INCYTE CORP INCY
COM · Common Stock · CUSIP 45337C102 · ISIN US45337C1027
American pharmaceutical company
- SectorHealth care
- IndustryServices-Commercial Physical & Biological Research
- HeadquartersWilmington, DE
- Founded2001
- Websiteincyte.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($47.5m this quarter). Holder counts are more reliable. Shares outstanding: 199.0m as of 2026-02-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $98.66. Options: 13 managers hold calls ($48.2m notional), 17 hold puts ($66.1m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 537 |
| Q4 2022 | 558 |
| Q1 2023 | 552 |
| Q2 2023 | 529 |
| Q3 2023 | 531 |
| Q4 2023 | 558 |
| Q1 2024 | 587 |
| Q2 2024 | 586 |
| Q3 2024 | 595 |
| Q4 2024 | 650 |
| Q1 2025 | 630 |
| Q2 2025 | 659 |
| Q3 2025 | 713 |
| Q4 2025 | 822 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 295 | 255 |
| Q2 2024 | 292 | 288 |
| Q3 2024 | 244 | 332 |
| Q4 2024 | 324 | 271 |
| Q1 2025 | 316 | 304 |
| Q2 2025 | 356 | 298 |
| Q3 2025 | 383 | 295 |
| Q4 2025 | 471 | 282 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $47.5m | $30.3m | 0.64 |
| Q2 2025 | $36.9m | $19.6m | 0.53 |
| Q3 2025 | $59.1m | $56.5m | 0.96 |
| Q4 2025 | $48.2m | $66.1m | 1.37 |
Biggest buyers
| MARSHALL WACE, LLP | Added | +1.1m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +718.3k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +540.5k |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Added | +527.7k |
| FIRST TRUST ADVISORS LP | Added | +520.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +506.8k |
| Pictet Asset Management Holding SA | Added | +489.4k |
| WORLDQUANT MILLENNIUM ADVISORS LLC | Added | +459.1k |
| Pacer Advisors, Inc. | Added | +454.6k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added | +446.6k |
Biggest sellers
| Bellevue Group AG | Reduced | -1.4m |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -1.2m |
| Man Group plc | Reduced | -834.2k |
| UBS Group AG | Reduced | -775.6k |
| Dodge & Cox | Reduced | -670.7k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -549.8k |
| PANAGORA ASSET MANAGEMENT INC | Reduced | -486.3k |
| Point72 Asset Management, L.P. | Sold out | -477.1k |
| JPMORGAN CHASE & CO | Reduced | -452.0k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -396.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $14.0m141.8k shares |
| JANE STREET GROUP, LLC | Reduced | $10.3m104.6k shares |
| CITADEL ADVISORS LLC | Added | $6.4m65.2k shares |
| GROUP ONE TRADING LLC | Added | $5.8m58.8k shares |
| IMC-Chicago, LLC | Added | $3.7m37.0k shares |
| SIMPLEX TRADING, LLC | Added | $3.1m31.6k shares |
| CITIGROUP INC | New | $2.9m29.8k shares |
| Walleye Capital LLC | New | $691.4k7.0k shares |
| Walleye Trading LLC | New | $424.7k4.3k shares |
| D. E. Shaw & Co., Inc. | New | $316.1k3.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $23.1m234.1k shares |
| DIADEMA PARTNERS LP | New | $9.9m100.0k shares |
| CITADEL ADVISORS LLC | Added | $5.2m52.5k shares |
| Caption Management, LLC | Reduced | $5.2m52.5k shares |
| JANE STREET GROUP, LLC | Added | $4.8m48.2k shares |
| IMC-Chicago, LLC | Added | $4.6m46.8k shares |
| SIMPLEX TRADING, LLC | Added | $3.8m38.0k shares |
| CITIGROUP INC | New | $2.9m29.8k shares |
| J. Goldman & Co LP | New | $2.0m20.3k shares |
| LMR Partners LLP | Reduced | $1.1m11.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BAKER BROS. ADVISORS LP
13D · may seek influence
-0.1 pts · filed 2026-05-11
