INCYTE CORP INCY
COM · Common Stock · CUSIP 45337C102 · ISIN US45337C1027
American pharmaceutical company
- SectorHealth care
- IndustryServices-Commercial Physical & Biological Research
- HeadquartersWilmington, DE
- Founded2001
- Websiteincyte.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($43.2m this quarter). Holder counts are more reliable. Shares outstanding: 193.5m as of 2025-02-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $69.06. Options: 18 managers hold calls ($68.6m notional), 16 hold puts ($38.3m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 537 |
| Q4 2022 | 558 |
| Q1 2023 | 552 |
| Q2 2023 | 529 |
| Q3 2023 | 531 |
| Q4 2023 | 558 |
| Q1 2024 | 587 |
| Q2 2024 | 586 |
| Q3 2024 | 595 |
| Q4 2024 | 650 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 313 | 230 |
| Q2 2023 | 238 | 287 |
| Q3 2023 | 298 | 212 |
| Q4 2023 | 268 | 257 |
| Q1 2024 | 295 | 255 |
| Q2 2024 | 292 | 288 |
| Q3 2024 | 244 | 332 |
| Q4 2024 | 324 | 271 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $23.6m | $37.9m | 1.61 |
| Q2 2024 | $51.7m | $42.3m | 0.82 |
| Q3 2024 | $49.9m | $43.0m | 0.86 |
| Q4 2024 | $68.6m | $38.3m | 0.56 |
Biggest buyers
| AQR CAPITAL MANAGEMENT LLC | Added | +801.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +798.9k |
| MORGAN STANLEY | Added | +690.8k |
| Sound Shore Management Inc /CT/ | Added | +595.7k |
| Pictet Asset Management Holding SA | Added | +556.2k |
| LSV ASSET MANAGEMENT | Added | +544.1k |
| MACKENZIE FINANCIAL CORP | Added | +466.0k |
| Caisse de depot et placement du Quebec | Added | +411.2k |
| PANAGORA ASSET MANAGEMENT INC | Added | +402.6k |
| Bridgewater Associates, LP | Added | +363.1k |
Biggest sellers
| MIZUHO SECURITIES USA LLC | Reduced | -2.0m |
| Point72 Asset Management, L.P. | Reduced | -1.1m |
| VANGUARD GROUP INC | Reduced | -802.3k |
| MARSHALL WACE, LLP | Reduced | -692.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -604.5k |
| BlackRock, Inc. | Reduced | -567.3k |
| JUPITER ASSET MANAGEMENT LTD | Reduced | -555.9k |
| CITADEL ADVISORS LLC | Reduced | -551.4k |
| D. E. Shaw & Co., Inc. | Reduced | -532.0k |
| Invesco Ltd. | Reduced | -526.4k |
Biggest calls
| Point72 Asset Management, L.P. | New | $23.1m334.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $12.7m184.0k shares |
| Hudson Bay Capital Management LP | New | $6.9m100.0k shares |
| GROUP ONE TRADING LLC | Added | $5.1m73.9k shares |
| JANE STREET GROUP, LLC | Added | $4.7m67.9k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $3.2m46.2k shares |
| CITADEL ADVISORS LLC | Reduced | $3.2m46.1k shares |
| SIMPLEX TRADING, LLC | Added | $2.8m41.2k shares |
| WOLVERINE TRADING, LLC | Added | $2.0m29.7k shares |
| BARCLAYS PLC | New | $1.9m27.0k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $9.8m142.0k shares |
| JANE STREET GROUP, LLC | Added | $7.4m107.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $5.8m84.0k shares |
| TORONTO DOMINION BANK | New | $2.9m42.4k shares |
| TORNO CAPITAL, LLC | Not comparable | $2.8m40.0k shares |
| BARCLAYS PLC | New | $1.9m27.0k shares |
| CANTOR FITZGERALD, L. P. | New | $1.6m23.8k shares |
| Walleye Capital LLC | Added | $1.2m17.6k shares |
| BNP PARIBAS FINANCIAL MARKETS | New | $1.1m156 shares |
| WOLVERINE TRADING, LLC | Reduced | $1.1m15.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BAKER BROS. ADVISORS LP
13D · may seek influence
-0.1 pts · filed 2026-05-11
