.2m 13.10% Unchanged
30 JANUS HENDERSON GROUP PLC 0.07% of their portfolio LONDON, X0 1,545,4191.5m $120.5m $120.5m 0.07% Added +99.7k +99,723
31 MONTANOVA CAPITAL, LLC 4.61% of their portfolio New York, NY 1,492,3831.5m $113.9m $113.9m 4.61% Reduced -119.2k -119,178
32 T. Rowe Price Investment Management, Inc. 0.07% of their portfolio BALTIMORE, MD 1,476,9481.5m $112.7m $112.7m 0.07% Reduced -505.8k -505,759
33 WESTFIELD CAPITAL MANAGEMENT CO LP 0.52% of their portfolio BOSTON, MA 1,406,6091.4m $107.3m $107.3m 0.52% Added +468.1k +468,058
34 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 1,402,6211.4m $107.0m $107.0m 0.02% Reduced -317.4k -317,428
35 GW&K Investment Management, LLC 0.97% of their portfolio BOSTON, MA 1,377,7261.4m $105.1m $105.1m 0.97% Added +242.3k +242,333
36 Duquesne Family Office LLC 3.50% of their portfolio New York, NY 1,369,0501.4m $104.4m $104.4m 3.50% Added +775.6k +775,580
37 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,352,9991.4m $103.2m $103.2m 0.01% Added +245.3k +245,333
38 LORD, ABBETT & CO. LLC 0.37% of their portfolio JERSEY CITY, NJ 1,350,5871.4m $103.0m $103.0m 0.37% Reduced -106.6k -106,623
39 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 1,222,6271.2m $93.3m $93.3m 0.02% Added +470.4k +470,401
40 EVENTIDE ASSET MANAGEMENT, LLC 1.80% of their portfolio Boston, MA 1,181,6751.2m $90.2m $90.2m 1.80% Added +80.7k +80,682
41 VOYA INVESTMENT MANAGEMENT LLC 0.05% of their portfolio ATLANTA, GA 1,170,8561.2m $89.3m $89.3m 0.05% Added +622.0k +621,989
42 Nuveen, LLC 0.03% of their portfolio CHARLOTTE, NC 1,158,0941.2m $88.4m $88.4m 0.03% First filing
43 Bank of New York Mellon Corp 0.02% of their portfolio NEW YORK, NY 1,156,7501.2m $88.2m $88.2m 0.02% Reduced -281.7k -281,716
44 Vestal Point Capital, LP 5.86% of their portfolio NEW YORK, NY 1,075,0001.1m $82.0m $82.0m 5.86% Added +175.0k +175,000
45 TimesSquare Capital Management, LLC 1.31% of their portfolio NEW YORK, NY 1,064,1481.1m $81.2m $81.2m 1.31% Added +379.8k +379,764
46 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,059,6561.1m $80.8m $80.8m 0.01% Reduced -291.7k -291,709
47 LOOMIS SAYLES & CO L P 0.11% of their portfolio BOSTON, MA 1,009,4661.0m $77.0m $77.0m 0.11% Reduced -165.3k -165,325
48 Palo Alto Investors LP 14.34% of their portfolio PALO ALTO, CA 987,153987.2k $75.3m $75.3m 14.34% Reduced -616.3k -616,312
49 AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio KANSAS CITY, MO 872,123872.1k $66.5m $66.5m 0.04% Added +59.3k +59,343
50 JENNISON ASSOCIATES LLC 0.04% of their portfolio NEW YORK, NY 748,313748.3k $57.1m $57.1m 0.04% Reduced -25.5k -25,500
51 Alyeska Investment Group, L.P. 0.22% of their portfolio CHICAGO, IL 735,000735.0k $56.1m $56.1m 0.22% Reduced -200.8k -200,779
52 D. E. Shaw & Co., Inc. 0.07% of their portfolio New York, NY 734,880734.9k $56.1m $56.1m 0.07% Added +226.1k +226,093
53 Polar Capital Holdings Plc 0.34% of their portfolio London, X0 728,755728.8k $55.6m $55.6m 0.34% Reduced -1.2k -1,245
54 NOVO HOLDINGS A/S 4.21% of their portfolio HELLERUP, G7 724,666724.7k $55.3m $55.3m 4.21% Unchanged
55 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 2.58% of their portfolio Boston, MA 704,366704.4k $53.7m $53.7m 2.58% Added +65.5k +65,518
56 MARSHALL WACE, LLP 0.07% of their portfolio LONDON, X0 696,237696.2k $53.1m $53.1m 0.07% Reduced -368.0k -367,978
57 MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio NEW YORK, NY 679,191679.2k $51.8m $51.8m 0.05% Reduced -19.8k -19,815
58 BROWN ADVISORY INC 0.07% of their portfolio BALTIMORE, MD 672,450672.5k $51.3m $51.3m 0.07% Added +9.5k +9,453
59 Long Focus Capital Management, LLC 3.27% of their portfolio SAN JUAN, PR 630,800630.8k $48.1m $48.1m 3.27% Reduced -20.0k -20,000
60 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.13% of their portfolio Paris, I0 613,269613.3k $46.8m $46.8m 0.13% Reduced -41.6k -41,632
61 EMERALD ADVISERS, LLC 2.04% of their portfolio LEOLA, PA 594,013594.0k $45.3m $45.3m 2.04% Reduced -90.6k -90,623
62 Ensign Peak Advisors, Inc 0.09% of their portfolio SALT LAKE CITY, UT 589,399589.4k $45.0m $45.0m 0.09% Added +60.4k +60,350
63 Fiera Capital Corp 0.16% of their portfolio MONTREAL, A8 579,237579.2k $44.2m $44.2m 0.16% Reduced -2.6k -2,617
64 FRONTIER CAPITAL MANAGEMENT CO LLC 0.47% of their portfolio Boston, MA 557,587557.6k $42.5m $42.5m 0.47% Added +122.6k +122,581