Stated purposeItem 4 of Schedule 13D is supplemented and superseded, as the case may be, as follows: On May 8, 2026 the Adviser acquired beneficial ownership of 15,000 shares of common stock ("Common Stock") of Incyte Corporation (the "Issuer"), as a result of the exercise of 15,000 options to purchase Common Stock at $84.53 per share (the "Exercised Stock Options") held directly by Julian C. Baker. Julian C. Baker currently serves on the Issuer's board of directors (the "Board") as a representative of the Funds. The policy of the Funds and the Adviser does not permit managing members of the Adviser GP or full-time employees of the Adviser to receive compensation for serving as directors of the Issuer, and the Funds are instead entitled to the pecuniary interest in the Exercised Stock Options. Julian C… Full filing |
15.6% |
| BlackRock, Inc. 13G · institution filed 2025-10-17 | 7.8% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 6.3% |
| DODGE & COX 13G · institution filed 2026-05-14 | 6.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 2 | $525.2k | $525.2k |
| Q2 2024 | 0 | — | 2 | $1.2m | $1.2m |
| Q3 2024 | 0 | — | 5 | $3.0m | $3.0m |
| Q4 2024 | 0 | — | 3 | $839.7k | $839.7k |
| Q1 2025 | 0 | — | 3 | $3.3m | $3.3m |
| Q2 2025 | 0 | — | 2 | $227.6k | $227.6k |
| Q3 2025 | 0 | — | 4 | $3.4m | $3.4m |
| Q4 2025 | 0 | — | 7 | $30.0m | $30.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-19 | Tray Thomas Principal Accounting Officer | Sold plan | $277.4k2.8k shares |
| 2025-12-18 | Tray Thomas Principal Accounting Officer | Sold plan | $59.0k600 shares |
| 2025-12-17 | Morrissey Michael James EVP, Head of Tech. Operations | Sold plan | $420.5k4.3k shares |
| 2025-12-16 | Morrissey Michael James EVP, Head of Tech. Operations | Sold plan | $5.3m54.0k shares |
| 2025-12-11 | Mayes Patrick A EVP & Chief Scientific Officer | Sold plan | $24.2k255 shares |
| 2025-12-10 | Mayes Patrick A EVP & Chief Scientific Officer | Sold plan | $530.8k5.6k shares |
| 2025-12-02 | Stein Steven H EVP & Chief Medical Officer | Sold plan | $2.1m20.1k shares |
| 2025-12-01 | Stein Steven H EVP & Chief Medical Officer | Sold plan | $263.5k2.6k shares |
| 2025-11-24 | Tray Thomas Principal Accounting Officer | Sold plan | $61.8k600 shares |
| 2025-11-21 | Tray Thomas Principal Accounting Officer | Sold plan | $17.2k169 shares |
| 2025-11-17 | Denton Sheila A. EVP & General Counsel | Sold plan | $29.0k278 shares |
| 2025-11-10 | Hoppenot Herve Director | Sold plan | $19.8m187.5k shares |
| 2025-11-05 | Stein Steven H EVP & Chief Medical Officer | Sold plan | $534.8k5.2k shares |
| 2025-11-04 | Denton Sheila A. EVP & General Counsel | Sold plan | $60.6k598 shares |
| 2025-11-03 | Heeson Lee EVP, Head of Incyte Intl | Sold plan | $289.0k3.1k shares |
| 2025-10-15 | Denton Sheila A. EVP & General Counsel | Sold plan | $23.6k277 shares |
| 2025-10-03 | Denton Sheila A. EVP & General Counsel | Sold plan | $299.5k3.5k shares |
| 2025-10-02 | Denton Sheila A. EVP & General Counsel | Sold plan | $52.5k599 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 17.78% of their portfolio | 30.7m $3.0bn | Added +328 |
| VANGUARD GROUP INC 0.03% of their portfolio | 19.9m $2.0bn | Reduced -40.2k |
| BlackRock, Inc. 0.03% of their portfolio | 18.3m $1.8bn | Added +433.6k |
| Dodge & Cox 0.71% of their portfolio | 13.3m $1.3bn | Reduced -670.7k |
| STATE STREET CORP 0.03% of their portfolio | 9.7m $953.8m | Reduced -20.4k |
| AQR CAPITAL MANAGEMENT LLC 0.35% of their portfolio | 6.7m $663.7m | Reduced -1.2m |
| GEODE CAPITAL MANAGEMENT, LLC 0.03% of their portfolio | 5.0m $491.5m | Added +506.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.61% of their portfolio | 4.0m $392.9m | Reduced -549.8k |
| LSV ASSET MANAGEMENT 0.85% of their portfolio | 3.9m $388.5m | Reduced -52.3k |
| Invesco Ltd. 0.03% of their portfolio | 3.5m $343.1m | Added +405.6k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.18% of their portfolio | 3.1m $305.6m | Reduced -9.5k |
| MORGAN STANLEY 0.02% of their portfolio | 2.7m $263.1m | Added +23.1k |
