GUARDANT HEALTH INC GH
COM · Common Stock · CUSIP 40131M109 · ISIN US40131M1099
American biotechnology company
- SectorHealth care
- IndustryServices-Medical Laboratories
- HeadquartersPalo Alto, CA
- Founded2012
- Websiteguardanthealth.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($123.4m this quarter). Holder counts are more reliable. Shares outstanding: 124.7m as of 2025-07-25, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $52.04. Options: 16 managers hold calls ($89.1m notional), 19 hold puts ($126.4m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 329 |
| Q4 2022 | 293 |
| Q1 2023 | 281 |
| Q2 2023 | 303 |
| Q3 2023 | 299 |
| Q4 2023 | 296 |
| Q1 2024 | 260 |
| Q2 2024 | 284 |
| Q3 2024 | 273 |
| Q4 2024 | 300 |
| Q1 2025 | 345 |
| Q2 2025 | 368 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 145 | 139 |
| Q4 2023 | 120 | 164 |
| Q1 2024 | 130 | 164 |
| Q2 2024 | 148 | 132 |
| Q3 2024 | 134 | 128 |
| Q4 2024 | 145 | 122 |
| Q1 2025 | 178 | 154 |
| Q2 2025 | 193 | 161 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $21.3m | $56.0m | 2.63 |
| Q4 2024 | $29.5m | $56.8m | 1.92 |
| Q1 2025 | $69.7m | $102.1m | 1.47 |
| Q2 2025 | $89.1m | $126.4m | 1.42 |
Biggest buyers
| ROYAL BANK OF CANADA | Added | +1.6m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.6m |
| ARK Investment Management LLC | Added | +1.4m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.1m |
| FRANKLIN RESOURCES INC | Added | +1.0m |
| RTW INVESTMENTS, LP | New | +856.5k |
| Invesco Ltd. | Added | +763.8k |
| Man Group plc | Added | +739.8k |
| JENNISON ASSOCIATES LLC | New | +715.5k |
| Amova Asset Management Americas, Inc. | Added | +673.4k |
Biggest sellers
| CADIAN CAPITAL MANAGEMENT, LP | Reduced | -1.4m |
| Deep Track Capital, LP | Reduced | -1.2m |
| UBS Group AG | Reduced | -1.1m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -877.4k |
| Point72 Asset Management, L.P. | Reduced | -720.3k |
| CITADEL ADVISORS LLC | Reduced | -658.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -539.4k |
| BRAIDWELL LP | Reduced | -489.5k |
| DEUTSCHE BANK AG\ | Reduced | -428.5k |
| VOYA INVESTMENT MANAGEMENT LLC | Reduced | -396.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $31.2m600.4k shares |
| JANE STREET GROUP, LLC | Added | $17.6m338.6k shares |
| GROUP ONE TRADING LLC | Added | $7.3m141.2k shares |
| Caption Management, LLC | Added | $7.3m140.0k shares |
| CITADEL ADVISORS LLC | Reduced | $6.7m128.5k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $5.7m109.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.5m86.7k shares |
| Walleye Trading LLC | Added | $2.4m45.9k shares |
| Jefferies Financial Group Inc. | New | $2.1m40.0k shares |
| Balyasny Asset Management L.P. | New | $1.6m29.9k shares |
Biggest puts
| Parallax Volatility Advisers, L.P. | Added | $64.5m1.2m shares |
| Polar Asset Management Partners Inc. | Added | $20.8m400.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $8.8m169.3k shares |
| CITADEL ADVISORS LLC | Added | $6.3m121.0k shares |
| NOMURA HOLDINGS INC | Added | $4.6m88.8k shares |
| JANE STREET GROUP, LLC | Reduced | $4.6m88.4k shares |
| GROUP ONE TRADING LLC | Added | $3.9m75.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.2m62.2k shares |
| Walleye Trading LLC | Added | $2.1m40.7k shares |
