INCYTE CORP INCY
COM · Common Stock · CUSIP 45337C102 · ISIN US45337C1027
American pharmaceutical company
- SectorHealth care
- IndustryServices-Commercial Physical & Biological Research
- HeadquartersWilmington, DE
- Founded2001
- Websiteincyte.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($60.4m this quarter). Holder counts are more reliable. Shares outstanding: 202.7m as of 2026-07-21, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $113.30. Options: 16 managers hold calls ($72.9m notional), 12 hold puts ($41.1m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 537 |
| Q4 2022 | 558 |
| Q1 2023 | 552 |
| Q2 2023 | 529 |
| Q3 2023 | 531 |
| Q4 2023 | 558 |
| Q1 2024 | 587 |
| Q2 2024 | 586 |
| Q3 2024 | 595 |
| Q4 2024 | 650 |
| Q1 2025 | 630 |
| Q2 2025 | 659 |
| Q3 2025 | 713 |
| Q4 2025 | 822 |
| Q1 2026 | 815 |
| Q2 2026 | 858 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 244 | 332 |
| Q4 2024 | 324 | 271 |
| Q1 2025 | 316 | 304 |
| Q2 2025 | 356 | 298 |
| Q3 2025 | 383 | 295 |
| Q4 2025 | 471 | 282 |
| Q1 2026 | 413 | 392 |
| Q2 2026 | 476 | 341 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $59.1m | $56.5m | 0.96 |
| Q4 2025 | $48.2m | $66.1m | 1.37 |
| Q1 2026 | $41.3m | $38.0m | 0.92 |
| Q2 2026 | $72.9m | $41.1m | 0.56 |
Biggest buyers
| TWO SIGMA INVESTMENTS, LP | Added | +1.6m |
| HSBC HOLDINGS PLC | Added | +725.4k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +309.4k |
| DIMENSIONAL FUND ADVISORS LP | Added | +305.3k |
| JPMORGAN CHASE & CO | Added | +264.6k |
| JANE STREET GROUP, LLC | Added | +260.6k |
| KBC Group NV | Added | +243.6k |
| ARMISTICE CAPITAL, LLC | Added | +243.2k |
| PFA Pension, Forsikringsaktieselskab | Added | +232.6k |
| Fideuram Asset Management (Ireland) dac | New | +213.9k |
Biggest sellers
| LOS ANGELES CAPITAL MANAGEMENT LLC | Reduced | -1.6m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -986.2k |
| BlackRock, Inc. | Reduced | -945.5k |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -487.0k |
| UBS Group AG | Reduced | -370.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -342.3k |
| PANAGORA ASSET MANAGEMENT INC | Reduced | -329.0k |
| Pacer Advisors, Inc. | Reduced | -309.6k |
| Dodge & Cox | Reduced | -295.0k |
| RHUMBLINE ADVISERS | Reduced | -265.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $13.3m117.1k shares |
| CITADEL ADVISORS LLC | Added | $11.6m102.4k shares |
| MILLENNIUM MANAGEMENT LLC | New | $11.4m100.4k shares |
| PEAK6 LLC | New | $8.3m73.1k shares |
| JANE STREET GROUP, LLC | Reduced | $8.0m70.4k shares |
| IMC-Chicago, LLC | Added | $5.4m47.3k shares |
| TUDOR INVESTMENT CORP ET AL | New | $3.1m27.3k shares |
| GROUP ONE TRADING LLC | Added | $2.9m25.2k shares |
| JPMORGAN CHASE & CO | Reduced | $2.8m24.0k shares |
| SIMPLEX TRADING, LLC | Added | $2.4m20.8k shares |
Biggest puts
| DIADEMA PARTNERS LP | Unchanged | $11.9m105.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $11.3m99.3k shares |
| CITADEL ADVISORS LLC | Added | $5.9m52.1k shares |
| IMC-Chicago, LLC | Reduced | $2.9m25.6k shares |
| JPMORGAN CHASE & CO | Reduced | $2.8m24.0k shares |
| JANE STREET GROUP, LLC | Reduced | $2.6m23.3k shares |
| GROUP ONE TRADING LLC | New | $2.3m20.1k shares |
| Walleye Capital LLC | Reduced | $487.4k4.3k shares |
| SIMPLEX TRADING, LLC | Added | $396.8k3.5k shares |
| Walleye Trading LLC | Unchanged | $204.0k1.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BAKER BROS. ADVISORS LP
13D · may seek influence
-0.1 pts · filed 2026-05-11
