GRAIL INC GRAL
COM · Common Stock · CUSIP 384747101 · ISIN US3847471014
American biotechnology and pharmaceutical company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($347.1k this quarter). Holder counts are more reliable. Shares outstanding: 41.0m as of 2026-03-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $51.69. Options: 15 managers hold calls ($65.2m notional), 12 hold puts ($67.9m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2024 | 2 |
| Q2 2024 | 371 |
| Q3 2024 | 314 |
| Q4 2024 | 334 |
| Q1 2025 | 317 |
| Q2 2025 | 346 |
| Q3 2025 | 349 |
| Q4 2025 | 426 |
| Q1 2026 | 367 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 365 | 1 |
| Q3 2024 | 136 | 256 |
| Q4 2024 | 124 | 133 |
| Q1 2025 | 124 | 148 |
| Q2 2025 | 166 | 116 |
| Q3 2025 | 134 | 162 |
| Q4 2025 | 216 | 136 |
| Q1 2026 | 140 | 209 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $99.3m | $42.3m | 0.43 |
| Q3 2025 | $97.7m | $22.9m | 0.23 |
| Q4 2025 | $159.6m | $54.2m | 0.34 |
| Q1 2026 | $65.2m | $67.9m | 1.04 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +1.9m |
| Sessa Capital IM, L.P. | Added | +1.4m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +911.0k |
| Deep Track Capital, LP | Added | +700.0k |
| Jefferies Financial Group Inc. | New | +657.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +286.5k |
| CITIGROUP INC | Added | +234.6k |
| Casdin Capital, LLC | New | +230.0k |
| BANK OF AMERICA CORP /DE/ | Added | +205.6k |
| Alyeska Investment Group, L.P. | Added | +203.0k |
Biggest sellers
| CRCM LP | Sold out | -1.1m |
| PERCEPTIVE ADVISORS LLC | Sold out | -237.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -166.6k |
| BIT Capital GmbH | Sold out | -156.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Sold out | -152.6k |
| T. Rowe Price Investment Management, Inc. | Sold out | -119.4k |
| FMR LLC | Reduced | -106.9k |
| Blue Water Life Science Advisors, LP | Sold out | -99.0k |
| Allianz Asset Management GmbH | Reduced | -84.5k |
| BARCLAYS PLC | Reduced | -64.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $24.0m463.8k shares |
| CITADEL ADVISORS LLC | Added | $10.4m201.7k shares |
| JANE STREET GROUP, LLC | Reduced | $9.9m191.8k shares |
| GROUP ONE TRADING LLC | Reduced | $7.3m140.9k shares |
| IMC-Chicago, LLC | Added | $4.3m83.6k shares |
| Centiva Capital, LP | New | $2.6m50.0k shares |
| BNP PARIBAS FINANCIAL MARKETS | New | $2.3m450 shares |
| SIMPLEX TRADING, LLC | Reduced | $1.3m26.1k shares |
| PEAK6 LLC | Reduced | $1.1m20.9k shares |
| UBS Group AG | Unchanged | $584.0k11.3k shares |
Biggest puts
| Jefferies Financial Group Inc. | New | $33.6m650.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $17.5m337.8k shares |
| CITADEL ADVISORS LLC | Reduced | $3.2m61.4k shares |
| JANE STREET GROUP, LLC | Reduced | $3.0m57.5k shares |
| BNP PARIBAS FINANCIAL MARKETS | New | $2.8m550 shares |
| IMC-Chicago, LLC | Added | $2.8m54.1k shares |
| D. E. Shaw & Co., Inc. | Reduced | $2.3m45.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.3m24.6k shares |
| HRT FINANCIAL LP | New | $485.0k9.4k shares |
| TUDOR INVESTMENT CORP ET AL | Unchanged | $480.6k9.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BAKER BROS. ADVISORS LP 13G · institution +4.5 pts · filed 2026-05-15 | 9.8% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 9.6% |
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-07-28 | 7.9% |
| Farallon Capital Partners, L.P. 13G · passive investor +1.9 pts · filed 2026-05-11 | 7.8% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.6% |
| PRIMECAP MANAGEMENT CO/CA/ 13G · institution +0.4 pts · filed 2026-08-06 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), ILLUMINA, INC. (3.2%, 2026-02-17)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 2 | $1.5m | — |
| Q4 2024 | 0 | — | 2 | $2.2m | — |
| Q1 2025 | 0 | — | 3 | $445.1k | — |
| Q2 2025 | 0 | — | 3 | $7.1m | $914.0k |
| Q3 2025 | 0 | — | 2 | $474.1k | $311.4k |
| Q4 2025 | 0 | — | 3 | $15.1m | $1.8m |
| Q1 2026 | 0 | — | 3 | $4.0m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-09 | RAGUSA ROBERT P Chief Executive Officer, director | Sold | $357.3k7.5k shares |
| 2026-03-09 | Ofman Joshua J. President | Sold | $140.7k2.9k shares |
| 2026-03-09 | Freidin Aaron Chief Financial Officer | Sold | $119.3k2.5k shares |