Stated purposeItem 4 of Schedule 13D is supplemented and superseded, as the case may be, as follows: On May 8, 2026 the Adviser acquired beneficial ownership of 15,000 shares of common stock ("Common Stock") of Incyte Corporation (the "Issuer"), as a result of the exercise of 15,000 options to purchase Common Stock at $84.53 per share (the "Exercised Stock Options") held directly by Julian C. Baker. Julian C. Baker currently serves on the Issuer's board of directors (the "Board") as a representative of the Funds. The policy of the Funds and the Adviser does not permit managing members of the Adviser GP or full-time employees of the Adviser to receive compensation for serving as directors of the Issuer, and the Funds are instead entitled to the pecuniary interest in the Exercised Stock Options. Julian C… Full filing |
15.6% |
| BlackRock, Inc. 13G · institution filed 2025-10-17 | 7.8% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 6.3% |
| DODGE & COX 13G · institution filed 2026-05-14 | 6.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 4 | $8.2m | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 2 | $1.9m | $1.4m |
| Q4 2023 | 0 | — | 1 | $78.6k | $78.6k |
| Q1 2024 | 0 | — | 2 | $525.2k | $525.2k |
| Q2 2024 | 0 | — | 2 | $1.2m | $1.2m |
| Q3 2024 | 0 | — | 5 | $3.0m | $3.0m |
| Q4 2024 | 0 | — | 3 | $839.7k | $839.7k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-16 | Tray Thomas Principal Accounting Officer | Sold plan | $45.1k650 shares |
| 2024-12-13 | Tray Thomas Principal Accounting Officer | Sold plan | $45.9k650 shares |
| 2024-11-29 | Iyengar Vijay K EVP, GMAPPS | Sold plan | $455.5k6.0k shares |
| 2024-11-06 | Flannelly Barry P EVP & General Manager US | Sold plan | $293.2k3.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 22.68% of their portfolio | 30.7m $2.1bn | Added +446 |
| VANGUARD GROUP INC 0.02% of their portfolio | 19.6m $1.4bn | Reduced -802.3k |
| BlackRock, Inc. 0.02% of their portfolio | 16.5m $1.1bn | Reduced -567.3k |
| Dodge & Cox 0.60% of their portfolio | 14.9m $1.0bn | Reduced -356.5k |
| STATE STREET CORP 0.03% of their portfolio | 10.0m $692.8m | Reduced -520.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.42% of their portfolio | 4.1m $282.2m | Reduced -413.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 4.0m $278.3m | Added +103.9k |
| AQR CAPITAL MANAGEMENT LLC 0.31% of their portfolio | 3.5m $241.5m | Added +801.1k |
| LSV ASSET MANAGEMENT 0.55% of their portfolio | 3.5m $239.5m | Added +544.1k |
| Invesco Ltd. 0.04% of their portfolio | 3.0m $210.5m | Reduced -526.4k |
| MORGAN STANLEY 0.01% of their portfolio | 2.8m $196.0m | Added +690.8k |
| Bellevue Group AG 2.87% of their portfolio | 2.2m $149.0m | Added +6.9k |
| ARMISTICE CAPITAL, LLC 2.84% of their portfolio | 1.8m $122.1m | Reduced -428.3k |
| NORGES BANK 0.02% of their portfolio | 1.8m $121.9m | Added +81.7k |
| NORTHERN TRUST CORP 0.02% of their portfolio | 1.7m $117.2m | Added +150.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 1.6m $113.5m | Added +33.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.02% of their portfolio | 1.5m $106.1m | Added +156.8k |
| ACADIAN ASSET MANAGEMENT LLC 0.30% of their portfolio | 1.5m $104.8m | Reduced -484.7k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 1.3m $91.5m | Reduced -87.1k |
| Pictet Asset Management Holding SA 0.10% of their portfolio | 1.3m $90.7m | Added +556.2k |
| Point72 Asset Management, L.P. 0.24% of their portfolio | 1.3m $88.3m | Reduced -1.1m |