| Jefferies Financial Group Inc. | New | $2.1m40.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.3 pts · filed 2026-07-28 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.9%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 2 | $72.8k | $3.5k |
| Q4 2023 | 0 | — | 2 | $155.6k | $2.6k |
| Q1 2024 | 1 | $39.0k | 1 | $1.9k | $1.9k |
| Q2 2024 | 0 | — | 1 | $2.8k | $2.8k |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 4 | $625.1k | $175.4k |
| Q1 2025 | 0 | — | 3 | $170.4k | $19.3k |
| Q2 2025 | 0 | — | 6 | $12.9m | $12.7m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-18 | Tariq Musa Director | Sold plan | $158.9k3.2k shares |
| 2025-06-18 | POTTER MYRTLE S Director | Sold plan | $1.3k26 shares |
| 2025-06-17 | CLARK IAN T Director · By The Thornton-Clark Family Trust, J Thornton-Clark & I Clark TTE Account | Sold plan | $322.8k6.7k shares |
| 2025-06-16 | POTTER MYRTLE S Director | Sold plan | $130.5k2.6k shares |
| 2025-06-13 | Joyce Meghan V. Director | Sold plan | $157.6k3.3k shares |
| 2025-06-09 | Talasaz AmirAli Co-Chief Executive Officer, director | Sold plan | $3.9m77.9k shares |
| 2025-06-06 | Talasaz AmirAli Co-Chief Executive Officer, director | Sold plan | $2.0m39.8k shares |
| 2025-06-05 | Talasaz AmirAli Co-Chief Executive Officer, director | Sold plan | $84.0k1.7k shares |
| 2025-06-03 | Kalia Kumud Chief Information Officer | Sold | $185.6k4.0k shares |
| 2025-06-02 | Joyce Meghan V. Director | Sold plan | $4.2k100 shares |
| 2025-05-19 | Tariq Musa Director | Sold plan | $4.6k116 shares |
| 2025-05-02 | Talasaz AmirAli Co-Chief Executive Officer, director | Sold plan | $703.1k13.9k shares |
| 2025-05-01 | Talasaz AmirAli Co-Chief Executive Officer, director | Sold plan | $5.2m106.8k shares |
| 2025-04-17 | Tariq Musa Director | Sold plan | $5.2k116 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.01% of their portfolio | 12.2m $633.2m | Added +86.6k |
| BlackRock, Inc. 0.01% of their portfolio | 11.0m $571.4m | Reduced -194.4k |
| Capital International Investors 0.04% of their portfolio | 5.0m $259.0m | Reduced -171.3k |
| BAILLIE GIFFORD & CO 0.19% of their portfolio | 4.8m $250.3m | Reduced -251.2k |
| Deep Track Capital, LP 7.11% of their portfolio | 4.2m $221.2m | Reduced -1.2m |
| Invesco Ltd. 0.03% of their portfolio | 3.6m $185.2m | Added +763.8k |
| EVENTIDE ASSET MANAGEMENT, LLC 3.15% of their portfolio | 3.5m $180.0m | Reduced -107.8k |
| CADIAN CAPITAL MANAGEMENT, LP 9.27% of their portfolio | 3.2m $165.4m | Reduced -1.4m |
| CITADEL ADVISORS LLC 0.13% of their portfolio | 2.9m $152.9m | Reduced -658.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.03% of their portfolio | 2.9m $152.7m | Added +156.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.9m $152.0m | Added +13.1k |
| STATE STREET CORP 0.01% of their portfolio | 2.8m $147.8m | Added +39.6k |
| ARK Investment Management LLC 1.08% of their portfolio | 2.8m $146.9m | Added +1.4m |
| MILLENNIUM MANAGEMENT LLC 0.13% of their portfolio | 2.7m $141.6m | Added +1.6m |
| Driehaus Capital Management LLC 1.03% of their portfolio | 2.5m $128.8m | Added +542.5k |
| TWO SIGMA ADVISERS, LP 0.25% of their portfolio | 2.4m $123.9m | Added +14.0k |
| FRANKLIN RESOURCES INC 0.03% of their portfolio | 2.3m $120.7m | Added +1.0m |
| FULLER & THALER ASSET MANAGEMENT, INC. 0.42% of their portfolio | 2.2m $114.4m | Added +232.1k |
| Sumitomo Mitsui Trust Group, Inc. 0.07% of their portfolio | 2.0m $105.7m | Added +673.4k |