| 2026-03-05 | RAGUSA ROBERT P Chief Executive Officer, director | Sold | $51.9k980 shares |
| 2026-03-05 | Ofman Joshua J. President | Sold | $36.6k690 shares |
| 2026-03-05 | Freidin Aaron Chief Financial Officer | Sold | $34.7k655 shares |
| 2026-03-02 | RAGUSA ROBERT P Chief Executive Officer, director | Sold | $1.9m37.5k shares |
| 2026-03-02 | Ofman Joshua J. President | Sold | $852.9k17.0k shares |
| 2026-03-02 | Freidin Aaron Chief Financial Officer | Sold | $480.3k9.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 1.20% of their portfolio | 4.0m $208.2m | Added +1.9m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 1.00% of their portfolio | 3.3m $168.2m | Added +911.0k |
| BlackRock, Inc. 0.00% of their portfolio | 3.0m $153.4m | Added +10.3k |
| STATE STREET CORP 0.00% of their portfolio | 1.9m $97.8m | Added +64.4k |
| PRIMECAP MANAGEMENT CO/CA/ 0.08% of their portfolio | 1.8m $95.3m | Added +5.1k |
| Deep Track Capital, LP 1.84% of their portfolio | 1.7m $89.0m | Added +700.0k |
| Sessa Capital IM, L.P. 1.69% of their portfolio | 1.7m $88.9m | Added +1.4m |
| MORGAN STANLEY 0.01% of their portfolio | 1.6m $84.4m | Added +120.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.5m $78.9m | First filing |
| Arbiter Partners Capital Management LLC 36.27% of their portfolio | 1.0m $53.5m | Reduced -1.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 914.1k $47.2m | Added +205.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 827.9k $42.8m | Added +26.4k |
| Jefferies Financial Group Inc. 0.41% of their portfolio | 657.5k $34.0m | New |
| Alyeska Investment Group, L.P. 0.09% of their portfolio | 645.5k $33.4m | Added +203.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 581.9k $30.1m | Added +44.9k |
| RA CAPITAL MANAGEMENT, L.P. 0.23% of their portfolio | 428.3k $22.1m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 408.6k $21.1m | Added +191.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 349.1k $18.0m | Added +7.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 334.9k $17.3m | First filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 304.8k $15.8m | Added +286.5k |
| CITIGROUP INC 0.01% of their portfolio | 302.1k $15.6m | Added +234.6k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 292.1k $15.1m | Added +33.3k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 292.0k $14.6m | Reduced -34.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 270.0k $14.0m | Reduced -874 |
| Casdin Capital, LLC 0.90% of their portfolio | 230.0k $11.9m | New |
| Slow Capital, Inc. 1.53% of their portfolio | 228.3k $11.8m | Added +65.8k |
| Aberdeen Group plc 0.02% of their portfolio | 217.4k $11.2m | Added +92.5k |
| Carnegie Investment Counsel 0.22% of their portfolio | 217.1k $11.2m | Added +4.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 201.2k $10.4m | First filing |
| NATIXIS 0.04% of their portfolio | 199.4k $10.3m | New |
| TCW GROUP INC 0.07% of their portfolio | 191.3k $9.9m | Reduced -6.0k |
| UBS Group AG 0.00% of their portfolio | 185.4k $9.6m | Reduced -27.8k |
| Allianz Asset Management GmbH 0.01% of their portfolio | 183.1k $9.5m | Reduced -84.5k |
| Douglas Lane & Associates, LLC 0.12% of their portfolio | 161.5k $8.3m | Reduced -100 |
| Newtyn Management, LLC 0.83% of their portfolio | 150.0k $7.8m | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 148.8k $7.7m | Added +129.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 148.0k $7.6m | Added +1.9k |
| Voleon Capital Management LP 0.16% of their portfolio | 145.0k $7.5m | Reduced -3.0k |
| BRAIDWELL LP 0.25% of their portfolio | 142.8k $7.4m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 133.9k $6.9m | Reduced -1.9k |
| CAPITAL FUND MANAGEMENT S.A. 0.06% of their portfolio | 132.9k $6.9m | Added +19.7k |
| Invesco Ltd. 0.00% of their portfolio | 129.0k $6.7m | Reduced -9.0k |
| 180 WEALTH ADVISORS, LLC 0.75% of their portfolio | 127.3k $6.6m | Added +12.3k |
| Reynders McVeigh Capital Management, LLC 0.31% of their portfolio | 119.1k $6.2m | Added +6.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 116.8k $5.5m | Reduced -24.6k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 112.1k $5.8m | Added +3.8k |
