GYRE THERAPEUTICS INC GYRE
COM · Common Stock · CUSIP 403783103
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 111.5m as of 2026-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.59.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 16 |
| Q1 2024 | 22 |
| Q2 2024 | 31 |
| Q3 2024 | 38 |
| Q4 2024 | 41 |
| Q1 2025 | 46 |
| Q2 2025 | 49 |
| Q3 2025 | 48 |
| Q4 2025 | 44 |
| Q1 2026 | 56 |
| Q2 2026 | 61 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 24 | 10 |
| Q4 2024 | 20 | 14 |
| Q1 2025 | 23 | 16 |
| Q2 2025 | 34 | 15 |
| Q3 2025 | 23 | 26 |
| Q4 2025 | 24 | 15 |
| Q1 2026 | 29 | 13 |
| Q2 2026 | 43 | 16 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $0 | — |
| Q4 2025 | $0 | $85.4k | — |
| Q1 2026 | $0 | $13.9k | — |
| Q2 2026 | $0 | $0 | — |
Biggest buyers
| HSG Holding Ltd | New | +3.8m |
| Octagon Capital Advisors LP | New | +954.4k |
| BlackRock, Inc. | Added | +235.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +101.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +54.1k |
| NORTHERN TRUST CORP | Added | +35.7k |
| MORGAN STANLEY | Added | +33.0k |
| STATE STREET CORP | Added | +29.1k |
| Nuveen, LLC | New | +24.5k |
| Bank of New York Mellon Corp | Added | +19.6k |
Biggest sellers
| VANGUARD CAPITAL MANAGEMENT LLC | Reduced | -107.3k |
| Brevan Howard Capital Management LP | Sold out | -13.8k |
| SBI Securities Co., Ltd. | Reduced | -4.1k |
| FMR LLC | Reduced | -3.7k |
| Tower Research Capital LLC (TRC) | Reduced | -3.3k |
| UBS Group AG | Reduced | -2.3k |
| Allworth Financial LP | Reduced | -683 |
| SIMPLEX TRADING, LLC | Sold out | -674 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | Reduced | -473 |
| NISA INVESTMENT ADVISORS, LLC | Sold out | -102 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
GNI Group Ltd.
13D · may seek influence
filed 2026-05-06
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing |
69.1% |
Luo Ying
13D · may seek influence
filed 2026-05-06
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing |
8.6% |
Ma Songjiang
13D · may seek influence
filed 2026-05-07
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing |
6.3% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $236.8k | $236.8k |
| Q1 2025 | 0 | — | 1 | $1.1m | $1.1m |
| Q2 2025 | 0 | — | 1 | $204.4k | $204.4k |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 2 | $952.9k | $82.9k |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-06-18 | Ye Weiguo Chief Operating Officer | Sold | $19.1k3.0k shares |
| 2026-06-11 | Ye Weiguo Chief Operating Officer | Sold | $17.3k2.8k shares |
| 2026-06-10 | Ye Weiguo Chief Operating Officer | Sold | $39.9k6.4k shares |
| 2026-06-10 | Ye Weiguo Chief Operating Officer | Sold | $31.2k5.0k shares |
| 2026-06-09 | Ye Weiguo Chief Operating Officer | Sold | $89.0k14.5k shares |
| 2026-06-09 | Ye Weiguo Chief Operating Officer | Sold | $18.4k3.0k shares |
| 2026-06-05 | Ye Weiguo Chief Operating Officer | Sold | $98.6k15.4k shares |
| 2026-06-04 | Ye Weiguo Chief Operating Officer | Sold | $120.0k19.6k shares |
| 2026-05-26 | Ye Weiguo Chief Operating Officer | Sold | $24.4k4.0k shares |
| 2026-05-22 | Ye Weiguo Chief Operating Officer | Sold | $21.3k3.5k shares |
| 2026-05-21 | Ye Weiguo Chief Operating Officer | Sold | $78.8k12.8k shares |
| 2026-05-20 | Ye Weiguo Chief Operating Officer | Sold | $57.8k9.4k shares |
| 2026-05-19 | Ye Weiguo Chief Operating Officer | Sold | $58.1k9.1k shares |
| 2026-05-18 | Ye Weiguo Chief Operating Officer | Sold | $1.3k200 shares |
| 2026-05-15 | Ye Weiguo Chief Operating Officer | Sold | $87.1k13.1k shares |
| 2026-05-14 | Ye Weiguo Chief Operating Officer | Sold | $107.7k15.6k shares |
| 2026-05-06 | Luo Ying Chief Executive Officer, director · By Spouse | Sold plan | $81.5k10.1k shares |
| 2026-05-05 | Luo Ying Chief Executive Officer, director · By Spouse | Sold plan | $1.4k179 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| HSG Holding Ltd 2.06% of their portfolio | 3.8m $24.7m | New |
| BlackRock, Inc. 0.00% of their portfolio | 993.9k $6.6m | Added +235.3k |
| Octagon Capital Advisors LP 0.58% of their portfolio | 954.4k $6.3m | New |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 876.9k $5.8m | Reduced -107.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 533.0k $3.5m | Added +101.5k |