Stated purposeItem 4 of Schedule 13D is supplemented and superseded, as the case may be, as follows: On May 8, 2026 the Adviser acquired beneficial ownership of 15,000 shares of common stock ("Common Stock") of Incyte Corporation (the "Issuer"), as a result of the exercise of 15,000 options to purchase Common Stock at $84.53 per share (the "Exercised Stock Options") held directly by Julian C. Baker. Julian C. Baker currently serves on the Issuer's board of directors (the "Board") as a representative of the Funds. The policy of the Funds and the Adviser does not permit managing members of the Adviser GP or full-time employees of the Adviser to receive compensation for serving as directors of the Issuer, and the Funds are instead entitled to the pecuniary interest in the Exercised Stock Options. Julian C… Full filing |
15.6% |
| BlackRock, Inc. 13G · institution filed 2025-10-17 | 7.8% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 6.3% |
| DODGE & COX 13G · institution filed 2026-05-14 | 6.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 3 | $839.7k | $839.7k |
| Q1 2025 | 0 | — | 3 | $3.3m | $3.3m |
| Q2 2025 | 0 | — | 2 | $227.6k | $227.6k |
| Q3 2025 | 0 | — | 4 | $3.4m | $3.4m |
| Q4 2025 | 0 | — | 7 | $30.0m | $30.0m |
| Q1 2026 | 0 | — | 3 | $6.4m | $6.4m |
| Q2 2026 | 0 | — | 3 | $3.7m | $3.7m |
| Q3 2026 | 0 | — | 4 | $18.2m | $18.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-15 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $2.8m23.2k shares |
| 2026-08-19 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $1.4m10.8k shares |
| 2026-08-12 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $1.3m10.8k shares |
| 2026-08-05 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $1.3m10.6k shares |
| 2026-08-05 | Mayes Patrick A EVP & Chief Scientific Officer | Sold plan | $273.6k2.2k shares |
| 2026-08-03 | Mayes Patrick A EVP & Chief Scientific Officer | Sold plan | $729.2k6.1k shares |
| 2026-07-31 | Mayes Patrick A EVP & Chief Scientific Officer | Sold plan | $5.0m41.9k shares |
| 2026-07-31 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $1.9m15.9k shares |
| 2026-07-16 | Stein Steven H CMO & Head of Late-Stage Dev. | Sold plan | $215.3k1.9k shares |
| 2026-07-16 | Issa Mohamed Khairie EVP, Head of U.S. Commercial | Sold plan | $125.7k1.1k shares |
| 2026-07-15 | Stein Steven H CMO & Head of Late-Stage Dev. | Sold plan | $3.2m28.2k shares |
| 2026-06-04 | Tray Thomas Principal Accounting Officer | Sold plan | $263.9k2.6k shares |
| 2026-05-26 | Tray Thomas Principal Accounting Officer | Sold plan | $199.7k2.1k shares |
| 2026-05-19 | Clancy Paul J Director | Sold plan | $1.4m15.0k shares |
| 2026-04-17 | CAGNONI PABLO J President, Global Head of R&D | Sold plan | $1.8m18.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 17.48% of their portfolio | 30.8m $3.5bn | Added +17.9k |
| BlackRock, Inc. 0.03% of their portfolio | 18.0m $2.0bn | Reduced -945.5k |
| Dodge & Cox 0.71% of their portfolio | 12.0m $1.4bn | Reduced -295.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 11.0m $1.2bn | Added +94.2k |
| STATE STREET CORP 0.03% of their portfolio | 9.7m $1.1bn | Added +81.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.04% of their portfolio | 7.8m $883.2m | Added +31.9k |
| AQR CAPITAL MANAGEMENT LLC 0.21% of their portfolio | 5.3m $603.2m | Reduced -487.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio | 4.8m $536.5m | Added +47.6k |
| LSV ASSET MANAGEMENT 0.85% of their portfolio | 4.1m $467.5m | Added +203.7k |
| Invesco Ltd. 0.04% of their portfolio | 4.1m $462.6m | Added +209.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio | 3.6m $405.3m | Added +309.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.55% of their portfolio | 3.5m $398.1m | Reduced -139.4k |
| MORGAN STANLEY 0.02% of their portfolio | 2.9m $334.2m | Added +98.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.14% of their portfolio | 2.7m $311.2m | Reduced -85.8k |
| Robeco Institutional Asset Management B.V. 0.34% of their portfolio | 2.4m $276.8m | Reduced -72.6k |
