GRAIL INC GRAL
COM · Common Stock · CUSIP 384747101 · ISIN US3847471014
American biotechnology and pharmaceutical company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($966.1k this quarter). Holder counts are more reliable. Shares outstanding: 39.0m as of 2025-11-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $59.13. Options: 15 managers hold calls ($97.7m notional), 12 hold puts ($22.9m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2024 | 2 |
| Q2 2024 | 371 |
| Q3 2024 | 314 |
| Q4 2024 | 334 |
| Q1 2025 | 317 |
| Q2 2025 | 346 |
| Q3 2025 | 349 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 365 | 1 |
| Q3 2024 | 136 | 256 |
| Q4 2024 | 124 | 133 |
| Q1 2025 | 124 | 148 |
| Q2 2025 | 166 | 116 |
| Q3 2025 | 134 | 162 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $9.3m | $4.5m | 0.48 |
| Q1 2025 | $21.0m | $11.0m | 0.52 |
| Q2 2025 | $99.3m | $42.3m | 0.43 |
| Q3 2025 | $97.7m | $22.9m | 0.23 |
Biggest buyers
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +847.0k |
| JPMORGAN CHASE & CO | Added | +332.7k |
| GOLDMAN SACHS GROUP INC | Added | +292.5k |
| MORGAN STANLEY | Added | +284.9k |
| BANK OF AMERICA CORP /DE/ | Added | +183.6k |
| Allianz Asset Management GmbH | Added | +175.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Added | +158.9k |
| Catalio Capital Management, LP | New | +137.9k |
| CAPITAL FUND MANAGEMENT S.A. | Added | +131.6k |
| UBS Group AG | Added | +126.7k |
Biggest sellers
| CRCM LP | Reduced | -1.8m |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -908.0k |
| One Fin Capital Management LP | Reduced | -320.0k |
| Bank of New York Mellon Corp | Reduced | -220.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -130.3k |
| Rockefeller Capital Management L.P. | Reduced | -130.1k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -106.8k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -106.6k |
| D. E. Shaw & Co., Inc. | Reduced | -96.4k |
| VANGUARD GROUP INC | Reduced | -85.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $37.8m639.6k shares |
| JANE STREET GROUP, LLC | Reduced | $12.5m210.7k shares |
| CITADEL ADVISORS LLC | Reduced | $8.4m142.1k shares |
| GROUP ONE TRADING LLC | Added | $6.9m116.0k shares |
| IMC-Chicago, LLC | Reduced | $6.4m108.7k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $6.4m108.2k shares |
| D. E. Shaw & Co., Inc. | Added | $4.8m81.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.8m64.7k shares |
| PEAK6 LLC | New | $3.0m51.0k shares |
| Walleye Capital LLC | Added | $2.4m41.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $7.8m131.2k shares |
| CITADEL ADVISORS LLC | Reduced | $3.3m56.6k shares |
| IMC-Chicago, LLC | Added | $2.8m46.9k shares |
| JANE STREET GROUP, LLC | Added | $2.0m33.7k shares |
| Walleye Capital LLC | Reduced | $1.7m28.5k shares |
| GROUP ONE TRADING LLC | Reduced | $1.3m22.6k shares |
| SYMMETRY PEAK MANAGEMENT LLC | New | $1.2m19.5k shares |
| Walleye Trading LLC | Reduced | $1.0m17.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $656.0k11.1k shares |
| CANTOR FITZGERALD, L. P. | New | $591.3k10.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BAKER BROS. ADVISORS LP 13G · institution +4.5 pts · filed 2026-05-15 | 9.8% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 9.6% |
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-07-28 | 7.9% |
| Farallon Capital Partners, L.P. 13G · passive investor +1.9 pts · filed 2026-05-11 | 7.8% |
| STATE STREET CORP 13G · institution new · filed 2026-08-07 | 5.6% |
| PRIMECAP MANAGEMENT CO/CA/ 13G · institution +0.4 pts · filed 2026-08-06 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), ILLUMINA, INC. (3.2%, 2026-02-17)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 2 | $1.5m | — |
| Q4 2024 | 0 | — | 2 | $2.2m | — |
| Q1 2025 | 0 | — | 3 | $445.1k | — |
| Q2 2025 | 0 | — | 3 | $7.1m | $914.0k |
| Q3 2025 | 0 | — | 2 | $474.1k | $311.4k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-08-19 | Ofman Joshua J. President | Sold | $134.5k4.2k shares |
| 2025-08-19 | Freidin Aaron Chief Financial Officer | Sold | $28.1k877 shares |
