Vault-13

GYRE THERAPEUTICS INC GYRE

COM · Common Stock · CUSIP 403783103

61 institutional holders +5 vs Q1 2026
8,665,3758.7m shares reported held*
7.8% of all shares outstanding*
$57.1mreported value*
12 new 31 added 10 reduced 6 sold out net bought ≈ $34.7m (+5.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 111.5m as of 2026-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.59.

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0255075Q4 23: 16Q1 24: 22Q2 24: 31Q3 24: 38Q4 24: 41Q1 25: 46Q2 25: 49Q3 25: 48Q4 25: 44Q1 26: 56Q2 26: 6161Q4 23Q2 24Q4 24Q2 25Q4 25Q2 26
Numbers
QuarterHolders
Q4 202316
Q1 202422
Q2 202431
Q3 202438
Q4 202441
Q1 202546
Q2 202549
Q3 202548
Q4 202544
Q1 202656
Q2 202661

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q3 24: 24 bought or addedQ3 24: 10 cut or sold outQ4 24: 20 bought or addedQ4 24: 14 cut or sold outQ4 24Q1 25: 23 bought or addedQ1 25: 16 cut or sold outQ2 25: 34 bought or addedQ2 25: 15 cut or sold outQ2 25Q3 25: 23 bought or addedQ3 25: 26 cut or sold outQ4 25: 24 bought or addedQ4 25: 15 cut or sold outQ4 25Q1 26: 29 bought or addedQ1 26: 13 cut or sold outQ2 26: 43 bought or addedQ2 26: 16 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20242410
Q4 20242014
Q1 20252316
Q2 20253415
Q3 20252326
Q4 20252415
Q1 20262913
Q2 20264316

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$25k$50k$75k$100kQ3 25 calls: $0Q3 25 puts: $0Q3 25P/C —Q4 25 calls: $0Q4 25 puts: $85.4kQ4 25P/C —Q1 26 calls: $0Q1 26 puts: $13.9kQ1 26P/C —Q2 26 calls: $0Q2 26 puts: $0Q2 26P/C —
Numbers
QuarterCallsPutsP/C
Q3 2025$0$0—
Q4 2025$0$85.4k—
Q1 2026$0$13.9k—
Q2 2026$0$0—

Biggest buyers

HSG Holding Ltd New +3,750,299+3.8m
Octagon Capital Advisors LP New +954,416+954.4k
BlackRock, Inc. Added +235,313+235.3k
GEODE CAPITAL MANAGEMENT, LLC Added +101,536+101.5k
VANGUARD PORTFOLIO MANAGEMENT LLC Added +54,139+54.1k
NORTHERN TRUST CORP Added +35,696+35.7k
MORGAN STANLEY Added +33,050+33.0k
STATE STREET CORP Added +29,076+29.1k
Nuveen, LLC New +24,505+24.5k
Bank of New York Mellon Corp Added +19,606+19.6k

Biggest sellers

VANGUARD CAPITAL MANAGEMENT LLC Reduced -107,277-107.3k
Brevan Howard Capital Management LP Sold out -13,808-13.8k
SBI Securities Co., Ltd. Reduced -4,087-4.1k
FMR LLC Reduced -3,743-3.7k
Tower Research Capital LLC (TRC) Reduced -3,294-3.3k
UBS Group AG Reduced -2,324-2.3k
Allworth Financial LP Reduced -683-683
SIMPLEX TRADING, LLC Sold out -674-674
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Reduced -473-473
NISA INVESTMENT ADVISORS, LLC Sold out -102-102

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GNI Group Ltd. 13D · may seek influence filed 2026-05-06
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing
69.1% 86.3m≈ $558.6m 2026-05-06
Luo Ying 13D · may seek influence filed 2026-05-06
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing
8.6% 10.2m≈ $67.3m 2026-05-06
Ma Songjiang 13D · may seek influence filed 2026-05-07
Stated purposeItem 4 of the Statement is hereby amended and supplemented as follows: Agreement and Plan of Merger On May 4, 2026 (the "Merger Closing Date"), Gyre consummated the previously announced acquisition of Cullgen Inc., a Delaware corporation ("Cullgen"), in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated March 2, 2026 (the "Merger Agreement"), by and among the Company, Helix Merger Sub Corp., a Delaware corporation and wholly owned subsidiary of the Company ("Merger Sub"), and Cullgen. Pursuant to the Merger Agreement, Merger Sub merged with and into Cullgen, with Cullgen continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the "Merger"). Under the terms of the Merger Agreement, the Company acquired Cullg… Full filing
6.3% 7.3m≈ $48.4m 2026-05-07