| Amova Asset Management Americas, Inc. 1.05% of their portfolio | 2.0m $105.6m | Added +673.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 1.9m $100.1m | Reduced -71.8k |
| TWO SIGMA INVESTMENTS, LP 0.17% of their portfolio | 1.9m $96.5m | Added +28.7k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 1.8m $93.0m | Added +1.6m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.8m $91.9m | Added +1.1m |
| FEDERATED HERMES, INC. 0.14% of their portfolio | 1.5m $76.3m | Added +615.4k |
| NORGES BANK 0.01% of their portfolio | 1.2m $64.1m | Added +19.7k |
| UBS Group AG 0.01% of their portfolio | 1.2m $61.6m | Reduced -1.1m |
| NORTHERN TRUST CORP 0.01% of their portfolio | 1.2m $61.6m | Reduced -93.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.1m $59.7m | Reduced -20.6k |
| Temasek Holdings (Private) Ltd 0.21% of their portfolio | 1.0m $54.3m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.0m $52.7m | Added +16.8k |
| FMR LLC 0.00% of their portfolio | 987.7k $51.4m | Added +497.7k |
| Aristotle Atlantic Partners, LLC 1.48% of their portfolio | 932.0k $48.5m | Reduced -32.6k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 906.2k $47.2m | Added +54.2k |
| LORD, ABBETT & CO. LLC 0.15% of their portfolio | 887.7k $46.2m | Reduced -66.8k |
| MORGAN STANLEY 0.00% of their portfolio | 886.6k $46.1m | Reduced -53.9k |
| RTW INVESTMENTS, LP 0.63% of their portfolio | 856.5k $44.6m | New |
| BRAIDWELL LP 1.49% of their portfolio | 837.8k $43.6m | Reduced -489.5k |
| Man Group plc 0.09% of their portfolio | 806.1k $41.9m | Added +739.8k |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 715.5k $37.2m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 707.4k $36.8m | Added +221.0k |
| EMERALD ADVISERS, LLC 1.34% of their portfolio | 699.9k $36.4m | Added +168.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.05% of their portfolio | 675.2k $35.1m | Added +58.7k |
| Erste Asset Management GmbH 0.28% of their portfolio | 638.6k $33.2m | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio | 632.6k $32.9m | Added +54.3k |
| Railway Pension Investments Ltd 0.46% of their portfolio | 620.9k $32.3m | Unchanged |
| Polar Asset Management Partners Inc. 0.75% of their portfolio | 577.8k $30.1m | Added +52.1k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 566.4k $29.5m | Added +346.3k |
| Balyasny Asset Management L.P. 0.07% of their portfolio | 564.3k $29.4m | Reduced -274.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 549.6k $28.6m | Reduced -396.2k |
| GROUPAMA ASSET MANAGMENT 0.01% of their portfolio | 500.0k $576.1k | New |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 494.9k $25.8m | Added +331.8k |
| Nuveen, LLC 0.01% of their portfolio | 446.6k $23.2m | Added +371.8k |
| MPM BIOIMPACT LLC 3.99% of their portfolio | 442.7k $23.0m | Unchanged |
| Blue Water Life Science Advisors, LP 18.09% of their portfolio | 439.0k $22.8m | Reduced -255.0k |
| EMERALD MUTUAL FUND ADVISERS TRUST 1.32% of their portfolio | 415.8k $21.6m | Added +88.5k |
| BARCLAYS PLC 0.01% of their portfolio | 396.0k $20.6m | Added +152.6k |
| Granite Investment Partners, LLC 0.98% of their portfolio | 386.9k $20.1m | Reduced -32.1k |
| Trexquant Investment LP 0.22% of their portfolio | 376.7k $19.6m | Added +196.3k |
| FRED ALGER MANAGEMENT, LLC 0.09% of their portfolio | 373.7k $19.4m | Reduced -83.9k |