| 2025-07-15 | Freidin Aaron Chief Financial Officer | Sold plan | $311.4k8.0k shares |
| 2025-07-01 | DING CHUN R 10% owner · See Footnotes | Sold | $16.8m339.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 2.5m $145.7m | Added +16.9k |
| PRIMECAP MANAGEMENT CO/CA/ 0.09% of their portfolio | 2.0m $119.5m | Reduced -33.3k |
| CRCM LP 31.52% of their portfolio | 1.8m $109.0m | Reduced -1.8m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.8m $107.4m | Reduced -85.4k |
| BAKER BROS. ADVISORS LP 0.70% of their portfolio | 1.6m $96.4m | Unchanged |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.45% of their portfolio | 1.3m $79.8m | Added +847.0k |
| STATE STREET CORP 0.00% of their portfolio | 1.3m $77.9m | Added +69.5k |
| Arbiter Partners Capital Management LLC 41.99% of their portfolio | 1.0m $61.3m | Reduced -2.0k |
| MORGAN STANLEY 0.00% of their portfolio | 923.0k $54.6m | Added +284.9k |
| Sessa Capital IM, L.P. 1.17% of their portfolio | 786.1k $46.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 730.2k $43.2m | Reduced -27.5k |
| AQR CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 422.7k $24.3m | Reduced -908.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 412.2k $24.4m | Added +332.7k |
| One Fin Capital Management LP 7.90% of their portfolio | 380.0k $22.5m | Reduced -320.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 365.0k $21.6m | Added +292.5k |
| UBS Group AG 0.00% of their portfolio | 360.5k $21.3m | Added +126.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 340.5k $20.1m | Reduced -1.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 335.4k $19.8m | Added +183.6k |
| Allianz Asset Management GmbH 0.02% of their portfolio | 294.8k $17.4m | Added +175.0k |
| Aberdeen Group plc 0.03% of their portfolio | 269.4k $15.9m | Added +59.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 251.5k $14.9m | Added +158.9k |
| Carnegie Investment Counsel 0.27% of their portfolio | 245.3k $14.5m | Added +79.6k |
| TCW GROUP INC 0.12% of their portfolio | 233.2k $13.8m | Reduced -17.6k |
| Newtyn Management, LLC 1.45% of their portfolio | 200.0k $11.8m | Unchanged |
| CAPITAL FUND MANAGEMENT S.A. 0.10% of their portfolio | 175.2k $10.4m | Added +131.6k |
| Douglas Lane & Associates, LLC 0.14% of their portfolio | 168.3k $10.0m | Reduced -330 |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 160.2k $9.5m | Reduced -7.2k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 152.6k $9.0m | Reduced -130.3k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.01% of their portfolio | 150.3k $8.9m | Reduced -37.2k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 147.0k $8.7m | Reduced -106.6k |
| Slow Capital, Inc. 1.00% of their portfolio | 143.8k $8.5m | Added +1.0k |
| Catalio Capital Management, LP 1.51% of their portfolio | 137.9k $8.2m | New |
| Invesco Ltd. 0.00% of their portfolio | 136.5k $8.1m | Reduced -82.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 130.9k $7.7m | Reduced -220.1k |
| Reynders McVeigh Capital Management, LLC 0.33% of their portfolio | 120.6k $7.1m | Added +12.3k |
| 180 WEALTH ADVISORS, LLC 0.86% of their portfolio | 118.9k $7.0m | Added +5.3k |
| Squarepoint Ops LLC 0.01% of their portfolio | 112.3k $6.6m | New |
| FMR LLC 0.00% of their portfolio | 108.8k $6.4m | Added +81.3k |
| Pier Capital, LLC 0.98% of their portfolio | 105.6k $6.2m | Reduced -2.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 103.1k $6.1m | Reduced -50.4k |
| BARCLAYS PLC 0.00% of their portfolio | 94.0k $5.6m | Reduced -14.3k |
| Nuveen, LLC 0.00% of their portfolio | 67.6k $4.0m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 67.0k $4.0m | Added +6.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 67.0k $4.0m | Reduced -50.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 66.4k $3.9m | Added +30.2k |
| WIM INVESTMENT MANAGEMENT Ltd 0.95% of their portfolio | 63.0k $3.7m | Added +42.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 61.7k $3.6m | Reduced -81.6k |
| Voleon Capital Management LP 0.09% of their portfolio | 61.6k $3.6m | New |