| STATE STREET CORP 0.00% of their portfolio | 245.4k $1.6m | Added +29.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 184.3k $1.2m | Added +19.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 169.5k $1.1m | Added +35.7k |
| SBI Securities Co., Ltd. 0.02% of their portfolio | 166.8k $1.1m | Reduced -4.1k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 151.1k $995.6k | Added +13.4k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 124.0k $816.9k | Added +54.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 86.2k $568.3k | Added +13.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 62.8k $413.5k | Added +19.6k |
| MORGAN STANLEY 0.00% of their portfolio | 41.7k $274.7k | Added +33.0k |
| STRS OHIO 0.00% of their portfolio | 25.8k $170.0k | Added +4.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 25.3k $166.5k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 24.6k $171.4k | Added +2.8k |
| Nuveen, LLC 0.00% of their portfolio | 24.5k $161.5k | New |
| UBS Group AG 0.00% of their portfolio | 18.8k $123.6k | Reduced -2.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 18.5k $121.8k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.9k $118.2k | Added +7.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 16.9k $111.1k | Added +3.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 16.3k $107.4k | Added +12.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 15.0k $100.0k | New |
| FMR LLC 0.00% of their portfolio | 15.0k $98.7k | Reduced -3.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 13.2k $87.0k | Added +7.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 12.5k $82.5k | Added +2.0k |
| Polymer Capital Management (US) LLC 0.01% of their portfolio | 11.8k $77.6k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 10.0k $65.8k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 9.0k $59.4k | Added +6.9k |
| CITIGROUP INC 0.00% of their portfolio | 8.6k $56.6k | Added +8.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 8.4k $55.7k | Added +2.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 7.8k $50.5k | Added +2.6k |
| State of Alaska, Department of Revenue 0.00% of their portfolio | 5.2k $34.0k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 3.8k $24.9k | Added +2.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 3.5k $23.0k | Added +915 |
| BARCLAYS PLC 0.00% of their portfolio | 3.2k $21.3k | Added +928 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.7k $17.8k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.5k $16.3k | Reduced -3.3k |
| Legal & General Group Plc 0.00% of their portfolio | 2.1k $13.5k | Added +803 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 683 $4.5k | Unchanged |
| Activest Wealth Management 0.00% of their portfolio | 533 $3.5k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 246 $1.6k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 166 $1.1k | Reduced -473 |
| Sterling Capital Management LLC 0.00% of their portfolio | 161 $1.1k | Added +102 |
| GAMMA Investing LLC 0.00% of their portfolio | 146 $962 | Added +64 |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 82 $541 | New |
| Bare Financial Services, Inc 0.00% of their portfolio | 79 $521 | New |
| GoalVest Advisory LLC 0.00% of their portfolio | 50 $330 | Unchanged |
| Covestor Ltd 0.00% of their portfolio | 48 $0 | Added +34 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 44 $288 | Added +6 |
| Allworth Financial LP 0.00% of their portfolio | 38 $251 | Reduced -683 |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 20 $133 | Added +17 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 15 $99 | Added +12 |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 14 $94 | New |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 8 $53 | New |
| Optiver Holding B.V. 0.00% of their portfolio | 6 $40 | Reduced -96 |
| Smartleaf Asset Management LLC 0.00% of their portfolio | 6 $39 | Unchanged |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 1 $7 | New |
| Essential Partners LLC 0.00% of their portfolio | 1 $7 | Reduced -3 |
| MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio | 0 $0 | Reduced -12 |