| Cubist Systematic Strategies, LLC 0.19% of their portfolio | 329.3k $17.1m | Added +269.6k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 318.4k $16.2m | Reduced -38.3k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 318.1k $16.6m | Reduced -428.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 307.3k $16.0m | Reduced -539.4k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 305.6k $15.9m | Reduced -170.9k |
| First Turn Management, LLC 2.93% of their portfolio | 302.3k $15.7m | Reduced -13.4k |
| Iron Triangle Partners LP 2.47% of their portfolio | 300.0k $15.6m | Reduced -300.9k |
| Engineers Gate Manager LP 0.18% of their portfolio | 277.6k $14.4m | Added +33.2k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 262.5k $13.7m | Reduced -235.6k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 254.2k $13.2m | Reduced -65.2k |
| Hood River Capital Management LLC 0.18% of their portfolio | 245.7k $12.8m | Added +9.6k |
| PRUDENTIAL FINANCIAL INC 0.02% of their portfolio | 245.6k $12.8m | Reduced -8.8k |
| OSTERWEIS CAPITAL MANAGEMENT INC 0.60% of their portfolio | 240.3k $12.5m | Reduced -56.3k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 232.6k $12.1m | Added +169.1k |
| Swiss National Bank 0.01% of their portfolio | 212.1k $11.0m | Reduced -27.2k |
| Eagle Health Investments LP 2.72% of their portfolio | 212.0k $11.0m | New |
| Rathbones Group PLC 0.05% of their portfolio | 206.0k $10.7m | Added +3.8k |
| Nicholas Investment Partners, LP 0.94% of their portfolio | 203.0k $10.6m | Reduced -31.6k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 202.2k $10.5m | Reduced -12.0k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 195.2k $10.2m | Added +39.0k |
| SEGALL BRYANT & HAMILL, LLC 0.14% of their portfolio | 193.3k $10.1m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 193.3k $10.1m | Added +17.1k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 184.7k $9.6m | Added +9.3k |
| Mitsubishi UFJ Trust & Banking Corp 0.02% of their portfolio | 183.4k $9.5m | Reduced -86.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 183.4k $9.5m | Reduced -12.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 173.4k $9.0m | Reduced -877.4k |
| Aberdeen Group plc 0.02% of their portfolio | 173.3k $9.0m | Reduced -79.7k |
| Candriam S.C.A. 0.05% of their portfolio | 170.5k $8.9m | Reduced -2.4k |
| Sicart Associates LLC 3.01% of their portfolio | 165.5k $8.6m | Added +27.9k |
| TD Asset Management Inc 0.01% of their portfolio | 162.6k $8.5m | Added +118.9k |
| Allianz Asset Management GmbH 0.01% of their portfolio | 159.3k $8.3m | Added +14.7k |
| Legal & General Group Plc 0.00% of their portfolio | 158.1k $8.2m | Reduced -12.1k |
| Aquatic Capital Management LLC 0.16% of their portfolio | 156.0k $8.1m | Added +13.0k |
| California Public Employees Retirement System 0.01% of their portfolio | 151.7k $7.9m | Reduced -8.0k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.06% of their portfolio | 148.3k $7.7m | Reduced -4.7k |
| Cerity Partners LLC 0.01% of their portfolio | 144.4k $7.5m | Reduced -1.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 140.3k $7.3m | Added +388 |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 139.0k $7.2m | Reduced -311.5k |
| Hillsdale Investment Management Inc. 0.26% of their portfolio | 136.1k $7.1m | New |
| First Light Asset Management, LLC 0.87% of their portfolio | 128.9k $6.7m | Reduced -142.2k |