| 1 |
VANGUARD GROUP INC
0.01% of their portfolio |
Valley Forge, PA |
24,482,15524.5m
$388.5m |
$388.5m |
0.01% |
Added
+3.6m |
+3,583,129 |
| 2 |
BlackRock Inc.
0.01% of their portfolio |
New York, NY |
20,273,85920.3m
$321.7m |
$321.7m |
0.01% |
Reduced
-631.1k |
-631,127 |
| 3 |
JANUS HENDERSON GROUP PLC
0.18% of their portfolio |
LONDON, X0 |
17,684,81617.7m
$280.6m |
$280.6m |
0.18% |
Added
+2.2m |
+2,185,028 |
| 4 |
Redmile Group, LLC
13.22% of their portfolio |
LARKSPUR, CA |
17,503,41717.5m
$277.8m |
$277.8m |
13.22% |
Reduced
-227.0k |
-227,000 |
| 5 |
RA CAPITAL MANAGEMENT, L.P.
4.16% of their portfolio |
BOSTON, MA |
13,322,28813.3m
$211.4m |
$211.4m |
4.16% |
Added
+11.0m |
+10,992,330 |
| 6 |
WELLINGTON MANAGEMENT GROUP LLP
0.04% of their portfolio |
Boston, MA |
13,258,99713.3m
$210.4m |
$210.4m |
0.04% |
Added
+3.5m |
+3,506,098 |
| 7 |
STATE STREET CORP
0.01% of their portfolio |
BOSTON, MA |
9,551,8529.6m
$151.6m |
$151.6m |
0.01% |
Added
+1.6m |
+1,612,938 |
| 8 |
D. E. Shaw & Co., Inc.
0.18% of their portfolio |
New York, NY |
6,995,2397.0m
$111.0m |
$111.0m |
0.18% |
Added
+714.7k |
+714,723 |
| 9 |
Fairmount Funds Management LLC
11.32% of their portfolio |
WEST CONSHOHOCKEN, PA |
5,929,5925.9m
$94.1m |
$94.1m |
11.32% |
Reduced
-100.0k |
-100,000 |
| 10 |
FMR LLC
0.01% of their portfolio |
BOSTON, MA |
5,788,5555.8m
$91.9m |
$91.9m |
0.01% |
Added
+175.8k |
+175,813 |
| 11 |
GEODE CAPITAL MANAGEMENT, LLC
0.01% of their portfolio |
BOSTON, MA |
4,899,9754.9m
$77.8m |
$77.8m |
0.01% |
Added
+147.4k |
+147,425 |
| 12 |
MORGAN STANLEY
0.01% of their portfolio |
NEW YORK, NY |
4,829,0914.8m
$76.6m |
$76.6m |
0.01% |
Added
+1.5m |
+1,490,486 |
| 13 |
PRICE T ROWE ASSOCIATES INC /MD/
0.01% of their portfolio |
BALTIMORE, MD |
3,906,3703.9m
$62.0m |
$62.0m |
0.01% |
Added
+1.6m |
+1,584,109 |
| 14 |
Artisan Partners Limited Partnership
0.10% of their portfolio |
Milwaukee, WI |
3,724,5833.7m
$59.1m |
$59.1m |
0.10% |
Reduced
-1.3k |
-1,338 |
| 15 |
Pictet Asset Management Holding SA
0.07% of their portfolio |
CAROUGE, V8 |
3,708,1393.7m
$58.8m |
$58.8m |
0.07% |
First filing |
|
| 16 |
Nuveen Asset Management, LLC
0.02% of their portfolio |
CHICAGO, IL |
3,108,0393.1m
$49.3m |
$49.3m |
0.02% |
Added
+465.5k |
+465,505 |
| 17 |
Hood River Capital Management LLC
1.55% of their portfolio |
PALM BEACH GARDENS, FL |
3,044,4853.0m
$48.3m |
$48.3m |
1.55% |
Added
+60.8k |
+60,814 |
| 18 |
Boxer Capital, LLC
2.50% of their portfolio |
San Diego, CA |
2,961,0003.0m
$47.0m |
$47.0m |
2.50% |
Unchanged |
|
| 19 |
MAVERICK CAPITAL LTD
0.93% of their portfolio |
DALLAS, TX |
2,518,5272.5m
$40.0m |
$40.0m |
0.93% |
Reduced
-1.3m |
-1,268,371 |
| 20 |
VOLORIDGE INVESTMENT MANAGEMENT, LLC
0.20% of their portfolio |
JUPITER, FL |
2,512,2512.5m
$39.9m |
$39.9m |
0.20% |
Added
+481.3k |
+481,296 |
| 21 |
Woodline Partners LP
0.45% of their portfolio |
San Francisco, CA |
2,433,1612.4m
$38.6m |
$38.6m |
0.45% |
Reduced
-114.5k |
-114,478 |
| 22 |
NORTHERN TRUST CORP
0.01% of their portfolio |
CHICAGO, IL |
2,370,8642.4m
$37.6m |
$37.6m |
0.01% |
Reduced
-25.2k |
-25,182 |
| 23 |
JPMORGAN CHASE & CO
0.00% of their portfolio |
NEW YORK, NY |
2,198,4272.2m
$34.9m |
$34.9m |
0.00% |
Added
+1.3m |
+1,336,005 |
| 24 |
Nicholas Investment Partners, LP
2.45% of their portfolio |
RANCHO SANTA FE, CA |
2,067,5612.1m
$32.8m |
$32.8m |
2.45% |
Added
+843.4k |
+843,434 |
| 25 |
NORGES BANK
0.01% of their portfolio |
OSLO, Q8 |
2,055,0892.1m
$32.6m |
$32.6m |
0.01% |
Added
+1.9m |
+1,890,089 |
| 26 |
Sofinnova Investments, Inc.