| GOLDMAN SACHS GROUP INC 0.03% of their portfolio | 2.3m $261.4m | Reduced -45.4k |
| DIMENSIONAL FUND ADVISORS LP 0.05% of their portfolio | 2.3m $258.6m | Added +305.3k |
| TWO SIGMA INVESTMENTS, LP 0.17% of their portfolio | 2.0m $227.1m | Added +1.6m |
| NORTHERN TRUST CORP 0.02% of their portfolio | 1.8m $199.7m | Reduced -87.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.03% of their portfolio | 1.7m $191.9m | Reduced -36.7k |
| ACADIAN ASSET MANAGEMENT LLC 0.22% of their portfolio | 1.7m $188.7m | Reduced -235.8k |
| Legal & General Group Plc 0.04% of their portfolio | 1.6m $182.1m | Added +62.8k |
| FIRST TRUST ADVISORS LP 0.11% of their portfolio | 1.6m $180.0m | Added +87.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio | 1.5m $171.0m | Reduced -32.2k |
| VICTORY CAPITAL MANAGEMENT INC 0.09% of their portfolio | 1.5m $167.8m | Reduced -262.5k |
| Pacer Advisors, Inc. 0.42% of their portfolio | 1.4m $162.3m | Reduced -309.6k |
| FMR LLC 0.01% of their portfolio | 1.4m $156.6m | Added +208.9k |
| Caisse de depot et placement du Quebec 0.22% of their portfolio | 1.4m $155.4m | Reduced -150.0k |
| MARSHALL WACE, LLP 0.13% of their portfolio | 1.3m $148.5m | Added +57.0k |
| HSBC HOLDINGS PLC 0.07% of their portfolio | 1.3m $148.3m | Added +725.4k |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 1.3m $143.2m | Reduced -1.2k |
| AustralianSuper Pty Ltd 0.59% of their portfolio | 1.2m $135.6m | Added +59.3k |
| Amundi 0.03% of their portfolio | 1.2m $133.9m | Added +177.5k |
| ROYAL BANK OF CANADA 0.02% of their portfolio | 1.1m $128.3m | Added +77.9k |
| NORGES BANK 0.01% of their portfolio | 1.1m $126.9m | Not comparable |
| Bank of New York Mellon Corp 0.02% of their portfolio | 972.8k $110.3m | Reduced -16.9k |
| Man Group plc 0.20% of their portfolio | 952.9k $108.0m | Added +22.8k |
| VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio | 943.5k $107.0m | Reduced -4.8k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.11% of their portfolio | 937.8k $106.3m | Reduced -1.1k |
| ARMISTICE CAPITAL, LLC 2.82% of their portfolio | 900.0k $102.0m | Added +243.2k |
| PANAGORA ASSET MANAGEMENT INC 0.31% of their portfolio | 881.9k $100.0m | Reduced -329.0k |
| UBS Group AG 0.01% of their portfolio | 767.9k $87.1m | Reduced -370.1k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 761.7k $87.3m | Added +264.6k |
| Sound Shore Management Inc /CT/ 2.64% of their portfolio | 757.7k $85.9m | Reduced -10.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.30% of their portfolio | 731.8k $83.0m | Reduced -986.2k |
| Gotham Asset Management, LLC 0.19% of their portfolio | 719.5k $81.6m | Added +42.9k |
| Pictet Asset Management Holding SA 0.08% of their portfolio | 713.4k $81.3m | Reduced -202.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 676.2k $76.7m | Reduced -239.3k |
| MACKENZIE FINANCIAL CORP 0.07% of their portfolio | 634.9k $72.0m | Added +85.2k |
| CITIGROUP INC 0.03% of their portfolio | 586.4k $66.5m | Added +96.8k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.24% of their portfolio | 579.0k $65.6m | Reduced -1.6m |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 558.7k $63.3m | Reduced -135.1k |
| SEB Asset Management AB 0.24% of their portfolio | 558.5k $63.3m | Reduced -87.7k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.37% of their portfolio | 545.4k $61.8m | Added +79.7k |
| GLENMEDE TRUST CO NA 0.27% of their portfolio | 538.8k $61.1m | Added +15.5k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 532.4k $60.4m | Reduced -73.1k |
| Woodline Partners LP 0.18% of their portfolio | 512.7k $58.1m | Reduced -93.0k |
| JUPITER ASSET MANAGEMENT LTD 0.29% of their portfolio | 511.1k $57.9m | Added +28.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 500.9k $56.8m | Added +95.4k |