| Nuveen, LLC 0.00% of their portfolio | 108.0k $5.6m | Added +37.1k |
| WIM INVESTMENT MANAGEMENT Ltd 1.63% of their portfolio | 106.4k $5.5m | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 90.6k $4.7m | Added +9.1k |
| Legal & General Group Plc 0.00% of their portfolio | 86.2k $4.5m | Added +17.8k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 81.6k $4.2m | Added +41.3k |
| Swiss National Bank 0.00% of their portfolio | 69.4k $3.6m | Reduced -2.9k |
| GAMCO INVESTORS, INC. ET AL 0.03% of their portfolio | 66.8k $3.5m | Added +42.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 64.7k $3.3m | Reduced -36.8k |
| BARCLAYS PLC 0.00% of their portfolio | 61.3k $3.2m | Reduced -64.3k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 59.9k $3.1m | Added +39.7k |
| Rockefeller Capital Management L.P. 0.01% of their portfolio | 59.0k $3.1m | Reduced -9.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 58.1k $3.0m | Added +20.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 57.0k $2.9m | Reduced -4.6k |
| FMR LLC 0.00% of their portfolio | 56.3k $2.9m | Reduced -106.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 55.4k $2.9m | Reduced -5.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 55.2k $2.9m | Reduced -30.1k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 53.3k $2.5m | Added +12.4k |
| Man Group plc 0.01% of their portfolio | 51.1k $2.6m | Added +35.8k |
| Aquatic Capital Management LLC 0.07% of their portfolio | 50.4k $2.6m | New |
| Granahan Investment Management, LLC 0.12% of their portfolio | 49.6k $2.6m | Reduced -880 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 46.5k $2.4m | Reduced -600 |
| Legal Advantage Investments, Inc. 1.19% of their portfolio | 44.5k $2.3m | Added +11.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 44.5k $2.3m | Added +9.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 44.2k $2.3m | Reduced -166.6k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 43.8k $2.3m | Reduced -10.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 39.8k $2.1m | New |
| Legato Capital Management LLC 0.19% of their portfolio | 39.4k $2.0m | Added +26.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 39.2k $2.0m | Added +29.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 38.7k $2.0m | Reduced -26.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 38.3k $3.3m | Reduced -72 |
| LPL Financial LLC 0.00% of their portfolio | 36.4k $1.9m | Added +441 |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 34.8k $1.8m | Added +9.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 33.9k $1.8m | Reduced -33.5k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 33.8k $1.7m | Reduced -3.6k |
| Jackson Hole Capital Partners, LLC 0.28% of their portfolio | 33.0k $1.7m | Unchanged |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 31.8k $1.7m | Added +877 |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 31.5k $1.6m | Added +3.0k |
| GABELLI FUNDS LLC 0.01% of their portfolio | 30.3k $1.6m | Reduced -1.4k |
| Summit Financial, LLC 0.02% of their portfolio | 30.3k $1.6m | Added +19.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 30.2k $1.6m | Added +1.7k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 27.9k $1.4m | Reduced -1.3k |
| VAN ECK ASSOCIATES CORP 0.00% of their portfolio | 27.8k $1.4m | Added +278 |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 27.3k $1.4m | Added +21.6k |
| COMMERCE BANK 0.01% of their portfolio | 27.1k $1.4m | Added +185 |
| Gem Investment Advisors, LLC 1.36% of their portfolio | 26.8k $1.4m | Reduced -54.9k |
| PVG ASSET MANAGEMENT CORP 0.92% of their portfolio | 25.9k $1.5m | Added +16.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 24.8k $1.3m | Added +17.9k |
| PROFUND ADVISORS LLC 0.05% of their portfolio | 24.8k $1.3m | Added +2.0k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 24.0k $1.2m | First filing |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 22.5k $1.2m | Reduced -481 |
| IMC-Chicago, LLC 0.02% of their portfolio | 22.0k $1.1m | Added +7.0k |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 21.0k $1.0m | Added +12.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 20.4k $1.0m | Added +533 |
| Gotham Asset Management, LLC 0.00% of their portfolio | 20.0k $1.0m | Reduced -3.3k |