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q4 24: 0 buyingQ4 24: 1 sellingQ1 25: 0 buyingQ1 25: 1 sellingQ1 25Q2 25: 0 buyingQ2 25: 1 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 0 buyingQ4 25: 0 sellingQ1 26: 0 buyingQ1 26: 0 sellingQ1 26Q2 26: 0 buyingQ2 26: 2 sellingQ3 26: 0 buyingQ3 26: 0 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—1$236.8k$236.8k
Q1 20250—1$1.1m$1.1m
Q2 20250—1$204.4k$204.4k
Q3 20250—0——
Q4 20250—0——
Q1 20260—0——
Q2 20260—2$952.9k$82.9k
Q3 20260—0——
DateInsiderTradeSharesPrice ValueTheir holding
2026-06-18 Ye Weiguo Chief Operating Officer Sold 3,000 $6.35 $19.1k3.0k shares -<1%
2026-06-11 Ye Weiguo Chief Operating Officer Sold 2,800 $6.17 $17.3k2.8k shares -<1%
2026-06-10 Ye Weiguo Chief Operating Officer Sold 6,418 $6.21 $39.9k6.4k shares -1%
2026-06-10 Ye Weiguo Chief Operating Officer Sold 5,000 $6.24 $31.2k5.0k shares -1%
2026-06-09 Ye Weiguo Chief Operating Officer Sold 14,500 $6.14 $89.0k14.5k shares -2%
2026-06-09 Ye Weiguo Chief Operating Officer Sold 3,000 $6.15 $18.4k3.0k shares -<1%
2026-06-05 Ye Weiguo Chief Operating Officer Sold 15,401 $6.40 $98.6k15.4k shares -2%
2026-06-04 Ye Weiguo Chief Operating Officer Sold 19,575 $6.13 $120.0k19.6k shares -3%
2026-05-26 Ye Weiguo Chief Operating Officer Sold 4,000 $6.10 $24.4k4.0k shares -1%
2026-05-22 Ye Weiguo Chief Operating Officer Sold 3,500 $6.08 $21.3k3.5k shares -0%
2026-05-21 Ye Weiguo Chief Operating Officer Sold 12,820 $6.15 $78.8k12.8k shares -2%
2026-05-20 Ye Weiguo Chief Operating Officer Sold 9,400 $6.15 $57.8k9.4k shares -1%
2026-05-19 Ye Weiguo Chief Operating Officer Sold 9,120 $6.37 $58.1k9.1k shares -1%
2026-05-18 Ye Weiguo Chief Operating Officer Sold 200 $6.62 $1.3k200 shares -<1%
2026-05-15 Ye Weiguo Chief Operating Officer Sold 13,100 $6.65 $87.1k13.1k shares -2%
2026-05-14 Ye Weiguo Chief Operating Officer Sold 15,580 $6.91 $107.7k15.6k shares -2%
2026-05-06 Luo Ying Chief Executive Officer, director · By Spouse Sold plan 10,136 $8.04 $81.5k10.1k shares -<1%
2026-05-05 Luo Ying Chief Executive Officer, director · By Spouse Sold plan 179 $8.01 $1.4k179 shares -<1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 HSG Holding Ltd 2.06% of their portfolio NA, K3 3,750,2993.8m $24.7m $24.7m 2.06% New
2 BlackRock, Inc. 0.00% of their portfolio New York, NY 993,943993.9k $6.6m $6.6m 0.00% Added +235.3k +235,313
3 Octagon Capital Advisors LP 0.58% of their portfolio NEW YORK, NY 954,416954.4k $6.3m $6.3m 0.58% New
4 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 876,927876.9k $5.8m $5.8m 0.00% Reduced -107.3k -107,277
5 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 532,950533.0k $3.5m $3.5m 0.00% Added +101.5k +101,536
6 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 245,402245.4k $1.6m $1.6m 0.00% Added +29.1k +29,076
7 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 184,286184.3k $1.2m $1.2m 0.00% Added +19.0k +19,048
8 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 169,537169.5k $1.1m $1.1m 0.00% Added +35.7k +35,696
9 SBI Securities Co., Ltd. 0.02% of their portfolio TOKYO, M0 166,750166.8k $1.1m $1.1m 0.02% Reduced -4.1k -4,087
10 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 151,073151.1k $995.6k $995.6k 0.00% Added +13.4k +13,391
11 VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 123,953124.0k $816.9k $816.9k 0.00% Added +54.1k +54,139
12 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 86,23586.2k $568.3k $568.3k 0.00% Added +13.1k +13,113
13 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 62,75062.8k $413.5k $413.5k 0.00% Added +19.6k +19,606
14 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 41,69141.7k $274.7k $274.7k 0.00% Added +33.0k +33,050
15 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 25,80025.8k $170.0k $170.0k 0.00% Added +4.7k +4,700
16 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 25,26825.3k $166.5k $166.5k 0.00% Unchanged
17 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 24,59024.6k $171.4k $171.4k 0.00% Added +2.8k +2,760
18 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 24,50524.5k $161.5k $161.5k 0.00% New
19 UBS Group AG 0.00% of their portfolio ZURICH, V8 18,76318.8k $123.6k $123.6k 0.00% Reduced -2.3k -2,324