| SEI INVESTMENTS CO 0.05% of their portfolio | 498.0k $56.5m | Reduced -216.5k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.19% of their portfolio | 486.8k $55.2m | Reduced -6.9k |
| Swiss National Bank 0.03% of their portfolio | 476.9k $54.1m | Reduced -12.9k |
| Vinva Investment Management Ltd 0.35% of their portfolio | 462.8k $53.1m | Added +162.4k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.03% of their portfolio | 442.5k $50.2m | Reduced -165.4k |
| California Public Employees Retirement System 0.03% of their portfolio | 429.9k $48.7m | Reduced -53.5k |
| RHUMBLINE ADVISERS 0.04% of their portfolio | 428.5k $48.6m | Reduced -265.1k |
| Russell Investments Group, Ltd. 0.04% of their portfolio | 425.6k $48.3m | Reduced -212.6k |
| IEQ CAPITAL, LLC 0.22% of their portfolio | 424.7k $48.1m | Reduced -74.2k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.02% of their portfolio | 414.7k $47.7m | Added +3.9k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.03% of their portfolio | 412.3k $46.7m | Added +45.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 409.5k $46.4m | Reduced -342.3k |
| Nuveen, LLC 0.01% of their portfolio | 407.3k $46.2m | Reduced -84.2k |
| Sumitomo Mitsui Trust Group, Inc. 0.03% of their portfolio | 393.7k $44.6m | Reduced -28.7k |
| Vanguard Global Advisers, LLC 0.02% of their portfolio | 380.0k $43.1m | Reduced -7.9k |
| Swedbank AB 0.04% of their portfolio | 371.4k $42.1m | Added +8.9k |
| BARCLAYS PLC 0.01% of their portfolio | 351.2k $39.8m | Reduced -15.9k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 345.6k $39.2m | Added +8.8k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.06% of their portfolio | 339.9k $38.5m | Added +42.4k |
| CAPITAL FUND MANAGEMENT S.A. 0.27% of their portfolio | 336.3k $38.1m | Added +24.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.03% of their portfolio | 335.1k $38.0m | Added +45.4k |
| Grantham, Mayo, Van Otterloo & Co. LLC 0.08% of their portfolio | 318.6k $36.1m | Reduced -46.1k |
| Mitsubishi UFJ Trust & Banking Corp 0.08% of their portfolio | 312.1k $35.4m | Reduced -47.6k |
| Aware Super Pty Ltd as trustee of Aware Super 0.49% of their portfolio | 306.8k $34.8m | Reduced -8.8k |
| Arbejdsmarkedets Tillaegspension 0.74% of their portfolio | 298.4k $33.8m | Added +18.8k |
| KBC Group NV 0.07% of their portfolio | 270.9k $30.7m | Added +243.6k |
| Ensign Peak Advisors, Inc 0.05% of their portfolio | 270.0k $30.6m | Added +42.3k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 268.8k $30.5m | Added +260.6k |
| Illinois Municipal Retirement Fund 0.33% of their portfolio | 260.3k $29.5m | Added +5.3k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 257.0k $29.1m | Reduced -242.8k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 255.1k $28.9m | Added +42 |
| WINTON GROUP Ltd 0.93% of their portfolio | 254.4k $28.8m | Added +81.4k |
| PFA Pension, Forsikringsaktieselskab 0.07% of their portfolio | 252.5k $28.6m | Added +232.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.03% of their portfolio | 250.0k $28.3m | Added +8.7k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.19% of their portfolio | 245.8k $27.9m | Reduced -17.6k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.04% of their portfolio | 236.2k $26.7m | Added +320 |
| TODD ASSET MANAGEMENT LLC 0.47% of their portfolio | 234.4k $26.6m | Reduced -17.5k |
| Baird Financial Group, Inc. 0.04% of their portfolio | 224.9k $25.5m | Added +38.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 222.0k $25.2m | Reduced -3.5k |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.02% of their portfolio | 218.9k $24.8m | Added +35.1k |
| Quantinno Capital Management LP 0.03% of their portfolio | 214.4k $24.3m | Added +56.2k |