2.28% of their portfolio |
Menlo Park, CA |
2,045,2022.0m
$32.5m |
$32.5m |
2.28% |
Added
+1.2m |
+1,217,884 |
| 27 |
Avidity Partners Management LP
1.23% of their portfolio |
DALLAS, TX |
1,917,9071.9m
$30.4m |
$30.4m |
1.23% |
Reduced
-79.9k |
-79,893 |
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
0.01% of their portfolio |
SAN FRANCISCO, CA |
1,830,5751.8m
$29.1m |
$29.1m |
0.01% |
Added
+20.1k |
+20,113 |
| 29 |
EMERALD ADVISERS, LLC
1.39% of their portfolio |
LEOLA, PA |
1,811,3061.8m
$28.7m |
$28.7m |
1.39% |
Added
+827.6k |
+827,609 |
| 30 |
Bank of New York Mellon Corp
0.01% of their portfolio |
NEW YORK, NY |
1,796,1101.8m
$28.5m |
$28.5m |
0.01% |
Added
+703.1k |
+703,117 |
| 31 |
TWO SIGMA INVESTMENTS, LP
0.07% of their portfolio |
NEW YORK, NY |
1,628,2171.6m
$25.8m |
$25.8m |
0.07% |
Added
+812.7k |
+812,680 |
| 32 |
MILLENNIUM MANAGEMENT LLC
0.03% of their portfolio |
NEW YORK, NY |
1,605,7141.6m
$25.5m |
$25.5m |
0.03% |
Reduced
-1.1m |
-1,092,149 |
| 33 |
LORD, ABBETT & CO. LLC
0.04% of their portfolio |
JERSEY CITY, NJ |
1,518,9001.5m
$24.1m |
$24.1m |
0.04% |
Reduced
-319.1k |
-319,090 |
| 34 |
Artal Group S.A.
1.05% of their portfolio |
LUXEMBOURG, N4 |
1,512,1131.5m
$24.0m |
$24.0m |
1.05% |
Added
+746.6k |
+746,616 |
| 35 |
TANG CAPITAL MANAGEMENT LLC
3.36% of their portfolio |
SAN DIEGO, CA |
1,500,0001.5m
$23.8m |
$23.8m |
3.36% |
Added
+200.0k |
+200,000 |
| 36 |
EMERALD MUTUAL FUND ADVISERS TRUST
1.40% of their portfolio |
LEOLA, PA |
1,466,0631.5m
$23.3m |
$23.3m |
1.40% |
Added
+649.1k |
+649,069 |
| 37 |
Driehaus Capital Management LLC
0.30% of their portfolio |
Chicago, IL |
1,440,0521.4m
$22.9m |
$22.9m |
0.30% |
Added
+263.9k |
+263,922 |
| 38 |
QVT Financial LP
1.30% of their portfolio |
New York, NY |
1,375,9001.4m
$21.8m |
$21.8m |
1.30% |
Unchanged |
|
| 39 |
SILVERARC CAPITAL MANAGEMENT, LLC
7.73% of their portfolio |
BOSTON, MA |
1,307,4351.3m
$20.7m |
$20.7m |
7.73% |
Reduced
-112.6k |
-112,565 |
| 40 |
EVENTIDE ASSET MANAGEMENT, LLC
0.37% of their portfolio |
Boston, MA |
1,300,0001.3m
$20.6m |
$20.6m |
0.37% |
Unchanged |
|
| 41 |
TWO SIGMA ADVISERS, LP
0.05% of their portfolio |
NEW YORK, NY |
1,294,5181.3m
$20.5m |
$20.5m |
0.05% |
Added
+108.4k |
+108,400 |
| 42 |
CITADEL ADVISORS LLC
0.02% of their portfolio |
MIAMI, FL |
1,287,5421.3m
$20.4m |
$20.4m |
0.02% |
Added
+359.3k |
+359,302 |
| 43 |
GOLDMAN SACHS GROUP INC
0.00% of their portfolio |
NEW YORK, NY |
1,239,0991.2m
$19.7m |
$19.7m |
0.00% |
Reduced
-372.0k |
-372,003 |
| 44 |
DIMENSIONAL FUND ADVISORS LP
0.01% of their portfolio |
AUSTIN, TX |
1,180,7441.2m
$18.7m |
$18.7m |
0.01% |
Reduced
-8.5k |
-8,475 |
| 45 |
Candriam S.C.A.