| Swiss National Bank 0.00% of their portfolio | 59.3k $3.5m | Reduced -1.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 59.1k $3.5m | Reduced -39.6k |
| Rockefeller Capital Management L.P. 0.01% of their portfolio | 58.0k $3.4m | Reduced -130.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 54.2k $3.2m | Added +24.9k |
| CITIGROUP INC 0.00% of their portfolio | 49.7k $2.9m | Reduced -15.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 48.5k $2.9m | Reduced -849 |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 48.3k $2.9m | Added +13.8k |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 47.2k $2.8m | Reduced -13.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 46.6k $2.8m | Reduced -1.3k |
| LPL Financial LLC 0.00% of their portfolio | 46.1k $2.7m | Added +21.7k |
| WESBANCO BANK INC 0.07% of their portfolio | 44.5k $2.6m | Unchanged |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 43.0k $2.5m | Added +2.0k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 39.5k $2.3m | Reduced -96.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 36.6k $2.2m | Reduced -81 |
| GABELLI FUNDS LLC 0.01% of their portfolio | 34.5k $2.0m | Reduced -216 |
| Jackson Hole Capital Partners, LLC 0.33% of their portfolio | 33.0k $2.0m | Unchanged |
| Gotham Asset Management, LLC 0.01% of their portfolio | 32.4k $1.9m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 31.7k $1.9m | Added +2.3k |
| Verition Fund Management LLC 0.01% of their portfolio | 31.0k $1.8m | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 30.6k $1.9m | Reduced -3.6k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 30.3k $1.1m | Added +21.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 29.6k $1.8m | Added +2 |
| Mutual Advisors, LLC 0.05% of their portfolio | 29.6k $2.4m | New |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 29.5k $1.7m | Reduced -27.4k |
| Sheets Smith Investment Management 1.10% of their portfolio | 28.6k $1.7m | New |
| COMMERCE BANK 0.01% of their portfolio | 28.5k $1.7m | Added +9.3k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 27.9k $1.7m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 26.8k $1.6m | Reduced -8.4k |
| VAN ECK ASSOCIATES CORP 0.00% of their portfolio | 26.8k $1.6m | Added +268 |
| GAMCO INVESTORS, INC. ET AL 0.01% of their portfolio | 24.2k $1.4m | Reduced -5.5k |
| Trifecta Capital Advisors, LLC 0.19% of their portfolio | 21.6k $1.3m | Added +10.2k |
| CLOUGH CAPITAL PARTNERS L P 0.11% of their portfolio | 21.3k $1.3m | Added +4.7k |
| Legal Advantage Investments, Inc. 0.56% of their portfolio | 21.0k $1.2m | New |
| NWF Advisory Services Inc. 0.13% of their portfolio | 20.5k $1.2m | Reduced -150 |
| NWAM LLC 0.10% of their portfolio | 19.7k $1.8m | Reduced -914 |
| Cetera Investment Advisers 0.00% of their portfolio | 19.4k $1.1m | Added +3.7k |
| Perigon Wealth Management, LLC 0.02% of their portfolio | 19.3k $1.1m | Added +1.6k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 19.3k $1.1m | Added +7.6k |
| Quantinno Capital Management LP 0.00% of their portfolio | 18.6k $1.1m | Reduced -377 |
| MetLife Investment Management, LLC 0.01% of their portfolio | 18.4k $1.1m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 18.0k $1.1m | Reduced -295 |
| GILDER GAGNON HOWE & CO LLC 0.01% of their portfolio | 17.5k $1.0m | Added +5.0k |
| POLEN CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 16.7k $985.9k | Reduced -5.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 16.6k $983.1k | Reduced -2.1k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 16.5k $975.7k | Reduced -27.5k |
| HighTower Advisors, LLC 0.00% of their portfolio | 16.3k $966.5k | Added +1.5k |
| EXCHANGE TRADED CONCEPTS, LLC 0.01% of their portfolio | 16.2k $960.7k | Added +2.2k |
| Moloney Securities Asset Management, LLC 0.11% of their portfolio | 16.2k $958.9k | Reduced -23.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 15.8k $931.7k | Added +10.7k |
| Gladstone Institutional Advisory LLC 0.04% of their portfolio | 15.5k $918.5k | Added +937 |
| Mariner, LLC 0.00% of their portfolio | 15.5k $916.7k | Reduced -805 |
| Marex Group Ltd 0.01% of their portfolio | 15.0k $887.0k | Added +9.9k |