| Robeco Institutional Asset Management B.V. 0.17% of their portfolio | 1.3m $87.1m | Reduced -5.2k |
| Sound Shore Management Inc /CT/ 2.74% of their portfolio | 1.2m $83.0m | Added +595.7k |
| DEUTSCHE BANK AG\ 0.03% of their portfolio | 1.2m $81.2m | Added +217.1k |
| Legal & General Group Plc 0.02% of their portfolio | 1.2m $80.0m | Reduced -325.8k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 1.1m $77.9m | Added +78.8k |
| FMR LLC 0.00% of their portfolio | 1.1m $73.4m | Reduced -257.1k |
| KBC Group NV 0.20% of their portfolio | 1.1m $73.0m | Reduced -104.4k |
| HSBC HOLDINGS PLC 0.04% of their portfolio | 1.0m $71.9m | Reduced -204.9k |
| Candriam S.C.A. 0.41% of their portfolio | 1.0m $71.5m | Added +224.9k |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 948.2k $65.5m | Reduced -196.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 913.7k $63.1m | Added +305.3k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.22% of their portfolio | 891.7k $61.6m | Added +798.9k |
| UBS Group AG 0.01% of their portfolio | 810.7k $56.0m | Added +307.6k |
| Woodline Partners LP 0.37% of their portfolio | 800.1k $55.3m | Added +5.3k |
| California Public Employees Retirement System 0.04% of their portfolio | 782.9k $54.1m | Reduced -36.2k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 778.2k $53.8m | Reduced -95.3k |
| BARCLAYS PLC 0.03% of their portfolio | 741.7k $51.2m | Reduced -290.2k |
| Man Group plc 0.15% of their portfolio | 729.0k $50.4m | Reduced -75.9k |
| MACKENZIE FINANCIAL CORP 0.02% of their portfolio | 726.1k $48.3m | Added +466.0k |
| Connor, Clark & Lunn Investment Management Ltd. 0.22% of their portfolio | 704.1k $48.6m | Added +122.0k |
| Bridgewater Associates, LP 0.21% of their portfolio | 671.8k $46.4m | Added +363.1k |
| Amundi 0.02% of their portfolio | 670.4k $49.0m | Added +150.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 657.8k $45.4m | Reduced -67.1k |
| FEDERATED HERMES, INC. 0.10% of their portfolio | 640.1k $44.2m | Added +33.0k |
| GLENMEDE TRUST CO NA 0.22% of their portfolio | 637.0k $44.0m | Reduced -60.1k |
| MARSHALL WACE, LLP 0.05% of their portfolio | 585.7k $40.5m | Reduced -692.6k |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 576.5k $39.8m | Reduced -532.0k |
| Swedbank AB 0.05% of their portfolio | 567.4k $39.2m | Reduced -98.7k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 567.0k $39.2m | Reduced -176.0k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 545.9k $37.7m | Reduced -19.2k |
| Sofinnova Investments, Inc. 2.65% of their portfolio | 524.3k $36.2m | Reduced -189.9k |
| Russell Investments Group, Ltd. 0.05% of their portfolio | 511.4k $35.3m | Reduced -9.9k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 506.7k $35.0m | Added +20.9k |
| PANAGORA ASSET MANAGEMENT INC 0.15% of their portfolio | 485.0k $33.5m | Added +402.6k |
| JANE STREET GROUP, LLC 0.05% of their portfolio | 476.5k $32.9m | Added +329.8k |
| Applied Finance Capital Management, LLC 1.40% of their portfolio | 465.7k $32.2m | Reduced -6.0k |
| Swiss National Bank 0.02% of their portfolio | 462.5k $31.9m | Reduced -20.8k |
| Grantham, Mayo, Van Otterloo & Co. LLC 0.10% of their portfolio | 455.7k $31.5m | Reduced -125.4k |
| Sumitomo Mitsui Trust Group, Inc. 0.02% of their portfolio | 447.3k $30.9m | Reduced -36.4k |