0.13% of their portfolio |
STRASSEN, N4 |
1,122,5881.1m
$17.8m |
$17.8m |
0.13% |
Added
+130.0k |
+130,006 |
| 46 |
PANAGORA ASSET MANAGEMENT INC
0.11% of their portfolio |
BOSTON, MA |
1,098,4171.1m
$17.4m |
$17.4m |
0.11% |
Reduced
-19.6k |
-19,552 |
| 47 |
Invesco Ltd.
0.00% of their portfolio |
ATLANTA, GA |
1,086,1681.1m
$17.2m |
$17.2m |
0.00% |
Added
+50.5k |
+50,463 |
| 48 |
PINNACLE ASSOCIATES LTD
0.30% of their portfolio |
NEW YORK, NY |
1,016,1561.0m
$16.1m |
$16.1m |
0.30% |
Reduced
-193.8k |
-193,767 |
| 49 |
PRINCIPAL FINANCIAL GROUP INC
0.01% of their portfolio |
DES MOINES, IA |
984,664984.7k
$15.6m |
$15.6m |
0.01% |
Reduced
-3.2k |
-3,222 |
| 50 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP
0.02% of their portfolio |
BALA CYNWYD, PA |
974,887974.9k
$15.5m |
$15.5m |
0.02% |
Reduced
-340.8k |
-340,771 |
| 51 |
JANE STREET GROUP, LLC
0.02% of their portfolio |
NEW YORK, NY |
917,764917.8k
$14.6m |
$14.6m |
0.02% |
Added
+38.1k |
+38,064 |
| 52 |
Ensign Peak Advisors, Inc
0.03% of their portfolio |
SALT LAKE CITY, UT |
875,868875.9k
$13.9m |
$13.9m |
0.03% |
Added
+289.3k |
+289,275 |
| 53 |
PFM Health Sciences, LP
0.66% of their portfolio |
SAN FRANCISCO, CA |
869,889869.9k
$13.8m |
$13.8m |
0.66% |
New |
|
| 54 |
Rock Springs Capital Management LP
0.32% of their portfolio |
Baltimore, MD |
759,365759.4k
$12.1m |
$12.1m |
0.32% |
Added
+646.7k |
+646,745 |
| 55 |
RENAISSANCE TECHNOLOGIES LLC
0.02% of their portfolio |
NEW YORK, NY |
734,640734.6k
$11.7m |
$11.7m |
0.02% |
Reduced
-483.4k |
-483,400 |
| 56 |
Altium Capital Management LLC
6.66% of their portfolio |
NEW YORK, NY |
725,000725.0k
$11.5m |
$11.5m |
6.66% |
Added
+240.0k |
+240,000 |
| 57 |
Parkman Healthcare Partners LLC
2.09% of their portfolio |
STAMFORD, CT |
717,920717.9k
$11.4m |
$11.4m |
2.09% |
Reduced
-122.9k |
-122,891 |
| 58 |
Rhenman & Partners Asset Management AB
1.20% of their portfolio |
Stockholm, V7 |
700,000700.0k
$11.1m |
$11.1m |
1.20% |
Reduced
-50.0k |
-50,000 |
| 59 |
AMERICAN CENTURY COMPANIES INC
0.01% of their portfolio |
KANSAS CITY, MO |
699,116699.1k
$11.1m |
$11.1m |
0.01% |
Reduced
-1.2k |
-1,207 |
| 60 |
Granahan Investment Management, LLC
0.39% of their portfolio |
WALTHAM, MA |
681,377681.4k
$10.8m |
$10.8m |
0.39% |
Added
+254.6k |
+254,625 |
| 61 |
Man Group plc
0.03% of their portfolio |
LONDON, X0 |
663,647663.6k
$10.5m |
$10.5m |
0.03% |
New |
|
| 62 |
Rafferty Asset Management, LLC
0.05% of their portfolio |
New York, NY |
566,985567.0k
$9.0m |
$9.0m |
0.05% |
Added
+229.7k |
+229,699 |
| 63 |
BANK OF AMERICA CORP /DE/
0.00% of their portfolio |
CHARLOTTE, NC |
541,802541.8k
$8.6m |
$8.6m |
0.00% |
Added
+127.6k |
+127,624 |
| 64 |
Hennion & Walsh Asset Management, Inc.