20 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 18,48818.5k $121.8k $121.8k 0.00% New
21 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 17,93917.9k $118.2k $118.2k 0.00% Added +7.3k +7,326
22 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 16,86516.9k $111.1k $111.1k 0.00% Added +3.7k +3,749
23 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 16,29716.3k $107.4k $107.4k 0.00% Added +12.0k +12,007
24 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 15,03115.0k $100.0k $100.0k 0.00% New
25 FMR LLC 0.00% of their portfolio BOSTON, MA 14,97415.0k $98.7k $98.7k 0.00% Reduced -3.7k -3,743
26 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 13,19513.2k $87.0k $87.0k 0.00% Added +7.6k +7,590
27 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 12,52512.5k $82.5k $82.5k 0.00% Added +2.0k +1,987
28 Polymer Capital Management (US) LLC 0.01% of their portfolio NEW YORK, NY 11,78011.8k $77.6k $77.6k 0.01% New
29 Vanguard Global Advisers, LLC 0.00% of their portfolio MALVERN, PA 9,98310.0k $65.8k $65.8k 0.00% Unchanged
30 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 9,0119.0k $59.4k $59.4k 0.00% Added +6.9k +6,914
31 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 8,5868.6k $56.6k $56.6k 0.00% Added +8.0k +7,957
32 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 8,4468.4k $55.7k $55.7k 0.00% Added +2.8k +2,829
33 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 7,8317.8k $50.5k $50.5k 0.00% Added +2.6k +2,650
34 State of Alaska, Department of Revenue 0.00% of their portfolio JUNEAU, AK 5,2195.2k $34.0k $34.0k 0.00% Unchanged
35 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 3,7833.8k $24.9k $24.9k 0.00% Added +2.7k +2,659
36 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 3,4863.5k $23.0k $23.0k 0.00% Added +915 +915
37 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 3,2283.2k $21.3k $21.3k 0.00% Added +928 +928
38 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 2,7002.7k $17.8k $17.8k 0.00% Unchanged
39 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 2,4692.5k $16.3k $16.3k 0.00% Reduced -3.3k -3,294
40 Legal & General Group Plc 0.00% of their portfolio London, X0 2,0542.1k $13.5k $13.5k 0.00% Added +803 +803
41 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 683683 $4.5k $4.5k 0.00% Unchanged
42 Activest Wealth Management 0.00% of their portfolio AVENTURA, FL 533533 $3.5k $3.5k 0.00% Unchanged
43 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 246246 $1.6k $1.6k 0.00% New
44 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 166166 $1.1k $1.1k 0.00% Reduced -473 -473
45 Sterling Capital Management LLC 0.00% of their portfolio CHARLOTTE, NC 161161 $1.1k $1.1k 0.00% Added +102 +102
46 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 146146 $962 $962 0.00% Added +64 +64
47 Physician Wealth Advisors, Inc. 0.00% of their portfolio MIDVALE, UT 8282 $541 $541 0.00% New
48 Bare Financial Services, Inc 0.00% of their portfolio GAP, PA 7979 $521 $521 0.00% New
49 GoalVest Advisory LLC 0.00% of their portfolio New York, NY 5050 $330 $330 0.00% Unchanged
50 Covestor Ltd 0.00% of their portfolio LONDON, X0 4848 $0 $0 0.00% Added +34 +34
51 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 4444 $288 $288 0.00% Added +6 +6
52 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 3838 $251 $251 0.00% Reduced -683 -683
53 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 2020 $133 $133 0.00% Added +17 +17
54 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 1515 $99 $99 0.00% Added +12 +12
55 Integrated Wealth Concepts LLC 0.00% of their portfolio WALTHAM, MA 1414 $94 $94 0.00% New
56 Farther Finance Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 88 $53 $53 0.00% New
57 Optiver Holding B.V. 0.00% of their portfolio AMSTERDAM, P7 66 $40 $40 0.00% Reduced -96 -96
58 Smartleaf Asset Management LLC 0.00% of their portfolio BOSTON, MA 66 $39 $39 0.00% Unchanged
59 ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio CHICAGO, IL 11 $7 $7 0.00% New
60 Essential Partners LLC 0.00% of their portfolio RANCHO SANTA FE, CA 11 $7 $7 0.00% Reduced -3 -3
61 MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio Windsor, CT 00 $0 $0 0.00% Reduced -12 -12