| Robeco Institutional Asset Management B.V. 0.35% of their portfolio | 2.5m $245.0m | Added +161.4k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.72% of their portfolio | 2.3m $211.9m | Added +527.7k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.87% of their portfolio | 2.3m $225.6m | Added +540.5k |
| ACADIAN ASSET MANAGEMENT LLC 0.30% of their portfolio | 1.8m $182.2m | Reduced -396.5k |
| DIMENSIONAL FUND ADVISORS LP 0.04% of their portfolio | 1.8m $176.6m | Added +192.1k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 1.8m $173.9m | Added +38.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.03% of their portfolio | 1.7m $171.1m | Added +15.9k |
| Pacer Advisors, Inc. 0.44% of their portfolio | 1.7m $168.2m | Added +454.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio | 1.6m $155.5m | Added +71.1k |
| Legal & General Group Plc 0.03% of their portfolio | 1.5m $145.1m | Reduced -209.8k |
| VICTORY CAPITAL MANAGEMENT INC 0.08% of their portfolio | 1.5m $143.6m | Added +189.2k |
| Pictet Asset Management Holding SA 0.13% of their portfolio | 1.3m $130.1m | Added +489.4k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 1.3m $126.8m | Reduced -11.1k |
| FIRST TRUST ADVISORS LP 0.09% of their portfolio | 1.3m $126.1m | Added +520.3k |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 1.3m $125.8m | Added +116.4k |
| FMR LLC 0.01% of their portfolio | 1.2m $123.1m | Reduced -25.6k |
| NORGES BANK 0.01% of their portfolio | 1.2m $122.9m | Not comparable |
| ROYAL BANK OF CANADA 0.02% of their portfolio | 1.1m $110.3m | Reduced -369.4k |
| Caisse de depot et placement du Quebec 0.19% of their portfolio | 1.1m $109.8m | Reduced -386.8k |
| Man Group plc 0.21% of their portfolio | 1.1m $108.6m | Reduced -834.2k |
| ARMISTICE CAPITAL, LLC 2.66% of their portfolio | 1.1m $108.5m | Reduced -69.3k |
| MARSHALL WACE, LLP 0.10% of their portfolio | 1.1m $105.9m | Added +1.1m |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.0m $99.1m | Reduced -325.4k |
| Bank of New York Mellon Corp 0.02% of their portfolio | 1.0m $99.0m | Reduced -12.9k |
| PANAGORA ASSET MANAGEMENT INC 0.35% of their portfolio | 992.1k $98.0m | Reduced -486.3k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.11% of their portfolio | 978.1k $96.6m | Added +446.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 965.8k $95.4m | Added +184.5k |
| Sound Shore Management Inc /CT/ 2.92% of their portfolio | 929.8k $91.8m | Added +80.0k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 865.1k $85.5m | Added +280.4k |
| CITIGROUP INC 0.05% of their portfolio | 792.7k $78.3m | Added +232.7k |
| Amundi 0.02% of their portfolio | 774.2k $76.5m | Added +273.1k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.45% of their portfolio | 768.3k $75.9m | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.30% of their portfolio | 754.1k $74.5m | Added +182.9k |
| Russell Investments Group, Ltd. 0.08% of their portfolio | 743.3k $73.4m | Reduced -65.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 739.4k $73.0m | Added +718.3k |
| RHUMBLINE ADVISERS 0.05% of their portfolio | 684.3k $67.6m | Reduced -8.2k |
| UBS Group AG 0.01% of their portfolio | 680.1k $67.2m | Reduced -775.6k |
| SEI INVESTMENTS CO 0.06% of their portfolio | 663.4k $65.5m | Added +170.8k |
| AustralianSuper Pty Ltd 0.29% of their portfolio | 640.7k $63.3m | Added +427.5k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.04% of their portfolio | 638.7k $63.1m | Reduced -57.1k |
| Woodline Partners LP 0.23% of their portfolio | 600.6k $59.3m | Added +254.5k |
| HSBC HOLDINGS PLC 0.02% of their portfolio | 580.5k $57.4m | Added +292.7k |
| FEDERATED HERMES, INC. 0.09% of their portfolio | 562.1k $55.5m | Reduced -24.5k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 550.1k $54.3m | Added +25.6k |