0.53% of their portfolio |
Parsippany, NJ |
523,074523.1k
$8.3m |
$8.3m |
0.53% |
Added
+7.8k |
+7,795 |
| 65 |
VOYA INVESTMENT MANAGEMENT LLC
0.01% of their portfolio |
ATLANTA, GA |
515,136515.1k
$8.2m |
$8.2m |
0.01% |
Added
+86.9k |
+86,946 |
| 66 |
CM Management, LLC
8.42% of their portfolio |
GULF BREEZE, FL |
500,000500.0k
$7.9m |
$7.9m |
8.42% |
Unchanged |
|
| 67 |
Swiss National Bank
0.01% of their portfolio |
ZURICH, V8 |
480,800480.8k
$7.6m |
$7.6m |
0.01% |
Added
+4.7k |
+4,700 |
| 68 |
BRIDGER MANAGEMENT, LLC
2.72% of their portfolio |
NEW YORK, NY |
467,220467.2k
$7.4m |
$7.4m |
2.72% |
Unchanged |
|
| 69 |
SECTORAL ASSET MANAGEMENT INC
1.43% of their portfolio |
MONTREAL, A8 |
464,112464.1k
$7.4m |
$7.4m |
1.43% |
Added
+27.7k |
+27,665 |
| 70 |
Fisher Asset Management, LLC
0.00% of their portfolio |
PLANO, TX |
450,795450.8k
$7.2m |
$7.2m |
0.00% |
Reduced
-252.1k |
-252,122 |
| 71 |
Decheng Capital Management III (Cayman), LLC
2.20% of their portfolio |
Grand Cayman, E9 |
415,880415.9k
$6.6m |
$6.6m |
2.20% |
New |
|
| 72 |
Schonfeld Strategic Advisors LLC
0.06% of their portfolio |
NEW YORK, NY |
392,500392.5k
$6.2m |
$6.2m |
0.06% |
Added
+15.5k |
+15,531 |
| 73 |
Ikarian Capital, LLC
2.30% of their portfolio |
DALLAS, TX |
390,162390.2k
$6.2m |
$6.2m |
2.30% |
Reduced
-57.5k |
-57,538 |
| 74 |
ArrowMark Colorado Holdings LLC
0.07% of their portfolio |
Denver, CO |
383,780383.8k
$6.1m |
$6.1m |
0.07% |
Added
+219.3k |
+219,288 |
| 75 |
Birchview Capital, LP
2.56% of their portfolio |
BURLINGTON, VT |
380,000380.0k
$6.0m |
$6.0m |
2.56% |
Added
+190.0k |
+190,000 |
| 76 |
Tri Locum Partners LP
1.88% of their portfolio |
NEW YORK, NY |
369,912369.9k
$5.9m |
$5.9m |
1.88% |
Added
+72.1k |
+72,105 |
| 77 |
RHUMBLINE ADVISERS
0.01% of their portfolio |
BOSTON, MA |
364,396364.4k
$5.8m |
$5.8m |
0.01% |
Added
+449 |
+449 |
| 78 |
FRED ALGER MANAGEMENT, LLC
0.03% of their portfolio |
NEW YORK, NY |
354,859354.9k
$5.6m |
$5.6m |
0.03% |
Added
+316.2k |
+316,201 |
| 79 |
BARCLAYS PLC
0.00% of their portfolio |
LONDON, X0 |
342,727342.7k
$5.4m |
$5.4m |
0.00% |
Added
+76.2k |
+76,185 |
| 80 |
Squarepoint Ops LLC
0.03% of their portfolio |
NEW YORK, NY |
336,090336.1k
$5.3m |
$5.3m |
0.03% |
Added
+260.7k |
+260,714 |
| 81 |
NEW YORK STATE COMMON RETIREMENT FUND
0.01% of their portfolio |
ALBANY, NY |
324,926324.9k
$5.2m |
$5.2m |
0.01% |
Added
+40.5k |
+40,537 |
| 82 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
0.00% of their portfolio |
NEW YORK, NY |
306,020306.0k
$4.9m |
$4.9m |
0.00% |
Added
+12.2k |
+12,230 |
| 83 |
ALLIANCEBERNSTEIN L.P.