| Caisse de depot et placement du Quebec 0.06% of their portfolio | 416.2k $28.7m | Added +411.2k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.11% of their portfolio | 407.2k $28.1m | Added +197.4k |
| Ensign Peak Advisors, Inc 0.05% of their portfolio | 378.1k $26.1m | Added +67.4k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.22% of their portfolio | 355.6k $24.6m | Reduced -14.4k |
| TODD ASSET MANAGEMENT LLC 0.57% of their portfolio | 345.7k $23.9m | Reduced -13.0k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 344.8k $23.8m | Added +143.1k |
| Long Corridor Asset Management Ltd 17.12% of their portfolio | 330.0k $22.8m | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.06% of their portfolio | 327.3k $22.6m | Added +166.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 324.4k $22.4m | Added +139.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 323.6k $22.4m | Reduced -246.5k |
| CAPITAL FUND MANAGEMENT S.A. 0.21% of their portfolio | 308.3k $21.3m | Reduced -74.0k |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 306.2k $21.1m | Reduced -12.7k |
| Allianz Asset Management GmbH 0.03% of their portfolio | 295.2k $20.4m | Added +175.6k |
| CITIGROUP INC 0.02% of their portfolio | 286.3k $19.8m | Added +119.7k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 274.1k $18.9m | Added +27.9k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 268.8k $18.6m | New |
| Cubist Systematic Strategies, LLC 0.30% of their portfolio | 263.0k $18.2m | Added +192.0k |
| APG Asset Management N.V. 0.05% of their portfolio | 262.6k $17.5m | Added +115.4k |
| Trexquant Investment LP 0.21% of their portfolio | 262.3k $18.1m | New |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.02% of their portfolio | 248.9k $17.3m | Added +13.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 241.0k $16.6m | Added +1.8k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 229.9k $15.9m | Reduced -551.4k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.03% of their portfolio | 225.1k $15.5m | First filing |
| ASHFORD CAPITAL MANAGEMENT INC 1.83% of their portfolio | 224.4k $15.5m | Reduced -16.3k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.04% of their portfolio | 223.8k $15.5m | Added +75.1k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.03% of their portfolio | 219.3k $15.2m | Reduced -6.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 212.5k $14.7m | Reduced -8.2k |
| Andra AP-fonden 0.24% of their portfolio | 212.5k $14.7m | Added +15.5k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.24% of their portfolio | 210.2k $14.5m | First filing |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 209.5k $14.5m | Added +41.1k |
| HighTower Advisors, LLC 0.02% of their portfolio | 209.2k $14.4m | Reduced -516 |
| Engineers Gate Manager LP 0.25% of their portfolio | 205.7k $14.2m | Added +30.2k |
| READYSTATE ASSET MANAGEMENT LP 0.60% of their portfolio | 205.4k $14.2m | New |
| Rafferty Asset Management, LLC 0.05% of their portfolio | 203.3k $14.0m | Reduced -79.3k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 203.2k $14.0m | Added +3.2k |
| LBP AM SA 0.19% of their portfolio | 201.3k $13.9m | New |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 197.9k $13.7m | Added +26.8k |
| SECTOR GAMMA AS 4.69% of their portfolio | 197.4k $13.6m | Reduced -61.6k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 195.4k $13.4m | Added +182.8k |
| STEMPOINT CAPITAL LP 3.35% of their portfolio | 193.6k $13.4m | Added +64.1k |