| GLENMEDE TRUST CO NA 0.26% of their portfolio | 549.0k $54.2m | First filing |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.20% of their portfolio | 531.7k $52.5m | Added +459.1k |
| IEQ CAPITAL, LLC 0.16% of their portfolio | 525.2k $51.9m | Added +30.1k |
| California Public Employees Retirement System 0.03% of their portfolio | 480.2k $47.4m | Reduced -74.9k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 473.4k $46.8m | Added +29.2k |
| Nuveen, LLC 0.01% of their portfolio | 467.4k $46.2m | Added +14.7k |
| Candriam S.C.A. 0.23% of their portfolio | 460.1k $45.4m | Reduced -293.3k |
| Swiss National Bank 0.03% of their portfolio | 454.9k $44.9m | Reduced -19.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 443.4k $43.8m | Reduced -452.0k |
| Sumitomo Mitsui Trust Group, Inc. 0.03% of their portfolio | 438.4k $43.3m | Reduced -18.3k |
| Vinva Investment Management Ltd 0.54% of their portfolio | 436.0k $43.4m | Added +266.3k |
| MACKENZIE FINANCIAL CORP 0.05% of their portfolio | 410.4k $40.5m | Reduced -42.8k |
| Mitsubishi UFJ Trust & Banking Corp 0.09% of their portfolio | 399.6k $39.5m | Added +2.1k |
| Andra AP-fonden 0.48% of their portfolio | 396.3k $39.1m | Reduced -64.3k |
| BARCLAYS PLC 0.02% of their portfolio | 391.8k $38.7m | Reduced -96.3k |
| Swedbank AB 0.04% of their portfolio | 367.2k $36.3m | Reduced -4.6k |
| Gotham Asset Management, LLC 0.13% of their portfolio | 352.7k $34.8m | Added +118.3k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.02% of their portfolio | 346.7k $35.2m | Added +32.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 341.4k $33.7m | Added +17.0k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 336.1k $33.2m | Reduced -51.5k |
| Bridgewater Associates, LP 0.12% of their portfolio | 328.6k $32.5m | Added +197.3k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.05% of their portfolio | 323.1k $31.9m | First filing |
| NORDEA INVESTMENT MANAGEMENT AB 0.03% of their portfolio | 322.2k $31.9m | Added +291.3k |
| Grantham, Mayo, Van Otterloo & Co. LLC 0.07% of their portfolio | 296.3k $29.3m | Added +47.5k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.22% of their portfolio | 294.7k $29.1m | Reduced -61.1k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 294.1k $29.0m | Added +89.9k |
| PRUDENTIAL FINANCIAL INC 0.03% of their portfolio | 286.6k $28.3m | Reduced -40.1k |
| TODD ASSET MANAGEMENT LLC 0.55% of their portfolio | 283.5k $28.0m | Reduced -61.6k |
| KBC Group NV 0.06% of their portfolio | 267.4k $26.4m | Reduced -157.7k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 250.9k $24.8m | Added +129.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 246.5k $24.3m | Reduced -9.3k |
| Arbejdsmarkedets Tillaegspension 0.61% of their portfolio | 244.4k $24.1m | First filing |
| Illinois Municipal Retirement Fund 0.29% of their portfolio | 232.7k $23.0m | Added +9.9k |
| LBP AM SA 0.27% of their portfolio | 231.4k $22.9m | Reduced -7.3k |
| Cerity Partners LLC 0.03% of their portfolio | 224.9k $22.2m | Added +21.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 220.9k $21.8m | Added +5.6k |
| SECTOR GAMMA AS 4.93% of their portfolio | 218.8k $21.6m | Added +13.7k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.04% of their portfolio | 212.5k $21.0m | Added +206.0k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.03% of their portfolio | 210.1k $20.7m | Added +21.7k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.04% of their portfolio | 208.9k $20.6m | Added +84.2k |
| CWM, LLC 0.06% of their portfolio | 205.8k $20.3m | Added +9.4k |
| APG Asset Management N.V. 0.05% of their portfolio | 195.1k $16.4m | Reduced -37.4k |
| LAZARD ASSET MANAGEMENT LLC 0.03% of their portfolio | 192.6k $19.0m | Added +46.1k |
| BANK OF MONTREAL /CAN/ 0.01% of their portfolio | 190.6k $18.8m | Added +28.8k |