0.00% of their portfolio |
NASHVILLE, TN |
300,514300.5k
$4.8m |
$4.8m |
0.00% |
Unchanged |
|
| 84 |
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND
0.02% of their portfolio |
TORONTO, A6 |
300,000300.0k
$4.8m |
$4.8m |
0.02% |
New |
|
| 85 |
CREDIT SUISSE AG/
0.00% of their portfolio |
ZURICH, V8 |
293,041293.0k
$4.7m |
$4.7m |
0.00% |
Reduced
-24.7k |
-24,678 |
| 86 |
Hillsdale Investment Management Inc.
0.42% of their portfolio |
Toronto, A6 |
285,890285.9k
$4.5m |
$4.5m |
0.42% |
Reduced
-810 |
-810 |
| 87 |
Moody Aldrich Partners LLC
0.85% of their portfolio |
MARBLEHEAD, MA |
283,950283.9k
$4.5m |
$4.5m |
0.85% |
Added
+79.1k |
+79,094 |
| 88 |
FIRST MANHATTAN CO. LLC.
0.02% of their portfolio |
NEW YORK, NY |
283,400283.4k
$4.5m |
$4.5m |
0.02% |
Reduced
-1.4m |
-1,424,100 |
| 89 |
TD Asset Management Inc
0.01% of their portfolio |
Toronto, A6 |
282,400282.4k
$4.5m |
$4.5m |
0.01% |
Added
+184.5k |
+184,500 |
| 90 |
PRIMECAP MANAGEMENT CO/CA/
0.00% of their portfolio |
PASADENA, CA |
273,100273.1k
$4.3m |
$4.3m |
0.00% |
Unchanged |
|
| 91 |
BLAIR WILLIAM & CO/IL
0.02% of their portfolio |
CHICAGO, IL |
254,320254.3k
$4.0m |
$4.0m |
0.02% |
Reduced
-1.7k |
-1,685 |
| 92 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
0.01% of their portfolio |
WEST SACRAMENTO, CA |
246,379246.4k
$3.9m |
$3.9m |
0.01% |
Reduced
-26.8k |
-26,805 |
| 93 |
CITIGROUP INC
0.01% of their portfolio |
NEW YORK, NY |
245,551245.6k
$3.9m |
$3.9m |
0.01% |
Added
+50.9k |
+50,869 |
| 94 |
WELLS FARGO & COMPANY/MN
0.00% of their portfolio |
SAN FRANCISCO, CA |
242,843242.8k
$3.9m |
$3.9m |
0.00% |
Added
+18.8k |
+18,796 |
| 95 |
SEVEN EIGHT CAPITAL, LP
0.44% of their portfolio |
New York, NY |
238,930238.9k
$3.8m |
$3.8m |
0.44% |
Added
+141.9k |
+141,946 |
| 96 |
GROUP ONE TRADING LLC
0.15% of their portfolio |
CHICAGO, IL |
238,327238.3k
$3.8m |
$3.8m |
0.15% |
Added
+142.8k |
+142,766 |
| 97 |
BNP PARIBAS FINANCIAL MARKETS
0.01% of their portfolio |
PARIS, I0 |
236,082236.1k
$3.7m |
$3.7m |
0.01% |
Reduced
-142.4k |
-142,409 |
| 98 |
Sio Capital Management, LLC
1.14% of their portfolio |
NEW YORK, NY |
232,751232.8k
$3.7m |
$3.7m |
1.14% |
Reduced
-13.2k |
-13,170 |
| 99 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE
0.00% of their portfolio |
Toronto, A6 |
229,618229.6k
$3.6m |
$3.6m |
0.00% |
Added
+67.9k |
+67,919 |
| 100 |
DEUTSCHE BANK AG\
0.00% of their portfolio |
FRANKFURT AM MAIN, 2M |
225,066225.1k
$3.6m |
$3.6m |
0.00% |
Reduced
-3.1m |
-3,079,661 |