65 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 539,484539.5k $41.2m $41.2m 0.01% Added +52.6k +52,637
66 Cormorant Asset Management, LP 3.03% of their portfolio BOSTON, MA 525,000525.0k $40.1m $40.1m 3.03% Reduced -125.0k -125,000
67 Rock Springs Capital Management LP 2.25% of their portfolio Baltimore, MD 515,900515.9k $39.4m $39.4m 2.25% Reduced -34.1k -34,100
68 PERCEPTIVE ADVISORS LLC 1.38% of their portfolio NEW YORK, NY 509,300509.3k $38.9m $38.9m 1.38% Added +365.3k +365,300
69 TD Asset Management Inc 0.04% of their portfolio Toronto, A6 502,232502.2k $38.3m $38.3m 0.04% Reduced -24.7k -24,658
70 1832 Asset Management L.P. 0.07% of their portfolio TORONTO, A6 487,800487.8k $37.2m $37.2m 0.07% New
71 UBS Group AG 0.01% of their portfolio ZURICH, V8 477,636477.6k $36.4m $36.4m 0.01% Added +71.9k +71,911
72 BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio PARIS, I0 461,663461.7k $35.2m $35.2m 0.03% First filing
73 DEERFIELD MANAGEMENT COMPANY, L.P. 0.69% of their portfolio New York, NY 458,000458.0k $34.9m $34.9m 0.69% New
74 Candriam S.C.A. 0.22% of their portfolio STRASSEN, N4 455,408455.4k $34.7m $34.7m 0.22% Added +1.9k +1,888
75 Paradigm Biocapital Advisors LP 1.59% of their portfolio NEW YORK, NY 451,359451.4k $34.4m $34.4m 1.59% New
76 NWI MANAGEMENT LP 4.58% of their portfolio NEW YORK, NY 450,000450.0k $34.3m $34.3m 4.58% Added +171.0k +171,000
77 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.06% of their portfolio BALA CYNWYD, PA 448,614448.6k $34.2m $34.2m 0.06% Added +4.2k +4,179
78 Eagle Health Investments LP 8.78% of their portfolio Greenwich, CT 443,300443.3k $33.8m $33.8m 8.78% Reduced -70.4k -70,400
79 Allspring Global Investments Holdings, LLC 0.05% of their portfolio CHARLOTTE, NC 438,674438.7k $31.6m $31.6m 0.05% Added +15.6k +15,580
80 MAVERICK CAPITAL LTD 0.58% of their portfolio DALLAS, TX 425,125425.1k $32.4m $32.4m 0.58% New
81 VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio San Antonio, TX 409,114409.1k $31.2m $31.2m 0.03% Reduced -1.5k -1,463
82 RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio ST. PETERSBURG, FL 408,937408.9k $31.2m $31.2m 0.01% Added +45.5k +45,491
83 TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio NEW YORK, NY 406,903406.9k $31.0m $31.0m 0.07% Reduced -187.1k -187,093
84 First Turn Management, LLC 6.18% of their portfolio DEL MAR, CA 401,629401.6k $30.6m $30.6m 6.18% Reduced -45.4k -45,351
85 GROUPAMA ASSET MANAGMENT 0.02% of their portfolio PARIS, I0 400,000400.0k $970.2k $970.2k 0.02% Unchanged
86 SEI INVESTMENTS CO 0.04% of their portfolio OAKS, PA 395,979396.0k $30.2m $30.2m 0.04% Added +33.4k +33,363
87 FRED ALGER MANAGEMENT, LLC 0.16% of their portfolio NEW YORK, NY 378,331378.3k $28.9m $28.9m 0.16% Reduced -7.1k -7,129
88 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 374,815374.8k $28.6m $28.6m 0.03% Added +51.1k +51,080
89 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 372,000372.0k $28.4m $28.4m 0.01% Added +21.1k +21,061
90 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 355,722355.7k $27.1m $27.1m 0.04% Added +38.0k +37,969
91 EMERALD MUTUAL FUND ADVISERS TRUST 1.92% of their portfolio LEOLA, PA 353,831353.8k $27.0m $27.0m 1.92% Reduced -46.8k -46,793
92 Aberdeen Group plc 0.05% of their portfolio EDINBURGH, X0 336,357336.4k $25.7m $25.7m 0.05% Added +46.7k +46,704
93 Driehaus Capital Management LLC 0.24% of their portfolio Chicago, IL 331,459331.5k $25.3m $25.3m 0.24% Added +160.2k +160,170
94 Patient Square Capital LP 10.42% of their portfolio MENLO PARK, CA 330,250330.2k $25.2m $25.2m 10.42% Added +23.1k +23,083
95 Swiss National Bank 0.02% of their portfolio ZURICH, V8 329,300329.3k $25.1m $25.1m 0.02% Added +8.2k +8,200
96 ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio Berwyn, PA 325,307325.3k $24.8m $24.8m 0.01% Added +68.9k +68,949
97 SILVERARC CAPITAL MANAGEMENT, LLC 5.12% of their portfolio BOSTON, MA 321,366321.4k $24.5m $24.5m 5.12% Reduced -50.9k -50,864
98 C WorldWide Group Holding A/S 0.30% of their portfolio COPENHAGEN, G7 321,110321.1k $24.5m $24.5m 0.30% Reduced -22.0k -22,000
99 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.02% of their portfolio Toronto, A6 318,392318.4k $24.3m $24.3m 0.02% Added +5.2k +5,211
100 Artia Global Partners LP 7.12% of their portfolio MIAMI, FL 318,239318.2k $24.3m $24.3m 7.12% Added +150.3k +150,300